Krista Wilkinson

Krista Wilkinson
University of Manitoba | UMN · College of Medicine

About

24
Publications
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308
Citations
Introduction
Skills and Expertise

Publications

Publications (24)
Article
Background: Changes to pertussis vaccination programmes can have impacts on disease burden that should be estimated independently from factors such as age- and period-related trends. We used age-period-cohort (APC) models to explore pertussis incidence in Manitoba over a 25-year period (1992-2017). Methods: We identified all laboratory-confirmed...
Article
Full-text available
Background We studied lab-confirmed COVID-19 infection (LCCI) testing, incidence, and severity. Methods We included all Manitoba residents and limited our severity analysis to LCCI patients. We calculated testing, incidence and vaccination rates between March 8, 2020 and June 1, 2021. We estimated the association between patient characteristics an...
Article
Background Pertussis remains poorly controlled relative to other diseases targeted by childhood vaccination programs. We combined estimates from four population-based studies of pertussis vaccine effectiveness (VE) in three Canadian provinces using a meta-analytic approach to improve precision and explore regional variation in VE and durability of...
Article
A comprehensive review of observational pertussis vaccine effectiveness (VE) studies is needed to update gaps from previous reviews. We conducted a systematic review of VE and duration of protection studies for the whole-cell (wP) and acellular (aP) pertussis vaccines and conducted a formal meta-analysis using random effects models. Evidence contin...
Article
Objectives Understanding important transmission parameters, such as secondary attack rates, can help in strategizing, prioritizing, and planning interventions to curb morbidity and mortality due to COVID-19. Early reports suggest the risk of transmission of SARS-CoV-2 (the pathogen that causes COVID-19 disease) is high among household contacts of c...
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Full-text available
Background: After routine mumps immunization programs were implemented in Manitoba in the 1980s, incidence was low, with 0-9 cases of disease annually. In September 2016, a mumps outbreak began in fully vaccinated university students in Winnipeg, Manitoba. Objective: We describe the investigation of this province-wide mumps outbreak, which laste...
Article
Setting: The Winnipeg Regional Health Authority (WRHA) is one of the largest and most diverse health regions in Canada. Within the WRHA, the Population and Public Health (PPH) Surveillance Team provides epidemiological support across a variety of public health service areas. Intervention: We developed and deployed a risk-based data disclosure pr...
Article
Background: Pertussis persists in Manitoba despite the universal availability of pertussis vaccines. Recent cases have included previously vaccinated individuals, raising concerns about declining vaccine effectiveness (VE). We measured pertussis VE and duration of protection using Manitoba's provincial immunization and communicable disease registr...
Article
Introduction: Older adults are prioritized for influenza vaccination but also have lowered antibody responses to the vaccine. Higher-doses of influenza antigen may increase immune response and thus be more effective. Our objectives were to compare the efficacy and safety of the high-dose influenza vaccine to the standard-dose influenza vaccine in t...
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Full-text available
To identify predictive factors and mortality of patients with influenza admitted to intensive care units (ICU) we carried out a prospective cohort study of patients hospitalized with laboratory-confirmed influenza in adult ICUs in a network of Canadian hospitals between 2006 and 2012. There were 626 influenza-positive patients admitted to ICUs over...
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Full-text available
A multi-province outbreak of listeriosis occurred in Canada from June to November 2008. Fifty-seven persons were infected with 1 of 3 similar outbreak strains defined by pulsed-field gel electrophoresis, and 24 (42%) individuals died. Forty-one (72%) of 57 individuals were residents of long-term care facilities or hospital inpatients during their e...
Article
Objective: To determine trends, patient characteristics, and outcome of patients with healthcare-associated influenza in Canadian hospitals. Design: Prospective surveillance of laboratory-confirmed influenza among hospitalized adults was conducted from 2006 to 2012. Adults with positive test results at or after admission to the hospital were ass...
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Full-text available
Multiple observational studies have associated antiviral treatment of patients hospitalized with influenza with improved outcome, including reduced mortality. During the 2009-2010 H1N1 pandemic increased use of antiviral treatment of hospital patients was reported. We have carried out prospective surveillance for influenza in patients in a large ne...
Article
The degree to which the 2009-2010 influenza pandemic season differed from previous and subsequent influenza seasons in Canadian hospitals has not yet been assessed. Surveillance for laboratory-confirmed influenza among adults in 51 Canadian Nosocomial Infection Surveillance Program hospitals was conducted between November 1, 2006, and May 31, 2011....
Article
During October 2010-February 2011, an outbreak of 91 Salmonella Enteritidis (SE) infections in Alberta, Canada, was investigated by a local public health department (Alberta Health Services, Calgary Zone). Index cases initially were linked through a common history of consumption of food purchased from mobile food-vending vehicles (lunch trucks) ope...
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Full-text available
receive antiviral treatment during the pandemic than during the post-pandemic seasons (89.7% vs. 75.7%, p<0.001). A higher proportion of adults admitted to the ICU during the 2009 pandemic (94.2%) received antiviral treatment compared with the 2010-11 and 2011-12 seasons (84.6%, p<0.001). There was no difference in antiviral treatment among inpatie...
Article
Surveillance for pandemic H1N1 influenza was conducted between June 1, 2009, and May 31, 2010, among adults at 40 participating hospitals in the Canadian Nosocomial Infection Surveillance Program. The first wave was characterized by a higher proportion of Aboriginals and pregnant women as well as severe outcomes, compared to the second wave. Infect...
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Full-text available
In response to the spread of the pandemic H1N1 (pH1N1) influenza virus in 2009, the Canadian Nosocomial Infection Surveillance Program (CNISP) extended its seasonal influenza surveillance to year-round reporting in order to describe the epidemiology and outcomes of pH1N1 in hospitalized adults. This report describes the findings of the surveillance...
Article
Clostridium difficile is an important pathogen in Canadian health care facilities, and infection prevention and control (IPC) practices are crucial to reducing C difficile infections (CDIs). We performed a cross-sectional study to identify CDI-related IPC practices in Canadian health care facilities. A survey assessing facility characteristics, CDI...
Article
Full-text available
Open Medicine has provided an opportunity to acquire experience in peer review for a group of graduate students in the Department of Community Health Sciences at the University of Calgary. To date, approximately 40 students have regularly participated in the peer review of manuscripts for Open Medicine. Participating students attend group sessions...
Conference Paper
Background: The Canadian Nosocomial Infection Surveillance Program (a collaboration between the Public Health Agency of Canada and the Association for Medical Microbiology and Infectious Diseases – Canada) is a sentinel network of 56 mainly large teaching hospitals in Canadian cities. CNISP has conducted surveillance for seasonal influenza (flu) in...

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