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February 2017 - present
- PhD Student
- By using chemogenetic and imaging techniques to generate large-scale activation maps, this project aims to delineate opposing pathway and regional specific contributions of the subthalamic nucleus and dorsal striatum on action sequence timing in rodents.
January 2014 - November 2014
- Honours (Neuroscience)
- Showed that transient dysregulation of dopamine signaling in a developing drosophila arousal circuit permanently impairs behavioral responsiveness in adults.
Performing several actions in swift succession is often necessary to exploit known contingencies in the environment. However, after a change in the contingency rules, the ability to appropriately adapt rapid action sequences must be procured for continued success. By combining analyses of behavioural microstructure with circuit-specific tracing in...
In mammalian species, the capacity for goal-directed action relies on a process of cognitive-emotional integration, which melds the causal and incentive learning processes that link action-goal associations with the current value of the goal . Recent evidence suggests that such integration depends on a cortical-limbic-striatal circuit centered o...
The acquisition of goal-directed action requires the encoding of specific action-outcome associations involving plasticity in the posterior dorsomedial striatum (pDMS). We first investigated the relative involvement of the major inputs to the pDMS argued to be involved in this learning-related plasticity, from prelimbic prefrontal cortex (PL) and f...
The dopamine ontogeny hypothesis for schizophrenia proposes that transient dysregulation of the dopaminergic system during brain development increases the likelihood of this disorder in adulthood. To test this hypothesis in a high-throughput animal model, we have transiently manipulated dopamine signaling in the developing fruit fly Drosophila mela...
This project aims to delineate the opposing regional and pathway specific contributions of the subthalamic nucleus and dorsal striatum on action sequence timing in rodents.
Identify if transient dysregulation of the dopaminergic system during brain development increases the likelihood of aberrant attention-like behavior adulthood.