Krishnan ManikandanThe Fetal Clinic, Pondicherry · Maternal Fetal Medicine
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Citations since 2016
10 Research Items
January 2016 - present
Fetal Care Research Foundation, Chennai, India
- Senior Research Consultant
January 2015 - January 2018
Tamil Nadu Dr. M.G.R. Medical University, Mediscan Systems Chennai
Field of study
- Fetal Medicine
October 2012 - February 2013
HarvardX, Online Initiative of Harvard University
Field of study
- Quantitative Methods in clinical and public health research
Introduction: Pre-eclampsia contributes to maternal and fetal morbidity and mortality all over the world. Endothelial dysfunction is postulated to be the crux of the pathogenesis. Recent meta-analysis of aspirin trials showed aspirin to be effective when started early in pregnancy (at ≤ 16-week gestation). We aimed to study the effect of low-dose...
Optimum dose, route and duration of use of prophylactic magnesium sulphate in women with severe pre-eclampsia is still controversial. We compared the efficacy and safety of ‘low-dose Dhaka’ regime with ‘Loading dose only’ regime for seizure prophylaxis in severe preeclampsia using a randomised controlled trial in 402 women. The incidence of eclamps...
Down syndrome is the most common cause of intellectual disability among live born children and is amenable to prenatal detection. Screening for Down syndrome on a population basis requires a thorough understanding of the principles involved in the screening tests. We discuss the rationale behind the commonly available screening tests and the Indian...
To analyse the distribution and determinants of the first trimester screening risk for the detection of trisomy 21 in the population in and around Chennai, a south Indian metropolitan city.
Background: Preeclampsia is a multi-systemic, multi-organ dysfunction associated with increased maternal and perinatal complications. The presence of maternal ascites, a manifestation of endothelial dysfunction and increased capillary permeability, is shown to be associated with adverse outcomes. We aim to investigate the impact of maternal ascite...
Background Objective assessment of posterior fossa landmarks such as the measurement of brain stem width or intracranial translucency have not been consistently shown to be predictive of future posterior fossa abnormalities, other than the Arnold–Chiari II malformation. Objective To study the association between the objective and subjective assessm...
In the field of fetal medicine, correct interpretation and optimal utilization of diagnostic tests and signs have a major impact on the pregnancy outcome. The attributes of a diagnostic test, such as sensitivity and specificity, and the attributes of a test result such as positive and negative predictive values, and positive and negative likelihood...
Frusemide use in pregnancy is generally restricted to patients with cardiac decompensation. In the past, maternal administration of oral frusemide had been tried to identify non-functioning fetal kidneys by utilizing the diuretic effect of frusemide on the fetal kidneys. We report a case of primigravida with severe mitral stenosis presenting in pul...
Background: Hysteroscopic septal resection has become the treatment of choice for women with septate or subseptate uteri because of this procedure's increased safety and efficacy. The indications/benefits for septal resection should be balanced against the risks. This article presents a case that illustrates the potential catastrophe that can resul...
Malignancy complicating pregnancy represents one of the most challenging clinical situations. Lack of evidence and the presence of the dependent fetus contribute to the management dilemma. A 26-year-old primigravida presented at 23 weeks of gestation with a bulging substernal mass. Fine-needle aspiration was reported as mediastinal dysgerminoma. Sh...
The ex-utero intrapartum therapy (EXIT) is a procedure that provides valuable time for securing a compromised or a threatened airway in the fetus-neonate. Critical to this procedure is the maintenance of the uteroplacental circulation. Achieving complete uterine relaxation, maintaining the uterine volume and the maternal mean arterial pressure are...
Aspirin has been shown to prevent preeclampsia in high risk population but the effect size is far from optimal. Previous research has shown nitric oxide donor and precursors having important pathophysiological role in early implantation events and are potential targets for PE prophylaxis. We aimed to see if Isosorbide Mononitrate in addition to aspirin will significantly reduce PE incidence in high risk population
Large Scale data for the performance of FTS in Indian Population are sparse. The project is aimed to assess the performance of the accepted model in this population