Laila Craighero

University of Ferrara | UNIFE · Department of Neuroscience and Rehabilitation

The embodied approach argues that interaction with the environment plays a crucial role in brain development and that the presence of sensory effects generated by movements is fundamental. The movement of the fetus is initially random. Then, the repeated execution of the movement creates a link between it and its sensory effects, allowing the selec...

Robotic literature widely addresses deformable object manipulation, but few studies analyzed human manipulation accounting for different levels of deformability and task properties. We asked participants to grasp and insert rigid and deformable objects into holes with varying tolerances and depths, and we analyzed the grasping behavior, the reachin...

Every day, we make thousands of finger movements on the touchscreen of our smartphones. The same movements might be directed at various distal goals. We can type “What is the weather in Rome?” in Google to acquire information from a weather site, or we may type it on WhatsApp to decide whether to visit Rome with a friend. In this study, we show tha...

The observation of action seems to involve the generation of the internal representation of that same action in the observer, a process named motor resonance (MR). The objective of this study was to verify whether an experimental paradigm of action observation in a laboratory context could elicit cortical motor activation in 21 early Parkinson’s di...

There is experimental evidence that the brain systems involved in action execution also play a role in action observation and understanding. Recently, it has been suggested that the sensorimotor system is also involved in language processing. Supporting results are slower response times and weaker motor-related MEG Beta band power suppression in se...

For the past fifteen years, observation of actions has proved to be effective in the motor rehabilitation of stroke. Despite this, no evidence has ever been provided that this practice is able to activate the efferent motor system of a limb unable to perform the observed action due to stroke. In fact, transcranial magnetic stimulation cannot easily...

The discovery of neurons with sensory properties in frontal motor circuits, and the discovery that these circuits send modulatory signals to the sensory parietal areas, strongly challenged the classical idea of a motor system as a mere executor of commands, and suggested that the sensorimotor system may contribute to the cognitive processes necessa...

Scientific evidence points to a shared neural representation between performing and observing an action. The action observation notoriously determines a modulation of the observer’s sensorimotor system, a phenomenon called Motor Resonance (MR). Fibromyalgia (FM) patients suffer from a condition characterized by generalized musculoskeletal pain in w...

Neuropsychological, behavioral, and neurophysiological evidence indicates that the coding of space as near and far depends on the involvement of different neuronal circuits. These circuits are recruited on the basis of functional parameters, not of metrical ones, reflecting a general distinction of human behavior, which alternatively attributes to...

To achieve a seamless human-robot collaboration, it is crucial that robots express their intentions without perturbating or interrupting the task that a human partner is performing at that moment. Although it has not received much attention so far, this issue is important when robots assist humans in physical and manipulation tasks. The main questi...

Embodied cognition theories suggest that observation of facial expression induces the same pattern of muscle activation, and that this contributes to emotion recognition. Consequently, the inability to form facial expressions would affect emotional understanding. Patients with schizophrenia show a reduced ability to express and perceive facial emot...

Others' action observation activates in the observer a coordinated hand-eye motor program, covert for the hand (i.e. motor resonance), and overt for the eye (i.e. proactive gaze), similar to that of the observed agent. The biological motion hypothesis of action anticipation claims that proactive gaze occurs only in the presence of biological motion...

Already in uterus the hand moves with the typical accelerated-decelerated kinematics of goal-directed actions and, from the twenty-second week of pregnancy, the unborn shows the ability to modulate the velocity of the movement depending on the nature of the target. According to the direct matching hypothesis, this motor knowledge may be sufficient...

Objective: To compare the effects of unilateral, proximal arm robot-assisted therapy combined with hand functional electrical stimulation to intensive conventional therapy for restoring arm function in subacute stroke survivors. Design: This was a single blinded, randomized controlled trial. Setting: Inpatient Rehabilitation University Hospita...

Measuring changes in sensorimotor alpha band activity in nine-month-old infants we sought to understand the involvement of the sensorimotor cortex during observation of the Point-Light (PL) animation of a grasping hand. Attenuation of alpha activity was found both when the PL display moved towards the to-be-grasped object and when the object was de...

Objective: We tested the preliminary effects of bilateral anodal transcranial direct current stimulation (tDCS) in patients with disorders of consciousness. Design: Open label pilot study. Subjects: Ten chronic (greater than 12 months) patients in a minimally conscious state (MCS) following severe traumatic brain injury. Methods: The patients recei...

The aim of the study was to assess the efficacy of theatre activities in improving facial expression categorization in schizophrenia by means of a controlled psychophysical experiment performed on matched groups of participants, and appropriate statistical analyses on collected data. In two experiments we submitted participants to a four alternativ...

Motor resonance is considered to be an index of the automatic under threshold motor replica of the observed action. Similar actions may be quite different in terms of long-term goals (e.g., grasp to eat vs grasp to throw) and, recently, it has been proposed that the distal goal subtly modulates movements execution, and that observers automatically...

A long-term debate concerns whether the sensorimotor coding carried out during transitive actions observation reflects the low-level movement implementation details or the movement goals. On the contrary, phonemes and emotional facial expressions are intransitive actions that do not fall into this debate. The investigation of phonemes discriminatio...

The present study investigated whether 2-day-old newborns are able to discriminate two translating meaningless Point-Light Displays (PLD) videos, in which the shape of one of them changes compared to that of the other along the trajectory, independently from movement kinematics, and if this ability is present both when stimuli differed at the end o...

Electrophysiological and psychophysical data indicate that grasping observation automatically orients attention toward the incoming interactions between the actor’s hand and the object. The aim of the present study was to clarify if this effect facilitates the detection of a graspable object with the observed action as compared to an ungraspable on...

Motor resonance refers to the fact that an observed action is online subliminally reenacted. The aim of the present paper was to verify if, on equal terms of kinematics, the to-be-grasped object’s intrinsic properties are influencing the observers’ motor behaviour. A detection time and a single pulse transcranial magnetic stimulation experiment wer...

Cognitive embodiment refers to the hypothesis that cognitive processes of all kinds are rooted in perception and action. Recent findings in cognitive neuroscience revealed that the motor cortex, long confined to the mere role of action programming and execution, in fact, plays a crucial role in complex cognitive abilities.

Neurophysiological data indicate that the reachable peripersonal space and the unreachable extrapersonal space are represented in segregated parietofrontal circuits and that when the unreachable space becomes reachable because of tool use, it is automatically coded by the network selective for peripersonal space. Here we directly tested the role of...

Parietal and premotor cortices of the macaque monkey contain distinct populations of neurons which, in addition to their motor discharge, are also activated by visual stimulation. Among these visuomotor neurons, a population of grasping neurons located in the anterior intraparietal area (AIP) shows discharge modulation when the own hand is visible...

Besides linguistic communication, which is at the core of human communication, humans communicate using arm gestures, body postures, facial expressions, eye contact, and head and body movements. Communication may be intentional or non-intentional. It is very plausible that intentional communication is an evolutionarily late development of non-inten...

Classical models of language claim a clear-cut distinction between language production and perception, indicating for them a different localization in the brain, and limiting the involvement of the frontal lobe exclusively in motor functions. In this review we present empirical evidence pointing to a weaker separation between sensory and motor func...

Studying language as an object of the biological world requires the resolution of the mind-brain problem. While contemporary theoretical linguistics has addressed the problem adopting a dualistic approach (in which the representational and algorithmic nature of linguistic knowledge can be investigated independently by brain activity), cognitive neu...

Non-verbal communication enables efficient transfer of information among people. In this context, classic orchestras are a remarkable instance of interaction and communication aimed at a common aesthetic goal: musicians train for years in order to acquire and share a non-linguistic framework for sensorimotor communication. To this end, we recorded...

To verify if the link between observed hand actions and executed foot actions found in aplasics is essentially induced by the constant use of foot substituting the hand, we investigated if the vision of a grasping hand is able to prime a foot response in normals. Participants were required to detect the time-to-contact of a hand grasping an object...

Coordinated action between music orchestra performance, driven by a conductor, is a remarkable instance of interaction/communication. However, a rigorous testing of inter-individual coordination in an ecological scenario poses a series of technical problems. Here we recorded violinists' and conductor's movements kinematics in an ecological interact...

Recent studies of corticospinal excitability during observation of grasping and lifting of objects of different weight have highlighted the role of agent’s kinematics in modulating observer’s motor excitability. Here, we investigate whether explicit weight-related information, provided by written labels on the objects, modulate the excitability of...

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A vast body of social and cognitive psychology studies in humans reports evidence that external rewards, typically monetary ones, undermine intrinsic motivation. These findings challenge the standard selfish-rationality assumption at the core of economic reasoning. In the present work we aimed at investigating whether the different modulation of a...

The central role of sensory-motor representations in cognitive functions is almost universally accepted. However, determining the link between motor execution and its sensory counterpart and when, during ontogenesis, this link originates are still under investigation. The aim of the present study is to investigate whether at birth this link is alre...

Two experiments were performed to explore a possible visuomotor priming effect. The participants were instructed to fixate a cross on a computer screen and to respond, when the cross changed colour (“go” signal), by grasping one of two objects with their right hand. The participants knew in advance the nature of the to-be-grasped object and the app...

Broca's area is classically associated with speech production. Recently, Broca's area has also been implicated in speech perception and non-linguistic information processing. With respect to the latter function, Broca's area is considered to be a central area in a network constituting the human mirror system, which maps observed or heard actions on...

The pervasiveness of word-finding difficulties in aphasia has motivated several theories regarding management of the deficit and its effectiveness. Recently, the hypothesis was advanced that instead of simply accompanying speech gestures participate in language production by increasing the semantic activation of words grounded in sensory-motor feat...

The work of Paul Broca has been of pivotal importance in the localization of some higher cognitive brain functions. He first reported that lesions to the caudal part of the inferior frontal gyrus were associated to expressive deficits. Although most of his claims are still true nowadays, the emergence of novel techniques as well as the use of compa...

Several transcranial magnetic stimulation (TMS) studies have reported facilitation of the primary motor cortex (M1) during the mere observation of actions. This facilitation was shown to be highly congruent, in terms of somatotopy, with the observed action, even at the level of single muscles. With the present study, we investigated whether this mu...

http://www.scholarpedia.org/article/Premotor_theory_of_attention

The work of Paul Broca has been of pivotal importance in the localization of some higher cognitive brain functions. He first reported that lesions to the caudal part of the inferior frontal gyrus were associated with expressive deficits. Although most of his claims are still true today, the emergence of novel techniques as well as the use of compar...

Broca's area has been considered, for over a century, as the brain centre responsible for speech production. Modern neuroimaging and neuropsychological evidence have suggested a wider functional role is played by this area. In addition to the evidence that it is involved in syntactical analysis, mathematical calculation and music processing, it has...

This paper reviews experimental evidence and presents new data supporting the idea that human language may have evolved from hand/mouth action representation. In favor of this hypothesis are both anatomical and physiological findings. Among the anatomical ones is the fact that the monkey homologue of human Broca's area is a sector of ventral premot...

Although point-to-point reaching motions have received a lot of attention, the way these movements are controlled remains incompletely resolved. Different controllers seem to be recruited depending on the task. Unconstrained reaching movements in space are strongly curved, in opposition to the widely accepted view of quasi-straightness. We argue th...

In the present study, we used transcranial magnetic stimulation (TMS) to investigate the influence of phonological and lexical properties of verbal items on the excitability of the tongue's cortical motor representation during passive listening. In particular, we aimed to clarify if the difference in tongue motor excitability found during listening...

The aim of the present work was to test the ability to predict the instant at which a grasping hand touches an object. Our hypothesis was that, because of the activation of the mirror-neuron system, the same predictive process necessary for action execution should be active during observation. Experimental evidence indicates, however, that not only...

The study of articulatory features in speech requires highly sophisticated instruments. Most of them are available at the CRIL research centre (Centro di Ricerca Interdisciplinare sul Linguaggio – University of Salento – Lecce) where the equipment usually found for articulatory studies in the most advanced international research centres is accessib...

In this chapter we discuss the mirror-neurons system, a cortical network of areas that enables individuals to understand the meaning of actions performed by others through the activation of internal representations, which motorically code for the observed actions. We review evidence indicating that this capability does not depend on the amount of v...

Transcranial magnetic stimulation (TMS) has been used to study motor configuration in three ways. TMS can be used to provide a controllable and physiologically specified input to the skeletomotor system. Second, use of TMS has been as an online probe of cortical motor excitability. Third, TMS can be used to interfere with cognitive-motor processes...

We study the behavior of 12 pairs of undergraduate students while they were involved in a simple coordination game requiring motor interaction. Three experimental conditions were defined according to whether a monetary prize was given to both or only one subject, if the couple was in successfully completing the required assignment. Electromyographi...

This paper reports about our investigation on action understanding in the brain. We review recent results of the neurophysiology of the mirror system in the monkey. Based on these observations we propose a model of this brain system which is responsible for action recognition. The link between object affordances and action understanding is consider...

The recent finding that Broca's area, the motor center for speech, is activated during action observation lends support to the idea that human language may have evolved from neural substrates already involved in gesture recognition. Although fascinating, this hypothesis can be questioned because while observing actions of others we may evoke some i...

This paper presents data and theoretical framework supporting a new interpretation of the role played by Broca's area. Recent brain imaging studies report that, in addition to speech-related activation, Broca's area is also significantly involved during tasks devoid of verbal content. In consideration of the large variety of experimental paradigms...

This chapter reviews some literature data and presents some experimental results showing that, in addition to speech-related tasks, Broca's area is also significantly involved during tasks devoid of verbal content. The first part reviews a series of recent brain imaging studies that report, among others, the activation of areas 44/45. In considerat...

Humans are an exquisitely social species. Our survival and success depend critically on our ability to thrive in complex social situations. But how do we understand others? Which are the mechanisms underlying this capacity? In the present essay we discuss a general neural mechanism (“mirror mechanism”) that enables individuals to understand the mea...

A multi-channel time-resolved system for functional near-infrared spectroscopy was used to map cerebral hemodynamic response in brain cortex. Measurements over the motor area as identified by transcranial magnetic stimulation show high sensitivity of the system.

Traditionally, attention was conceived as a cognitive mechanism sub-served by specific, dedicated anatomical centers independent of those involved in data processing and action execution. Attention mechanism was seen either as unitary or as formed by two or more independent anatomical circuits. The premotor theory of attention challenges the notion...

Neuroscience research during the past ten years has fundamentally changed the traditional view of the motor system. In monkeys, the finding that premotor neurons also discharge during visual stimulation (visuomotor neurons) raises new hypotheses about the putative role played by motor representations in perceptual functions. Among visuomotor neuron...

In order to study the interaction between proprioceptive information and motor imagery, we herein investigate how compatible and incompatible postural signals influence corticospinal excitability during the mental simulation of hand movements. Subjects were asked to imagine themselves joining the tips of the thumb and the little finger while they m...

We continuously act on objects, on other individuals, and on ourselves, and actions represent the only way we have to manifest our own desires and goals. In the last two decades, electrophysiological experiments have demonstrated that actions are stored in the brain according to a goal-related organization. The authors review a series of experiment...

We investigated changes in the corticospinal pattern of activity in healthy volunteers during sustained noxious and non-noxious mechanical stimulation of the first hand digit, resulting from active (self-stimulation) or passive (externally-induced) pressing against a sharp or blunted tip. The results indicate that, in order to press a finger onto a...

The ability to detect an incoming visual stimulus is enhanced by knowledge of stimulus location (orienting of visuospatial attention). Although the brain mechanisms at the basis of this enhancement are not yet fully clarified, there is evidence that orienting of attention is accompanied by the activation of oculomotor circuits. It remains unclear,...

The ability to detect an incoming visual stimulus is enhanced by knowledge of stimulus location (orienting of visuospatial attention [1]). Although the brain mechanisms at the basis of this enhancement are not yet fully clarified, there is evidence that orienting of attention is accompanied by the activation of oculomotor circuits 2, 3, 4, 5 and 6....

A category of stimuli of great importance for primates, humans in particular, is that formed by actions done by other individuals. If we want to survive, we must understand the actions of others. Furthermore, without action understanding, social organization is impossible. In the case of humans, there is another faculty that depends on the observat...

In the last two decades the integrative role of the frontal premotor cortex (a mosaic of agranular/disgranular areas lying in front of the primary motor cortex) have been more and more elucidated. Among its various functions, sensorimotor transformation, and action representation storage, also for nonstrictly motor purposes, are the most intriguing...

The precise neural mechanisms underlying speech perception are still to a large extent unknown. The most accepted view is that speech perception depends on auditory-cognitive mechanisms specifically devoted to the analysis of speech sounds. An alternative view is that, crucial for speech perception, it is the activation of the articulatory (motor)...

The relations between stimuli triggering a hand grasping movement and the subsequent action were studied in normal human participants. Participants were instructed to prepare to grasp a bar, oriented either clockwise or counterclockwise, and to grasp it as fast as possible on presentation of a visual stimulus with their right hand. The visual stimu...

Patients affected by VI cranial nerve palsy were required to orient their attention in monocular vision and to detect a stimulus appearing either in attended or in unattended locations. Results showed that while during non-paretic eye vision stimulus detection in the attended location was faster than that in the unattended one, during paretic eye v...

Picking up an object requires two basic motor operations: reaching and grasping. Neurophysiological studies in monkeys have suggested that the visuomotor transformations necessary for these two operations are carried out by separate parietofrontal circuits and that, for grasping, a key role is played by a specific sector of the ventral premotor cor...