Laia Domingo

Laia Domingo
IMIM Hospital del Mar Medical Research Institute | IMIM · Epidemiology and Evaluation Group

PhD

About

75
Publications
5,478
Reads
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1,259
Citations
Additional affiliations
September 2011 - December 2011
University of Copenhagen
Position
  • Visiting researcher

Publications

Publications (75)
Article
Purpose: To study the impact of comorbidities, multimorbidity, second primary cancers and socioeconomic determinants on adherence to follow-up recommendations for long-term breast cancer survivors (LTBCS), defined as women who survive 5 years or more after a primary breast cancer. Methods: We identified women diagnosed with breast cancer between 20...
Article
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Introduction Patients' and companions' participation in healthcare could help prevent adverse events, which are a significant cause of disease and disability. Before designing interventions to increase participation, it is first necessary to identify attitudes to patient safety. This study aimed to explore patients' and companions' perceptions, att...
Article
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Purpose: To obtain reference norms of EORTC QLQ-C30, EORTC QLQ-BR23, and EQ-5D-5L, based on a population of Spanish non-metastatic breast cancer patients at diagnosis and 2 years after, according to relevant demographic and clinical characteristics. Methods: Multicentric prospective cohort study including consecutive women aged ≥ 18 years with a...
Article
Background: Oropharyngeal dysphagia can be highly concerning in hospitalized patients, increasing morbidity and mortality, making its early identification essential. We aimed to characterize dysphagia and its association with aspiration pneumonia and mortality in a tertiary hospital in Barcelona, Spain. Methods: Using data form all hospital disc...
Article
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Introduction: Drug-related problems (DRP) are events or circumstances in which drug therapy does or could interfere with desired health outcomes. In December 2019, a new coronavirus, SARS-CoV-2, appeared. Little knowledge about this type of infection resulted in the administration of various drugs with limited use in other pathologies. Evidence abo...
Article
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Purpose To identify adherence to follow-up recommendations in long-term breast cancer survivors (LTBCS) of the SURBCAN cohort and to identify its determinants, using real-world data. Methods We conducted a retrospective study using electronic health records from 2012 to 2016 of women diagnosed with incident breast cancer in Spain between 2000 and...
Article
Objective: Our objective was to evaluate the cost-effectiveness of the use of peripherally inserted central venous catheters (PICCs) by a vascular access team (VAT) versus central venous catheters (CVCs) for in-hospital total parenteral nutrition (TPN). Methods: The study used a cost-effectiveness analysis based on observational data retrospecti...
Article
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Objective: The aim of this study was to evaluate the existing survival rate and clinical-pathological differences among patients with breast cancer detected by mammographic screening. Materials and methods: This multicenter cohort study examined 1,248 patients who took part in a national screening program for the early detection of breast cancer...
Article
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Few studies have assessed the impact of the COVID-19 pandemic on non-COVID diseases and healthcare quality. We aimed to evaluate changes in rates of hospitalisations, complications, in-hospital mortality, and readmissions among patients with non-COVID diseases during a one-year period after the pandemic onset. From March 2018 to February 2021 a ret...
Article
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PurposeThis study aimed to evaluate health service utilization in Spain among long-term breast cancer survivors and to compare it with that among women with no history of breast cancer.Methods Study based on the SURBCAN cohort includes a sample of long-term breast cancer survivors and a sample of women without breast cancer from 5 Spanish regions....
Article
Introduction Complications and readmissions derived from surgical treatment of breast cancer have been less evaluated than recurrence and mortality. The aim of this study was to analyze the results of surgical treatment and prognosis in a screening population with known high surgical variability. Methods This multicenter study included 1086 women...
Article
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The disease management of long‐term breast cancer survivors (BCS) is hampered by the scarce knowledge of multimorbidity patterns. The aim of our study was to identify multimorbidity clusters among long‐term BCS and assess their impact on mortality and health services use. We conducted a retrospective study using electronic health records of 6512 BC...
Article
Objective To assess attitudes and perceptions from nursing staff, surgeons and anesthetists about compliance, utility, and impact on patient's safety of the surgical checklist in a teaching hospital. We also aimed to identify improvement opportunities for strengthening the usefulness of the checklist in the operating theater. Methods We carried ou...
Article
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Background Several studies have proposed personalized strategies based on women’s individual breast cancer risk to improve the effectiveness of breast cancer screening. We designed and internally validated an individualized risk prediction model for women eligible for mammography screening. Methods Retrospective cohort study of 121,969 women aged...
Preprint
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Background Complications and readmissions derived from surgical treatment of breast cancer have been scarcely evaluated. The studies that compare mastectomy with conservative, usually focus only in recurrence and/or mortality and sometimes the results are discordant in some aspects. The aim of this study was to analyze complications and readmission...
Article
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Objective Population-wide mammographic screening programs aim to reduce breast cancer mortality. However, a broad view of the harms and benefits of these programs is necessary to favor informed decisions, especially in the earliest stages of the disease. Here, we compare the outcomes of patients diagnosed with breast ductal carcinoma in situ in par...
Article
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Introduction: Breast cancer has become a chronic disease due to survival improvement and the need to monitor the side effects of treatment and the disease itself. The aim of the SURBCAN study is to describe comorbidity, healthcare services use and adherence to preventive recommendations in long-term breast cancer survivors and to compare them with...
Article
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Background: The impact of comorbidity on the risk of revision in patients undergoing Total Knee arthroplasty (TKA) and Total Hip Arthroplasty (THA) is not currently well known. The aim of this study was to analyze the impact of comorbidity on the risk of revision in TKA and THA. Methods: Patients recorded in the Catalan Arthroplasty Register (RA...
Article
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PurposeThe objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score.Methods The breast cancer MCC-Spain...
Article
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Background The effectiveness of breast cancer screening is still under debate. Our objective was to systematically review studies assessing personalized breast cancer screening strategies based on women’s individual risk and to conduct a risk of bias assessment. Methods We followed the standard methods of The Cochrane Collaboration and PRISMA decl...
Article
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Background: We aimed to identify the risk factors associated with early, late and long-term readmissions in women diagnosed with breast cancer participating in screening programs. Methods: We performed a multicenter cohort study of 1055 women aged 50-69 years participating in Spanish screening programs, diagnosed with breast cancer between 2000...
Article
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Background: Our aim was to assess the role of breast density on breast cancer mortality and recurrences, considering patient and tumour characteristics and the treatments received among women attending population-based screening programmes. Methods: We conducted a retrospective cohort study among women aged 50-69 years attending population-based...
Article
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The aim of this study is to determine the survival of patients with breast cancer treated with adjuvant chemotherapy (ACh) after the diagnosis by screening, taking comorbidity into account. This multicenter cohort study examined a population of patients taking part in four national screening programs for the early detection of breast cancer (locali...
Article
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To assess the cost-effectiveness of the primary prevention of fragility hip fractures through opportunistic risk-based screening using FRAX® among women aged 70 to 89 years, and the subsequent treatment with alendronate in women at high-risk, from the Spanish national health system perspective. We performed a discrete-event simulation model. Women...
Poster
Full-text available
Poster presented in the International Cancer Screening Network 2019 in Rotterdam in reference to the article: Javier Louro, Margarita Posso, Michele Hilton Boon, Marta Román, Laia Domingo, Xavier Castells & María Sala. A systematic review and quality assessment of individualised breast cancer risk prediction models. Br J Cancer. 2019 May 22. doi:...
Article
Objective: To analyse trends in the use of diagnostic test in breast cancer screening programs in Spain. Materials and methods: Retrospective study of 542,695 women who had undergone at least one screening mammogram in any of the screening centres of three administrative regions in Spain, between 1996 and 2011. Process measures were: overall rec...
Article
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Background: Individualised breast cancer risk prediction models may be key for planning risk-based screening approaches. Our aim was to conduct a systematic review and quality assessment of these models addressed to women in the general population. Methods: We followed the Cochrane Collaboration methods searching in Medline, EMBASE and The Cochr...
Article
Background: The effect of changes in mammographic density over time on the risk of breast cancer remains inconclusive. Methods: We used information from four centres of the Breast Cancer Screening Program in Spain in the period 1996-2015. We analysed individual level data from 117,388 women first screened age 50-54, with at least two screening e...
Article
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Background Monitoring results regarding the effectiveness of knee and hip arthroplasties may be useful at the clinical, economic and patient level and help reduce the number of prosthesis revisions. In Spain, and specifically in Catalonia, there is currently no systematic monitoring of the different prosthesis models available on the market. Within...
Article
Rationale, aims, and objectives To externally validate the PREDICT tool in a cohort of women participating in a population‐based breast cancer screening programme who were diagnosed with breast cancer between 2000 and 2008 in Spain. Methods A total of 535 women were included in the validation study. We calculated predicted 5‐year survival using th...
Article
Background: We aimed to evaluate survival and disease-free survival in different subtypes of interval cancers by breast density, taking into account clinical and biological characteristics. Methods: We included 374 invasive breast tumors (195 screen-detected cancers; 179 interval cancers, classified into true interval, false-negatives, occult tu...
Conference Paper
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Introduction: Integrated care interventions are extremely complex as they tend to involve multiple actors and different care levels. When evaluating such programmes indicators provide several benefits in comparison with other approaches. The Agència de Qualitat i Avaluació Sanitàries de Catalunya, through a new collaborative approach, has been work...
Presentation
Full-text available
Introduction Integrated care interventions are extremely complex as they tend to involve multiple actors and different care levels. When evaluating such programmes indicators provide several benefits in comparison with other approaches. The Agència de Qualitat i Avaluació Sanitàries de Catalunya, through a new collaborative approach, has been worki...
Article
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Women with benign breast diseases (BBD) have a high risk of breast cancer. However, no biomarkers have been clearly established to predict cancer in these women. Our aim was to explore whether estrogen receptor (ER), progesterone receptor (PR), and Ki67 expression stratify risk of breast cancer in screened women with BBD. We conducted a nested case...
Article
Introduction The implementation of National Prostheses Registries allows us to obtain a large amount of data and make conclusions in order to improve the use of them. Sweden was the first country to implement a National Prostheses Registry in 1979. Catalonia has been doing this since 2005. The aim of our study is to analyse the evidence that suppor...
Article
Background and aim: The Catalonian Arthroplasty Register (RACat) is a public health-based population register used to analyse and evaluate hip and knee replacements in Catalonia. The aim of this study is to present the outcomes after 10 years in operation (January 2005-December 2014). Methodology: Using the information from the RACat and the min...
Article
Background and aim The Catalonian Arthroplasty Register (RACat) is a public health-based population register used to analyse and evaluate hip and knee replacements in Catalonia. The aim of this study is to present the outcomes after 10 years in operation (January 2005 to December 2014). Methodology Using the information from the RACat and the mini...
Article
INTRODUCTION Our purpose is to present the potential for health technology assessment that arthroplasty registers may offer. METHODS A revision of the health assessment uses and information collected by arthroplasty registers was made. The information provided from international networks like NORE, ISAR and ICOR was also considered. Arthroplasty r...
Article
Introduction: The implementation of National Prostheses Registries allows us to obtain a large amount of data and make conclusions in order to improve the use of them. Sweden was the first country to implement a National Prostheses Registry in 1979. Catalonia has been doing this since 2005. The aim of our study is to analyse the evidence that supp...
Article
Full-text available
Background To date, the study of the risks and benefits of breast cancer screening has not included the onset of persistent pain after breast cancer treatment within the context of population-based screening programs. Our purpose was to investigate the prevalence of persistent pain and associated factors in women diagnosed with breast cancer (scree...
Conference Paper
Antecedentes/Objetivos: El Registro de Artroplastias de Cataluña (RACat) es un registro poblacional que desde el año 2005 recopila in- formación de las artroplastias de rodilla y cadera realizadas en los hospitales públicos de Cataluña. El objetivo de este estudio es presentar los resultados de los 10 primeros años de funcionamiento del registro....
Article
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The aim was to develop a conceptual framework for the assessment of new healthcare initiatives on chronic diseases within the Spanish National Health System. A comprehensive literature review between 2002 and 2013, including systematic reviews, meta-analysis, and reports with evaluation frameworks and/or assessment of initiatives was carried out; i...
Conference Paper
Full-text available
Introduction: Nowadays European health systems are facing the challenge of offering long-term care and support services to an increasing number of older people with a high prevalence of frailty, (multi) morbidity and disability. More and more integrated care initiatives are being implemented in healthcare systems to address the health and social de...
Article
Purpose To assess the risk of breast cancer in women with false-positive screening results according to radiologic classification of mammographic features. Materials and Methods Review board approval was obtained, with waiver of informed consent. This retrospective cohort study included 521 200 women aged 50-69 years who underwent screening as part...
Article
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Objective: To compare accuracy measures for mammographic screening in Norway, Spain, and the US. Methods: Information from women aged 50-69 years who underwent mammographic screening 1996-2009 in the US (898,418 women), Norway (527,464), and Spain (517,317) was included. Screen-detected cancer, interval cancer, and the false-positive rates, sens...
Article
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In the context of a population-based screening program, we aimed to evaluate the major mammographic features and clinicopathological characteristics of breast tumors at diagnosis and the associations between them, focusing on tumors with the worst prognosis. We analyzed cancers diagnosed in a cohort of 645,764 women aged 45-69 years participating i...
Article
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Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influ...
Article
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Background Interval cancers are primary breast cancers diagnosed in women after a negative screening test and before the next screening invitation. Our aim was to evaluate risk factors for interval cancer and their subtypes and to compare the risk factors identified with those associated with incident screen-detected cancers. Methods We analyzed d...
Article
The consolidation of population-based screening programs for breast cancer and the debate on the risk-benefit balance have coincided with the opportunity and need for research to improve the effectiveness of these programs. In Spain, in parallel to other countries with population-based programs, research on screening has evolved from the early desc...
Article
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PURPOSE: To provide a complete evaluation of the long-term impact of full-field digital mammography (FFDM) on the improvement of early diagnosis in a population-based screening program. METHODS: We included 82,961 screen-film mammograms (SFM) and 79,031 FFDM from women aged 50-69 screened biennially from 1995-2010 in Spain and followed-up to 2012....
Article
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The one-size-fits-all paradigm in organized screening of breast cancer is shifting towards a personalized approach. The present study has two objectives: 1) To perform an economic evaluation and to assess the harm-benefit ratios of screening strategies that vary in their intensity and interval ages based on breast cancer risk; and 2) To estimate th...
Article
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Interval cancers are tumors arising after a negative screening episode and before the next screening invitation. They can be classified into true interval cancers, false-negatives, minimal-sign cancers, and occult tumors based on mammographic findings in a retrospective review of screening and diagnostic mammograms. This study aimed to describe tum...
Article
Background: The development and progression of true interval breast cancers (tumors that truly appear after a negative screening mammogram) is known to be different from screen-detected cancers. However, the worse clinical behavior of true interval cancers is not fully understood from a biologic basis. We described the differential patterns of gen...
Article
Women with a false-positive result after a screening mammogram have an increased risk of cancer detection in subsequent participations, especially after assessments involving cytology or biopsy. We aimed to compare women's personal characteristics, tumoral features and the radiological appearance of cancers with and without a previous false-positiv...
Article
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Background The aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences. Methods For this purpose, we evaluated clinical-pathological parameters and proliferative and apoptotic activities in a series...
Article
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Background: Long-term data on breast cancer detection in mammography screening programs are warranted to better understand the mechanisms by which screening changes the breast cancer pattern in the population. We aimed to analyze 17 years of breast cancer detection rates inside and outside screening in two Danish regions, emphasizing the influence...
Article
The question of whether screen detection confers an additional survival benefit in breast cancer is unclear and subject to several biases. Our aim was to examine the role of the diagnostic method (screen-detected, symptom-detected, and true interval cancers) and the clinical-pathological features in relapse-free survival and overall survival in bre...
Article
Introduction Interval cancer (IC) rate, risk factors and biological characteristics have been scarcely evaluated. In January 2010 started a multicentric project with the aim to estimate rates and determinants of IC and to compare their characteristics with those detected in the routine screening mammography. Methods Information from women aged 45/...
Article
Introduction Since 2000 Digital Mammography (DM) has been commercially available and implemented in many breast cancer screening programs. Although available information suggests that differences, if exist, are low, complete evaluation of DM is needed to perform a more accurate balance of risks and benefits of these programs. Our purpose was to com...
Article
To compare tumour characteristics between cancers detected with screen-film mammography (SFM) and digital mammography (DM) and to evaluate changes in positive predictive values (PPVs) for further assessments, for invasive procedures and for distinct radiological patterns in recalled women. 242,838 screening mammograms (171,191 SFM and 71,647 DM) fr...
Article
The aim of this study was to report the prevalence of intestinal parasites in stool specimens from outpatients in Catalonia (Spain), and to evaluate the association of age, seasonality, and gender on general parasitisation and by the most frequent detected species. A total of 13,913 samples from 8,313 patients (1-3 specimens per patient) reporting...
Article
To analyze phenotypic classification and other risk factors for interval breast cancer, focusing on true interval and false negative cancers. A nested case-control study was performed among 115 cancers detected between two screening mammograms (interval cancers) and 115 screen-detected cancers diagnosed between 1995 and 2008 in a population-based b...

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