Laetitia G. Garcia

Laetitia G. Garcia
Université Catholique de Louvain - UCLouvain | UCLouvain · Louvain Drug Research Institute (LDRI)

PhD in Biomedical & Pharmaceutical Sciences

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3
Publications
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187
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Publications

Publications (3)
Table 1 . MICs of antibiotics for Staphylococcus aureus with a normal...
Antibiotic activity against small-colony variants of Staphylococcus aureus: Review of in vitro, animal and clinical data
Article
Full-text available
  • Mar 2013
The pathogen Staphylococcus aureus uses various strategies for persisting in the host, among which switching to a small-colony variant (SCV) phenotype is of particular biological and therapeutic significance. Phenotypically, SCVs are characterized by a slow growth rate, atypical colony morphology and unusual biochemical features, constituting a rea...
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Figure 1. Concentration-dependent activities of four antistaphylococcal...
Table 1 . Strains used in this study (origin, resistance phenotype and...
Figure 2. 24 h concentration-dependent activity of ceftaroline against...
Table 3 . Recursive partitioning analysis of the values of the...
Activity of ceftaroline against extracellular (broth) and intracellular (THP-1 monocytes) forms of methicillin-resistant Staphylococcus aureus: Comparison with vancomycin, linezolid and daptomycin
Article
Full-text available
  • Nov 2012
Background: Ceftaroline fosamil is approved for treatment of acute bacterial skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We examined the activity of its active metabolite (ceftaroline) against intracellular forms of S. aureus in comparison with vancomycin, daptomycin and linezolid. Methods: Tw...
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FIG 1 Comparative phagocytosis and intracellular survival of S. aureus...
FIG 2 Concentration-response curves of gentamicin, moxifloxacin, and...
FIG 3 Influence of N -acetylcysteine on the intracellular activity of...
Influence of the Protein Kinase C Activator, Phorbol Myristate Acetate (PMA), on the Intracellular Activity of Antibiotics against Hemin and Menadione Auxotrophic Small-Colony Variant (SCV) Mutants of Staphylococcus aureus and their wild-type parental strain in Human THP-1 Cells
Article
Full-text available
  • Dec 2012
In a previous paper (Garcia et al, 2012, 56 (7): 3700-3711), we studied the intracellular fate of menD and hemB mutants (corresponding to menadione- and hemin-dependent SCVs, respectively) of the parental COL MRSA strain and the pharmacodynamic profile of intracellular activity of a series of antibiotics in human THP-1 monocytes. We have now examin...
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