Kuo-Hsuan Chung

Kuo-Hsuan Chung
Taipei Medical University | TMU · Department of Psychiatry

MD

About

64
Publications
3,795
Reads
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682
Citations
Additional affiliations
August 2008 - present
Taipei Medical University
Position
  • Professor (Assistant)
May 2006 - present
Taipei Medical University Hospital
Position
  • Attending physician

Publications

Publications (64)
Article
Background Neuroinflammation and brain structural abnormalities are found in bipolar disorder (BD). Elevated levels of cytokines and chemokines have been detected in the serum and cerebrospinal fluid of patients with BD. This study investigated the association between peripheral inflammatory markers and brain subregion volumes in BD patients. Meth...
Article
Objective: Over a half century, lithium has been used as the first-line medication to treat bipolar disorder. Emerging clinical and laboratory studies suggest that lithium may exhibit cardioprotective effects in addition to neuroprotective actions. Fractalkine (CX3CL1) is a unique chemokine associated with the pathogenesis of mood disorders and ca...
Article
Introduction Studies have reported higher risks of mortality for patients with schizophrenia, compared to the general population. This study aimed to evaluate the risk of all-cause, sudden death, and cardiovascular mortality among patients with schizophrenia in terms of types of antipsychotics. Methods A retrospective cohort study assessed the ris...
Article
Background: Heart failure is the leading cause of mortality in older people with bipolar disorder (BD). Studies examining cardiac structure and function in middle-aged patients with BD by using echocardiography and cardiac strain imaging are scant. Methods: We recruited 48 patients with bipolar I disorder (BD-I) older than 45 years to undergo conve...
Article
Background Atherosclerosis can result in serious cardiovascular disease (CVD) and is associated with inflammation and psychopharmacological treatment in bipolar disorder. We attempt to investigate the effects of lithium and inflammation on the atherosclerotic development in older bipolar adults at high risk for cardiovascular disease. Methods The...
Article
Full-text available
Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved therapy in major depressive disorder. However, its treatment efficacy on depression after traumatic brain injury (TBI) remains inconclusive. We conducted a meta-analysis to assess the effectiveness of executing rTMS over dorsolateral prefrontal cortex (DLPFC) on depression, cogn...
Article
Full-text available
Background The use of sedatives or hypnotics and the recurrence of depression have not been adequately explored. This study investigated the roles of sedative-hypnotics in patients with major depressive disorder (MDD). Various characteristics of sedative-hypnotic use were tested as risk factors for recurrence.Methods Clinical records of 15,510 pati...
Preprint
UNSTRUCTURED The improvement of accurate management of mental illness has become an increasing concern in recent decades. Efforts to understand mental illness have progressed from treating the mind as an isolated system to involving both mind and body as an interactive response. This study attempts to express and ontologize the relationships betwee...
Article
Full-text available
Mood state assessment (MSA) is increasingly important for diagnosis and treatment of depression. Recent years, many approaches have been proposed for the process of MSA. When using a single approach for MSA, the user often has to deal with possible noisy data and unacceptable error rates. Novelty: In order to improve the accuracy of MSA, in this pa...
Article
Background and objectives Patients with bipolar disorder (BD) tend to have accelerated decline in executive function during the aging. Thus far, only few studies have examined the effect of obesity on frontal cortical volumes in young patients with BD. Herein we aimed to ascertain the association between body mass index (BMI) and frontal cortical v...
Preprint
Full-text available
Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved therapy in major depressive disorder. However, its treatment efficacy on depression after traumatic brain injury (TBI) remains inconclusive. We conducted a meta-analysis to assess the effectiveness of executing rTMS over dorsolateral prefrontal cortex (DLPFC) on depression, cogn...
Article
Objectives Patients with bipolar disorder are at high risk of cardiovascular diseases. Among cardiovascular diseases, coronary heart disease and stroke are the leading causes of premature death and both share the pathogenesis of arterial atherosclerosis. Increased carotid intima-media thickness is sensitive for detecting early atherosclerosis and a...
Article
Objective: Obesity, aging, and pathophysiology of schizophrenia (SCZ) may collectively contribute to the gray matter loss in brain regions of SCZ. We attempted to examine the association between volumes of specific brain regions, body mass index (BMI), inflammatory markers, and clinical features in older SCZ patients. Method: Clinically stable o...
Article
Aim: Older community-dwelling patients with severe mental illness (SMI), particularly those with illness onset at young age, constitute a group of survivors with unique long-term care needs. Using an Asian sample in Taiwan, we attempted to find out the differences in outcomes related to physical health, cognition, and social functioning between ol...
Article
Background: Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant. Objective: This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan. Methods: A total of 564 first, fourth and seven...
Article
Aim Older patients with bipolar disorder (BD) are at a high risk of stroke. Silent stroke could be neglected in BD patients after middle age, particularly in those with illness onset at the young age. Therefore, we investigated the morbidity and related factors for stroke in older BD patients with typical‐onset age. Methods Older patients with bip...
Article
Background Bipolar disorder (BD) and aging appear to be associated with inflammatory activation. Inflammatory processes might affect hippocampal function, neurogenesis, and gray matter loss. This study investigated the relationship between BD-specific brain regions and the total gray matter volume, peripheral inflammatory markers, and clinical feat...
Article
Patients with schizophrenia have higher mortality and shortened life expectancy than the general population, and cardiovascular disease (CVD) accounts for up to 50% cases of early mortality in schizophrenia. We determined risk factors, particularly pathophysiological changes, for early circulatory mortality in schizophrenia. In this multi-instituti...
Article
Objective Serum lipid levels may be associated with the affective severity of bipolar disorder, but data on lipid profiles in Asian patients with bipolar disorder and the lipid alterations in different states of opposite polarities are scant. We investigated the lipid profiles of patients in the acute affective, partial, and full remission state in...
Article
Full-text available
The impacts of antidepressants on the pathogenesis of dementia remain unclear despite depression and dementia are closely related. Antidepressants have been reported may impair serotonin-regulated adaptive processes, increase neurological side-effects and cytotoxicity. An ‘astroglio-centric’ perspective of neurodegenerative diseases proposes astroc...
Article
Full-text available
Although evidence suggests that homocysteine levels are elevated in severe mental illness in children, findings regarding homocysteine levels in youth with anxiety and depression are scarce. Therefore, this study examined the association of homocysteine levels with anxiety and depression in a community sample of students aged 6–13 years. In total,...
Article
Aim: We attempted to determine risk factors, particularly pathophysiological changes, for the early cardiovascular mortality in bipolar disorder. Methods: A total of 5416 in-patients with bipolar I disorder were retrospectively followed through record linkage for cause of death. A total of 35 patients dying from cardiovascular disease (CVD, ICD...
Article
Full-text available
Depression and dementia are common mental health problems and are associated in several ways. Early-life depression is associated with increased risk of later life dementia, and depression can present as a preclinical symptom or consequence of dementia. Despite the plausible relationship between these two clinical entities, the potential associatio...
Data
The plot of log(-log(survival function)) versus log of survival time. (TIF)
Data
Kaplan-Meier estimates of study and control group patients who developed dementia after 5 years of index date. (TIF)
Article
This is the first case of Sneddon syndrome-related psychotic symptoms leading to a suicide attempt, although a previous study by Laurence et al. reported a case of a suicide attempt in the context of bipolar symptoms related to Sneddon syndrome.
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Full-text available
Evidence of associations between psychopathology and obesity in childhood remains inconsistent, and most studies have been conducted in Western countries. This study investigated psychological and physiological correlates of obesity in a community sample of children in Taiwan. In total, 302 children (157 overweight/obese and 145 healthy-weight chil...
Article
Objective: Patients with bipolar disorder are at a high risk for comorbid alcohol use disorder, and both disorders are associated with poor outcomes and multiple morbidities. This study aimed to explore not only the psychosocial functioning and psychopathological outcomes but also the medical morbidity of patients with bipolar disorder with and wi...
Article
Patients with schizophrenia before reaching geriatric age are at high risk of circulatory mortality. However, investigations are lacking on the characteristics of physiological measurement among these at-risk patients. In this study, we followed acutely inpatients with schizophrenia disorder for cause of death through record linkage to the Death Ce...
Article
Full-text available
To profile plasma antibodies of patients with bipolar disorder (BD), an E. coli proteome microarray comprising ca. 4200 proteins was used to analyze antibody differences between BD patients and mentally healthy controls (HCs). The plasmas of HCs and patients aged 18-45 years with bipolar I disorder (DSM-IV) in acute mania (BD-A) along with remissio...
Article
Full-text available
Previous epidemiological studies have established insomnia as a major risk factor for mood, anxiety, and substance use disorders. However, the associations between insomnia with sedative-hypnotic prescriptions and various psychiatric disorders have not been thoroughly examined. The current study involved evaluating the risk of psychiatric disorders...
Article
Compared to data on adolescents and adults, limited research has been conducted on biological correlates among young children with possible psychological difficulties, especially in Asian countries. By focusing on various peripheral biochemical indicators, we investigated potential biological correlates of psychological states in a community sample...
Article
Objective: Quetiapine is a dibenzothiazepine derivative, similar to clozapine, which has the highest risk of causing blood dyscrasias, especially neutropenia. There are some case reports about this side effect of quetiapine, but possible risk factors are seldom discussed and identified. A case of a patient with hepatocellular carcinoma that develo...
Article
ObjectiveA proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode...
Article
Full-text available
Background While chronobiological studies have reported seasonal variation in panic attacks (PA) episodes, information on the timing of PA by week-days may enable better understanding of the triggers of PA episodes and thereby provide pointers for suitable interventional approaches to minimize PA attacks. This study investigated weekly variation in...
Article
Full-text available
Objective The aim of the present study was to examine the long-term effects of bipolar disorder (BD) on brain structure (gray matter volumes).Methods Fifty-four adults with BD [mean (standard deviation) age = 64.4 (5.4) years] underwent brain MR imaging along with comprehensive clinical assessment. Total gray matter, hippocampal, and amygdala volum...
Article
Recent research demonstrated that bladder pain syndrome/interstitial cystitis (BPS/IC) is associated with many coexisting physical and psychiatric conditions. In this study, we explored the potential association between anxiety disorder (AD) and BPS/IC using a case-controlled population-based approach in Taiwan. Data on the sampled subjects analyze...
Article
Full-text available
Objective: C-reactive protein (CRP), a marker of underlying low-grade inflammation, has been associated with the pathophysiology of bipolar disorder. Additionally, bipolar disorder may be accompanied by functional or structural cerebral alterations. We attempted to discover whether serum high-sensitivity CRP (hs-CRP) levels are linked to the struc...
Article
Purpose Bipolar disorder, medical comorbidity, and aging effects increase the risk for cognitive impairment in patients with bipolar disorder. In addition, brain atrophy in late life plays an important role in cognitive dysfunction. We attempted to find out the specific clinical characteristics that may identify patients with bipolar disorder at hi...
Article
Full-text available
Patients with bipolar disorder are at high risk of developing strokes in the older life. Silent cerebral infarctions (SCIs) could be common in the elderly patients with bipolar disorder, but only small sample size reports are available. The purpose of this study was to assess the proportion of SCIs and determine the risk factors for cerebral infarc...
Article
Weight gain and increased production of leptin may be associated with immuno-modulation and insulin resistance in bipolar disorder. The links among inflammatory markers, leptin, and insulin of bipolar patients from acute mania to full remission remain unclear. Thirty-three healthy, bipolar I patients under 45 years of age were enrolled. We measured...
Article
This study aims to explore the association between bipolar disorder and the risk of gout using a nationwide population-based dataset. We used the 1996-2006 data from the Taiwan National Health Insurance Research Database. The study cohort comprised 24,262 patients who had visited outpatient departments for the treatment of bipolar disorder in the y...
Article
Insulin resistance, quantified by hyperinsulinemia, has been identified as a preclinical state for metabolic syndrome. Acute medicated bipolar patients are vulnerable to hyperinsulinemia in early remission. We examined the proportion of fasting serum insulin levels in remitted bipolar patients and considered what factors may contribute to hyperinsu...
Article
Background: Cardiovascular disease is the principal cause of death among patients with bipolar disorder and schizophrenia. We hypothesized that a combination of psychophysiology and the use of lithium, along with antipsychotics, alter electrocardiophysiological activity in bipolar and schizophrenic patients. Purpose: The goal of this study was to e...
Article
A 3-year nationwide population-based data set was used to explore methods of suicide (violent vs. nonviolent) and possible contributing factors among cancer patients in Taiwan. A total of 1,065 cancer inpatients who committed suicide were included as our study sample. The regression shows that those who had genitourinary cancer were 0.55 times (p =...
Article
The authors investigated the differences in cognitive function, medical burden, and sociodemographic characteristics between elderly community-dwelling bipolar patients and age-matched and education-matched normal individuals. Case-control study. Taipei Medical University Hospital, with 75 psychiatric beds, and Taipei City Psychiatric Center-a 612-...
Article
Full-text available
Despite the wealth of studies investigating methods of committing suicide, very few studies have been undertaken in which the focus has been placed on the long-term trend in suicide methods. The aim of this study is therefore to examine the changes in suicide methods in Taiwan. Our study uses 1995-2004 'cause of death' data, obtained from the Depar...
Article
Full-text available
Despite urban-rural disparities in suicide rates having been reported in prior studies, there is scant information on the impact of urbanicity on suicide methods. This study investigates violent and nonviolent suicide methods in Taiwan and their association with urbanicity. We use a Taiwanese nationwide mortality database covering the period Januar...
Article
Serum lipids have been found to play important roles in the pathophysiology of mood disorders. The aim of the present study was therefore to investigate the relationship between symptom dimensions and serum cholesterol and triglyceride levels, and to explore correlates of lipid levels during acute mood episodes of bipolar I disorder in Taiwan. Meas...

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