Lachlan Dalli

Lachlan Dalli
Monash University (Australia) · Department of Medicine

Bachelor of Biomedical Science

About

23
Publications
589
Reads
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78
Citations
Citations since 2016
23 Research Items
77 Citations
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201620172018201920202021202201020304050

Publications

Publications (23)
Article
Background Administrative data are used extensively for research purposes, but there remains limited information on the quality of these data for identifying comorbidities related to stroke. Objective To compare the prevalence of comorbidities of stroke identified using International Classification Diseases, Australian Modification (ICD-10-AM) or...
Article
BACKGROUND Real-world evidence is limited on whether antihypertensive medications help avert major adverse cardiovascular events (MACE) after stroke without increasing the risk of falls. We investigated the association of adherence to antihypertensive medications on the incidence of MACE and falls requiring hospitalization after stroke. METHODS A...
Article
Full-text available
Background: Discharge planning is recommended to optimise the transition from acute care to home for patients admitted with stroke. Despite this guideline recommendation, many patients do not receive a discharge care plan. Also, there is limited evidence on factors influencing the provision of discharge care plan post-stroke. We evaluated patient,...
Article
Background Evidence is growing on anticancer effects of statins. We investigated whether the effectiveness of treatment with statins after ischemic stroke on mortality is influenced by a history of cancer. Methods Analyses of 90-day survivors of ischemic stroke (2012–2016; 45 hospitals) using linked registry and administrative data. Dispense of st...
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Full-text available
Objectives Data linkage can provide sufficient breadth and size of data, to draw reliable estimates of effectiveness, at a population level using real-world data. We compared differences in survival and hospital presentations following stroke or transient ischaemic attack (TIA), based on whether a Medicare funded chronic disease management plan was...
Article
Full-text available
Introduction: Observational studies are increasingly being used to provide evidence on the real-world effectiveness of medications for preventing vascular diseases, such as stroke. We investigated whether the real-world effectiveness of treatment with lipid-lowering medications after ischemic stroke is affected by prevalent user bias. Methods: A...
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Full-text available
Although medication adherence is commonly measured in electronic datasets using the proportion of days covered (PDC), no standardized approach is used to calculate and report this measure. We conducted a scoping review to understand the approaches taken to calculate and report the PDC for cardiovascular medicines to develop improved guidance for re...
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Full-text available
Purpose of Review To critically appraise literature on recent advances and methods using “big data” to evaluate stroke outcomes and associated factors. Recent Findings Recent big data studies provided new evidence on the incidence of stroke outcomes, and important emerging predictors of these outcomes. Main highlights included the identification o...
Article
Purpose: To describe types of mental health treatment accessed by community-based stroke survivors and factors associated with access. Methods: A sub-group of registrants from the Australian Stroke Clinical Registry completed a supplementary survey 2.5 years post-stroke. Self-reported information about depression/anxiety and treatment access wer...
Article
Background It is unclear whether survivors of stroke or transient ischemic attack (TIA) routinely receive, and understand, education about secondary prevention medications. Objectives To investigate whether survivors of stroke/TIA understand explanations about their prescribed prevention medications and associations with medication adherence, cont...
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Full-text available
Introduction: Treatment with several therapeutic classes of medication is recommended for secondary prevention of stroke. We analysed the associations between the number of classes of prevention medications supplied within 90 days post-discharge for ischemic stroke (IS)/transient ischemic attack (TIA) and survival. Patients and methods: Retrospe...
Article
Background and Purpose Although a target of 80% medication adherence is commonly cited, it is unclear whether greater adherence improves survival after stroke or transient ischemic attack (TIA). We investigated associations between medication adherence during the first year postdischarge, and mortality up to 3 years, to provide evidence-based targe...
Article
Objectives To assess the agreement between pharmaceutical claims data and patient-reported medication use after stroke. Methods Claims data from the Pharmaceutical Benefits Scheme were used to estimate medication use for a subset of participants registered in the Australian Stroke Clinical Registry in 2016. Estimates on medication use were validat...
Article
Background and Purpose Conditions associated with frailty are common in people experiencing stroke and may explain differences in outcomes. We assessed associations between a published, generic frailty risk score, derived from administrative data, and patient outcomes following stroke/transient ischemic attack; and its accuracy for stroke in predic...
Article
Introduction Stroke is a leading cause of death and disability. Since 2012, our innovative national data linkage program, has enabled the successful linkage of data from the Australian Stroke Clinical Registry (AuSCR) with national and state-based datasets to investigate the continuum of stroke care and associated outcomes. Objectives and Approach...
Article
Introduction To prevent further vascular events, prescribing of multiple classes of medications (antihypertensive, antithrombotic and lipid-lowering) is recommended in national clinical guidelines following ischaemic stroke. Objectives and Approach Using real-world data, we determined the association between optimal combination pharmacotherapy (su...
Article
Introduction Despite being recommended in clinical guidelines for secondary prevention of stroke, there are limited real-world data on outcomes associated with use of statins post-stroke. Objectives and Approach We aimed to investigate the association between statin use and cardiovascular mortality post-stroke. We conducted a retrospective cohort...
Article
Objective To investigate whether certain patient, acute-care, or primary-care factors are associated with medication initiation and discontinuation in the community post-stroke or TIA. Methods Retrospective cohort study using prospective data on adult patients with first-ever acute stroke/TIA from the Australian Stroke Clinical Registry (April 201...
Article
Purpose: Prescribed daily dose (PDD), the number of doses prescribed to be taken per day, is used to calculate medication adherence using pharmacy claims data. PDD can be substituted by (1) 1 dose per day (1DD), (2) an estimate based on the 75th percentile of days taken by patients to refill a script (PDD75 ) or (3) the World Health Organisation's...
Article
Background and Purpose— Readmissions after stroke are common and appear to be associated with comorbidities or disability-related characteristics. In this study, we aimed to determine the patient and health-system level factors associated with all-cause and unplanned hospital readmission within 90 days after acute stroke or transient ischemic attac...
Article
Background and Purpose— Despite evidence to support the prescription of antihypertensive medications before hospital discharge to promote medication adherence and prevent recurrent events, many patients with stroke miss out on these medications at discharge. We aimed to examine patient, clinical, and system-level differences in the prescription of...

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