Kyle Isaacson

• Bioengineering PhD
• Formulation Scientist at Phospholutions

While commonly known for degradation of the extracellular matrix, matrix metalloproteinases (MMPs) exhibit broad potential for use in targeting of bioactive and imaging agents in cancer treatment. MMPs are upregulated at all stages of expression in cancers. A comprehensive analysis of published literature on expression of all MMP subtypes at the ge...

Radiation-induced proctitis (RIP) is the most common clinical adverse effect for patients receiving radiotherapy as part of the standard course of treatment for ovarian, prostate, colon, and bladder cancers. RIP limits radiation dosage, interrupts treatment, and lowers patients' quality of life. A prophylactic treatment that protects the gastrointe...

Photography usually requires optics in conjunction with a recording device (an image sensor). Eliminating the optics could lead to new form factors for cameras. Here, we report a simple demonstration of imaging using a bare CMOS sensor that utilizes computation. The technique relies on the space variant point-spread functions resulting from the int...

Cerebral aneurysms (CA), an abnormal bulge in the arteries that supply blood to the brain, are prone to rupture and can cause hemorrhagic stroke. Physicians can treat CA by blocking blood flow to the aneurysmal sac via clipping of the aneurysm neck via open procedure, or endovascular occlusion of the aneurysm with embolic materials to promote throm...

We asked young scientists to write a rule that all principal investigators (PIs) should be required to follow to improve the experience of young scientists in their lab. Read a selection of their suggestions below. Follow NextGen Voices on Twitter with hashtag #NextGenSci. —Jennifer Sills

We asked young scientists to write a rule that all principal investigators (PIs) should be required to follow to improve the experience of young scientists in their lab. Read a selection of their suggestions below.

Various polymers used in controlled release applications exhibit solution-based thermal responses. Unfortunately, very few characterization and imaging techniques permit resolution of individual polymers during their thermally-triggered phase transitions. Here, we demonstrate the use of temperature-ramp liquid-cell transmission electron microscopy...

Radiation-induced proctitis (RIP) is a debilitating adverse event that occurs commonly during lower abdominal radiotherapy. The lack of prophylactic treatment strategies leads to diminished patient quality of life, disruption of radiotherapy schedules, and limitation of radiotherapy efficacy due to dose-limiting toxicities. Semisynthetic glycosamin...

An agricultural formulation for conveying nutrients to a plant includes Poly (aminoamide) (PAMAM) dendrimers and a fertilizer active ingredient .

Chronic toxicity evaluations of nanotechnology-based drugs are essential to support initiation of clinical trials. Ideally such evaluations should address the dosing strategy in human applications and provide sufficient information for long-term usage. Herein, we investigated one-year toxicity of non-surface modified silica nanoparticles (SNPs) wit...

Silk-elastinlike protein polymers (SELPs) self-assemble into nanostructures when designed with appropriate silk-to-elastin ratios. Here, we investigate the effect of insertion of a matrix metalloproteinase-responsive peptide sequence, GPQGIFGQ, into various locations within the SELP backbone on supramolecular self-assembly. Insertion of the hydroph...

The invention generally relates to agrochemical compositions and methods of making and using same. Specifically, the disclosed agrochemical compositions comprise high molecular weight non-polymeric residues or polymer backbones, and pesticide residues covalently attached thereto. Such compositions can be useful in, for example, controlling plant gr...

Rationale: Intraoperative bleeding impairs physicians' ability to visualize the surgical field, leading to increased risk of surgical complications and reduced outcomes. Bleeding is particularly challenging during endoscopic-assisted surgical resection of hypervascular tumors in the head and neck. A tool that controls bleeding while marking tumor m...

To mark the 30th anniversary of the Americans with Disabilities Act, we asked young scientists this question: What one thing would you change about the training or careers in your field to improve accessibility for people with visible and/or invisible disabilities? A selection of their responses is below. Follow NextGen Voices on Twitter with hasht...

We asked young scientists to write an advertisement that answers this question: How will food options, food availability, and individuals' food choices change in the future? A selection of their suggested marketing campaigns is below. Follow NextGen Voices on Twitter with hashtag #NextGenSci. Read previous NextGen Voices survey results at https://s...

Many PhD students have no intention of remaining in academia, and outdated university curricula do them a disservice by not offering training for careers in industry, argues Kyle Isaacson, a PhD student in biomedical engineering.

Technology is described for methods and systems for imaging an object (110). The method can include an image sensor (116) exposed to light (114) from an object (110) without passing the light through an image modification element. Light intensity of the light (114) can be stored as data in a medium. The image data can be analyzed at a processor (90...

Interstitial cystitis (IC), also known as painful bladder syndrome, is a debilitating chronic condition with many patients failing to respond to current treatment options. Rapid clearance, mucosal coating, and tight epithelium create strong natural barriers that reduce the effectiveness of many pharmacological interventions in the bladder. Intraves...

In her Working Life, “Paying it forward as a mentor” (3 August, p. 522), B. Abderrahman describes how a mentor's encouragement can help shape a career. She then explains how her positive mentorship experience inspired her to mentor others. We asked young scientists to describe one quality of a mentor you've had that you will try to emulate when you...

We asked young scientists this question: How do broad interests benefit your science? Scientists with a variety of hobbies responded that their extracurricular activities have enhanced a wide range of skills, from creativity to communication to resilience. Many also mentioned the value of clearing their minds and relaxing. Follow NextGen and share...

We asked young scientists: Are our schools and universities adequately prepared to educate young people for future challenges? What is the most pressing issue in your field, and what one improvement could your country make to its current education system to prepare students to face it? The responses expressed concerns about the current state of edu...

We gave young scientists this challenge: What is the purpose of a postdoc? Address this question by writing a job advertisement for the perfect postdoc position. We received responses from scientists around the world representing a variety of fields. Some wrote advertisements for their ideal postdoc job and benefits, no matter how fantastical. Othe...

Purpose: Novel embolic therapies are needed to improve cerebral aneurysm (CA) healing and reduce the risk of recanalization. Embolization and flow diversion are the standards of care to prevent intracranial hemorrhage in high-risk patients.[1] However, metal embolization coils and flow diversion devices require larger catheters for delivery, requir...

Recombinant silk-elastinlike protein polymers (SELPs) combine the biocompatibility and thermoresponsiveness of human tropoelastin with the strength of silk. Direct control over structure of these monodisperse polymers allows for precise correlation of structure with function. This work describes the fabrication of the first SELP nanogels and evalua...

Photography usually requires optics in conjunction with a recording device (an image sensor). Eliminating the optics could lead to new form factors for cameras. Here, we report a simple demonstration of imaging using a bare CMOS sensor that utilizes computation. The technique relies on the space variant point-spread functions resulting from the int...