Kulvinder kochar kaur

Dr kulvinder kaur centre for human reproduction,Jalandhar,Punjab,India. · Reproductive neuroendocrinoligy andinfertility(Obstt &Gynae)

Recently we had reviewed role of glucose transporter GLUT4, along with endoplasmic reticulum (ER) as well as inflammatory stress,in DMgeneration[26] . Uptake of glucose in muscles along with ATs are based on the insulin responsive glucose transporter GLUT4 that gets encoded by the soluble carrier family 2 member 4 (SLC2A4)gene,that got cloned 3deca...

Moraes Brito., et al. [8], with the objective of identifying the basic agents present in Pequi pulp in addition to oil (hydrophilic as well as lipophilic) besides validating their modulatory actions on Oxidative stress (OS) of peripheral blood mononuclear cells which got cocultured with MCF7 breast cancer cells. Regarding identification in addition...

Stroke represents an acute cerebrovascular disease that puts the human life in significant danger besides a poorer quality of life.This adds a considerable burden on society in addition to their families.In the last decade the dysbiosis of Intestinal flora has evoked remarkable interest . Subsequent to stroke, Intestinal microbial dysbiosis results...

Earlier we had reviewed comprehensively how there is need for antibiotics therapy for chronic endometritis (CE) prior to IVF/ ICSI stimulation in view of better outcomes of IVF/ICSI, with full details of microbiome alterations in endometrium. However recently a report has documented escalated abortion rates subsequent to antibiotics therapy. There...

Inspite of massive evaluation of the pathophysiological modes there is the absence of insight regarding modes of premature ovarian aging that results in diminished ovarian reserve (DOR) in addition to probably infertility in case of young women. Short Communication Inspite of massive evaluation of the pathophysiological modes there is the absence o...

Earlier we had reviewed the roles of Kisspeptins in reproduction in 2012 and subsequently the confusion over progesterone in positive feedback effects with challenges in the earlier explanations offered. Since then, a lot of work has been done in rodents as the mammalian species to explain the part of epigenetics further. Estrogen generated by the...

Inspite of the hurdles in evaluation of Recurrent implantation failure, there has been forward progression existent with regards to therapeutic strategies for aiding in these RIF patients. Of the maximum attractive approaches three like utilization of I) peripheral blood mononuclear cells (PBMC), ii) Subcutaneous administration of Granulocyte Colon...

Earlier wehad reviewed on the aetiopathogenesis of Type 1 diabetes mellitus(T1D) along with role of gutmicrobiota(GM) ,genes ,immunotherapies besides the role ofGM in obesity ,type 2 diabetes and probiotics in detail. Whereas the pathogens for autoimmune diseases continue to be mostly not clear ,genetic proneness as well as environmental factors ha...

Objective- Premature ovarian insufficiency (POI) comprises of enhanced gonadotropins, specifically follicle stimulating hormone (FSH) and irregularity/ lack of menstruation inwomen< 40yrs of age.Having reviewed literatureearlier with a case report on genetics of POI with the advent of whole exon sequencing,here we aimed to update the same. Methods-...

vTreatment of endometriosis might prevent a number of complications associated with pregnancy [4]. Various theories have been given regarding the pathophysiology of adverse pregnancy outcomes. This might be secondary to a proinflammatory event that is associated with high levels of cytokine production. Along with changes in the inner myometrium cal...

Earlier we had reviewed the part of epigenetic modifications in Diabetic Kidney Disease (DKD), other etiological factors in Chronic Kidney Disease (CKD) besides role of bilirubin in DKD, role of probiotics and prebiotics in obesity, T2DM, NAFLD. Here our objective was to evaluate the part of gut microbiota (GM), bone health and vascular calcificati...

Breast Cancer(BC) representsone of the commonest cancer in case of women.During 2018 it was calculated that mortality of 627.800 women occurred due to BC. BC has multiple factors contributing to its etiology besides is a chronic disease.Earlier we updated the pathophysiology &treatment of BC.Despite significant advancements have beenmade regarding...

As a result androgen receptors blockade with utilization of flutamide in a dosage of 600mg /day x12wk in women having PCOS as per NIH definition causes reduction in total cholesterol (TC) ,triglycerides (TG), along with low density lipoprotein(LDL)irrespective of obesity, despite akin dose of flutamide delivered orally for 1 yr in case of overweigh...

Breast Cancer (BC) represents one of the commonest cancer in case of women. During 2018 it was calculated that mortality of 627, 800 women occurred due to BC. BC has multiple factors contributing to its etiology besides is a chronic disease. Earlier we updated the pathophysiology and treatment of BC. Despite significant advancements have been made...

Breast Cancer (BC) represents one of the commonest cancer in case of women. During 2018 it was calculated that mortality of 627, 800 women occurred due to BC. BC has multiple factors contributing to its etiology besides is a chronic disease. Earlier we updated the pathophysiology and treatment of BC. Despite significant advancements have been made...

ABSTRACT Aim: There is escalating incidence of obesity in developing along with developed countries, believed tobe a main risk for different metabolic diseases inclusive of type2 Diabetes mellitus (T2D) Non alcoholic fatty liver disease(NAFLD), atherosclerosis besides ischemic cardiovascular disease(CVD). Earlier while in an endeavour to find diffe...

Congenital adrenal hyperplasia (CAH) represents a disorder that takes place secondary to the deficiency of the adrenal enzymes, most commonly 21 hydroxylases (21OH) along with the commonest autosomal recessive condition in humans. In case of milder non canonical type (NCCAH), normal quantities are generated at the cost of adrenocorticotropic hormon...

Earlier we have reviewed regarding how patients of AN who present with primary/secondary hypothalamic amenorrhoea were markedly recalcitrant to any forms oftreatment besides deficiency in reward appreciation .Furthermore we concentrated on the pathophysiology of obesity along with its association with type2 diabetes mellitus( T2DM), besides non-alc...

Earlier we had reviewed the role of herbal treatment, epigenetic modes, other mechanistic pathophysiological roles like macrophage polarization, epigenetics, role of adipokines &treatment using role of empagliflozin Extracellular Vesicles (ECV's), gut microbiota (GM) in Diabetes mellitus (DM) here we concentrated on more work on ER stress, inflamma...

Bilirubin has been believed to be a robust endogenous antioxidant along with anti-inflammatory molecule possessing the capacity of working on cellular pathway in the form of a hormone. Diabetic Kidney Disease (DKD), is in general a usually encountered complication, reflecting a frequent etiology of end stage renal Disease(ESRD) as reviewed by us ea...

Earlier we had reviewed the part of curcumin as an anti-oxidant, anti-inflammatory, neuro shielding, anticancer, hapatoprotect-ing, as well as cardio shielding actions. Further its bioavailability issues, bio effectiveness as well as safety parameters along with quality properties of Curcumin were further tackled, besides its role in PCOS. Here we...

Klein Levine Syndrome (KLS) represents an uncommon sleep disorder having the properties of exaggeration of sleep, sexual loss of inhibition, escalation of food consumption besides mental impairment. Here we report a case of KLS who had the first episode at age of 16 as in other cases occurring in adolescent males with male preponderance. Initially,...

Citation: Kaur KK, Allahbadia GNK, Singh M. Mode of actions of bile acids in avoidance of colorectal cancer development; and their therapeutic applications in cancers-a narrative review. J Pharm Nutr Sci 2022; 12. Abstract: Bile Acids (BAs) possess a considerably significant part in the form of emulsifiers in digestion besides absorption of dietary...

ABSTRACT Worldwide male factor Infertility contributes to 20-70% of couples attempting to conceive. Some male Pediatric generational disorders inclusive of Cryptorchidism, hypospadias, testicular besides other acquired cancers of childhood, infections, torsions, Spina Bifida along with Pediatric varicocoele have correlated with future infertility....

ABSTRACT Having reviewed the role of gut microbiota(GM)in human obesity, type 2 Diabetes mellitus(T2DM), Non alcoholic fatty liver disease(NAFLD), metabolic syndrome(MetS) and further extension to development of neuropsychiatric diseases(NPD), here we did a minireview regarding gut virome and impact of triad symbiosis. An escalating research divulg...

In view of pregnancy possessing the properties of mild however considerable significant inflammatory action under physiological circumstances, ongetting complicated byobesity the chances of a continuous inflammatory state enhances with subsequent numerous consequences with additional complications correlated with acute inflammation. Regarding this...

In view of pregnancy possessing the properties of mild however considerable significant inflammatory action under physiological circumstances, ongetting complicated byobesity the chances of a continuous inflammatory state enhances with subsequent numerous consequences with additional complications correlated with acute inflammation. Regarding this...

Earlier we have reviewed regarding how patients of AN who present with primary/secondary hypothalamic amenorrhoea were markedly recalcitrant to any forms of treatment besides deficiency in reward appreciation .Furthermore we concentrated on the pathophysiology of obesity along with its association with type2 diabetes mellitus (T2DM), besides non-al...

Earlier we reviewed the role of NOD-like receptor protein (NLRP3) inflammasomes in different patients presenting with various metabolic disorders inclusive of type 2 diabetes mellitus (T2DM) obesity, metabolic syndrome (MetS), non-alcoholic fatty liver disease (subjects NAFLD), non-alcoholic steatohepatitis (NASH). Thus, here we present a mini revi...

World wide vaccination routines have aided in reduction of newer Hepatitis B virus(HBV)Infections. Nevertheless,it has been determined that about 300 million individuals possess Chronic HBV)Infections(CHB) along with possess a greater risk of generation of Hepatocellular carcinoma(HCC). HBV continues to be a robust ,health issue of considerable, si...

The 2 nd as well as 3 rd trimester of pregnancy is key regarding the anatomical along with functional generation of the GIT as well as the correlated digestive functions. Subsequent to premature birth,there is the presence of immaturity of both digestive along with absorptive events as well as that of the GI motility poses considerable hurdles. Inf...

Abstract Bilirubin has been believed to be a robust endogenous antioxidant along with antiinflammatory molecule possessing the capacity of working on cellular pathway in the form of a hormone. Diabetic Kidney Disease(DKD),is in general a usually encountered complication ,reflecting a frequent etiology of end stage renal Disease(ESRD)as reviewed by...

upto 300 words) Type2 Diabetes mellitus(T2D) refers to a syndrome that by definition is secondary to numerous extents of βcells failure in addition to reduction in insulin sensitivity.Despite ,a lot of metabolic Impairment ,most patientsare classified as either presenting with T1D or T2D.Recently Ahlqvist etal.posited a new system of classification...

Various theories have been given regarding the pathophysiology of adverse pregnancy outcomes. This might be secondary to a proinflammatory event that is associated with high levels of cytokine production. Along with changes in the inner myometrium called the ‘’junctional zone’’. The complications included preterm birth, placenta praevia, and small...

A case report of a 32 year old patient presenting with inoperable recurrent endometrioma following previous 3 laporotomies with incapacitating pain and very poor General physical examination(GPE) and poor qualityof life(QOL) with recurrent vomittings and dehydration setting in managed with leuprolide acetate 3.75 mg depot injection after which tran...

Numerous studies have pointed that the PI3K/ PTEN/ AKT signaling pathways arethe key controllers of generation of germ cells precursors labeled as Primordial germ cells in addition to sustenanceof follicular pool .Earlier we have already highlighted the role of MAPK/ERK along with Hippo/MST pathways; mammalian target of rapamycin complex (mTORC); e...

Earlier we reviewed the role of NOD-like receptor protein (NLRP3) inflammasome in different patients presenting with various metabolic disorders is type 2 Diabetes mellitus obesity, Metabolic Syndrome (MetS), non-alcoholic fatty liver disease subjects NAFLD, non-alcoholic steatohepatitis (NASH). Thus Here we conducted a systematic review utilizing...

Key mechanisms involved in the regulation of intestinal microbiota during NASH progression. Intestinal dysbiosis results in disruption of intestinal SCFAs, bile acids, and choline metabolic homeostasis, as well as increases LPS and endogenous alcohol production and NLPR3/6 activation, subsequently affecting the progression of ANSH. (A) SCFAs inhibi...

Non alcoholic fatty liver disease(NAFLD)is believed to be amongst the maximum Prevalent chronic liver disease globally secondaryto pacey escalating obesity, type 2 Diabetes mellitus(T2DM), metabolic syndrome(MetS). In the form of a hepatic presentation of a metabolic disease NAFLD initiates with hepatic accrual along with propagation towards hepati...

Kochar Kaur., et al. Currently regulation in addition to avoidance of weight accru-al, represent factors of maximum significance existent regarding factors in avoidance of mortality along with disease globally [1]. Regulation of appetitie is based on variation of neurological, psychological along with cultural factor s. Regarding the physiological...

The SARS-CoV2 pandemic has impacted the life of the population globallyfrom 2020.The association amongst the new viral infection besides pathogenesis of various neurodegenerative diseases(NDD) got evaluated in different studies .In this review our objective was to carry out assessment, of the available publications regarding Parkinson'sdisease(PD)...

300 word limit) For survival fatty acids are necessary,working as substrates forbioenergy generation, structural constitutents along with signaling molecules.With their key part, evolutionary modes bycells for fatty acids formation from alternative carbonresources via a event labelled as de novo'' lipogenesis(DNL). Inspite of the knowledge of signi...

Earlier we had highlighted with regards to what can be the future options for fertility preservation with regards to the patients in whom a diagnosis cancer has been made at a young age, besides stand to lose fertility subsequently to the initiation of chemotherapy or secondary to surgery in case of a primary malignancy of testis or adjacent organs...

What is the method by which the generation of unbelievable cognitive capacity in addition to its working with the utilization of intellect.?What is the reason for5-10% adults for the generation of neurodevelopmental diseases or conditions like autism or dyslexia?For receipt of answers to these queries needs a greater insight in the context of the w...

For survival fatty acids are necessary, working as substrates for bioenergy generation, structural constitutents along with signaling molecules. With their key part, evolutionary modes bycells for fatty acids formation from alternative carbon resources via a event labelled as de novo’’ lipogenesis ( DNL). In spite of the knowledge of significance r...

Nonalcoholic fatty liver disease (NAFLD) is a rapidly escalating disorder which impacts a large population worldwide. Nevertheless, cardiovascular disease (CVD) represents the biggest etiology for mortality with regards to patients of NAFLD. Atherogenic dyslipidemia, possessing the properties of plasma hypetriglyceridemia, enhancement of small dens...

Non alcoholic fatty liver disease(NAFLD) is a rapidly escalating disorder which impacts a large population worldwide. Nevertheless, cardiovascular disease(CVD) represents the biggest etiology for mortality with regards to patients of NAFLD. Atherogenic dyslipidemia, possessing the properties of plasma hypetriglyceridemia , enhancement of small dens...

A case report of a 32 year old patient presenting with inoperable recurrent endometrioma following previous 3 laporotomies with incapacitating pain and very poor General physical examination(GPE) and poor qualityof life(QOL) with recurrent vomittings and dehydration setting in managed with leuprolide acetate 3.75 mg depot injection after which tran...

Chronic Kidney Disease(CKD) by deifinition is a propagating along with irreversible deletion of renal function in association with alterations in Kidney structure that accompanies the Kidney wounding, besides correlated with risks of bad results in view of the correlation with numerous complication, inclusive of metabolic acidosis, anaemia,changes...

Vitamin K possesses numerous significant role in human health. More recently researchers have a established that healthy diet consumption possessing good fats, Vitamins, minerals, polyphenolics possesses anti-inflammatory actions can act in antiaging role. Earlier the belief was that Vitamin K acts basically as an anticoagulant, besides part in cal...

Abstract The CRISPR/Cas9-techique again emerged in 2012 with the generation of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based gene editing that represents a modulation tool that has been obtained from the defense system of the some bacteria, against viruses in addition to plasmids. This is a neconomical, simple approac...

A case report of a 32 year old patient presenting with inoperable recurrent endometrioma following previous 3 laporotomies with incapacitating pain and very poor General physical examination(GPE) and poor qualityof life(QOL) with recurrent vomittings and dehydration setting in managed with leuprolide acetate 3.75 mg depot injection after which tran...

The CRISPR/Cas9-techique again emerged in 2012 with the generation of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based gene editingthat represents a modulation tool that has been obtained from the defense system of the some bacteria,against viruses in addition to plasmids.This is a neconomical ,simple approach that has g...

Iron constitutes an essential element that is implicated innumerous physiological functions. In the context of the pancreatic β cells, they act as components of the Fe –S cluster proteins, which are a must for the appropriate insulin generation and processing. As far as mitochondria are concerned , in the form of a constituent of the respiratory ch...

The generation of early follicles, in particular the activation of primordial follicles (PFs) is controlled via a network of signaling pathways at a strict level. Earlier we had reviewed the signaling pathways associated with cancer like MAPK/ERK along with Hippo/MST signaling, in addition to the details of PI3K/AKT pathway and Hippo signaling path...

Artificial Intelligence (AI) is an expanding field to optimize results in medicine with special emphasis in radiology with optimization of images. Similarly in reproductive medicine it has taken over in the last few years. Ideally embryo assessment as well as selection decides the ultimate fate of the in vitro fertilization (IVF) event. The objecti...

How the male attributes in the generation of a healthy embryo, there exists a need for a sperm that is of good quality with minimum genome injury whose estimationis usually are done by the determination of sperm Deoxyribonucleic Acid (DNA) breakdown or the Sperm DNA Fragmentation (SDF). SDF usually guides with regards to the quality of sperm chroma...

Cumulus cells (CC) get initiated from the granulosa cells (GCs) that are undifferentiated, which differentiate into mural GCs (MGCs) as well as CCs at the time of antrum generation in the follicles by the allocation of residence. CCs represent cells that are supporting cells with regards to oocytes from the milieu, that aids in oocytes growth as we...

Evaluation of Diabetesmellitus (DM)kinds has demonstrated significant patterns.Of these the ones of maximum importance are inclusive of Oxidative stress ,inflammation in addition to cellular demise .Till date drug treatments for DM are not optimal ,hence need for innovative therapy has assumed great significance that is key for trying to discover t...

ow the male attributes in the generation of a healthy embryo, there exists a need for a sperm that is of good quality with minimum genome injury whose estimationis usually are done by the determination of sperm Deoxyribonucleic Acid (DNA) breakdown or the Sperm DNA Fragmentation (SDF). SDF usually guides with regards to the quality of sperm chromat...

Scrub typhus represents a robust Public Health ailment that is Prevalent in the Asia-Pacific region that is inclusive of although not restricted to Korea, China, India, Taiwan Indonesia, Thailand, Sri Lanka, as well as the Phillipines, This area has been referred to as the tsutsugumashi triangle. One billion people have a threat globally to get aff...

Earlier we reviewed how the Extra cellular vesicles (ECV) s might work as biomarkers in case of both female as well as male reproductive diseases that is inclusive of ART, besides the methods of obtaining the same. Here in extension of the same Li evaluated the ECVs obtained from the uterine fluid aspirated with observing small noncoding ribonuclei...

Evaluation of Diabetesmellitus (DM)kinds has demonstrated significant patterns. Of these the ones of maximum importance are inclusive of Oxidative stress,inflammation in addition to cellular demise .Till date drug treatments for DM are not optimal,hence need for innovative therapy has assumed great significance that is key for trying to discover th...

Vitamin C causes escalated cortisol generation in and caused potentiation of anti-inflammatory and endothelialcy to protection actions of glucocorticoids (GC/External GC steroids are the ones that have been evidenced to be the single disease- modulating treatment for COVID-19 [1]. (see Figure 1 for modes of Vitamin C in mitigation of COVID-19. Furt...

Background-With the initiaI identification of capacity of generation of heterotopic bone Bone morphogenetic proteins (BMP) represent growthfactors that possess numerous functions from the transforming growth factor beta(TGF-β) superfamily,With the utilization of cellular along with molecular genetic approaches, more recently studies have implied th...

Whipples disease (WD) represents a chronic infectious disease that was initially detailed by George Whipple in 1907. As per Whipple the intestinal lipodystrophy that was visualized was secondary to the aberrant lipid metabolism as well as not an infection. In 1952 it was thought to be due to bacterial causation along with antibiotic therapy attempt...

The commonest etiology of acute kidney injury (AKI) is Sepsis that results in an escalation of morbidity and mortality in the hospital intensive care units. Existentially, the therapy of septic AKI rather than being defi nitive or curative is just supportive, without tackling the pathophysiology. Usually, Sepsis gets correlated with systemic infl a...

Polycystic ovary syndrome (PCOS) represents one of most common endocrine condition in case of reproductive women, that mostly presents in the form of a menstrual disorder, hirsutism, infertility [1]. Despite lot of therapies exist like utilization of Oral contraceptives to hamper the maturation of ovarian follicles in the form of long time PCOS tre...

Earlier we had reviewed on the different classification methods of Polycystic ovary syndrome (PCOS) ,the work of Sir –Petermann and Ibanez group in prepubarchal girls in PCOS and correlation with antimullerian hormone (AMH) amounts and different forms of therapy in PCOS].Here we tried to review the newer aspects of AMH association with PCOS pathoph...

In adolescents it has been believed that dysmenorrhea is a symptom that every girl has to go through as the fundamental symptomthat is inevitable prior to becoming a woman. The thought to incorporate in the prototype is that primary dysmenorrhea in the absence ofany anatomic etiology is chiefly not a disorder having any physical connotations. These...

At present restricted therapies that are existent with regards to COVID-19. The significant antiinflammatory, immunomodulatory, antioxidant, antithrombotic, antiviral characteristics of Vitamin C makes it a promising agent for avoidance in addition to abrogate COVID-19 infection, thus has a role as an adjunctive treatment for the critical care of C...

Endometrial cancer (EC) is the most common gynecological cancer in post menopausal women in developed countries and the incidence is increasing in view of increased obesity and aging of the population. Multiple classifications have been developed right from the International Federation of Gynecology and Obstetrics (FIGO) Classification, those based...

There has been a significant escalation of type2 diabetes mellitus( T2DM), all over the world in particular more recently, secondary to population, age, obesity in addition to the sedentary life styles stranges. The determination as per the projections has been that 230 million people would be diabetic by the year2030. The properties of T2DM are dy...

India possesses a greater tuberculosis (TB) load in contrast to any other country, that accounts for a calculated 25% of the global load. Drug resistant tuberculosis (DR-TB) is a biggest public health difficulty in India. Massive alterations In the drug regimens is the requirements, for patients with DR-TB, that are mostly correlated with poor stic...

Bone morphogenetic proteins (BMP) are growth factors possessing multiple functions that belong to the transforming growth factor beta (TGF-β) superfamily. With the use of cellular as well as molecular genetic strategies recent research work pointed that the intraovar-ian BMP's act in the form of potent functional controllers of function of the foll...

Iron constitutes an essential element that is implicated innumerous physiological functions. In the context of the pancreatic β cells, they act as components of the Fe-S cluster proteins, which are a must for the appropriate insulin generation and processing. As far as mitochondria are concerned , in the form of a constituent of the respiratory cha...

Diabetes mellitus (DM) represents a significant lifestyle disease. Of the types of DM, type 2 DM aids maximuminthedevelopmentofcardiovasculardisease(CVD)alongwithdiabeticcardiomyopathy(DbCM),which iscorrelatedwithsignificantmortalityalongwithcomorbidityindiabeticpatients.DbCMisanon-canonicalcardiac illness that exhibits cardiac remodelling occurs whe...

Congenital adrenal hyperplasia (CAH) represents a disorder that takes place secondary to the deficiency of the adrenal enzymes, most commonly 21 hydroxylases (21OH) along with the commonest autosomal recessive condition in humans. In case of milder non canonical type (NCCAH), normal quantities are generated at the cost of adrenocorticotropic hormon...

menal and worthy keynote presentation onPotential role of epigenetic modulation in prevention or therapy forDiabetic kidney disease-still a dream or a realityat the 3rd Annual Summit on Diabetes, Obesity and Heart held during December 10, 2021 in Webinar

Neurological conditions, represent a group of disorders that are responsible for the commonest etiologies of death all over the world which account practically for total cases of initiation of dementia in the aged ,besides their capacity ofhavinga negative impact on the motor capacity,mental and cognitive abilities andhaving a sense of total well b...

Curcumin represents a yellow polyphenolic pigment derived from the plant Curcuma longa(turmeric)rhizome that has been put in utilization over centuries for cuisine art besides coloring of foods,as a constituent of separate medicinal formulations that has been used over and over in Ayurveda along with Chinese medicine.In the current decades it has b...

Type2 Diabetes mellitus (T2D) refers to a syndrome that by definition is secondary to numerous extents of βcells failure in addition to reduction in insulin sensitivity. Despite, a lot of metabolic Impairment, most patients are classified as either presenting with T1D or T2D. Recently Ahlqvist et al. posited a new system of classification for adult...

Chromosomal mosaicism, implying the co-occurrence of cells having possession of separate Chromosomal amount, has got illustrated in human embryos for the past3 decades. The initial versions that were generated with regards to preimplantation genetic testing for aneuploidy (PGT-A) did not estimate mosaicism, in view of classically just the evaluatio...

Neurological conditions , represent a group of disorders that are responsible for the commonest etiologies of death all over the world which account practically for total cases of initiation of dementia in the aged ,besides their capacity ofhavinga negative impact on the motor capacity,mental and cognitive abilities andhaving a sense of total well...

The discovery of Crotonoylation of proteins was an observation of an innovative type of post-translational modifications (PTMs) that takes place usually on the lysine residues alias lysine Crotonoylation (Kcr). Kcr has been evolutionarily conserved, besides is controlled by a series of enzymes as well as co-enzymes that is inclusive of lysine Croto...

The discovery of Crotonoylation of proteins was an observation of an innovative type of post-translational modifications (PTMs) that takes place usually on the lysine residues alias lysine Crotonoylation (Kcr). Kcr has been evolutionarily conserved, besides is controlled by a series of enzymes as well as co-enzymes that is inclusive of lysine Croto...

The diagnosis along with management of Breast cancer(BC) are going through a prototype switch from the one size fitting all towards the period of individualized medicine. With the advances in diagnosis that is inclusive of sophisticated methods like molecular imaging in addition to genomic expression profile aid in enhancement of tumor characterist...

Mitochondria represent complicated intra cellular organelles which classically have been isolated as the powerhouse of eukaryotic cells secondary to their key part in the bioenergetic metabolism. In more recent decades, the escalation of mitochondrial research has got invoked in researchers that have illustrated that these organelles are much great...

Diabetic Nephropathy (DN) represents one of the worst Diabetes complications as well as remains the commonest etiology of end stage renal disease(ESRD), that is the last stage of chronic renal disease. At present haemodialysis or transplantation are the commonest modes for treatment of ESRD. There are drawbacks for both methods, that include costly...

Hirschsprung disease (HSCR), represents a neurocristopathy, secondary to impairment in migration, proliferation, differentiation in addition to survival of the neural crest cells resulting in gut agangliosis. Its presentation is usually just following birth having an impact on 1/5000 live births all over the world. a significant enhancement in our...

The role of uterine factor in infertility has been exemplified by better pregnancy rates found in gestational carriers even with use of donor egg IVF instead of own uteri in infertile women. Not only were PR’s improved but further it was shown that even beyond window of implantation time it reduced rates of prematurity ,low birth weight and further...

Cancer in addition to the correlated radiotherapy, along with chemotherapy, possess significant deleterious actions on the male reproductive capacity, resulting in a lot of men infertile. Fertility preservation has become a critical issue with regards to survivors in the last 2 decades,with a lot of professional organizations, have published litera...

Diabetic Nephropathy (DN) represents one of the worst Diabetes complications as well as remains the commonest etiology of end stage renal disease(ESRD), that is the last stage of chronic renal disease. At present haemodialysis or transplantation are the commonest modes for treatment of ESRD. There are drawbacks for both methods, that include costly...

Our insight has escalated over the past decade regarding the understanding of Molecular mechanisms underlying the generation of preeclampsia, with us reviewing the role of epigenetics in the development of preeclampsia along with intra uterine growth restriction (IUGR) generation. Matrix Metalloproteinases (MM's) MMP's represent calcium-based zinc-...