Lakshmanan Govindan

• Doctor of Philosophy
• Researcher at University of Madras

The fibula, situated laterally in the leg, receives vital nutrition through nutrient arteries during embryonic bone growth and early ossification. This study aims to assess the direction, distance, location, number, and foraminal index of nutrient foramina in dry fibulae from the South Indian population. A descriptive cross-sectional analysis invol...

Background/Objectives: Phloroglucinol (PHL), a phenolic compound extracted from the brown alga Rosenvingea intricata, exhibits potent antioxidant and anticancer properties. This study aims to extract, purify, and characterize PHL, and further develop functionalized zinc oxide nanoparticles (ZnO NPs) loaded with PHL to enhance its therapeutic potent...

The current study aims to investigate the rat hepatotoxicity caused by acetaminophen (APAP) which is the main factor for drug-induced liver failure. Although the precise mode with which APAP damages the liver is unknown, recent research has demonstrated that the enzyme cytochrome P450 is affected, resulting in increased metabolite production result...

Calotropis procera produces a latex used in traditional medicine because of its components which are found to be biologically active. The latex of C. procera has many benefits such as pain reduction, antimicrobial attitude and other precious attributes. Latex lysozyme (LL) is a particular protein contained in C. procera plant having a promising ant...

The present study analyzes the efficacy of the ethanolic extract of C. papaya leaves (ECP) against HgCl2-induced nephrotoxicity. The effects on the biochemical and percentage of body and organ weight against HgCl2-induced nephrotoxicity in female Wistar rats were studied. Wistar rats were divided into five groups with six animals in each group: con...

Cleome viscosa L., a member of the family Cleomaceae, is a potential medicinal plant, known for several bioactive properties such as: anticancer, antidiabetic, antioxidant, anti-inflammatory, antimi-crobial, wound healing, etc. Our study aimed to isolate a bioactive compound and assess its antibacterial activity. The crystal compound imperatorin wa...

The synthesis of metal nanoparticles (Mt NPs) using fungi as the reducing agent has economic and environmental benefits because of the increased yield and reduced eco-toxicity over chemical synthesis. The fast-growing fungi can be cultivated under controlled conditions to produce bioactive secondary molecules, enzymes, and proteins that facilitate...

Orthosiphon diffuses (Lamiaceae) is one of those plants which have tremendous value with respect to the chemical constituents and pharmacological properties. So, in the current paper, the plant had been reviewed for its traditional claims, pharmacological activities and chemistry hoping for the future research on the plant. The methanol extract of...

Antibacterial compounds from aquatic sources have the potential to contribute significantly to the treatment of the ever-increasing drug-resistant infectious diseases. The chitin 2-acetamido-2-deoxy-hexopyranose from the freshwater prawn Caridina gracilirostris showed antibacterial activity against Staphylococcus aureus. Two different types of chit...

Study Objective Although laparoscopic radical hysterectomy (LRH) and robotic radical hysterectomy (RRH) are both minimally invasive procedures commonly performed for the treatment of early-stage cervical cancer, there is little high quality data on the head-to-head comparison of these two procedures. We sought to perform the largest study to date t...

Study Objective Although many studies have been performed, no consensus exists as to the ideal entry for laparoscopic gynecologic surgery. We sought out to compare the safety of direct trocar insertion with that of the Veress needle entry technique in gynecologic laparoscopic surgery. This is the largest analysis to date on this subject. Design Me...

The primary goal of this research is to examine the α-amylase inhibitory effect of phytoconstituents found in the roots of the Cyclea peltata plant. The extract will also be used to investigate the effect of root extract on α-amylase inhibition assay. The roots were gathered, processed, and extracted in petroleum ether before being kept at 4ºC. The...

In this contribution, ethanolic extracts of Cuminum cyminum (C. cyminum) seeds were evaluated in terms of phytochemical content, total phenol and flavonoid contents. As far as the analytical techniques are concerned, UV-Vis, FTIR, HPLC, NMR (1H and 13C) and ESI-MS were performed. The binding capacity of five different antidiabetic enzymes was teste...

Lemon grass is a widely cultivated plant, whose extracts are known to possess anti-cancer properties. However, studies related to the effect of different solvent extracts of lemon grass on lung cancer cell lines are scarce. This study was conducted to study the effect of various extracts on the viability of the A549 lung carcinoma cell line. Four s...

creative commons attribution noncommercial License 4.0. Which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. Abstract Anti-dandruff shampoos like synthetic or herbal are marketed to combat the problem of dandruff. To test t...

Murraya paniculata (MP) can be used as a reducing agent to produce silver nanoparticles (AgNPs) using a simple procedure. AgNPs are characterized in morphological and chemical properties, antioxidant activity, and cytotoxicity. The morphology of AgNPs derived from MP shows a face-centered cubic structure, spherical shape with an average particle si...

A 24 kDa leucine-rich protein from ion exchange fractions of Solanum trilobatum, which has anti-bacterial activity against both the Gram-negative Vibrio cholerae and Gram-positive Staphylococcus aureus bacteria has been purified. In this study, mass spectrometry analysis identified the leucine richness and found a luminal binding protein (LBP). Cir...

The intense research on marine sources have brought many potential candidates that spanning variety of industries such as in various industries, such as baking, brewing, wine, bioethanol and pharmaceutical protein production. However, only little attention has been given to marine yeasts. The present study aimed to isolate the marine soil yeasts fo...

The present study aims to evaluate the hepatoprotective activity of extract Eichhornia crassipeson carbon tetrachloride (CCl4) induced hepatoprotective in rats. The animals were daily treated with the extract ofEichhornia crassipesat a dose of 100, 200 & 400 mg/kg body weight for 21 days. Animals administrated orally with CCl4 treated with Silymari...

Silver nanoparticles play an important role in controlling mosquito population as well as multidrug resistant pathogens. An aqueous extract of Pedalium murex L. was used for the synthesis of silver (Ag) nanoparticles and its antibacterial activity. The green synthesis of nanoparticles in plants is cost-effective and eco-friendly approach. To identi...

The effect of infrared radiation (IR) on the physicochemical characteristics, pectin methylesterase activity (PME), hydroxymethylfurfural (HMF) content, microbiological activity, color, and sensory aspects on black lime juice was studied. IR was compared to conventional thermal heating (CTH) in batch infrared extraction pasteurizer, designed to all...

Medicinal plants play a pivotal role in curing various human ailments. The incidence in the frequency of diseases due to pathogenic microorganisms has increased alarmingly due to the development of resistance to existing drugs and the present scenario necessitate the continuous search for new classes of antimicrobial agents preferably from natural...

Background: Tobacco chewing and alcohol abuse are accepted as 'two-hit' hypothesis of cardiac arrest and liver disease. However, there are few research articles on identifying genes which connect lipid and glucose metabolism by liver markers enzymes. Objectives: To diagnoses of alcoholic liver disease were made based on the combination of history o...

Medicinal plants contain high levels of natural antioxidants and exhibited strong antioxidant activity. Plants contain a large variety of free radical scavenging molecules, such as flavonoids, anthocyanins, carotenoids, dietary glutathionine, and vitamins. Phenols are a main cluster of antioxidant phytochemicals with curious assets that can play a...

Abstarct: Breast cancer is the most common lethal cancer in women and the second most common among women worldwide. chemical carcinogen which interacts with membrane lipids, proteins, DNA and consequently induces free radical production. Cancer cell show various degree of differentiation, and there, normally is an inverse relation between the degre...

This work reports the synthesis of silver nanoparticles (AgNPs) using aqueous extract of Plumbago auriculata, and evaluates their antibacterial and larvicidal activities. The synthesized silver nanoparticles were characterized by various spectroscopy techniques, such as FTIR, XRD, TEM, EDX, Zeta potential, and DLS. The synthesized AgNPs exhibited s...

Medicinal plants contain various secondary metabolites. The present study analyzed the essential oil of buds from clove (Syzygium aromaticum L.; Family: Myrtaceae) using gas chromatography-mass spectrometry (GC-MS). GC-MS analysis showed the presence of six major phytoconstituents, such as eugenol (66.01%), caryophyllene (19.88%), caryophyllene oxi...

Allantoin, a crystalline compound was isolated from the methanolic extract of Cleome viscosa and it was reported for first time from this plant. The structure of Allantoin was elucidated by single crystal XRD and it was further confirmed through FTIR and ESI-MS spectroscopy techniques. It was crystallized in monoclinic crystal system with the space...

Green synthesis of silver nanoparticles was successfully done using Cleome viscosa plant extract, simple, rapid, eco-friendly and a cheaper method. In this study, we used C. viscosa extract for synthesizing silver nanoparticles which reduces silver nitrate into silver ions. The obtained AgNPs were characterized by UV, FTIR, XRD, FESEM-EDAX and TEM...

Plants are one of the potential hotspots for which the yield of high esteem bioactive intensifies that had therapeutic properties may be utilized as pharmacologically active compounds. In this study, Plumbago auriculata was refined on altered MS medium supplemented with individual and diverse mix of plant development controllers (IBA, IAA, GA3 and...

Several studies are going on worldwide directed towards finding natural antioxidants from plant origin which possess strong antioxidant activity. The aim of the present study was to find out chemical composition, radical scavenging activity and antioxidant activity of essential oil from Glycosmis pentaphylla. Essential oil was extracted from fresh...

Achyranthes aspera, L. a member of Amaranthaceae family, a small herb of great economic importance in developing countries because of its several industrial and medicinal values. Roots of Achyranthes aspera was successively extracted with hexane, dichloromethane, ethyl acetate and methanol by Soxhlet extraction then concentrated to dryness in a rot...