Lakshmana Rao Atmakuri

More than two decades has passed after the introduction of Clinical Pharmacy and Toxicology in Pharmacy Curriculum. During these periods not only new subjects but also new pharmacy courses have been introduced. Clinical Pharmacy is one of the new subject introduced in the syllabus of graduate course in Pharmacy around the beginning of 1990’s. A si...

Aim: In this chapter, the influence of selected dose of Allium sativum (84 mg/1.5 kg bd.wt) on the pharmacodynamics and pharmacokinetics of selected dose of gliclazide (5.6 mg/1.5 kg bd.wt) was studied in normal rabbits. Materials and Methods: Materials required were purchased from Sai Chemicals, Visakhapatnam, India. Inbred adult Wistar rabbits of...

Calotropis procera belongs to the family Asclepiadaceae is an herb grows throughout the tropics. It is used as antibacterial, anthelmintic and antitumo ragent. Also used in the treatment of cough, toothache, jaundice and wound healing agent in colic ulcers. The present study was aimed to evaluate the local anesthetic activity of crude chloroform ex...

Aim: To study the anticancer activity of isolated compounds from root of Coccinia grandis whole plant by SRB assay method on DU-145 and PC-3 human prostate cancer cell lines. Materials and methods: Anticancer activity of isolated constituents of Coccinia grandis was performed on SCC-29B and Ishikawa cancer cell lines by the Advanced Centre for Trea...

All around the world COVID-19 pandemic has influenced human life massively since 2019. Although many precautionary measures are followed worldwide, it is strongly believed that this vicious pandemic can be controlled only by an effective and safer vaccine. After the outbreak of COVID-19, China first initiated the vaccine development strategies and...

Pharmacology has become a broad discipline. It involves the study and description of the actions of drugs on cells, tissues and the whole body. It includes findings about drug beneficial and adverse effects. A single text book cannot adequately cover every aspect of the subject. During our interaction with students as well as those of other univers...

For the assessment of the curative effect of Manosa alliacea on Freud's adjuvant (FA) arthritis on Swiss albino rats. Methanol extract from M. alliacea (MEMA) was administered orally at 200 mg/kg and 400 mg/kg, 28 days after FA immunization. For control and treatment groups, paw volume, body weight, hematological parameters, X-ray, and histological...

Potluri et al.: Effect of Methanolic Extract of Ipomoea marginata Desr. This research was performed to analyze the antinociceptive task of methanolic extract of Ipomoea marginata in addition to in silico evaluation of the antinociceptive task of the separated constituents from Ipomoea marginata versus cyclooxygenase 2 enzyme together with absorptio...

Hydroxychloroquine (HCQ) and its derivatives have recently gained tremendous attention as a probable medicinal agent in the COVID-19 outbreak caused by SARS-CoV-2. An efficient agent to act directly in inhibiting the SARS-CoV-2 replication is yet to be achieved. Thus, the goal is to investigate the dynamic nature of HCQ derivatives against SARS-CoV...

Melissa officinalis (Lamiaceae) was used to treat multiple human afflictions. Literary works demonstrated that it has many biological activities. Today's research aims to recognise Melissa officinalis phyto-derived anti-viral compounds against main protease and spike protein of COVID-19, to gain insight into the molecular interactions. In the curre...

A sensitive and selective liquid chromatography/tandem mass spectrometry method was recommended by the authors for the determination orally bioavailable farnesoid X receptor agonist obeticholic acid along with its glycine conjugate glycoobeticholic acid human plasma. Obeticholic acid_d5 and glycoobeticholic acid_d5 were used as internal standards,...

Background: Zingiber officinale (Zingiberaceae) has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Methods: Today, research study intended to recognize the Phyto-derived anti-viral substances from Zingiber officinale against COVID-19 main protease enzyme and to underst...

Objectives: Mansoa alliacea has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our analysis work aims to distinguish phyto-derived anthelmintic substances from M. alliacea against the enzyme β-tubulin and to consider the cause of its function in the molecular basis on...

Mansoa alliacea Lam. (Family: Bignoniaceae) is a native plant from Amazonian basin in South America. Plant derivatives are used as an anti-inflammatory, anti-oxidant, antiseptic and anti-bacterial. The study was aimed to determine the pharmacognostic and phy-tochemicals present in Mansoa alliacea. Micro and Organoleptic characteristics of fresh and...

ABSRACT: Pharmaceutical waste is any waste that contains medicinal drugs that are expired, unused, contaminated damaged or no longer needed and need to be disposed appropriately. Pharmaceutical waste management is essential in order to protect the humans and environment from the hazardous compounds. We need to find out the sources of these wastes a...

3D organ models have gained attention in preclinical testing systems and in the alternative to animal testing. 3D printing is new, rapid expanding in health care system and many other areas. The development of human organ models is still in its minor state. Although have major drawbacks such as expensive and controversy over predictive value of var...

As per studies in 2015, about 90.5 million people had cancer. About 14.1 million new cases occur a year (not including skin cancer other than melanoma). It caused about 8.8 million deaths (15.7% of deaths). The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer and stomach cancer. The major cancer treatments ar...

Background The development of sound bioanalytical LC-MS (liquid chromatography-mass spectroscopy) method(s) is of paramount importance during the process of drug discovery, development and culminating in a marketing approval. The use of oral antidiabetic agents has been increased significantly from last decades and till now no bioanalytical method...

Cinnamon has been utilized to remedy a lot of afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our research study is intended to recognize the phyto-derived antiviral substances from Cinnamon against COVID-19 main protease enzyme and to understand the in silico molecular basis of its activity. In th...

Background: The current study assesses the anthelmintic impact of root extracts of Pavetta tomentosa on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the β-Tubulin (PDB ID: 1SA0). Methods: In this study, P. tomentosa root was subjected to extraction using methanol and water. In vitro, anthel...

The main components of sambong (Blumea balsamifera) are listed in this article. The whole plant and its crude extracts, as well as its isolated constituents, display numerous biological activities, such as antitumor, hepatoprotective, superoxide radicalscavenging, antioxidant, antimicrobial and anti-inflammation, anti-plasmodial, anti-tyrosinase, p...

Objectives: The main objective of the present work is to develop a simple, precise, specific and stability method indicating reverse phase high performance liquid chromatography method for simultaneous estimation of teneligliptin and metformin in bulk and tablet dosage form. Materials and methods: The analysis was performed with a Kromasil C18 c...

Objectives: To evaluate the in vivo antioxidant activity of chloroform extract fractions of Indigofera barberi (whole plant) against paracetamolinduced toxicity in rats. Materials and methods: For 7 days, rats were treated with different chloroform extract fractions and toxicity was induced with a single dose of paracetamol by intraperitoneal in...

Obsessive-compulsive disorder (OCD) features a pattern of unreasonable thoughts and fears (obsessions) that lead you to do repetitive behaviours (compulsions). These obsessions and compulsions interfere with daily activities and cause significant distress. You may try to ignore or stop your obsessions, but that only increases your distress and anxi...

Objectives: The aim was the synthesis of novel substituted 5-[morpholino(phenyl)methyl]-thiazolidine-2,4-diones and screening for their in vivo hypoglycemic activity and in vitro anti-inflammatory activity, as well as molecular docking studies to find out active potential lead molecules. Materials and methods: Substituted aromatic aldehydes, thi...

Ficus palmata (FI) is an important and widely used medicinal plant. It is principally used as an item of diet in the treatment of constipation and diseases of the lungs and bladder. The sap is used in the treatment of warts. Ficus palmata plant is used in various disease e.g. gastrointestinal, hypoglycemic, antitumor, anti-ulcer, anti-diabetic, lip...

Development of anthelmintic resistance and high cost of conventional anthelmintic drugs lead to evaluation of medicinal plant as an alternative source of anthelminitics. Delonix regia also known as flame of forest, distributed throughout Madagascar,, India, Africa and Australia. The present study was aimed to investigate the anthelmintic activity o...

A simple, accurate and precise RP-HPLC method was developed for the simultaneous estimation of the linagliptin and empagliflozin in tablet dosage form. Chromatogram was run through Kromasil 250 x 4.6 mM, 5mM column, mobile phase containing 0.1% o-phosphoric acid buffer and acetonitrile in the ratio of 60:40%v/v was pumped through column at a flow r...

Purpose: In the existing work different sustained release matrix tablets of eplerenone were prepared with dried mucilage of Aloe vera, guar gum and povidone K30 by using different binder: tablet weight ratios viz. 1:20, 2:20, 3:20, 4:20 and 5:20. Method: During this process Aloe vera leaves are procured, extracted, dried and characterized to obtain...

A simple, sensitive, rapid and highly efficient LC-MS/MS method was developed for the determination of Candesartan and Hydrochlorothiazide simultaneously in human plasma. The method employed Zorbax eclipse C18 (150 X 4.6 mm, 5µ) column using acetate buffer: acetonitrile (25:75%, v/v) as the mobile phase. The mobile phase flow rate is 1 mL/min which...

Helicobacter pylori (H. pylori) were identified in dental plaque, raising the possibility of future gastritis and peptic ulceration. The aim of the present study was the assessment the association of H. pylori of dental plaque and stomach in a more homogenous population and also to determine the diagnostic value of dental plaque for gastric infecti...

Various fractions obtained from chloroform extract of Indigofera barberi (whole plant) was scrutinized in albino rats for hepatoprotective activity on paracetamol instigated hepatic injury. Into 11 groups rats were divided. 5 animals in each group. By giving paracetamol orally at a dose of 2 gm/kg hepatic injury was acquired. With fraction D, hepat...

Oxaprozin is a popular non-steroidal anti-inflammatory drug (NSAID) and its chronic oral use is clinically restricted due to its gastrointestinal (GI) complications. In order to circumvent the GI complications, oxaprozin was amended as a prodrug in a one-pot reaction using N,N-carbonyldiimidazole as an activating agent. Dextran of average molecular...

Objective: To analyze the pharmacognostic characteristics and physiochemical parameters of the root of Eranthemum nigrum (E. nigrum). Methods: Microscopic characters and powder analysis had been carried out with the help of a microscope. The physiochemical properties such as loss on drying, total ash value, acid insoluble ash value, water soluble a...

Ulcers are caused by imbalance between the gastro duodenal mucosal defensive factors such as bicarbonate, mucus versus aggressive factors like acid and pepsin secretion. The drug treatment of peptic ulcer has significantly brought down the morbidity and mortality and need of surgical interventions which may be attributed to the advent of H2 blocker...

Paliperidone is a well-known dopamine antagonist of the atypical antipsychotic class. In the present study, Paliperidone was formulated as ER release tablets using natural and synthetic polymers separately or in combination. The aim of ER release formulation is to reduce the frequency of dosing. Tablets are prepared by direct compression method. Th...

Gomphrena serrata (Amaranthaceae) has been utilized for many ailments in the conventional system ethnomedicinally; most significantly against bronchial asthma, diarrhea, hay fever, pains, tonic, carminative, diabetes, dermatitis, and piles. The key challenge experienced in the standardization of herbal drugs is the correct identification of the pla...

Objective: To analyze the pharmacognostic characteristics and physiochemical parameters of the leaves of Eranthemum nigrum (E. nigrum). Methods: Microscopic characters and powder analysis had been carried out with the help of a microscope. The physiochemical properties such as loss on drying, total ash value, acid insoluble ash value, water soluble...

Objective: To analyze the pharmacognostic characteristics and physiochemical parameters of the stem of Gomphrena serrata (G. Serrata). Methods: Micro, as well as macroscopic characteristics, were investigated. Physicochemical parameters had been done by implementing WHO suggested parameters; preliminary phytochemical and fluorescent evaluation of s...

Introduction: A sensitive and rapid method for quantitation of Sofosbuvir in human plasma has been established using ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS). Materials and methods: Sofosbuvir d3 was used as an internal standard. Sofosbuvir and internal standard in plasma sample we...

Novel HPTLC and stability indicating RP-HPLC methods were developed for simultaneous estimation of Moxifloxacin (MOX) and Dexamethasone (DEX) in ophthalmic dosage form. For HPTLC method, the separation was carried out on HPTLC aluminum plates using acetonitrile:water:ammonia (8:1:0.5 v/v/v) as mobile phase and developed plates were read at 266 nm....

A novel approach was used to develop and validate a bioanalytical RP-HPLC method for the simultaneous estimation of Paracetamol and Cefixime in rabbit plasma using Cefaclor as internal standard. Evaluation of the content of drugs were done by employing a mixture of Phosphate buffer (pH6.4) and Acetonitrile (80:20, v/v) as the mobile phase and measu...

The main objective of the present work is to develop simple, precise, accurate and reproducible UV-spectrophotometric and stability indicating RP-HPLC methods for simultaneous estimation of gatifloxacin (GAT) and dexamethasone (DEX) in ophthalmic dosage form. Dual wavelength spectrophotometric method, which involves solving of simultaneous equation...

Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural...

A novel approach was used to develop and validate a bioanalytical RP-HPLC method for the simultaneous estimation of Indomethacin and Omeprazole in rabbit plasma using Rabeprazole as internal standard. Evaluation of the content of drugs were done by employing a mixture of phosphate buffer (pH 4.6) and acetonitrile (65:35, v/v) as the mobile phase an...

A Simple, validated, accurate and precise simultaneous UV Spectrophotometric method has been developed for the simultaneous estimation of Rizatriptan Benzoate (RIZ) and Naproxen Sodium (NAP) in pharmaceutical dosage form. Rizatriptan Benzoate exhibits absorption maximum at 282.9nm and Naproxen Sodium shows absorption maximum at 261.8nm in methanol....

A simple, rapid, accurate and precise isocratic reversed phase high performance liquid chromatographic method has been developed and validated for simultaneous estimation of Bromhexine and Erythromycin in tablet dosage forms. The chromatographic separation was carried out on Hypersil BDS C18 column (150 mm x 4.6 mm I.D., 5 μm particle size) with a...

The present study depicts the development of a validated reversed-phase high performance liquid chromatographic method for the determination of the everolimus in presence of degradation products or pharmaceutical excipients. Stress study was performed on everolimus and it was found that it degrade sufficiently in oxidizing and acidic conditions but...

Background: Michelia nilagirica belonging to the family Mangoliaceae is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. Objective: Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rat...

Objective: Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for protective effect and mechanism as gastroprotective agent. Methods: Adult male Wistar rats weighing 120-180 gm were used for the experiment. All the animals were fasted for 24 hrs prior to the experiments. Groups were treated wit...

Michelia nilagirica belonging to the family Mangoliaceae is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for the antidiabetic activity in wistar albino rats. An acute treatment o...

A novel, precise, accurate, rapid and cost effective isocratic reverse-phase high performance liquid chromatographic (RP-HPLC) method was developed, optimized and validated for the simultaneous estimation of Montelukast Sodium (MON) and Desloratadine (DES) in pharmaceutical dosage forms. The drugs were estimated using Hypersil BDS C18 (250 mm × 4.6...

Objective: The main objective of this work is to develop simple, precise, accurate and reproducible UV-Spectrophotometric and Stability indicating RP-HPLC methods for simultaneous estimation of Gatifloxacin (GAT) and Flubiprofen sodium (FLU) in ophthalmic dosage form. Methods: Dual wavelength spectrophotometric method which involves solving of simu...

A simple, precise, reliable, rapid and reproducible reversed-phase high performance liquid chromatographic method was developed and validated for the simultaneous estimation of Emtricitabine and Tenofovir disoproxil fumarate. Chromatography is carried out isocratically on C8 Phenomenex Luna (4.6X250 mm) column with a mobile phase composed of aceton...

Objective: To develop an accurate, precise and linear Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method and validate as per ICH guidelines for the quantitative estimation of Ribavirin (200mg) in tablets. Methods: The optimized method uses a reverse phase column, Enable Make KromasilC18 (250 X 4.6 mm; 5μ), a mobile phase of phosp...

A stability-indicating RP-HPLC method was developed and validated for the estimation of Tolvaptan in bulk and pharmaceutical dosage forms. An Hypersil BDS stationary phase with mobile phase consisting of 0.02M phosphate buffer having pH 3.1 adjusted with orthophosphoric acid and acetonitrile in the ratio of 35:65 V/V. The flow rate was mainta at 25...

A simple, precise and rapid HPLC method has been developed for the simultaneous determination of Metformin and Vildagliptin in pharmaceutical dosage form. The method was carried out using Sunfire BDS C8 column (250 mm x 4.6 mm, 5 µm) and mobile phase comprised of disodium hydrogen phosphate pH 7.0±0.05 as buffer and acetonitrile in the ratio of 60:...

A simple, rapid, sensitive, accurate and precise HPLC method has been developed and validated for the estimation of Paliperidone in bulk and its pharmaceutical dosage forms. The method was carried out using Thermosil Symmetry C18 (100 x 4.6 mm I.D., 5 μm particle size) column and mobile phase comprised of ammonium acetate buffer pH 4.0 and acetonit...

A simple, reproducible and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of moexipril and hydrochlorthiazide in tablets. A column having 150 mm × 4.6 mm i.d. in isocratic mode with mobile phase containing acetonitrile:phosphate buffer (45:55; adjusted to pH 3) was used. The flow rat...

A simple, rapid, economic, sensitive and precise HPLC method has been developed for the simultaneous determination of rosuvastatin and ezetimibe in pharmaceutical dosage form. The method was carried out using Sunfire BDS C18 250X4.6 mm ID, 5 um column and mobile phase comprised of ammonium acetate in water as buffer, pH adjusted to 6.50±0.05 with d...

A new simple high performance thin layer chromatographic method for simultaneous determination of antidiabetic drugs, metformin hydrochloride and sitagliptin phosphate in bulk and tablet dosage form were investigated. Chromatographic separation of the drugs were performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase...

A rapid, sensitive and precise HPLC method was developed for the estimation of trospium chloride in pure and tablet dosage forms. Seperation of the drug was achieved on a reverse phase Azilent C18 column using a mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 60:40v/v. The flow rate was 1 ml/min and the detection wave l...

In the information regarding the use of Elaeocarpus ganitrus leaves for several disorders systemic studies were carried out in our laboratory to establish the antidiabetic potential of chitosan based extract of Elaeocarpus ganitrus and antidiabetic activity of aqueous extract of Elaeocarpus ganitrus. In the present study rats were used as experimen...

Biosurfactants or surface active agents are produced by microorganisms. These molecules reduce surface tension both aqueous solutions and hydrocarbon mixtures. Although a large number of biosurfactant producers have been reported in the literature, biosurfactant research, particularly related to production nhancement and economics, has been confine...

A sensitive, accurate and precise new spectrophotometric method has been developed for the determination of propranolol hydrochloride using Alizarin RedS and Erythrosin-B. We have proposed new spectrophotometric methods for the determination of propranolol in bulk samples and pharmaceutical preparations basing on the reaction of propranolol with Al...

An accurate and precise HPLC method was developed for the determination of lisinopril. Separation of the drug was achieved on a reverse phase C8 column using a mobile phase consisting of phosphate buffer and methanol in the ratio of 35:65v/v. The flow rate was 0.8 mL/min and the detection wavelength was 215 nm. The linearity was observed in the ran...

The hepatoprotective activity of ethanolic extract of fruits of Alstonia scholaris was evaluated by carbon tetrachloride (CCL4)-induced hepatotoxicity in rats. The toxicant CCL4 was used to induce hepatotoxicity at a dose of 2 ml/kg as 1:1 mixture with olive oil. The ethanolic extract of fruits of Alstonia scholaris was administered in the dose of...

A new simple high performance thin layer chromatography method for simultaneous determination of gemifloxacin mesylate and ambroxol hydrochloride in bulk and tablet dosage form were investigated. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica ge160 F254 as a stationary phase and solvent system consist...

Transdermal drug delivery systems have been designed to provide controlled continuous delivery of drugs via the skin to the systemic circulation. Transdermal drug delivery offers controlled release of the drug into the patient, it enables a steady blood level profile, resulting in reduced systemic side effects and sometimes, improved efficacy over...

In microbiological and clinical studies, cerium oxide (CeO 2) nanoparticles have been shown to protect cells in culture from lethal stress. Cardiac-specific expression of monocyte chemoattractant protein-1 (MCP-1) in mice causes ischemic cardiomyopathy associated with activation of endoplasmic reticulum (ER) stress. CeO 2 nanoparticles protect agai...

A new simple, rapid, sensitive RP-HPLC method for the simultaneous determination of telmisartan and hydrochlorothiazide in pharmaceutical dosage forms was developed. Telmisartan has absorption maxima at 296 nm and hydrochlorothiazide has absorption maxima at 280 nm. For the simultaneous estimation of telmisartan and hydrochlorothiazide the detectio...

An accurate and precise HPLC method was developed for the determination of telmisartan. Separation of the drug was achieved on a reverse phase C 8 column using a mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 40:60 v/v. The flow rate was 0.9 ml/min and the detection wavelength was 229 nm. The linearity was observed in...

A simple, rapid, sensitive and precise High Performance Liquid Chromatographic (HPLC) method has been developed for the estimation of gatifloxacin in its pharmaceutical dosage forms. In this method RP-C18 column (150mmx4.6mm I.D., 5 m particle size) with mobile phase consisting of acetonitrile and 0.05M phosphate buffer in the ratio of 25:75 v/v in...

A simple, rapid, accurate and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Piperacillin and Tazobactum in pharmaceutical dosage forms. Chromatography was carried out on a C18 column using a mixture of ammonium acetate and methanol in the ratio of 65:35 v/v as the mobil...

A method has been developed and validated for the estimation of abacavir, lamivudine and zidovudine by high performance liquid chromatography (HPLC) on a C 18 column with UV detection at 270 nm. The mobile phase composition that provides an optimal resolution of components in an acceptable elution time in water: methanol (70: 30 v/v) with 0.1 % pot...

An accurate and precise HPLC method was developed for the simultaneous determination of perindopril and amlodipine. Separation of the drugs was achieved on a reverse phase C 18 column using mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 65: 35 v/v. The flow rate was 0.6 mL/min and the detection wavelength was 237 nm. T...

An accurate and precise RP-HPLC method was developed for the determination of perindopril in tablet dosage forms. Separation of die drug was achieved on a reverse phase Cig column using a mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 65:35 v/v. The flow rate was 0.6 ml/min and die detection wavelength was 209 nm. The...

A rapid, sensitive, accurate and precise HPLC method has been developed for the estimation of ranolazine. Separation of the drug was achieved on a reverse phase C 8 column using a mobile phase consisting of phosphate buffer and acetonitrile in the ratio of 30: 70 v/v. The flow rate was maintained at 0.5 mL/min and the detection wavelength was set a...

The leaves of the plant Lantana camara were extracted with different solvents and screened for their antibacterial and analgesic activities. The chloroform and methanolic extract of the plant Lantana camara has showed the presence of four alkaloid compounds each. Antibacterial activity was evaluated using MIC method against bacteria. The analgesic...

INTRODUCTION Montelukast sodium is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor. Montelukast sodium is described chemically as [R-(E)]-1-[[[1-[3-[2-(7-chloro-2quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy -1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic acid, mono...

A rapid, sensitive and precise HPLC method was developed for the estimation of exemestane in pure and tablet dosage forms. Separation of the drug was achieved on a reverse phase C8 column using a mobile phase consisting of water and methanol in the ratio of 50:50 v/v. The flow rate was 1 mL/min and the detection wavelength 249 nm. The linearity was...

A simple, rapid, sensitive and precise high performance liquid chromatographic (HPLC) method has been developed for the estimation of mycophenolate mofetil in bulk and tablet dosage form. In this method RP-C18 column (250mmx4.6mm I.D., 5μm particle size) with mobile phase consisting of acetonitrile and 0.03M phosphate buffer in the ratio of 60:40 v...

A simple, rapid, sensitive and precise high performance liquid chromatographic method has been developed for the estimation of temozolomide in pharmaceutical dosage forms. In this method RP-C 18 column (250 mm × 4.6 mm I.D., 5 μm particle size) with mobile phase consisting of acetate buffer and methanol in the ratio of 75:25 v/v in isocratic mode w...

A new, simple, specific, sensitive, rapid, accurate and precise RP-HPLC method was developed for the estimation of quetiapine in bulk and pharmaceutical formulations. Quetiapine was chromatographed on a reverse phase C18 Waters column (75x4.6 mm I.D., particle size 3.5 μm) in a mobile phase consisting of phosphate buffer (pH 3.0 adjusted with ortho...