Laisa Socorro Briongos-Figuero

• MD, PhD
• Medicina Interna at Hospital Universitario "Rio Hortega"

Introduction This study aimed to evaluate the impact of infographics and social media threads (SMT) on academic performance in the Musculoskeletal Medical and Surgical Pathology (MMSP) course. Additionally, gender differences in the effectiveness of these tools were examined. Methods A within-subject educational intervention study was conducted ov...

Background: In vitro studies have shown that genistein inhibits the CYP240 enzyme, which is involved in the degradation of 1,25-dihydroxycholecalciferol and its precursor 25-hydroxycholecalciferol, and increases their plasma levels. However, no clinical studies have primarily assessed the synergistic effect of isoflavones on vitamin D levels. The a...

Background The joint influence of metabolic patterns on bone fragility has been rarely evaluated. We assessed the prospective association of plasma metabolic patterns with incident osteoporosis-related bone fractures in the Hortega Study participants. Redox balance plays a key role in bone metabolism. We also assessed differential associations in p...

Background: Osteoporosis and obesity are major public health problems that are closely correlated, as they share various features, including a genetic predisposition. A genetic correlation between obesity and osteoporosis due to the biological common pathways of bone and fat metabolism, which implies pleiotropic genes regulating has been described...

The most widely accepted etiopathogenesis hypothesis of the origin of osteoporosis and its complications is that they are a consequence of bone aging and other environmental factors, together with a genetic predisposition. Evidence suggests that oxidative stress is crucial in bone pathologies associated with aging. The aim of this study was to dete...

Background Since the first cases of COVID-19 were reported in Wuhan, the nutritional status of individuals infected with the virus has not been included in the risk profiles prepared. However, nutritional status, along with other factors, is decisive in the evolution of patients with other infectious diseases. The nutritional status of individuals...

Background and objectives Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representative sample of a general po...

Osteoporosis is the most common bone disorder worldwide and is associated with a reduced quality of life with important clinical and economic consequences. The most widely accepted etiopathogenic hypothesis on the origin of osteoporosis and its complications is that they are a consequence of the synergic action of environmental and genetic factors....

Objectives: Spanish population lifespan is one of the longest in the world. Moreover, it is known that elderly people have less chronic illnesses associated with aging. Our aims were to determine how Clinical Risk Group (CRG) predicts future use of healthcare resources in extremely elderly people without diabetes (T2DM) and to explore CRG correlat...

Purpose The Hortega Study is a prospective study, which investigates novel determinants of selected chronic conditions with an emphasis on cardiovascular health in a representative sample of a general population from Spain. Participants In 1997, a mailed survey was sent to a random selection of public health system beneficiaries assigned to the Un...

Background: The association of low-level exposure to metals and metal mixtures with cardiovascular incidence in the general population has rarely been studied. We flexibly evaluated the association of urinary metals and metal mixtures concentrations with cardiovascular diseases in a representative sample of a general population from Spain. Method...

Cardiovascular risk increases in women after menopause. Unfavorable lipid‐lipoprotein changes due to a lack of estrogens may have an important role in this context. Estrogen actions are mainly mediated by their binding to two estrogen receptors (ERs) whose signaling may be conditioned by different factors. Calcium, vitamin D, and genistein, among o...

Objective: The aim of this study was to evaluate the relationship between vitamin D levels at baseline and after 12 weeks of supplementation/exposure to sunlight and VDR genotypes (BsmI, TaqI and ApaI) and haplotypes in a homogeneous population of postmenopausal women. Methods: We made a prospective study in which 151 women were randomized to tw...

Objective To study the association of genes involved in the mitochondrial respiratory chain (MRC) pathway with body mass index (BMI) and obesity risk. Design This work studies three cross-sectional populations from Spain, representing three provinces: HORTEGA (Valladolid, Northwest/Centre), SEGOVIA (Segovia, Northwest/centre) and PIZARRA (Malaga,S...

Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑di...

La gastroparesia diabética es una complicación caracterizada por el enlentecimiento del vaciamiento gástrico sin obstrucción mecánica que afecta a la morbilidad y calidad de vida de los pacientes. Entre el 5-12% de los pacientes presentan síntomas sugestivos de gastroparesia que se mantienen en el tiempo. Los mecanismos patogénicos aún no están cla...

La diabetes mellitus (DM) se ha asociado a diferentes procesos tumorales. Existen diversos factores de riesgo de cáncer de páncreas y se estima que el 1% de los mayores de 50 años con diagnóstico reciente de DM desarrollará una neoplasia pancreática que habitualmente se encuentra en estadio avanzado. El diagnóstico precoz sigue siendo clave en el p...

Aims: The objective of this study was to determine whether vitamin D and genistein supplementation had an additive beneficial effect on levels of vitamin D and bone markers and whether this effect was mediated by genes regulating isoflavone metabolism. Materials and methods: We carried out a prospective study in postmenopausal women randomized t...

Background: Selenium and single-nucleotide-polymorphisms in selenoprotein genes have been associated to diabetes. However, the interaction of selenium with genetic variation in diabetes and oxidative stress-related genes has not been evaluated as a potential determinant of diabetes risk. Methods: We evaluated the cross-sectional and prospective...

Supplementary material

Background To identify metabolomic and genomic markers associated with the presence of clustering of cardiometabolic risk factors (CMRFs) from a general population. Methods and Findings One thousand five hundred and two subjects, Caucasian, > 18 years, representative of the general population, were included. Blood pressure measurement, anthropomet...

Objective: Angiotensin-converting enzyme (ACE) has been related to cardiovascular physiology and bone remodeling. Our aim was to assess the relationship among ACE polymorphisms, cardiovascular risk, and osteoporotic fractures. Material and methods: We prospectively enrolled 71 patients with hypertension from 2001 to 2014. Sociodemographic and me...

Objective. The effects of normocalcemic hyperparathyroidism (NHPT) on bone remain unclear. The objective of this study was to evaluate differences in the trabecular bone score (TBS) in NHPT patients and asymptomatic hypercalcemic hyperparathyroidism (HHPT) patients. Methods. We performed a prospective study which enrolled consecutive patients with...

Metastasis to breast from extra-mammary sites is much less common as compared to primary ones and only few cases are reported in the literature. Furthermore, very little is known about prognosis and treatment of patients with solid neoplasms metastatic to the breast. If a breast lump is found, it is recommended to perform a bilateral mammogram spec...

Objective: Angiotensin-converting enzyme (ACE) has been related to cardiovascular physiology and bone remodeling. Our aim was to assess the relationship among ACE polymorphisms, cardiovascular risk, and osteoporotic fractures. Material and Methods: We prospectively enrolled 71 patients with hypertension from 2001 to 2014. Sociodemographic and medic...

Atraumatic subtrochanteric and diaphyseal (atypical) femoral fractures are a rare, but important adverse event in patients treated with potent anti-resortive agents. The mechanisms involved are unknown and particularly the association with genetic variants has not been explored. The aim of the study was to identify rare genetic variants that could...

Primary meningeal lymphomas are very rare and those derived from T cells are even more infrequent (less than 5% of primary central nervous system lymphomas). Cerebellopontine angle involvement in the primary T-cell lymphoma is exceptional. Clinical presentation depends on the type of lesions, and histological diagnosis is needed. We present a rare...

Introduction: The relationship between osteoporosis and arterial hypertension has not been clearly established, with alterations in calcium metabolism having been reported in the latter which may explain their association. Our objective was to establish the relationship between the A986S polymorphism of the calcium-sensing receptor (CaSR) and the p...

Hospital mortality is a leading indicator of quality of healthcare and a valuable tool for planning and management. Infectious diseases represent a substantial part of the activity of internal medicine.Our aim was to describe the characteristics of in-hospital mortality due to infectious diseases and associated risk factors in our environment. A re...

La relación entre osteoporosis e hipertensión arterial no está claramente establecida, habiéndose descrito en ésta última alteraciones del metabolismo del calcio que podrían explicar su asociación. Nuestro objetivo fue establecer la relación entre el polimorfismo A986S del receptor sensor del calcio (CaSR) y la presencia de fracturas clínicas osteo...

Conocer la importancia otorgada a diferentes aspectos de la atención recibida y el grado de satisfacción de los familiares de pacientes durante la fase final de la vida.

To identify factors related with the risk to develop microalbuminuria using combined genomic and metabolomic values from a general population study. One thousand five hundred and two subjects, Caucasian, more than 18 years, representative of the general population, were included. Blood pressure measurement and albumin/creatinine ratio were measured...

The aim of this longitudinal retrospective ecological study was to evaluate the consumption of anti-osteoporotic medications and the evolution of pertrochanteric and femoral neck (FN), subtrochanteric and diaphyseal hip fractures between 2005 and 2010. Data were obtained from our Hospital Admissions Service (absolute number of fractures) and the Te...

Urinary tract infection (UTI) caused by resistant bacteria is becoming more prevalent. We investigate characteristics and associated risk factors for UTIs resulting from extended-spectrum beta-lactamase (ESBL)-producing enterobacteria. Retrospective study of urinary tract isolates of ESBL-producing enterobacteria in adults (2009 and 2010). We inclu...

Sarcoidosis is a multisystem disorder of unknown etiology characterized by the presence of non-caseating granulomas in the organs affected. Sarcoid arthropathy is a rare manifestation, and sacroiliitis is an unusual first manifestation of the disorder.

Little is known about the impact of comorbid psychiatric symptoms in health related quality of life (HRQL) in patients with HIV infection. The aim of this investigation was to describe depressive symptoms and the impact in HRQL in HIV infected people. A cross-sectional study over 150 HIV-outpatients in a tertiary hospital was designed. Depression d...

Objectives Access to antiretroviral treatment (ART) has become essential to delay HIV clinical progression and increase survival, so improving Health Related Quality of Life (HRQL). The aim of this investigation was to describe factors associated with ART and their impact on HRQL in HIV infected patients.

Access to antiretroviral treatment (ART) has become essential to delay HIV clinical progression and increase survival, so improving Health Related Quality of Life (HRQL). The aim of this investigation was to describe factors associated with ART and their impact on HRQL in HIV infected patients. A cross-sectional study on 150 HIV-outpatients in a te...

Health-related quality of life (HRQL) is used in the assessment of chronic illness. Regarding HIV infection, HRQL assessment is an objective for physicians and institutions since antiretroviral treatment delays HIV clinical progression. The aim of this study was to determine the factors with the most influence on HRQL in HIV-infected people and to...

Nowadays, HIV-infected patients have higher rates of cardiovascular diseases than non-infected patients because these patients now live longer and have to deal with the complications of ageing. Noncompaction left-ventricular cardiomyopathy is a rare disorder characterized by the persistence of embryonic pattern of myoarchitecture with arrest in end...

Objetives: Health related quality of life (HRQL) is a new clinical marker used in the assessment of chronic illness. The aim of this investigation was to describe clinical and sociodemographic factors most influential in HRQL in HIV infected people.Methods: A cross-sectional study over 150 patients in a tertiary hospital. HRQL data were collected b...

The human immunodeficiency virus (HIV) infection is a disease with great sociosanitary impact. Since 1981, when the first cases of AIDS were described, more than 60 million people have become infected. During these 25 years there have been a lot of advances in the infection management and we know that prevention and early diagnosis are crucial. Fam...

The human immunodeficiency virus (HIV) infection is a disease with great sociosanitary impact. Since 1981, when the first cases of AIDS were described, more than 60 million people have become infected. During these 25 years there have been a lot of advances in the infection management and we know that prevention and early diagnosis are crucial. Fam...