Kylie O'Brien

Kylie O'Brien
Pintail Limited

PhD, BSc

About

11
Publications
4,806
Reads
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330
Citations
Additional affiliations
May 2006 - September 2007
National University of Ireland, Maynooth
Position
  • PhD Student

Publications

Publications (11)
Article
Background The majority of childhood cancer survivors are at risk of treatment-related adverse health outcomes. Survivorship care to mitigate these late effects is endorsed, but it is not available for many adult survivors of childhood cancer in Europe. The PanCareFollowUp project was initiated to improve their health and quality of life (QoL) by f...
Article
Aims: Survival after cancer diagnosed during childhood or adolescence continues to improve with new treatments and supportive therapies. Optimal long-term care requires that risks to vulnerable organs are clearly defined and translated into guidelines that are implemented into practice. PanCareLIFE is a pan-European consortium that addresses survi...
Article
Full-text available
Tics and compulsions in comorbid Tourette's syndrome (TS) and obsessive-compulsive disorder (OCD) are associated with chronic hyperactivity of parallel cortico/amygdalo-striato-thalamo-cortical (CSTC) loop circuits. Comorbid TS- & OCD-like behaviors have likewise been observed in D1CT-7 mice, in which an artificial neuropotentiating transgene encod...
Technical Report
Full-text available
Overweight, obesity and associated diseases are major societal challenges for the health of European citizens. Most individuals can manage to lose weight, but few manage to maintain their weight loss in the long term. The key challenge in managing obesity in Europe and beyond is therefore not weight loss per se, but weight loss maintenance. The ove...
Article
Full-text available
Background: Lifestyle interventions targeting physical activity, sedentary time and dietary behaviours have the potential to initiate and support behavioural change and result in public health gain. Although men have often been reluctant to engage in such lifestyle programs, many are at high risk of several chronic conditions. We have developed an...
Article
There is increasing evidence that hydrogen peroxide (H(2)O(2)) may act as a neuromodulator in the brain, as well as contributing to neurodegeneration in diseased states, such as Parkinson's disease. The ability to monitor changes in endogenous H(2)O(2)in vivo with high temporal resolution is essential in order to further elucidate the roles of H(2)...
Article
Efflux of a number of important neurochemicals, including D-serine, L-serine, taurine, glutamate, and gamma-aminobutyric acid (GABA), from mouse cortical brain slices housed in a 7 microL perfusion chamber was monitored using online microdialysis-CE (MD-CE). Analyte concentrations could be measured every 20-27 s using the MD-CE instrument. Stimulat...
Article
Uptake of the neuromodulator D-serine by isolated larval tiger salamander (Ambystoma tigrinum) retinas was measured using capillary electrophoresis (CE). Excised retinas were incubated in Ringer's solution in the presence of 5 microM D-serine. The supernatant was removed after 30 min, mixed with 4-fluoro-7-nitrobenz-2-oxa-1,3-diazole (NBD-F) to flu...
Article
Release of neurotransmitters and other primary amine-containing analytes from intact, isolated larval salamander (Ambystoma tigrinum) retinas maintained in a 6.5-microL perfusion chamber was monitored using online microdialysis-capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). Primary amines were derivatized online with...
Article
Cell extraction and further sample preparation for nucleotide pool analysis using capillary electrophoresis was faster and simpler using volatile extraction solvents (e.g. organic solvents and de-ionized water) compared to the commonly applied acids dissolved in water (e.g. perchloric acid and trichloracetic acid). Temperature had to be controlled...
Article
A high-throughput method is described for the analysis of D-serine and other neurotransmitters in tissue homogenates. Analysis is performed by microdialysis-capillary electrophoresis (CE) with laser-induced fluorescence (LIF) detection in a sheath flow detection cell. Sample pretreatment is not required as microdialysis sampling excludes proteins a...

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Cited By

Projects

Projects (5)
Project
PanCareFollowUp (www.pancarefollowup.eu) is an EU-funded project that aim is to improve the quality of life for survivors of childhood and adolescent cancer by bringing evidence-based, person-centred care to clinical practice in the real world.
Project
PD-MitoQUANT (https://www.pdmitoquant.eu/) is an Innovative Medicines Initiative (IMI) project that brings together academic experts, SMEs, pharmaceutical companies from the European Federation of Pharmaceutical Industries and Associations (EFPIA) and patient advocacy organisation Parkinson’s UK to: (i) improve our understanding of mitochondrial dysfunction in Parkinson’s, (ii) identify and validate molecular drivers and mechanisms in Parkinson’s, and (iii) discover innovative therapeutic targets that can be further progressed by the EFPIA partners in the future. This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 821522. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA and Parkinson’s UK. The material presented and views expressed here reflect the author’s view and neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained herein.
Project
PanCareLIFE is an EU-funded project (Grant No. 602030) investigating late effects of childhood cancer treatment that impact fertility and hearing impairment (ototoxicity) and health-related quality of life. www.pancarelife.eu