Kristen Mackiewicz Seghete

Kristen Mackiewicz Seghete
Oregon Health and Science University | OHSU · Department of Psychiatry

PhD

About

27
Publications
1,887
Reads
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380
Citations
Citations since 2017
15 Research Items
232 Citations
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Publications

Publications (27)
Article
Existing and emerging evidence indicates that perinatal depression is a key contributor to preventable morbidity and mortality during and after childbearing. Despite this, there are few effective options for prevention and treatment that are readily accessible for and appealing to pregnant people. Aspects of routine health care systems contribute t...
Article
Full-text available
Objective One route to improve adolescent addiction treatment outcomes is to use translational approaches to help identify developmental neuroscience mechanisms that undergird active treatment ingredients and advance adolescent behavior change. Methods This sample included 163 adolescents (ages 15-19) randomized to motivational interviewing (MI) v...
Poster
Insufficient and excessive gestational weight gain (GWG) are important predictors of adverse maternal and offspring health outcomes. The Institute of Medicine recommends that all individuals, regardless of pre-pregnancy body mass index (BMI), gain weight during pregnancy. Individuals who receive appropriate GWG recommendations from providers have g...
Article
Full-text available
Introduction: There is a dire need for research regarding the implications of opioid use during pregnancy on fetal and childhood development to better inform both medical practice and policy. The Healthy Brain and Child Development Study will examine brain and behavioral development from birth through the first decade of life. Due to large scope an...
Poster
Pregnant individuals face a higher susceptibility to heightened stress and commonly experience pregnancy-specific stress. Stress during pregnancy has far-reaching effects on maternal health, birth outcomes, and the fetal environment. The current study examined the effects of maternal psychological health during pregnancy on pregnancy-specific stres...
Poster
Pregnancy is marked with increased stress and heightened activation of the hypothalamic-pituitary-adrenal (HPA) axis, the body’s stress response system. Elevated stress activation during pregnancy produces a dysregulated HPA-axis affecting maternal peripartum and postpartum health, the fetal environment, and offspring development. The drastic chang...
Poster
Insufficient and excessive gestational weight gain (GWG) are important predictors of adverse maternal and offspring health outcomes. The Institute of Medicine (IOM) recommends that all individuals, regardless of pre-pregnancy body mass index (BMI), gain weight during pregnancy. Individuals who receive appropriate GWG recommendations from providers...
Article
Full-text available
Characterizing typologies of childhood adversity may inform the development of risk profiles and corresponding interventions aimed at mitigating its lifelong consequences. A neurobiological grounding of these typologies requires systematic comparisons of neural structure and function among individuals with different exposure histories. Using seed-t...
Article
Objective: Preventive interventions for postpartum depression (PPD) are critical for women at elevated risk of PPD. Mindfulness based cognitive therapy - perinatal depression (MBCT-PD) is a preventive intervention that has been shown to reduce risk for PPD in women with a prior history of depression. The objective of this clinical trial is to exam...
Article
Full-text available
Purpose of Review This review examines how research focused on treatment for opioid use in perinatal populations and preventive interventions for postpartum psychopathology have remained separate, despite significant overlap. Recent Findings Guidelines for best practice in caring for pregnant women with opioid use disorder suggest the use of medic...
Article
Full-text available
Objective: In adolescence, sensation seeking is associated with earlier onset of alcohol use, which is a risk factor for a variety of negative consequences later in life. Individual differences in sensation seeking are related to brain function in the nucleus accumbens (NAcc), a brain region that undergoes considerable structural development durin...
Article
Cognitive control, which relies on the protracted development of frontal-parietal regions into adolescence, is a brain process that may be particularly vulnerable to the impact of childhood abuse. In this study, we used functional magnetic resonance imaging (fMRI) to examine associations between the age of onset of childhood abuse and alterations t...
Article
Full-text available
Background Although limited, the literature suggests alterations in activation of cognitive control regions in adults and adolescents with a history of childhood abuse. The current study examined whether such alterations are increased in the face of emotionally-distracting as compared to emotionally neutral information, and whether such alterations...
Article
This study used the power of neuroimaging to identify the neural systems that remove information from working memory, a thorny issue to examine because it is difficult to confirm that individuals have actually modified their thoughts. To overcome this problem, brain activation as measured via fMRI was assessed when individuals had to clear their mi...
Article
Although protracted prefrontal grey matter development is associated with concomitant executive function (EF) development in adolescents, few studies have explored the relationship between white matter and EF. This study examined the relationship between white matter microstructure and two aspects of EF, inhibition and task-switching, in a sample o...
Article
Full-text available
This study used functional magnetic resonance imaging (fMRI) to examine the neural systems activated during an intertemporal choice task in a group of 14- to 19-year-old adolescents, as well as the relationship of such activation patterns to individual differences in the self-reported ability to engage in nonimmediate thinking (i.e., less impulsive...
Article
Altered behavioral performance and brain activation during spatial working memory (SWM) tasks have been demonstrated in individuals with an alcohol use disorder (AUD). It is possible that alterations in processing during SWM may be present prior to initiation of heavy alcohol use in adolescents with a family history of AUDs (family history positive...
Article
In this randomized controlled trial, cognitive-behavioral group therapy (CBGT) for social anxiety disorder (SAD) was compared to group psychotherapy (GPT), a credible, structurally equivalent control condition that included only nonspecific factors of group treatment (such as group dynamics). Participants were 45 college students at the University...
Data
fMRI group differences for task blocks compared to fixation. (DOC)
Data
Whole-brain exploratory relationships between fMRI blocked Stroop activity and self-report measures of cognitive/social control. Whole-brain correlation analyses between the contrast of I-N blocks and individual self-report measures of cognitive/social control were performed separately for adolescents and adults, including and age as a covariate of...
Data
Between-group blocked differences in the three Stroop task conditions compared to fixation. Clusters of BOLD activity demonstrating significant between-group differences are displayed for the contrasts: A. Incongruent blocks (I) compared to fixation, B. Congruent blocks (C) compared to fixation, and C. Neutral blocks (N) compared to fixation. Red v...
Data
Relationships between blocked fMRI stroop activity (I-N) and self-report measures of cognitive/social control. (DOC)
Article
Full-text available
Adolescence is commonly characterized by impulsivity, poor decision-making, and lack of foresight. However, the developmental neural underpinnings of these characteristics are not well established. To test the hypothesis that these adolescent behaviors are linked to under-developed proactive control mechanisms, the present study employed a hybrid b...

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