Kristin Nordin- PhD
- Affiliated Researcher at Karolinska Institutet
Kristin Nordin
- PhD
- Affiliated Researcher at Karolinska Institutet
About
25
Publications
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Introduction
Affiliated researcher at the Aging Research Center (ARC) at Karolinska Institutet, Stockholm. My research centers on the hippocampus and its role in various memory functions across the lifespan. I am especially interested in the variation in properties and representations along the hippocampal long-axis, for instance the organization of hippocampal large-scale connectivity and its implications for episodic and spatial memory.
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Publications
Publications (25)
fMRI studies have identified distinct resting-state functional connectivity (RSFC) networks associated with the anterior and posterior hippocampus. However, the functional relevance of these two networks is still largely unknown. Hippocampal lesion studies and task-related fMRI point to a role for the anterior hippocampus in non-spatial episodic me...
The hippocampus interacts with distributed brain regions to support memory and shows significant volume reductions in aging, but little is known about age effects on hippocampal whole-brain structural covariance. It is also unclear whether the anterior and posterior hippocampus show similar or distinct patterns of whole-brain covariance and to what...
The hippocampal longitudinal axis has been linked to dissociated functional networks relevant to episodic memory. However, the organization of axis-dependent networks and their relation to episodic memory in aging remains less explored. Moreover, age-related deterioration of the dopamine (DA) system, affecting memory and functional network properti...
The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. A multidimensional account of the hippocampus functional integration with neocortex, however, remains to be established and evaluated in terms of functional specialization and cognitive decline in aging. Here, we identify two long-axis modes of corti...
Decades of research on functional brain mapping have highlighted the importance of understanding the functional organization of the cerebral cortex. Recent advances have revealed a gradient of functional organization spanning from primary sensory to transmodal cortices. This gradient-like axis of connectivity has been hypothesized to be aligned wit...
The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of its functional integration with neocortex, extending the traditional framework emphasizing functional differences between shar...
A key question in human neuroscience is to understand how individual differences in brain function are related to cognitive differences. However, the optimal condition of brain function to study between-person differences in cognition remains unclear. Additionally, there is a lack of objective biomarkers to accurately predict cognitive function, wi...
A key question in human neuroscience is to understand how individual differences in brain function are related to cognitive differences. However, the optimal condition of brain function to study between-person differences in cognition remains unclear. Additionally, there is a lack of objective biomarkers to accurately predict cognitive function, wi...
The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of its functional integration with neocortex, extending the traditional framework emphasizing functional differences between shar...
Age-related alterations in cortico-striatal function have been highlighted as an important determinant of declines in flexible, higher-order, cognition in older age. However, the mechanisms underlying such alterations remain poorly understood. Computational accounts propose age-related dopaminergic decreases to impoverish neural gain control, possi...
A key question in human neuroscience is to understand how individual differences in brain function are related to cognitive differences. However, the optimal condition of brain function to study between-person differences in cognition remains unclear. Additionally, there is a lack of objective biomarkers to accurately predict cognitive function, wi...
The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of its functional integration with neocortex, extending the traditional framework emphasizing functional differences between shar...
The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of its functional integration with neocortex, extending the traditional framework emphasizing functional differences between shar...
Structural decline of the hippocampus occurs in heterogeneous patterns across its spatial extent, and is an important determinant of episodic memory dysfunction in aging. However, evidence indicate that the anatomical landmark uncal apex, used to demarcate anterior and posterior hippocampal subregions, changes position as the hippocampus atrophies....
Decreasing integrity of striato-cortical circuits has been highlighted as an important determinant of declines in flexible, higher-order cognition in older age. Here, leveraging multi-modal (fMRI, PET) neuroimaging data from a large adult lifespan sample, we demonstrate older age to be associated with less specific functional coupling between the c...
Recent work has recognized a gradient-like organization in cortical function, spanning from primary sensory to transmodal cortices. It has been suggested that this axis is aligned with regional differences in neurotransmitter expression. Given the abundance of dopamine D1-receptors (D1DR), and its importance for modulation and neural gain, we teste...
Age-related alterations in D1-like dopamine receptor (D1DR) have distinct implications for human cognition and behavior during development and aging, but the timing of these periods remains undefined. Enabled by a large sample of in vivo assessments (n = 180, age 20 to 80 years of age, 50% female), we discover that age-related D1DR differences pivo...
![Figure 1: Average [ 11 C]SCH23390 BPND in early adulthood (age < 40 y,...](publication/360852638/figure/fig1/AS:11431281095499312@1667918750926/Average-11-CSCH23390-BPND-in-early-adulthood-age-40-y-n60-Bar-graph-mean-se_Q320.jpg)
The dopamine (DA) system, particularly D1-like DA receptors (D1DR), declines across the adult life. The functional consequences of reduced D1DR has been hypothesized to vary across life periods, but the precise timing of these periods is unknown. To examine distinct phases in age-related D1DR reductions, we studied 180 healthy adults (90 females, 2...
Concomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age-related cognitive decline is crucial in promoting healthy aging. Here, we present the DopamiNe, Age, connectoMe, and Cognition (DyNAMiC) project, a multimodal, prospective 5-year longitudinal study spanning the adult human lifespan. DyNAMiC examines...
Using the multivariate method partial least squares (PLS) we examined potential age differences in the structural whole-brain covariance of the anterior and posterior hippocampus between young, middle-aged and older adults (N = 221). The expression of identified covariance patterns was further assessed in relation to episodic and spatial memory, po...
Men and women in three age-groups performed a spatial navigation task requiring them to remember their position in relation to their starting point. Performance was equally affected by age for men and women and men outperformed women in all three age-groups. Hippocampal volume was however only reduced with age in men, in bilateral anterior regions.
Episodic memory performance often decreases with age, especially for associative memory. The anterior hippocampus is frequently engaged during associative encoding, and is also the part of the hippocampus that shows age-related reductions in volume. Although much is known about differences between young and old adults, less is known about those in...
In previous research, a female advantage has been
found in object location tasks, assessing item and spatial source memory.
The parahippocampus is believed to have a specific role in source memory,
with the anterior part being involved in item processing and the posterior
part in processing of contextual information. However, findings are
not ubiqu...
Spatial navigation performance depends on strategy, favoring hippocampus-mediated allocentric strategies employing cognitive maps over response-oriented egocentric strategies mediated by the caudate nucleus. This distinction is reflected in neural activation but also in grey matter volume. Men overall outperform women on spatial memory tasks, and f...
