Kristen Severi

Kristen Severi
New Jersey Institute of Technology | NJIT · Federated Department of Biological Sciences

PhD

About

24
Publications
7,815
Reads
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1,221
Citations
Citations since 2016
19 Research Items
910 Citations
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2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
Introduction
Researching zebrafish neural circuits and behavior. In 2018 I joined the Federated Dept. of Biological Sciences at NJIT / Rutgers-Newark. I did my graduate work in the lab of Dr. Florian Engert (Harvard University) and Dr. Don O'Malley (Northeastern University). I did my postdoctoral research at the ICM (Paris, France) in the lab of Dr. Claire Wyart, and at UPMC in the lab of Dr. Volker Bormuth.
Additional affiliations
September 2012 - present
May 2006 - September 2012
Harvard University
Position
  • Graduate Researcher
September 2004 - June 2011
Northeastern University
Position
  • Lab instructor
Description
  • Taught 2-3 lab sections of Anatomy and Physiology per semester. Emphasis on dissection and clinical application.
Education
September 2004 - November 2011
Northeastern University
Field of study
  • Biology
September 2000 - May 2004
Dickinson College
Field of study
  • Biology

Publications

Publications (24)
Article
Full-text available
Collective behavior may be elicited or can spontaneously emerge by a combination of interactions with the physical environment and conspecifics moving within that environment. To investigate the relative contributions of these factors in a small millimeter-scale swimming organism, we observed larval zebrafish, interacting at varying densities under...
Article
A recent study of motor control in zebrafish demonstrates the critical role of an excitatory neural relay network in the transformation of a unilateral turn command into a subsequent bilateral swim signal. A rapid and smooth transition between these motor phases is critical for successfully escaping danger.
Preprint
Full-text available
Collective behavior may be elicited or can spontaneously emerge by a combination of interactions with the physical environment and conspecifics moving within that environment. To investigate the relative contributions of these factors in a small millimeter-scale swimming organism, we observed larval zebrafish, interacting at varying densities under...
Article
Locomotion is an essential behavior for the survival of all animals. The neural circuitry underlying locomotion is therefore highly robust to a wide variety of perturbations, including injury and abrupt changes in the environment. On the short term, fault tolerance in neural networks allows locomotion to persist immediately after mild to moderate i...
Article
Full-text available
Mauthner cells are the largest neurons in the hindbrain of teleost fish and most amphibians. Each cell has two major dendrites thought to receive segregated streams of sensory input: the lateral dendrite receives mechanosensory input while the ventral dendrite receives visual input. These inputs, which mediate escape responses to sudden stimuli, ma...
Preprint
Full-text available
Mauthner cells are the largest neurons in the hindbrain of teleost fish and most amphibians. Each cell has two major dendrites thought to receive segregated streams of sensory input: the lateral dendrite receives mechanosensory input while the ventral dendrite receives visual input. These inputs, which mediate escape responses to sudden stimuli, ma...
Article
Electrical stimulation of various brainstem nuclei has revealed sites capable of initiating and modulating locomotion. However, subsequent experiments have revealed that these regions are functionally heterogeneous. Modern techniques including molecular-genetic methods to label cell types and optogenetic approaches to manipulate neural activity are...
Article
Full-text available
Locomotion in vertebrates relies on motor circuits in the spinal cord receiving inputs from the hindbrain to execute motor commands while dynamically integrating proprioceptive sensory feedback. The spatial organization of the neuronal networks driving locomotion in the hindbrain and role of inhibition has not been extensively investigated. Here, w...
Article
Graphical Abstract Highlights d Optimized, genetically encoded botulinum neurotoxin silences synaptic output in vivo d Excitatory V2a interneurons drive high-frequency components of fast locomotion d Silencing of V2as shifts locomotor frequency downward during the slow regime In Brief Silencing of neuronal populations in moving animals remains a ch...
Article
Full-text available
Vertebrate locomotion at different speeds is driven by descending excitatory connections to central pattern generators in the spinal cord. To investigate how these inputs determine locomotor kinematics, we used whole-field visual motion to drive zebrafish to swim at different speeds. Larvae match the stimulus speed by utilizing more locomotor event...
Article
Full-text available
The zebrafish larva stands out as an emergent model organism for translational studies involving gene or drug screening thanks to its size, genetics, and permeability. At the larval stage, locomotion occurs in short episodes punctuated by periods of rest. Although phenotyping behavior is a key component of large-scale screens, it has not yet been a...
Article
Full-text available
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Here we describe red, single-wavelength GECIs, "RCaMPs," engineered from circular permutation of the thermostable red fluorescent protein mRuby. High-resolution crystal structures of mRuby, the red sensor RCaMP, and the recently published red GECI R-GECO1 gi...
Article
Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific manner. In recent years, such methods have been applied to uncover causal relationships between activity in specified neuronal circuits and behavior in the larval zebrafish. In this small, transparent, genetic model organism, noninvasive manipulation and moni...
Article
Full-text available
A basic question in the field of motor control is how different actions are represented by activity in spinal projection neurons. We used a new behavioral assay to identify visual stimuli that specifically drive basic motor patterns in zebrafish. These stimuli evoked consistent patterns of neural activity in the neurons projecting to the spinal cor...

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