Kuninori Iwayama

Kuninori Iwayama
Hokkaido University of Science · Faculty of Pharmaceutical Sciences

Doctor of Pharmacy

About

25
Publications
613
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30
Citations
Introduction
Low-dose and long-term of macrolide antibiotics, Palmoplantar pustulosis

Publications

Publications (25)
Article
In this study, questionnaires on children’s medication practice were given to parents to survey the actual state of children’s internal medicine and methods of reducing the bitter taste of medication in children who refused to take their medication. Based on the results of the survey, the effect of bitterness intensity and bitter taste reduction me...
Article
This study retrospectively investigated the clinical usage of macrolide antibiotics prescribed in Asahikawa Medical University Hospital. To determine the effectiveness of macrolide therapy, clinical laboratory test values before and after treatment and changes in respiratory function in patients who received long-term, low-dose administration of ma...
Article
The present study investigated the effects of pH and alcohol concentration on the dissolution of triazolam tablets, a benzodiazepine sleep-inducing drug. The efficacy of the generic drug (tabIets B-E) was compared with that of the brand-name drug (tablet A). A dissolution test was performed using solutions at pH 1.2 and 5.6, to simulate normal gast...
Article
Full-text available
Introduction: In pharmacotherapy for inflammatory bowel disease (IBD), good medication adherence is necessary to control the condition. However, some patients show poor adherence. Pharmacists need to provide appropriate medication guidance to improve medication adherence. Community pharmacists often have to provide medication guidance in case of in...
Article
Full-text available
Introduction and objectives: Macrophage-induced inflammation plays a key role in defense against injury and harmful pathogens. Autophagy and the inflammatory response are associated; however, the relationship between the autophagy pathway and lipopolysaccharide (LPS)- induced inflammatory responses remains unknown. We aimed to determine the effect...
Article
Background/aim: Recent lung cancer treatments include an immune checkpoint inhibitor (ICI) pembrolizumab, platinum-based agents, plus an additional cytotoxic anticancer agent. Nutritional indices, such as the geriatric nutritional risk index (GNRI) and the prognostic nutritional index (PNI), are known to correlate with the prognosis of cancer chem...
Article
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Carbapenems are antimicrobial agents commonly used to treat extended-spectrum β-lactamase (ESBL)-producing bacteria. Although cefmetazole (CMZ) is considered effective for ESBL-producing Escherichia coli (ESBL-EC) bacteremia, previous studies showed its limitations, including the influence of the initial antimicrobial agent. Here, we examined the e...
Article
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Introduction Sotorasib is a crucial therapeutic agent for patients with non-small cell lung cancer (NSCLC) harboring the KRAS p.G12C mutation. Despite its efficacy, the relationship between blood sotorasib concentrations and side effects remains largely unexplored. Methods This study enrolled five patients with KRAS p.G12C-positive NSCLC treated w...
Article
Background/aim: Osimertinib blood levels and their impact on treatment continuation in patients with EGFR mutation-positive lung cancer is not known. This study investigated the drug blood levels and risk factors affecting treatment continuation. Patients and methods: Fifty-six patients with recurrent and inoperable epidermal growth factor recep...
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Full-text available
Background/aim: Interstitial lung disease (ILD) is a serious adverse event (AE) associated with the use of immune checkpoint inhibitors (ICIs). However, the risk factors for developing ICI-related ILD remain poorly understood. Therefore, this study investigated the effect of concomitant analgesics on developing ICI-related ILD using the Japanese A...
Article
Considering the current situation of serious antimicrobial resistance, a national action plan on antimicrobial resistance (AP) has been passed in Japan. As it is essential to determine the extent to which dentists are aware of AP, a mail-based questionnaire survey regarding recognition of the AP was performed by targeting dentists in Sapporo city....
Article
Full-text available
Palmoplantar pustulosis (PPP) is a chronic inflammatory dermatosis characterized by sterile pustules on the palms and soles. To treat the symptoms, antimicrobial agents such as tetracyclines, macrolides, and cephalosporins are effective for PPP due to their anti-inflammatory effects. To date, there have been no reports on the response rates and tim...
Article
Background and Objective: The antibiotic minocycline (MINO) is known to have anti-inflammatory activity. This study aimed to examine the effects of MINO on hydrogen peroxide (H2O2)-induced cell death and interleukin (IL)-8 production, which have been shown to increase during inflammation, using small airway epithelial cells (SAECs). Materials and M...
Article
Full-text available
Background: It is well known that low-dose, long-term macrolide therapy is effective against chronic inflammatory airway diseases. Oxidative stress is considered to be a key pathogenesis factor in those diseases. However, the mechanism of action of low-dose, long-term macrolide therapy remains unclear. We have reported that clarithromycin (CAM), wh...
Article
One-dose packages are useful for managing complicated medication regimens for older patients. We experienced a case of Bayaspirin® tablet 100 mg (BA) and Micardis® tablet 40 mg (Mic 40) that were fused in a one-dose package at the time of medicine reconciliation. To our knowledge, there are no previous reports assessing the quality of these tablets...
Article
Full-text available
Background Clarithromycin (CAM), a representative macrolide antibiotic, has been used widely at low doses for long-term therapy of chronic inflammatory airway diseases. Anti-inflammatory effects of macrolide antibiotics were first discovered in clinical practice. Although oxidative stress is known as a key pathogenesis factor in chronic airway infl...
Article
We examined the effects of 8 macrolide antimicrobial agents, including 14-, 15- and 16-membered ring lactone and ketoride derivatives, on hemolysis induced by lysophosphatidylcholine (LPC) in human erythrocytes. LPC induced hemolysis at concentrations above the critical micelle concentration (4 µM). Vitamin E (α-tocopherol), used as a reference dru...
Article
Drugs are sometimes covered with oblate or agar jelly. It is said that the medicinal effect of drugs covered with oblate is slow, but no studies have reported results confirming this. Therefore, we examined the dissolution behavior when the drug was covered with oblate or agar jelly. Three types of commercially available formulations of benzodiazep...

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