Kuldeep Dhama

Kuldeep Dhama
Indian Veterinary Research Institute | IVRI · Division of Pathology

M.V.Sc., Ph.D. (Gold Medalist) Highly Cited Researcher
Looking for collaborators- experts in Microbiol, Biotechnol, Biomedicine, for high Impact Factor Publications

About

1,107
Publications
1,389,122
Reads
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22,656
Citations
Introduction
26 Yrs Experience, Animal Disease Diagnosis/Control, Zoonosis, 20 Res Projects; Guided 18 MVSc/PhD scholars 900 Research/Review articles, 8 Books, 70 Chapters, Best Paper Awards 55; Recognitions: 06; Member 20 Societies; FRSM (UK), FWRA. EIC-AAVS, Co-EIC JEBAS, JPAM, JAR, JIIP, IAD, Ed. Board -VQ, VMS, JPEH, TOJV; Reviewer- 60 Int. Journals. Member, Wildlife Hlth Specialist Group (IUCN); NAAS Assoc, India. Worked as Nodal Officer, WTO. h-index 76. To promote sci & research
Additional affiliations
September 1996 - July 2016
Indian Veterinary Research Institute
Position
  • Principal Investigator
Description
  • Handled 16 Research Projects on Diagnosis, Vaccine Development & Control of Important Infectious Pathogens of Animals (BHV-1, BTV, BRV, BCV, CAV, EDS-76, FPV, TPV, IBV, DPV, NDV, PRD, ARV, IBDV). Currently developing DNA vaccine & r-ELISA for CAV.
Education
September 1999 - September 2002
Indian Veterinary Research Institute
Field of study
  • Avian Diseases (Major); Vety. Immunology & Vety. Virology (Minor)
September 1992 - July 1994
Indian Veterinary Research Institute
Field of study
  • Veterinary Immunology (Major); Veterinary Virology (Minor)
August 1987 - July 1992
G. B. Pant University of Agriculture and Technology, Pantnagar
Field of study
  • Veterinary Sciences & Animal Husbandry

Publications

Publications (1,107)
Article
Hand, foot, and mouth disease (HFMD) is a highly contagious disease caused by viruses of the genus Enterovrirus, family Picornaviridae, especially serotypes coxackivirus A16 (CVA16), A6 (CVA6) and enterovirus 71 (EV71). The disease was first recognized in New Zealand in 1956 and afterwards spread widely. Currently, HFMD outbreaks occur frequently i...
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Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of Mycoplasma capricolum subsp. capripneumonia in male Angora rabbits (1 yea...
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Background: Solid organ rejection post-SARS-CoV-2 vaccination or COVID-19 infection is extremely rare but can occur. T-cell recognition of antigen is the primary and central event that leads to the cascade of events that result in rejection of a transplanted organ. Objectives: To describe the results of a systematic review for solid organ rejection...
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Objective: To trace and understand the origin of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through various available literatures and accessible databases. Background: While the world enters the third year of the coronavirus disease 2019 pandemic and the health and socio-economic impacts continue to mount, the origin and mechan...
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COVID-19 causes acute respiratory illness in humans. The direct consequence of the spread of the virus is the need to find appropriate and effective solutions to reduce its spread. Similar to other countries, the pandemic has spread in Algeria, with noticeable variation in mortality and infection rates between regions. We aimed to estimate the prop...
Preprint
Monkeypox (MPX) is a zoonotic disease caused by the Monkeypox virus (MPXV) belonging to the Orthopoxvirus family. It results in a smallpox-like disease in humans. The first human case of MPX was seen in the Democratic Republic of Congo (DPR) in 1970, and the disease has remained mostly contained in Africa, causing occasional outbreaks. It was in 20...
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Hepatitis E virus (HEV) is an important public health problem and is responsible for both acute and chronic viral hepatitis. Public health implications of HEV are derived from its transmission route, either water-borne or food-borne, and its zoonotic potential. Not only in developing countries, but HEV cases are also found in a high number in devel...
Article
The advancement of Aquatic Biotechnology has encouraged the use of experimental procedures to improve aquatic animal production. One of the experimental techniques is the protein recombination technique used for this purpose. Recombinant DNA technology is a useful and valuable tool for producing large amounts of protein from different fish species....
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Background: Cases of myocarditis development have been reported after administration of messenger ribonucleic acid (mRNA)-based coronavirus disease (COVID-19) vaccines. However, the reports vary among the studies, and the types of mRNA vaccines with potential to cause myocarditis remain unidentified. The objective was to assess the cumulative preva...
Article
Goatpox, sheeppox, and peste-des-petits-ruminants (PPR) are economically important virus diseases affecting goats and sheep, which often cause coinfection/comorbidities in the field. Coinfection with these viruses leads to enhanced infection in natural scenarios in terms of morbidities and mortalities. Currently, individual live attenuated vaccines...
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Background Abnormalities in hematology and comorbidities might have a role in chronic kidney disease (CKD) patients. However, the exact relationships between hematological parameters and the severity of CKD are not well understood. Also, the underlying mechanisms remain under investigation. The present study aimed to evaluate the association of dif...
Article
The ongoing SARS-CoV-2 evolution process has generated several variants due to its continuous mutations, making pandemics more critical. The present study illustrates SARS-CoV-2 evolution and its emerging mutations in five directions. First, the significant mutations in the genome and S-glycoprotein were analyzed in different variants. Three linear...
Article
Medicinal plants with active ingredients have shown great potential as natural and sustainable additives in livestock and poultry diets as growth promoters, performance, feed conversion ratio, digestibility of nutrient enhancers, and antioxidants and immune system modulators. Among active ingredients, phytosterols, which are plant-based bio-factors...
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to a severe respiratory illness and alters the gut microbiota, which dynamically interacts with the human immune system. Microbiota alterations include decreased levels of beneficial bacteria and augmentation of opportunistic pathogens. Here, we describe critical facto...
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Mycotoxins are secondary metabolites, and some important groups of mycotoxins are aflatoxins, ochratoxins, ergot alkaloids, citrinin,patulin and fusarium, which include trichothecenes, fumonisins and zearalenone. Ochratoxins are one of the most lethal mycotoxins; specifically, Ochratoxins A (OTA), which is perilous to the productivity and wellbeing...
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Adipose tissue-derived stromal vascular fraction (AdSVF) comprises a heterogeneous cell population, including the multipotent mesenchymal stem cells, hematopoietic stem cells, immune cells, endothelial cells, fibroblasts, and pericytes. As such, multipotent adipose tissue-derived mesenchymal stem cells (AdMSCs), are one of the important components...
Article
Cancer is being considered as a serious threat to human health globally due to limited availability and efficacy of therapeutics. In addition, existing chemotherapeutic drugs possess a diverse range of toxic side effects. Therefore, more research is welcomed to investigate the chemo-preventive action of plant-based metabolites. Ampelopsin (dihydrom...
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Internet of things (IoT) integrates several technologies where devices learn from the experience of each other thereby reducing human-intervened likely errors. Modern technologies like IoT and machine-learning enable the conventional to patient-specific approach transition in healthcare. In conventional approach the biggest challenge faced by healt...
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India is one of the world’s large and fastest-growing economies. With the expanding development, the usage of plastic for anthropogenic activities has expanded many folds and India alone generated around 3.3 million metric tonnes of plastic in the financial year 2019. 79 percent of the plastic generated worldwide enters our land, water, and environ...
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The present investigation deals with the first report of newer species of caryophyllid cestodes, Lytocestus haryanii n.sp. (Caryophyllidea: Lytocestidae) in the freshwater catfish, Clarias batrachus Linnaeus 1758 (Siluriformes: Clariidae) of river Yamuna from Yamuna Nagar, Haryana, India from July 2018 to June 2020. These helminthes are the most co...
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Crusted scabies is a rare form of scabies that presents with more severe symptoms than those of classic scabies. It is characterized by large crusted lesions, extensive scales, thick hyperkeratosis, and contains a large number of highly contagious itch mites. Crusted scabies is more prevalent in immunocompromised, malnourished, and disabled individ...
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Plant based medicine has been extensively acknowledged by all contemporary medical systems from the ancient age. Taking herbal supplements throughout pregnancy has always been healthy practice for both the mother and the fetus. Alkaloids have the highest medicinal relevance of all secondary metabolites; yet, consuming natural plant alkaloids during...
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Recently, the researchers in South Africa have identified two game-changing lineages of Omicron variant called as BA.4 and BA.5, reflecting continuous emergence and evolution of Omicron, and due to which resurgence of COVID-19 cases are noticed again in South Africa .............
Article
Nanotechnology has encouraged new and amended materials (metal nanoparticles) for therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) are versatile nanoscale entities, widely used to diagnose and treat cancer. Evidence suggested that metal NPs can modulate the expression of various intracellular and extra-cell...
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Very recently, since May 13, 2022, multiple cases of monkeypox have been identified and reported to the World Health Organization (WHO) in nearly 12 non-African countries that are not endemic for monkeypox virus. Monkeypox disease is endemic and normally limited to West and Central Africa, however its epidemiology has been reported to be changing a...
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Cardiovascular disease (CVD) makes our heart and blood vessels dysfunctional and often leads to death or physical paralysis. Therefore, early and automatic detection of CVD can save many human lives. Multiple investigations have been carried out to achieve this objective, but there is still room for improvement in performance and reliability. This...
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Poultry is the most important source of animal protein in the world, and it is also one of the largest users of antibiotics as growth promoters.Medicinal properties of Allium sativum (Garlic) have been recognised since ancient times. The emergence of multi-drug resistant diseases in poultry is linked to antibiotic use in poultry feed. Therefore,gar...
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Platelet-rich plasma (PRP) is a category of platelet concentrate containing a supraphysiological concentration of platelets in a small volume of plasma. The present study was undertaken to analyze the global trends in canine PRP research and to gain a better understanding of the ongoing research trends. The literature search was performed using the...
Article
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and mutating into newer variants over time, which gain higher transmissibility, disease severity, and spread in communities at a faster rate, resulting in multiple waves of surge in Coronavirus Disease 2019 (COVID-19) cases. A highly mutated and transmissible SARS-CoV-2 Omi...
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In response to the ongoing COVID-19 pandemic, biologists are working hard to screen many species of wild animals to logically pinpoint the exact origin of the virus. Now, researchers are more alert after the second consequence of zoonotic viral diseases during the pandemic period. Previously, an editorial by Wong et al. appeared in Zoological Resea...
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Subclinical mastitis (SCM), the asymptomatic inflammation of breast tissue, is the most common form of mastitis in livestock. SCM prevalence and risk factors in dairy animals in Western Chitwan, Bagmati Province, Nepal, were the primary objectives of this study. Out of 243 dairy animals, 104 representing 42.8% were positive for SCM in the Californi...
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Stem cell, a wonder cell, acts as a basic unit for an individual development in early prenatal life, and repairs and regenerates the tissue and/ organ in post-natal life. The stem cell research although conducted extensively is still in its infancy for standardized therapeutics. Among various stem cells types, multi-potential mesenchymal stem cell...
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Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in...
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Presently, monkeypox has emerged in multiple countries with many confirmed cases, posing a global public health threat. A link has been found between air travel and the international spread of infectious diseases including the previous spread of monkeypox. This article highlights the spread of COVID-19 through air travel, and then monkeypox spread...
Article
Scrub typhus is a vector-borne, zoonotic disease caused by Orientia tsutsugamushi. Several members of the genus Leptotrombidium have gained importance due to their potential role as vectors as well as reservoirs for O. tsutsugamushi. The larvae of Leptotrombidium species are primary parasites of ground-dwelling rodents. However, changes in climate,...
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Historically, passive immunotherapy is an approved approach for protecting and treating humans against various diseases when other alternative therapeutic options are unavailable. Human polyclonal antibodies (hpAbs) can be made from convalescent human donor serum, although it is considered limited due to pandemics and the urgent requirement. Additi...
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Onosma bracteata Wall. is an important medicinal and immunity-enhancing herbs. This plant is commonly used in the preparation of traditional Ayurvedic drugs to treat numerous diseases. Inspired by the medicinal properties of this plant, the present study aimed to investigate the antiproliferative potential and the primary molecular mechanisms of th...
Article
The demand for dairy products is expanding around the world, which leads to the growth of the dairy industry and the accumulation of waste. There is a large amount of whey, dairy sludge, and wastewater (processing, cleaning and sanitary)that is produced. They have a high nutritional concentration, biological oxygen demand (BOD), chemical oxygen dem...
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The application of high doses of mineral feed additives in the form of inorganic salts increases the growth performance of animals, but at the same, due to their low bioavailability, can contaminate the environment. Therefore, there is a need to find a replacement of administering high doses of minerals with an equally effective alternative. The ap...
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A compound that could inhibit multiple targets associated with SARS-CoV-2 infection would prove to be a drug of choice against the virus. Human receptor-ACE2, receptor binding domain (RBD) of SARS-CoV-2 S-protein, Papain-like protein of SARS-CoV-2 (PLpro), reverse transcriptase of SARS-CoV-2 (RdRp) were chosen for in silico study. A set of previous...
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The demand for poultry products is increasing day by day. The utilization of antibiotics is banned in feeds due to concerns about their harmful effects. Hence, medicinal herbs such as turmeric (Curcuma longa) are used as an alternative. The various biological properties of turmeric are effective in improvising the overall health and production of...
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Swine coronaviruses (SCoVs) are one of the most devastating pathogens affecting the livelihoods of farmers and swine industry across the world. These include transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine respiratory coronavirus (PRCV), porcine hemagglutinating encephalomyelitis virus (PHEV), swine acute...
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Plant-based remedies hold a special place despite the wide availability of synthetic pharmaceuticals due to their potent benefits and fewer side effects. Antibiotics are used to cure bacterial diseases and improve health conditions in animals; however, the increased misuse of antibiotics is posing a serious threat to animal health due to the develo...
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Flavonoids are considered to be an important part of plant-based bioactive metabolites with signi cant medicinal properties. Currently, there are no vaccines available for Nipah virus (NiV) therefore alternative therapeutic methods can play an important role. The present investigation was carried out to analyze possible molecular interactions of M...
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Fish and aquatic-derived zoonotic diseases have caused considerable problems in the aquaculture industry and fishery around the worldworldwide. In particular, the zoonotic diseases can pose widespread threats to humans. With the world's growing population and potential global trade of aquaculture and fish, the risk of environmental contamination an...
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The detection and diagnosis of Breast cancer at an early stage is a challenging task. With the increase in emerging technologies such as data mining tools, along with machine learning algorithms, new prospects in the medical field for automatic diagnosis have been developed, with which the prediction of a disease at an early stage is possible. Earl...
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Salmonella enterica serotype typhi is a gram-negative, rod-shaped bacterium, and has flagella with the human body as its only reservoir. Typhoid fever was found to cause 21.7 million illnesses and 216,000 fatalities worldwide in 2000, and the International Vaccine Institute estimated 11.9 million cases and 129,000 deaths in low- and middle-income c...
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Background COVID-19 household transmissibility remains unclear in Pakistan. To understand the dynamics of Severe Acute Respiratory Syndrome Coronavirus disease epidemiology, this study estimated Secondary Attack Rate (SAR) among household and close contacts of index cases in Pakistan using a statistical transmission model. Methodology A retrospect...
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As a landmark, scientific investigation in cytokine signaling and interferon-related anti-viral activity, signal transducer and activator of transcription (STAT) family of proteins was first discovered in the 1990s. Today, we know that the STAT family consists of several transcription factors which regulate various molecular and cellular processes,...
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Background and objective Adipose-derived mesenchymal stem cells (AdMSC) are multipotent adult mesenchymal cells isolated and cultured from the stromal vascular fraction derived from adipose tissue. The present study was conducted to analyze the global trends in AdMSC research using bibliometric and visual analysis tools. Methods The literature sea...
Article
In the beginning of 2022, we have highlighted the proposed concept of simultaneous attack of Delta (most deadly) and Omicron (most mutated) in the immunocompromised people, which is an extremely rare event. A combination of the Delta (AY.4) and BA.1 omicron variants has been named as BA.1 x AY.4 recombinant by the World Health Organization, first d...
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Antibiotic resistance is a major emerging issue in the health care sector, as highlighted by the WHO. Filamentous Thermosensitive mutant Z (Fts-Z) is gaining significant attention in the scientific community as a potential anti-bacterial target for fighting antibiotic resistance among several pathogenic bacteria. The Fts-Z plays a key role in bacte...
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Natural antioxidants applied as feed additives can improve not only animals’ health and overall performance but also increase their resistance to environmental stress such as heat stress, bad housing conditions, diseases, etc. Marine organisms such as seaweeds – red, brown, and green macroalgae contain a plethora of biologically active substances,...
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Valsartan is an anti-hypertensive drug routinely used to treat patients with hypertension. It is generally recommended to be used for patients of age above six years. Valsartan is a type 1 angiotensin receptor (AT1) receptor blocker. Studies have shown the anti-neoplastic activity of AT1 receptor blockers. However, few contradictory reports have re...
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Background: Although vaccination is underway, antiviral drugs against coronavirus disease 2019 (COVID-19) are lacking. Remdesivir, a nucleoside analog that works by inhibiting the viral RNA-dependent RNA polymerase (RdRp), is the only fully approved antiviral for the treatment of COVID-19. However, it is limited to intravenous use and is usually re...
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The current study aims at the neuropharmacological properties of ethanol, acetone, and ethyl acetate leaf extracts of Chassalia curviflora in mouse models. The neuropharmacological properties were studied in Swiss albino mice, which were provided doses of 50, 100, and 200 mg/kg body weight in thiopental sodium-induced sleeping time, and 100 and 200...
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Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp) are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 (COVID‐19) pandemic and its future variants of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus that causes COVID‐19. Molnupiravir is a nucleoside analog tha...
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A comprehensive study on the pathogenicity and host immune response was conducted in White Pekin ducklings after experimental infection with an Indian isolate of duck enteritis virus (DEV). The virus was found to be highly pathogenic and pantropic, which rapidly multiplied in various organs, mainly in the spleen and liver showing higher viral load...
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Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and human-to-human transmission had major roles in the amplification of MARV outbreaks in African coun...
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Hybrid immunity has been accepted as the most robust immunity to fight against SARS-CoV-2. The hybrid immunity against the virus is produced in individuals who have contracted the disease and received the COVID-19 vaccine. This happens due to the cumulative effect of natural and acquired (vaccine) immunity, which provides higher antibody responses...