Kyle C. Caires

Kyle C. Caires
University of Hawaiʻi at Mānoa | UH Manoa · Department of Human Nutrition, Food and Animal Sciences

Stem Cell Biology, Ph.D.

About

24
Publications
2,446
Reads
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266
Citations
Additional affiliations
August 2010 - February 2016
Berry College
Position
  • Professor (Assistant)
August 2007 - February 2011
Washington State University
Position
  • PhD Student
August 2005 - May 2007
Washington State University
Position
  • Research Assistant

Publications

Publications (24)
Article
Full-text available
The Japanese black cattle breed (Wagyu) has an improved metabolism, which allows them to have a higher marbling score when compared with other cattle breeds. However, this may affect other aspects of the animal's physiology, including hormone secretion and their reproductive success, such as their response to synchronization protocols and embryo pr...
Article
Full-text available
Mitochondrial DNA hypervariable region 1 diversity in Nigerian goats – CORRIGENDUM - Moses Okpeku, Sunday O. Peters, Ikhide G. Imumorin, Kyle C. Caires, Varun K. Sharma, Mathew Wheto, Rakesh Tamang, Adeyemi S. Adenaike, Michael O. Ozoje, Kumarasamy Thangaraj
Article
Full-text available
Goats make up the largest group of ruminant livestock in Nigeria and are strategic in bridging animal protein supply gap and improving the economy of rural households. The hypervariable region 1 (HVR1) of the caprine mitochondrial genome was investigated to better understand genetic diversity important for improving selection for animal breeding an...
Article
Full-text available
The Physiology and Endocrinology Symposium titled “Reproductive Success in Ruminants: A Complex Interaction Between Endocrine, Metabolic and Environmental Factors” was held at the Joint Annual Meeting of the American Dairy Science Association and American Society of Animal Science (ASAS) from July 20 to 24, 2014, in Kansas City, MO and was chaire...
Article
Full-text available
This study's objective was to determine seasonal and diurnal vs. nocturnal home range size, as well as predation for free-ranging farm cats at a livestock unit in Northwest Georgia. Seven adult cats were tracked with attached GPS units for up to two weeks for one spring and two summer seasons from May 2010 through August 2011. Three and five cats w...
Article
Full-text available
Background: Johne's disease is an incurable wasting condition that affects ruminant and non-ruminant animals. Each year, Johne's is responsible for losses in the billions of dollars in the United States cattle industry alone. Mycobacterium avium subspecies paratuberculosis (MAP) is the microorganism responsible for Johne's disease. MAP can spread v...
Article
Full-text available
A balance between self-renewal and differentiation of spermatogonial stem cells (SSCs) is required to maintain sperm production throughout male life. The seminiferous epithelium is organized into stages of spermatogenesis based on the complement of germ cell types within a tubular section of the testis. The stages exist in close physical proximity...
Article
The mechanisms governing the ontogeny of Sertoli cells during testis development in boars remains unknown. The objective of the current study was to determine the pattern of Sertoli cell maturation in porcine testis tissue and identify mechanisms governing the developmental plasticity of these cells. We hypothesize the existence of heterogeneous Se...
Article
Ethanol is a known modulator of neural stem cell development, but the consequences of ethanol toxicity on the cell fate decisions of spermatogonial stem cells (SSCs) is poorly understood. Using an in vivo treatment and stem cell transplantation approach, we investigated the effects of acute ethanol exposure on formation of the growing adult SSC pop...
Article
Full-text available
The objective of the present study was to investigate vascular endothelial growth factor A (VEGFA) isoform regulation of cell fate decisions of spermatogonial stem cells (SSC) in vivo. The expression pattern and cell-specific distribution of VEGF isoforms, receptors, and coreceptors during testis development postnatal d 1-180 suggest a nonvascular...
Article
The objective of the present study was to investigate VEGFA isoform regulation of cell fate decisions of spermatogonial stem cells (SSC) in vivo. The expression pattern and cell specific distribution of VEGFA ligands, receptors and co-receptors during testis development suggest that VEGFA isoforms may regulate early germ cell differentiation. Immun...
Article
Spermatogonial stem cells (SSCs) and their ability to self-renew provide a continual supply of differentiating germ cells to maintain the demands of fertility throughout adult male life. The SSC population is formed shortly after birth, forms a niche microenvironment with somatic cells and begins to initiate differentiation to support tissue functi...
Article
A balance between self-renewal and differentiation of spermatogonial stem cells (SSCs) is required to maintain sperm production throughout adult life in males. The mature seminiferous epithelium is organized into small clusters (or stages of spermatogenesis) based on the presence and precise complement of germ cells types within a tubular section o...
Chapter
Introduction Spermatogenesis Transcriptomics of testis in bulls Reproductive genomics in boars Future research directions References
Article
Full-text available
Spermatogonial stem cells (SSCs) are a self-renewing population of adult stem cells capable of producing progeny cells for sperm production throughout the life of the male. Regulation of the SSC population includes establishment and maintenance of a niche microenvironment in the seminiferous tubules of the testis. Signaling from somatic cells withi...
Article
Full-text available
Vascular endothelial growth factor-A (VEGFA) is a hypoxia-inducible peptide essential for angiogenesis and targets nonvascular cells in a variety of tissues and cell types. The objective of the current study was to determine the function of VEGF during testis development in bulls. We used an explant tissue culture and treatment approach to test the...
Article
Somatic and germ cell maturation precedes the start of spermatogenesis and is coordinated, so efficient spermatogenesis will occur in the adults. The present study was conducted to evaluate endocrine regulation of germ and somatic cell homeostasis in the neonatal boar testis associated with the establishment of spermatogenesis. Testis tissue obtain...
Article
Ectopic testis tissue xenografting provides a useful model for investigating factors that regulate germ cells and the supporting somatic cells in the mammalian testis. The role for VEGF as an endothelial cell mitogen has been well documented and recent work has suggested nonendothelial cell targets for VEGF-A in testicular germ cells. In addition,...

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Projects

Projects (3)
Project
The Wagyu cattle breed has an improved metabolism, which allows it to have a higher marbling score when compared to other cattle breeds. However, this can affect other aspects of the animal's physiology, including hormone secretion and reproductive success, such as its response to embryo production and synchronization protocols. The objective of the project is to characterize the reproductive performance of Wagyu cattle in reproductive animals submitted to Superovulation and FIV protocols.