Lakshmi Dave

Ministry for Primary Industries

Advancing sustainable diets for nutrition security and sustainable development necessitates clear nutrition metrics for measuring nutritional quality of diets. Food composition, nutrient requirements, and dietary intake are among the most common nutrition metrics used in the current assessment of sustainable diets. Broadly, most studies in the area...

Dietary transitions, such as eliminating meat consumption, have been proposed as one way to reduce the climate impact of the global and regional food systems. However, it should be ensured that replacement diets are, indeed, nutritious and that climate benefits are accurately accounted for. This study uses New Zealand food consumption as a case stu...

Food insecurity and non-communicable diseases (NCDs) are arguably two of the most pressing concerns of our times. Globally, 820 million people face chronic hunger and over 2 billion suffer from one or more forms of micronutrient deficiencies (hidden hunger). Based on a detailed analysis of multiple factors responsible for food insecurity and its nu...

It is well known that endogenous bioactive proteins and peptides play a substantial role in the body's first line of immunological defence, immune-regulation and normal body functioning. Further, the peptides derived from the luminal digestion of proteins are also important for body function. For example, within the peptide database BIOPEP (http://...

The authors would like to make the following corrections about the published paper [...]

Background Increasing attention is being directed at the environmental, social, and economic sustainability of the global food system. However, a key aspect of a sustainable food system should be its ability to deliver nutrition to the global population. Quantifying nutrient adequacy with current tools is challenging. Objective To produce a comput...

Objectives While the environmental, social and economic sustainability of the current global food system attracts increasing research, its ability to nourish the global population must be prioritised. Our objective was to produce a computational model illustrating the nutritional adequacy of the current global food system and allow investigation of...

Background Recent in silico and in vitro studies have shown that gastrointestinal endogenous proteins (GEP) are a source of bioactive peptides. To date, however, the presence of such peptides in the lumen of the digestive tract has not been demonstrated. Objective We investigated the generation of GEP-derived bioactive peptides in the growing pig...

Human gastrointestinal endogenous proteins (GEP) including digestive enzymes, hormones, mucins, serum albumin, and proteins from sloughed-off epithelial cells and bacterial cells are a consistent source of proteins in the human gastrointestinal tract. Their potential role as a cryptomic, exogenous source of bioactive peptides has only recently been...

This chapter will familiarise the reader with: • Gastrointestinal endogenous proteins • An emerging paradigm in the area of dietary and gut endogenous protein‐derived bioactive peptides • The current knowledge on gut endogenous protein‐derived peptides • The implications of simultaneous generation of both dietary protein‐ and gut endogenous protei...

Human gastrointestinal endogenous proteins (GEP) include the proteins mucins, serum albumin, digestive enzymes, and proteins from sloughed epithelial and microbial-cells. GEP play a vital role in the digestion of food, but are also simultaneously digested by proteases and peptidases of the gastrointestinal tract (GIT). Recent studies suggest that d...

A recently proposed paradigm suggests that, like their dietary counterparts, digestion of gastrointestinal endogenous proteins (GEP) may also produce bioactive peptides. With an aim to test this hypothesis, in vitro digests of four GEP namely; trypsin (TRYP), lysozyme (LYS), mucin (MUC), serum albumin (SA) and a dietary protein chicken albumin (CA)...

Dietary proteins are known to contain bioactive peptides that are released during digestion. Endogenous proteins secreted into the gastrointestinal tract represent a quantitatively greater supply of protein to the gut lumen than those of dietary origin. Many of these endogenous proteins are digested in the gastrointestinal tract but the possibility...

Food-derived bioactive peptides are regarded as important modulators of several physiological processes occurring both systemically and locally within the gastrointestinal tract (GIT). However, the concentrations of food-derived bioactive peptides in the GIT, and therefore attendant physiological effects, are likely to be highly variable given the...

A number of dietary proteins are known to be sources of bioactive peptides which are released during gastrointestinal digestion. Interestingly, the quantity of endogenous protein excreted into the gastrointestinal tract is significantly higher than that of dietary origin. These endogenous proteins are also digested and absorbed in the gastrointesti...