Kristina Alexanderson

Kristina Alexanderson
Karolinska Institutet | KI · Department of Clinical Neuroscience

About

557
Publications
55,824
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
11,416
Citations
Additional affiliations
March 2003 - October 2020
Karolinska Institutet
Position
  • Group Leader

Publications

Publications (557)
Article
Full-text available
Background Pregnancy and childbirth entail increased risks of sickness absence (SA). Many women work in education and care, two branches characterised by high SA levels; it is not known if the link between childbirth and SA in these branches differs between private and public sectors. We examined SA and disability pension (DP) in relation to childb...
Article
Full-text available
Objective 1) identify different trajectories of annual mean number of sickness absence (SA) and disability pension (DP) days among privately employed white-collar workers in the trade and retail industries and 2) investigate if sociodemographic and work-related characteristics were associated with trajectory membership. Methods A longitudinal popu...
Article
Background: To characterize geospatial patterning of disadvantage in Sweden, we examined whether municipal-level indicators of socioeconomic disadvantage and disability pension (DP) rate were clustered, whether the different geospatial clusters were overlapping and whether the findings were similar among women and men. Methods: Administrative na...
Article
Objective: investigate future sickness absence (SA) and disability pension (DP) among privately employed white-collar employees in the trade and retail industry. Methods: A prospective population-based cohort study of all 192,077 such workers in Sweden in 2012, using linked microdata from nationwide registers. Descriptive statistics of annual SA...
Article
Objectives: Early withdrawal from work is common among people with multiple sclerosis (PwMS). However, little is known about how this is influenced by the type of employment. The aims were to explore the distributions of self-employed and other types of employment (employed or no earnings from work) before and after MS diagnosis and its associatio...
Article
Full-text available
Purpose To longitudinally investigate overall and diagnosis-specific sickness absence (SA) and disability pension (DP) in colorectal cancer (CRC) survivors and references and to identify potential risk factors. Methods This longitudinal register-based cohort study included all patients living in Sweden, diagnosed with a first primary CRC in 2008–2...
Article
Full-text available
We aimed to examine the association between exposure to work stress and chronic disease incidence and loss of chronic disease-free life years in the Danish workforce. The study population included 1,592,491 employees, aged 30–59 in 2000 and without prevalent chronic diseases. We assessed work stress as the combination of job strain and effort-rewar...
Article
Full-text available
The clustering of social disadvantage with attention‐deficit/hyperactivity disorder (ADHD) in young adulthood is not well understood. We examined the clustering of ADHD with low educational attainment and unemployment in young adulthood; whether such clustering is stronger when unemployment is prolonged; and whether further clustering of disability...
Article
Full-text available
Background Early treatment with disease modifying therapies (DMTs) for multiple sclerosis (MS) has been associated with lower disability progression; the aim was to explore its association with cost of illness (COI) in MS. Methods All people with relapsing-remitting MS in the Swedish MS register, aged 20–57 years and receiving their first MS DMT i...
Article
Full-text available
Objective: A variety of interventions aiming to influence physicians' sickness certification practice have been conducted, most are, however, not evaluated scientifically. The aim of this systematic literature review was to obtain updated knowledge about interventions regarding physicians' sickness certification practice and to summarize their pos...
Article
Full-text available
Background Trajectory analyses are being increasingly used in efforts to increase understanding about the heterogeneity in the development of different longitudinal outcomes such as sickness absence, use of medication, income, or other time varying outcomes. However, several methodological and interpretational challenges are related to using trajec...
Article
Full-text available
The increasing workforce participation at higher ages may impact social insurance systems, however, this has hardly been studied at all. We studied associations between sociodemographic factors and prior sickness absence and disability pension, with having paid work and sickness absence after age 65, and if such associations changed over time. We u...
Article
Full-text available
Background Given current discussions about extending working lives, more knowledge is needed on working conditions associated with labour market status in older age. Objective To explore associations between combinations of job demands and job control among workers aged 55–64 years and their labour market status 11 years later. Methods A populati...
Article
Full-text available
Background The proportion of people working beyond age 65 is increasing. We aimed to explore whether sickness absence (SA) and disability pension (DP) due to mental, somatic, or both diagnoses when aged 60–64 were associated with being in paid work when aged 66–71. Methods This prospective population-based cohort study included all 98,551 individu...
Article
Full-text available
Background The knowledge is scarce about sickness absence (SA) and disability pension (DP) among pedestrians injured in a traffic-related accident, including falls. Thus, the aim was to explore the frequencies of types of accidents and injuries and their association with SA and DP among working-aged individuals. Methods A nationwide register-based...
Article
Full-text available
Objectives To explore physicians’ experiences of using the national sickness certification guidelines introduced in 2007 and the types of information they used, in general and in different types of clinics. Design Cross-sectional survey. Setting Most physicians working in Sweden in 2017. Participants A questionnaire was sent to 34 718 physicians...
Article
Full-text available
Background: General practitioners’ (GP) contacts with sick-listed patients’ employers have been shown to be of importance for return to work. This study aimed to explore GPs’ contacts with sick-listed patients’ employers and factors associated with such contacts. Methods: In this cross-sectional study, 4228 GPs responded to a nationwide questionnai...
Conference Paper
Full-text available
problem assessment and providing tailored work-related support, including follow-up. In order to provide work-related support in clinical care, behavioral change of healthcare professionals is necessary. To change their behavior, a program, two training sessions for healthcare professionals and practical tools (screening list, conversation cards an...
Article
Full-text available
Background Multiple sclerosis (MS) can impact working life, sickness absence (SA) and disability pension (DP). Different types of occupations involve different demands, which may be associated with trajectories of SA/DP among people with MS (PwMS). Objectives To explore, among PwMS and references, if SA/DP differ according to type of occupation. F...
Article
Full-text available
Background High emotional demands at work can affect employees’ health and there is a need to understand whether such an association might be modified by other working conditions. We aimed to examine emotional demands at work as a risk factor for long-term sickness absence and analyse whether influence, possibilities for development, role conflicts...
Article
Full-text available
Background Paid work is one of the most important aspects in life among working-aged women diagnosed with breast cancer. Despite several attempts, no previous study provides a comprehensive overview from the women’s perspective about factors of importance for being able to work or not. Therefore, the aim of this study was to gain knowledge about fa...
Article
Full-text available
Background Colorectal cancer (CRC) has negative long-term impacts on survivors’ health and work capacity. We aimed to investigate specialized healthcare use and sickness absence and disability pension among CRC survivors and matched references. Material and methods In this longitudinal register-based cohort study, 6679 patients with a first primar...
Article
Background Aim: To examine the association of work stress with future chronic disease incidence and loss of chronic disease-free life years in the Danish workforce. Method A population-based prospective register-based cohort study of all employees aged 30-59 in 2000 in Denmark, without chronic diseases at baseline (n = 1,592,491). Using job exposu...
Preprint
Full-text available
We aimed to examine the association between exposure to work stress and chronic disease incidence and loss of chronic disease-free life years in the Danish workforce. The study population included 1,592,491 employees, aged 30 to 59 in 2000 and without prevalent chronic diseases. We assessed work stress as the combination of job strain and effort-re...
Article
Full-text available
Background Predicting the duration of sickness absence (SA) among sickness absent patients is a task many sickness certifying physicians as well as social insurance officers struggle with. Our aim was to develop a prediction model for prognosticating the duration of SA due to knee osteoarthritis. Methods A population-based prospective study of SA...
Article
Objective: Knowledge regarding sickness absence (SA) and disability pension (DP) following a road traffic injury, is lacking. The aim of this study was to investigate SA and DP among injured car occupants before and after a crash, accounting for permanent medical impairment (PMI). Further, to explore associations between injured body region, car m...
Article
Full-text available
Purpose Labour market marginalisation (LMM), i.e. long-term unemployment (LTU), long-term sickness absence (LTSA) and disability pension (DP), among young individuals with common mental disorders (CMDs) are a challenge for the welfare system, and refugees and non-refugee migrants seem particularly vulnerable. The aim was to investigate the risk of...
Article
Full-text available
Background Multiple sclerosis (MS) is a chronic disease associated with increased healthcare utilisation and productivity losses.Objective The objective of this study was to explore the progression of healthcare costs and productivity losses before and after diagnosis of MS in comparison to that of a population-based matched reference group.Methods...
Article
Full-text available
Observational research studies from various countries suggest that women’s working patterns across the life course are often fragmented compared to men’s. The aim of our investigation was to use nationwide register data from Sweden to examine the extent to which generation and time of entry to the work force explain the sex differences in work part...
Article
Full-text available
Aims: The aim of this study was to examine sickness absence and disability pension (SA/DP) during working lifespan among individuals diagnosed with carpal tunnel syndrome (CTS) and their matched references, accounting for sociodemographic factors. Methods: We used a register cohort of 78,040 individuals aged 19–60 years when diagnosed with CTS in s...
Article
Full-text available
Background Women’s return to work after diagnosis of breast cancer (BC) is becoming more prevalent. However, register-based national investigation on sickness absence (SA) and disability pension (DP) in BC women is lacking. The aim of the study was to explore SA and DP before and after a first BC diagnosis and the possibility to predict new cancer-...
Article
Full-text available
This article summarizes results from two primary studies investigating gender differences in antidepressant prescription, consumption, and sick-leave certification in persons with depression diagnosis. The women to men ratio was about 2 in both study populations. A somewhat higher proportion of men were prescribed antidepressants, and among those o...
Article
Full-text available
Importance Pediatric-onset multiple sclerosis (PoMS) is associated with significant cognitive and physical disability. Whether this disability translates into differences in educational achievements and earnings is unknown. Objective To evaluate the association between PoMS and educational level and income throughout adulthood. Design, Setting, a...
Article
Full-text available
Oncologists frequently have sickness certification (SC) consultations, however, little is known about their experiences of such tasks. Objective: To investigate oncologists' experiences of organisational prerequisites for SC tasks, and if lack of resources was related to experiencing SC as problematic. Method: Questionnaire data from 342 oncolo...
Article
Full-text available
Objectives The aim was to describe the course of sickness absence (SA), disability pension (DP) and work-related economic situation defined as earnings (EA) and disposable income (DI), after spontaneous subarachnoid haemorrhage (SAH). Associations of SA, DP, EA and DI with demographic factors were also studied. Design A longitudinal cohort study o...
Article
Full-text available
Objectives Working-aged colorectal cancer (CRC) patients have a much better survival, indicating the importance of their future work situation. We investigated trajectories of sickness absence and disability pension (SADP) days before and after CRC diagnosis, and risk factors associated with different trajectories. Methods A longitudinal, populati...
Preprint
Full-text available
Background Whether clustering of social disadvantage in young adulthood is associated with attention-deficit/hyperactivity disorder (ADHD) is poorly understood. We examined clustering of ADHD with low educational attainment and unemployment in young adulthood; whether such clustering is stronger when unemployment was prolonged; and whether further...
Article
Full-text available
Objectives To explore sequences of annual states of activity and sickness absence (SA) or disability pension (DP) (SA/DP) among working-aged people with multiple sclerosis (PwMS) as well as characteristics associated with the identified types of working-life sequences. Design Nationwide Swedish register-based cohort study from 1 year prior to 5 ye...
Article
Full-text available
Background Bicyclists are the road user group with the highest number of severe injuries in the EU, yet little is known about sickness absence (SA) and disability pension (DP) following such injuries. Aims To explore long-term patterns of SA and DP among injured bicyclists, and to identify characteristics associated with the specific patterns. Me...
Article
Full-text available
Objective To investigate associations of morbidity with subsequent sickness absence (SA) and disability pension (DP) among initially nulliparous women with no, one or several childbirths during follow-up. Design Longitudinal register-based cohort study. Setting Sweden. Participants Nulliparous women, aged 18 to 39 years and living in Sweden on 3...
Article
Full-text available
Objective: The aim of this study was to examine the association between combinations of job demands/control and future sickness absence (SA) and disability pension (DP) trajectories over 11 years. Methods: A population-based prospective cohort study of female (n = 1,079,631) and male (n = 1,107,999) employees in 2001. With group-based trajectory a...
Article
Full-text available
Background Early initiation of disease-modifying treatment (DMT) is associated with better disability outcomes in multiple sclerosis (MS). However, little is known of how treatment decisions affect socio-economic outcomes. Objective To estimate the long-term impact of early initiation of DMT on the income of MS patients. Methods In total, 3610 MS...
Article
Full-text available
Background Comorbidities are common among people with multiple sclerosis (PwMS); yet, their impact on the cost-of-illness (COI) in MS is unknown. Objective Explore the heterogeneity in COI trajectories among newly diagnosed PwMS in relation to type of comorbidity. Methods A nationwide longitudinal cohort study, using prospectively collected Swedi...
Article
Background Childbirth has been suggested to increase sickness absence (SA) and disability pension (DP). This may vary by occupation; however, knowledge in this field remains limited. We explored SA and DP in the years before and after childbirth among women in four occupational groups and among those without any occupation. Methods We conducted a...
Article
Background Working-aged colorectal cancer (CRC) patients have a much better survival nowadays, indicating the importance of their future work situation. We aimed to investigate trajectories of sickness absence and disability pension (SADP) days before and after CRC diagnosis and in references, and risk factors associated with different trajectories...
Article
Background As discussions about extending working lives are ongoing, more knowledge is warranted on working conditions that are associated with labour market status in older age. Aim Among employees aged 55-64 years, associations between job demands/job control with their labour market status 11 years later were explored. Methods A population-bas...
Article
Full-text available
Background There are difficulties in clinical assessment of patients' health, and there is a need for evaluating instruments that measures self‐rated health over time and that are based on the patient's own experiences of their health situation. Aim To describe the trajectory of self‐rated health given in a retrospective health‐line and its corres...
Article
Full-text available
Objective Back pain is the leading cause for years lived with disability globally and among the main reasons for sickness absence (SA) and disability pension (DP). The objective of this study was to explore the occurrence of SA and DP and to estimate productivity losses among individuals with back pain compared with among matched population-based r...
Article
Full-text available
Background: Knowledge about sickness absence (SA) and disability pension (DP) among privately employed white-collar workers is very limited. Aims: This study aimed to explore SA and DP among privately employed white-collar women and men using different measures of SA to investigate differences by branch of industry, and to analyse the association b...
Article
Full-text available
Objectives: Investigate prospective associations between combinations of job demands/job control and future labor market situation. Methods: A population-based prospective cohort study of 2,194,694 individuals in paid work. Using multinomial logistic regression, we calculated the association between combinations of job demands/control in 2001, a...
Article
Full-text available
Background: Childbirth has been suggested to increase sickness absence (SA) and disability pension (DP). This may vary by occupation; however, knowledge in this field remains limited. We explored SA and DP in the years before and after childbirth among women in four occupational groups and those without occupation. Methods: We studied nulliparou...
Article
Full-text available
Background: A maintained psychological wellbeing is important in order to continue working longer and remain active into older age. However, little is known about impact of different organizational factors, such as downsizing, on the mental health of older workers exiting the labor market. The aim in this study was to investigate trajectories of p...
Technical Report
Studien baseras på enkätsvar från de 13 750 sjukskrivande läkare i Sverige som år 2017 svarat på en enkät om sitt arbete med sjukskrivning av patienter; 6968 av dem hade även skrivit kommentarer om detta, s.k. fritextsvar. Svaren jämfördes med de från tre liknande enkäter från år 2012, 2008 resp 2004. Resultaten visar att 53 procent av de sjukskriv...
Article
Full-text available
Depression and anxiety are associated with unemployment and disability pension, while autism spectrum disorder (ASD) is less studied. We aimed to first identify unemployment trajectories among young adults with and without ASD, and then to examine their social determinants. Finally, we used the trajectories as determinants for subsequent disability...
Article
Full-text available
Background Multiple sclerosis (MS) typically onsets when of working age and may reduce work capacity. Previous studies have examined the risk of sickness absence (SA) and disability pension (DP) among MS patients, however, limited knowledge is available on whether MS patients have an excess risk for SA/DP when compared with the general population i...
Article
Full-text available
Objectives This study aimed to examine the association between job strain and incident coronary heart disease (CHD) in Denmark, while accounting for changes of job strain. Methods We included all employees residing in Denmark in 2000, aged 30-59 years with no prevalent CHD (N=1 660 150). We determined exposure to job strain from 1996-2009 using a j...
Article
Full-text available
Background: After breast cancer (BC) diagnosis, work incapacity often occurs among working-age women. We investigated the trajectories of previous and subsequent sickness absence and/or disability pension (SA/DP) days, and risk factors for consistently high levels of future SA/DP among these women. Methods: This longitudinal cohort study include...
Article
Full-text available
Objectives Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASD) and learning disabilities (LD) have an early onset and often persist into adulthood, although their relative contribution to incapacity for work is unclear. We examined this issue among young adults with ADHD, ASD or LD taking into account socioeconomic fact...
Article
Full-text available
Objective: To determine whether patients with cluster headache have more sickness absence and disability pension days compared to matched references and possible associations with sociodemographic characteristics. Methods: We performed a registry study of all patients who had received specialized health care for cluster headache (ICD-10 code G44...
Article
Full-text available
Aims: We examined the extent to which associations between education and cardiovascular disease (CVD) morbidity and mortality are attributable to income and work stress. Methods and results: We included all employed Danish residents aged 30-59 years in 2000. Cardiovascular disease morbidity analyses included 1 638 270 individuals, free of cardio...