Krishna Murthy Potla

Krishna Murthy Potla
Bapatla Engineering College | BEC · Department of Chemistry

Ph.D

About

54
Publications
5,465
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
280
Citations
Introduction
Skills and Expertise

Publications

Publications (54)
Patent
Full-text available
COVID-19 pandemic has significantly increased high deaths, infectivity and hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a foremost problem in the world presently. Currently, all research institutions and pharmaceutical industries are keen in developing new vaccines and more effective drugs that could inhibit the...
Patent
Full-text available
The current invention provides most promising and novel anti-cancer drug candidates screened against important tyrosine kinase proteins such as Bcr-Abl kinase (PDB ID: 1IEP), C-kit tyrosine kinase (PDB ID: 1T46) and Src-Abl tyrosine kinase homology model protein (PDB ID: 4csv). In siico anti-cancer activity of the compounds 2f, 2e, 2h, and li revea...
Patent
Full-text available
COVID-19 pandemic has led us to design and develop novel organic molecules as medicinally promising drugs which can prevent the SARS-CoV-2 virus of the infected patients. The current invention provides potential anti-viral drugs docked against anti COVID-19 protein targets: SARS-CoV-2 main protease, drug-likeness, efficacy, molecular docking, physi...
Article
The present study reports structural, spectroscopic signatures, reactivity parameters, and in silico anti-depressant activity of the title compound 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol (DMATP). The structure of the DMATP compound has been unambiguously obtained through single crystal X-ray diffraction, vibrational spectroscopy, and therma...
Patent
Full-text available
Abstract : COVID-19 pandemic has led us to design and develop novel organic molecules as medicinally promising lead molecules which can prevent the SARS-CoV-2 virus of the infected patients. The current invention provides potential anti-viral drugs docked against anti-COVID-19 protein targets: SARS-CoV-2 main protease, drug-likeness, efficacy, mole...
Article
Full-text available
A new class of benzoxazaphosphinine-2-one derivatives were synthesized by the reaction of 2-(3a,4,5,6,7,7a-hexahydro-1H-benzo[d]imidazol-2-yl)phenol with salicylic acid and thionyl chloride (SOCl2) via three-step process, and were obtained in good to excellent yields (77–95%) The designed compounds were evaluated for their in vitro antioxidant, ant...
Article
Triazole-based Schiff bases, 4-{[4-(dimethylamino)benzylidene]amino}-5-methyl-4H-1,2,4-triazole-3-thiol [DBAMTT] and 5-methyl-4-[(thiophene-2-ylmethylidene)amino]-4H-1,2,4-triazole-thiol [MTATT], were studied for their corrosion inhibitory action on maraging steel in the temperature range 30–45 °C in a 2:1 mixture of HCl and H2SO4. Both the inhibit...
Article
The ortho-CF 3 substituent and the N-H bond are in syn-conformation within the title molecule. In the amide and acid functionalities, the carbonyl groups are directed in opposite directions to each other and their related-CH 2 groups. Syn conformation is observed for the acid functionality, where the carbonyl C = O and hydroxyl O-H bonds are direct...
Article
The present work reports an analysis of the structure, spectroscopic signatures, nonlinear optical properties and docking studies of synthesized 3-(2-amino-2-oxoethyl)-5-methylhexanoic acid (abbreviated as AOEMHA) with the empirical formula C19H17NO3. The structure in the solid state determined by the single crystal X-ray diffraction technique reve...
Article
Full-text available
In the present investigation, we report an analysis of the structural, spectroscopic characterization, reactivity parameters, topological studies, and molecular docking studies of the synthesized ethyl 3-[(pyridin-2-yl)amino]propanoate (abbreviated to EPYAPP), C 10 H 14 N 2 O 2. The molecular and crystal structure was determined by using the single...
Article
In the present investigation, we report an analysis of the structural, spectroscopic characterization, reactivity parameters, topological studies, and molecular docking studies of the synthesized ethyl 3-[(pyridin-2-yl)amino]propanoate (abbreviated to EPYAPP), C10H14N2O2. The molecular and crystal structure was determined by using the single-crysta...
Article
The present work reports an analysis of the structural, spectroscopic signatures, nonlinear optical properties and docking studies of synthesized 3-(2-amino-2-oxoethyl)-5- methylhexanoic acid (brevity as AOEMHA) with empirical formula C19H17NO3. The structure in the solid state determined by single crystal X-ray diffraction technique revealed that...
Article
Full-text available
A new class of phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole were synthesized in good to excellent yields (78-96%) by an in situ, three-step process. All the synthesized molecules were evaluated for anti-bacterial and anti-fungal activities using in vitro and in silico methods. The results revealed that the compounds 4...
Article
The polluted water sources pose a serious issue concerning the various health hazards they bring along. Due to various uncontrolled anthropogenic and industrial activities, a great number of pollutants have gained entry into the water systems. Among all the emerging contaminants, anionic species such as fluoride cause a major role in polluting the...
Article
The inhibitory action of a synthesized Schiff base (5-methyl-4-[(E)-(thiophen-2-ylmethylidene)amino]-4H-1,2,4-triazole-3-thiol) [MTATT] on the corrosion behaviour of maraging steel in 1 M HCl was investigated by electrochemical techniques like Tafel polarization studies and electrochemical impedance spectroscopy. According to experimental data, inh...
Article
Full-text available
In the present study, a new series of a-Aminophosphonates bearing 6-amino-1,3-dimethyluracil was synthesized in good to excellent yields (78-95%) by one-pot, three-component reaction of 6-amino-1,3-dimethyluracil, aromatic aldehydes and diethylphosphite via Kabachnik-Fields reaction by using an eco-friendly Eaton's reagent. All the compounds were s...
Article
The corrosion inhibition competence of 4-{[4-(dimethylamino)benzylidene]amino}-5-methyl-4H-1,2,4-triazole-3-thiol (DBTT) on 316 stainless steel (316 SS) in 2.5 M H2SO4 was studied using various electrochemical as well as weight-loss measurements. The alloy surface was examined by scanning electron microscopy (SEM) and energy dispersive X-ray spectr...
Article
The present work reports an analysis of the structure, spectroscopic signatures, nonlinear optical properties and docking studies of synthesized 3-(2-amino-2-oxoethyl)-5-methylhexanoic acid (abbreviated as AOEMHA) with the empirical formula C19H17NO3. The structure in the solid state determined by the single crystal X-ray diffraction technique reve...
Article
Full-text available
Copper(II), palladium(II) complexes [Cu(L1) 2 ] (1), [Pd(L1) 2 ] (2), [Cu(L2) 2 Cl 2 .H 2 O] (3), [Pd(L2) 2 Cl 2 ] (4), of 2-aminoquinolin-8-ol (L1) and 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole (L2) were synthesized and physico-chemically characterized by spectroscopic techniques like IR, UV-Visible and elemental analysis. The structures...
Article
Full-text available
An efficient and eco-friendly protocol has been accomplished for a series of novel α-diaminophosphonates by a one-pot, three-component system via Kabachnik-Fields reaction of 4,4′-methylenedianiline, a variety of aryl/heteroaryl aldehydes and diphenylphosphite employing polyethylene glycol (PEG-400) as a green solvent at 80 °C. All products were ob...
Article
In this work the 4,6-dichloro-2-(methylsulfonyl)pyrimidine (DCMSP) has been synthesized from 4,6-dichloro-2-(methylthio)pyrimidine, its molecular and electronic structure was authenticated by detailed spectroscopic signature studies (via SCXRD, FT-Raman, FT-IR and ( ¹ H & ¹³ C) NMR), Hirshfeld surface analysis and DFT calculations. The solid-state...
Article
In the present study, the title compound 1,7-bis(4-bromophenyl)heptane-1,7-dione (BBPHD) was synthesized according to the procedure described in literature, and its solid state crystal structure was characterized by the single crystal x-ray diffraction study. The complete crystallographic information has been reported in the present work. Physicoch...
Article
The title compound 2-(6-hydroxy-1-benzofuran-3-yl) acetic acid (abbreviated as HBFAA) has been synthetized and characterized by FT-IR, FT-Raman and NMR spectroscopic techniques. Solid state crystal structure of HBFAA has been determined by single crystal X-ray diffraction technique. The crystal structure features O-H⋯O and C-H⋯O intermolecular inte...
Article
CaZrO3 ceramic pigment exhibits high chemical, thermal and structural stability. However, its application as a host for various luminophores/activators has not been clearly explored. In the present investigation, CaZrO3 doped with Eu³⁺, as a potential orange-red phosphor has been demonstrated. Ca1-xZrO3:Eux (x = 0.01–0.09) nanophosphor is prepared...
Article
A new compound N-(2,5-dimethyl-4-nitrophenyl)-4-methylbenzenesulfonamide (NDMPMBS) has been derived from 2,5-dimethyl-4-nitroaniline and 4-methylbenzene-1-sulfonyl chloride. Structure was characterized by SCXRD studies and spectroscopic tools. Compound crystallized in the monoclinic crystal system with P21/c space group a = 10.0549, b = 18.967, c =...
Article
AKT as a result of inactivation of tumor suppressor PTEN has been found in a variety of human tumors. AKT has long been considered an attractive target for the treatment of cancers. A computational multivariate regression was carried out on a set of 61 pyridine based analogs to study the influence of physico-chemical properties on AKT inhibition. A...
Article
We have report a facile, ecofriendly and cost-effective approach to remove toxic heavy metal ions of Pb(II) by magnetically separable reduced graphene oxide/iron oxide (RGO/Fe3O4) nanocomposite synthesized via green method utilizing Murrayakoenigii (Mk) leaves extract as reducing and capping agent. The synthesized RGO/Fe3O4 nanocomposite were chara...
Article
4-(benzofuran-2-yl)-2-methyl-6-phenylpyrimidine(BFMPP) has been synthesized and characterized by FT-IR, ¹H &¹³CNMR and Mass spectrometry techniques. Single crystals of title compound were grown by slow evaporation solution growth technique at room temperature and crystal structure has been determined by single crystal X-ray diffraction technique. T...
Article
The title molecule, C 6 H 6 Br 2 N 2 , is almost planar (r.m.s. deviation for the non-H atoms = 0.012 Å). In the crystal, inversion dimers linked by pairs of N—H...N hydrogen bonds generate R2² (8) loops.
Article
The title molecule, C6H6Br2N2, is almost planar (r.m.s. deviation for the non-H atoms = 0.012 A˚ ). In the crystal, inversion dimers linked by pairs of N—HN hydrogen bonds generate R22(8) loops.
Article
In this study, 1-benzofuran-2-carboxylic acid was synthesized and characterized by FT-IR, 1HNMR and single crystal XRD analysis. The compound crystallizes in monoclinic system with space group P21/n and Z = 4. Its vibrational frequencies and optimized geometric parameters has been calculated using DFT method with UB3LYP/6-31G (d, p) basis sets by G...
Article
Full-text available
In the title compound, C 7 H 5 BrO 3 , the dihedral angle between the aromatic ring and the carboxylic acid group is 4.8 (4)°, and an intramolecular O—H...O hydrogen bond closes an S (6) ring. In the crystal, carboxylic acid inversion dimers linked by pairs of O—H...O hydrogen bonds generate R 2 2 (8) loops. Short Br...Br contacts [3.4442 (5) Å] be...
Article
Full-text available
The title compounds, C 10 H 11 BrO 4 , (I), and C 9 H 9 BrO 4 , (II), are derivatives of bromo–hydroxy–benzoic acids. Compound (II) crystallizes with two indepen- dent molecules (A and B) in the asymmetric unit. In both (I) and (II), the O— CH 2 —O—CH 3 side chain is not in its fully extended conformation; the O—C— O—C torsion angle is 67.3 (3) � i...
Article
Full-text available
In this study, 1-benzofuran-2-carboxylic acid was synthesized and characterized by FT-IR, 1HNMR and single crystal XRD analysis. The compound crystallizes in monoclinic system with space group P21/n and Z = 4. Its vibrational frequencies and optimized geometric parameters has been calculated using DFT method with UB3LYP/6-31G (d, p) basis sets by G...
Article
Full-text available
The title compound, C10H8BrNO2, is almost planar (r.m.s. deviation for the non-H atoms = 0.031 Å) and the conformation across the C=N bond is trans. Further, the O atom of the benzo­furan ring is syn to the N atom of the oxime group. In the crystal, inversion dimers linked by pairs of O—H⋯N hydrogen bonds generate R 2 2(6) loops. Very weak aromatic...
Article
1,4-Bis(1-naphthylmethyl)piperazine N 2 type of ligand synthesized from piperazine and 1-(chloromethyl) naphthalene. The Pd(II), Cu(II), Fe(III) and Mn(II) complexes of ligand N 2 were synthesized by taking 1:1 ration of M:N 2 . The ligand and complexes have been characterized by elemental analyses, 1 H-NMR, FT-IR, UV-Vis., spectroscopic techniques...
Article
1,4-Bis(1-piperidineethyl)piperazine tetradentate N4 type of ligand synthesized from piperazine and 1-(2-chloroethyl)piperidine HCl. The Cu(II), Pd(II), Fe(III) and Mn(II) complexes of ligand N4 were synthesized by taking 1:1 ration of M:N4. The ligand and complexes have been characterized by elemental analyses, 1H-NMR, FT-IR, UV-Vis., spectroscopi...
Article
Novel, robustic, simple, mobile and inexpensive method developed for determination of Chromium in milk and water samples with three novel and facile ligands potassium allyl xanthate, potassium isoamyl xanthate and potassium cinamyl xanthate in presence of NH4Cl-NH4OH at pH 8.2 for Kaxan/Kixan and 8.6 for Kcxan. The ligands produce catalytic hydroge...
Article
A facile, rapid, sensitive and inexpensive spectrophotometric method for the determination of propoxur in insecticidal formulations (samples dissolution in methanol) and fortified water, grains (extraction with CHCl 3). Propoxur, also known as undeen or arprocarb contains the active ingredient 2-isopropoxyphenyl-N-methylcarbamate. Alkaline hydrolys...
Article
This study presents Carbosulfan determination by a novel, robustic, mobile, inexpensive, and sensitive spectrophotometric method is developed for the determination of the carbamate pesticide carbosulfan in water and grains. An extractive method, which is based on alkaline hydrolysis of carbosulfan into phenol followed by coupling with diazotized 4-...
Article
This paper deals with the power quality improvement in a conventional electronic load controller (ELC) used for isolated pico-hydropower generation based on an asynchronous generator (AG). The conventional ELC is based on a six-pulse uncontrolled diode bridge rectifier with a chopper and an auxiliary load. It causes harmonic currents injection resu...

Network

Cited By