Lærke Bay Marcussen- Master of Science
- Research Assistant at Aarhus University
Lærke Bay Marcussen
- Master of Science
- Research Assistant at Aarhus University
About
6
Publications
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76
Citations
Introduction
I am interested in the pathogenesis of immune-related diseases. Currently, metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH), particularly molecular changes in the hepatic microvasculature. I investigate how junctional proteins and aquaporins in liver sinusoidal endothelial cells (LSECs) are altered during disease progression and affect endothelial barrier function. I also worked with diagnostic tests and alternative functions of the human antibodies.
Current institution
Publications
Publications (6)
Restriction endonucleases are expressed in all bacteria investigated so far and play an essential role for the bacterial defense against viral infections. Besides their important biological role, restriction endonucleases are of great use for different biotechnological purposes and are indispensable for many cloning and sequencing procedures. Metho...
In the current study, we describe a novel DNA sensor system for specific and quantitative detection of mycobacteria, which is the causative agent of tuberculosis. Detection is achieved by using the enzymatic activity of the mycobacterial encoded enzyme topoisomerase IA (TOP1A) as a biomarker. The presented work is the first to describe how the cata...
Real-time detection of enzyme activities may present the easiest and most reliable way of obtaining quantitative analyses in biological samples. We present a new DNA-biosensor capable of detecting the activity of the potential anticancer drug target tyrosyl-DNA phosphodiesterase 1 (TDP1) in a very simple, high throughput, and real-time format. The...
Sensors capable of quantitative real-time measurements may present the easiest and most accurate way to study enzyme activities. Here we present a novel DNA-based sensor for specific and quantitative real-time measurement of the enzymatic activity of the essential human enzyme, topoisomerase I. The basic design of the sensor relies on two DNA stran...
