Krishnaveni Manubolu

• Doctor of Philosophy
• Associate professor at Narayana Pharmacy College JNTUA

The pharmaceutical sector contributes to resource depletion and environmental contamination by producing a large volume of packaging trash. This chapter examines design techniques for pharmaceutical packaging that aim to improve recyclability and reduce waste. The emphasis is on environmentally friendly methods, such as choosing eco-friendly materi...

Increasing progress has been made through technological advancements, and certain places are now more disconnected from the natural world. All matter, whether living or nonliving, originates from maternal nature. A destructive characteristic of humankind is the gap that remains between nature and humans despite all of these advancements and progres...

Introduction Vildagliptin is a dipeptidyl peptidase 4-related inhibitor that is often utilised in the treatment of type-2 diabetes. It is possible that sustained therapeutic levels of vildagliptin for a prolonged length of time might be achieved by controlled release of the drug in the gastrointestinal system, which would result in an improvement i...

Broccoli (Brassica oleracea var. italica) is a nutrient-rich cruciferous vegetable known for its potent bioactive compounds, which exhibit significant anti-inflammatory and therapeutic properties. This review explores the diverse pharmacological benefits of broccoli, emphasizing its role in managing inflammation-related disorders and other health c...

Cabbage (Brassica oleracea), a member of the Brassicaceae family, has been widely recognized for its nutritional value and therapeutic benefits. Recent studies have highlighted its significant anti-inflammatory properties, attributed to its rich phytochemical composition, including glucosinolates, flavonoids, and vitamins C and K. These bioactive c...

Cauliflower (Brassica oleracea var. botrytis), a cruciferous vegetable, is a rich source of bioactive compounds with significant anti-inflammatory properties. Chronic inflammation, a key factor in the progression of various diseases such as cardiovascular, metabolic, and autoimmune disorders, can be mitigated by natural dietary interventions. The b...

Artificial intelligence AI is a sophisticated model or algorithm that has transformed a number of industries, including the medical field. In generative artificial intelligence, content is created using models or algorithms. Generative AI in healthcare revealed numerous new application domains for illness diagnosis. It has given models new outputs...

This chapter discusses the impact of renal and hepatic diseases on pharmacokinetics. Antidiabetics, aminoglycosides, ACE inhibitors, and other drug pharmacokinetics, related to the diseases, are mentioned. Renal and hepatic diseases significantly alter the pharmacokinetics of drugs, necessitating dose adjustments to ensure efficacy and avoid toxici...

Therapeutic drug monitoring (TDM), a fundamental component of clinical pharmacokinetics, enables the personalization of medication therapy to maximize effectiveness and reduce side effects. The ideas, applications, and clinical practice implications of TDM are thoroughly examined in this chapter. First, the theory underpinning TDM is explained, str...

Pharmacokinetics and drug metabolism are significantly impacted by inhibition of biliary excretion, which in turn, affects drug toxicity and efficacy. Drugs and their metabolites are excreted from the body through the biliary system, which is mostly carried out by transporter proteins found in hepatocytes. It is crucial to comprehend the mechanisms...

Pharmaceutical drug interactions present a significant danger to medication efficacy, safety, and therapeutic outcomes in clinical pharmacokinetics. This comprehensive chapter emphasizes the importance of pharmaceutical medication interactions by looking at their causes, classifications, and clinical effects to maximize patient care. Pharmacokineti...

Myxopyrum smilacifolium Blume geographical occurrence is southern part of India and its usage for the treatment of various diseases has been marked in Traditional Medicine. The present study was aimed to examine the phytoconstituents in Myxopyrum smilacifolium Blume for antiarthritic activity by insilico approach. Antiarthritic activity of phytocon...

Aim The aim of the work is a formulation and in vitro evaluation of the vildagliptin microsphere using pectin and xanthan gum. Objective Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor extensively associated with the therapy of type-2 diabetes mellitus. A controlled release of the drug in the gastrointestinal tract may aid in maintainin...

Spices have played a crucial role in human history, shaping cultures, trade routes, and culinary traditions for millennia. The diverse and fascinating world of spices, examining their origins, cultural significance, economic impact, and the multifaceted roles they play in both traditional and modern societies. Black pepper (Piper nigrum) stands as...

Aquasomes are nanoparticles fabricated from ceramics developed to enhance proteins and peptides stability, providing an adequate residence time in circulation. It consists of ceramic core coated with poly hydroxyl oligomer, on which protein and peptide drug can be adsorbed. Aquasomes preparation, characterization, and application in protein and pep...

RECENT RESEARCH TRENDS IN PHARMACEUTICAL SCIENCES (VOLUME- 1): EDITED BOOK

HOSPITAL AND COMMUNITY PHARMACY TEXT BOOK

This work is aimed to design blank microspheres using natural polymers such as pectin, and xanthan gum in order to achieve controlled release. The microspheres were prepared by ionotropic gelation method using different ratios of sodium alginate-pectin, and sodium alginate-xanthan gum polymers. The blank microspheres were prepared to understand the...

In the present study "Millingtonia hortensis", a herbal aqueous extract of leaves are investigated to find anti-inflammatory activity by invitro evaluation. Millingtonia hortensis (BIGNONIACEAE) subjected for Invitro anti-inflammatory activity was evaluated by albumin protein denaturation method. Millingtonia hortensis leaf aqueous extract was prep...

The main objective of the present research study was to fabricate Vildagliptin floating microspheres by ionotropic gelation using natural polymer, Abelmoschus esculentus obtained from the fruits of Abelmoschus esculentus in combination with sodium alginate. Microspheres were prepared and optimized using central composite rotatable design model usin...

Lycopene is one of the nutrient antioxidant. Apart from that it is having different beneficial roles in the human body. The present review is about the lycopene uses. It is a component of human redox defence mehcnisms against free radicals. As lycopene is having antioxidant property it is well known for its anticancer, cardiovascular diseases, idio...

Topical delivery gained popularity for the treatment of local skin disorders. Topical formulations have the potential to deliver the drug to the site of action and can achieve the therapeutic benefit. Apart from the delivery of drugs through the skin it can maintain the long residence time with the skin. Among the topical formulations emulgel emerg...

The aim of work is to extract and characterize the Vigna mungo polymer solvent using acetone and ethanol. Natural polymers contribution towards formulation of dosage forms is appreciable as they are biocompatible, biodegradable and safe. So extraction and characterization of Vigna mungo polymer helps in the interaction studies of preformulation. In...

The aim of the present research is to investigate acute toxicity profiling of isolated Vigna mungo new natural polymer. Safety administration is the primitive criterion for any drug substance. To explore the safety and toxicity profiling of the novel polymer, this study was carried out. Vigna mungo novel polymer was isolated from the pulverised see...

An attempt was made to formulate and evaluate alginate floating microspheres of gliclazide as a model drug by ion cross-linking technique or ion gelation method using cacl2 as cross-linking agent. The microspheres were formulated using sodium alginate (as release retardant agent) with a view to deliver drug at controlled/sustained manner in GIT and...