Laith Abbas Al-Huseini

• MBChB, MSc, MRes, PhD
• Professor (Assistant) at University of Warith Al-Anbiyaa

الكتاب يعتبر من الكتب المهمة لجميع الكوادر الطبية وخاصة طلاب الصيدلة أثناء التدريب الصيفي، وتعتبر أيضًا دليلاً لتعلم الأسماء العلمية والأسماء التجارية وطريقة عملها واستخداماتها الصحيحة والآثار الجانبية، وبعض الملاحظات عن الدواء وبطريقة مبسطة وبأسلوب سلس يجذب القارئ اعتمد الكتاب على الكتب المنهجية الرئيسية في علم الأدوية والصيدلة السريرية والعلاجيا...

Background: Chronic heart insufficiency and death in acute myocardial infarction (MI), with ST-segment elevation, happens as an effect of abrupt obstruction of the coronary artery and causing the supplied cardiomyocyte to turn into ischemic state, ending in permanent damage and scar tissue formation if circulation is failed. Methods and materials:...

Rotaviruses, a major cause of gastroenteritis in children worldwide accounts for around half a million deaths annually. Vaccine against the virus has been recommended by the WHO to be involved in the national immunization program.To evaluate the genetic characterization of rotavirus among children with acute gastroenteritis in Babylon province is w...

Cerebral I/R causes oxygen deprivation to the brain tissue and generation of reactive oxygen species (ROS) which can stimulate immune responses, leading to inflammatory cells activation and infiltration. Methods: Rats were subjected to general anesthesia during which an occlusion of bilateral common carotid arteries for half hour then reperfusion f...

Ischemic stroke has been ranked as the second cause of death in patients worldwide. Inflammation which is activated during cerebral ischemia/reperfusion is an important mechanism leading to brain injury. We aimed to investigate the effect of Berberine on cerebral ischemia/reperfusion injury and its effect to treat the inflammation. The study was ca...

Ischemic stroke has been ranked as the second cause of death in patients worldwide. Inflammation which is activated during cerebral ischemia/reperfusion (I/R) is an important mechanism leading to brain injury. The present study aimed to investigate the effect of Berberine on cerebral I/R injury and the role of inflammation in this process. Material...

Background: Interruption of blood flow may result in considerable tissue damage via ischemia/ reperfusion injury induced oxidative stress in brain tissues. The present study aimed to investigate the effects of myricetin treatment in rats cerebral I/R injury. Material and Methods: The study was carried out on 36 Wistar-albino rats, divided into four...

Background: Ischemic cerebrovascular disease causes oxygen deprivation to the brain tissue. Reperfusion, which can occur spontaneously through dissolution of the thrombus or by therapeutic recanalization, leads to the generation of reactive oxygen species (ROS)and induces inflammation which further damages the brain tissue. Methods: Animal model of...

Background: Diarrhea is a main cause of morbidity and mortality in children under 5 years old. Globally it is responsible for approximately four billion cases and three million deaths annually. In developing countries, it causes two million deaths each year. The major causative organism is rotavirus which is responsible for one-third of hospitaliza...

Gastroenteritis caused by rotavirus infection is one of the major healthcare problem affecting millions of children all over the world. WHO has recommended vaccine against rotavirus to be involved in the national immunisa-tion programmes. In Iraq, rotavirus vaccine has been started since 2012 and in the current study, we aimed to estimate the effec...

Gastroenteritis caused by rotavirus infection is one of the major healthcare problem affecting millions of children all over the world. WHO has recommended vaccine against rotavirus to be involved in the national immunisation programmes. In Iraq, rotavirus vaccine has been started since 2012 and in the current study, we aimed to estimate the effect...

Background: Diarrhea is a main cause of morbidity and mortality in children under 5 years old. Globally it is responsible for approximately four billion cases and three million deaths annually. In developing countries, it causes two million deaths each year. The major causative organism is rotavirus which is responsible for one-third of hospitaliza...

Background: Hypertension-induced cardiac dysfunction is variable among different anti-hypertensive medications. This study compares the effects of telmisartan and enalapril on echocardiographic parameters in hypertensive patients. Materials and methods: This was a randomised single blinded study. Eighty hypertensive patients were included in thi...

Urinary tract infections (UTIs) are considered to be the most common bacterial infection during pregnancy. Early diagnosis and proper treatment have a great impact on both mother health and pregnancy outcome. The antibiotic chosen should have a good maternal and fetal safety profile. In this paper, we screened pregnant women for UTIs at different s...

Dendritic cells (DCs) are critical for the initiation of immune responses including activation of CD8 T cells. Intracellular reactive oxygen species (ROS) levels influence DC maturation and function. Intracellular heme, a product of catabolism of heme-containing metalloproteins, is a key inducer of ROS. Intracellular heme levels are regulated by he...

Nrf2 is a redox-responsive transcription factor that has been implicated in the regulation of DC immune function. Loss of Nrf2 results in increased co-stimulatory molecule expression, enhanced T cell stimulatory capacity, and increased reactive oxygen species (ROS) levels in murine immature DCs (iDCs). It is unknown whether altered immune function...

Nrf2 is a redox sensitive transcription factor vital for the maintenance of cellular homeostasis. Dendritic cells (DCs) are potent APCs responsible for the initiation of an immune response. Our previous study highlights the role of Nrf2 in DC function (increased costimulatory receptors expression and T cell stimulatory capacity) and intracellular s...

Dendritic cells (DCs) are critical mediators of immunity and immune tolerance by orchestrating multiple aspects of T cell activation and function. Immature DCs (iDCs) expressing low levels of co-stimulatory receptors are highly efficient at antigen capture but are poor activators of T cells. Maturation of DCs is associated with increased expression...