Krishna Das Saha

• PhD.
• Principal Technical Officer at Indian Institute of Chemical Biology

A pentadentate diamide ligand, N,N′‐di(pyridine‐2‐yl)pyridine‐2,6‐dicarboxamide (L¹H2) and its tetranuclear Cu(II) complex [Cu4(L¹)2(μ3‐OH)2(H2O)3(ClO4)](ClO4) ⋅ H2O are reported. X‐ray crystal structure of the complex reveals that it has an open‐book type architecture. Two central copper atoms are connected to each other by two hydroxo bridges. Ea...

Lung cancer has become progressively widespread, posing a challenge to traditional chemotherapeutic drugs such as platinum compounds and paclitaxel (PTX) owing to growing resistance. Along with that, the chemotherapeutic drugs infer major side effects. The usage of natural compounds as chemosensitizers to boost the efficacy of these chemotherapeuti...

While peptide‐based drug development is extensively explored, this strategy has limitations due to rapid excretion from the body (or shorter half‐life in the body) and vulnerability to protease‐mediated degradation. To overcome these limitations, a novel strategy for the development of a peptide‐based anticancer agent is introduced, utilizing the c...

The WHO declared the Coronavirus Outbreak in 2019 (COVID-19), caused by the SARSCOV- 2 virus, as a pandemic on 11 March 2020. When the world was trying to contain the first wave of the outbreak, the newer mutated strains emerged in the UK and South Africa, and accelerated cases of daily infections in some parts of the globe ignited tribulations afr...

While peptide-based drug development is now extensively explored, this strategy does have limitations, which come from their rapid excretion from the body (or shorter half-life in the body), and vulnerability to protease-mediated degradation. To overcome these limitations, here we introduce a novel strategy for the development of a peptide-based an...

Nanoparticles (NPs) are encapsulating agents that exist in the nanometer range. They can be classified into different classes based on their properties, shapes, or sizes. Metal NPs, fullerenes, polymeric NPs, ceramic NPs, and luminescent nanoporous hybrid materials are only a few examples. This study explored the anticancer potential of quercetin a...

Ferroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an Hallmark of Non Alcoholic Fatty Liver Disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Variou...

Swietenia macrophylla King in Hook (SM) is known to have several medicinal properties. Chloroform extracts of SM seeds (SMCE) as well as two isolated limonoids swietenine (1) and swietenolide (2) showed significant in vitro anti-CRC activity in human colon carcinoma (HCT116) cell line. 2 (IC50 = 5.6 µM) was found to be two times more potent than 1...

New Pd (II) and Pt (II) complexes (C1/C2) with a O,N,N donor pincer ligand, 4‐hydroxy‐3‐((E)‐1‐(((Z)‐phenyl (pyridin‐2‐yl)methylene)hydrazono)ethyl)‐2H‐chromen‐2‐one (HL) were synthesized and methodically characterized by several spectroscopic and XRD techniques. Absorption and fluorescence techniques were used to assess the mechanism of interactio...

Objective Grape Seed Extract is a natural source of various polyphenols, which have been shown to possess potent antioxidant and free radical-scavenging activities. The earlier studies have reported that grape seed extract exhibits broad-spectrum pharmacological activities. Therefore, studying the hepatoprotective effects and elucidation of mechani...

New Pd(II) and Pt(II) complexes, [Pd(L)Cl] (1) and [Pt(L)Cl] (2) with O,N,S donor azo-thioether pincer ligand (HL) are synthesized and thoroughly characterized by spectroscopic techniques. X-ray structures of the complexes...

The epigallocatechin‐rich polyphenolic fraction of Assam variety white tea, traditionally used for the management of diverse inflammatory ailments and health drink, was investigated through eco‐friendly green aqueous extraction, TLC, and HPLC characterization, phytochemical screening, in vitro DPPH assay, anti‐proteinase, MTT assay on synovial fibr...

N-rich organic materials bearing polyphenolic moieties in their building networks and nanoscale porosities are very demanding in the context of designing efficient biomaterials or drug carriers for the cancer treatment. Here, we report the synthesis of a new triazine-based secondary-amine- and imine-linked polyphenolic porous organic polymer materi...

The special features of cyclodextrins (CDs), hydrophilic outer surfaces and hydrophobic inner surfaces, allow for development of inclusion complexes. The two bioactive strong antioxidant hepatoprotective compounds, Morin and vitamin E, are water insoluble. The present study aimed to prepare Morin-vitamin E-β-cyclodextrin inclusion complex loaded ch...

Current drugs are inefficient for the treatment of visceral leishmaniasis an immunosuppressive ailment caused by Leishmania donovani. Regrettably, there is no plant-origin antileishmanial drug present. P2X7R is constitutively present on macrophage surfaces and can be a putative therapeutic target in intra-macrophage pathogens with function attribut...

Chronic exposure to arsenic over a period of time induces toxicity, primarily in liver but gradually in all systems of the body. Morin hydrate (MH; 2′,3,4′,5,7-pentahydroxyflavone), a potent flavonoid abundantly...

Green gold nanoparticles (GNPs) were prepared from black tea extract (BTE) and used to examine the chemosensitivity of doxorubicin in colon cancer cell line HCT116. BTE-GNPs were prepared by a single-step method and characterized by UV-Vis spectroscopy, FTIR spectroscopy, SEM, DLS and zeta-potential. The MTT assay was performed to determine the cyt...

Peptide based low molecular weight supramolecular hydrogels hold promising aspects in various fields of application especially in biomaterial and biomedical sciences such as drug delivery, wound healing, tissue engineering, cell proliferation, etc due to their extreme biocompatibility. Unlike linear peptides, cyclic peptides have more structural ri...

Recently unfolded mechanisms showed lipid droplet helps in pathogen survival and paralyzes host immune response. In the present study, we showed the extent of lipid droplet(LD) generation in Leishmania donovani infection, the signaling involved, and their function concerning pathogenicity. RAW 264.7 and J774A.1 cells were used to infect with L. don...

New Pd(II) and Pt(II) complexes, [Pd(HL)Cl2] (C1) and [Pt(L)Cl] (C2) with ONN donor pincer ligand, 5-(diethylamino)-2-((Z)-((E)-(phenyl(pyridin-2-yl)methylene)hydrazono)methyl)phenol (HL) are synthesized and thoroughly characterized by spectroscopic techniques. X-ray structures of the complexes...

Background NLRP3 inflammasome activation plays a critical role in mediating inflammation and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and hepatocellular carcinoma. Melatonin (MLT) controls high-fat diet-induced NASH in the murine model by modulating NLRP3 mediated inflammation. P2X7R-mediated inflammasome...

Colon cancer is the second highest contributor of cancer-related deaths throughout the world. Treatment strategies with tannic acid and vitamin E are envisaged as desirable and safe owing to their robust antioxidative and anti-inflammatory potential. In the present report, these bioactives have been nanoencapsulated in poly(d,l-lactide-co-glycolic...

The current therapy for cancer treatment, especially in leukemic survivor emphasis, needs to be evolved more. In the current scenario, the microbial source of different origins, including live, attenuated, or genetically modified microbial species or cellular components in active or inactive form or cellular metabolites could be a very promising th...

Cancer detection and diagnosis are grounded mainly on the identification of several unfamiliar features of abnormal cells such as atypical mutations in genetic materials (i.e., genes), qualitative as well as quantitative variations in vital proteins function and quantities, and also detecting changes in various physiological and morphological prope...

Abstract Biosensors are rational or scientific devices that are generally used to convert any measurable and biochemical signal of a molecule or chemical entity into an analytical and useful, visual outcome based on physicochemical principle. A wide variety of stimulus are generally used by biosensors to transform qualitative or quantitative change...

Abstract Cancer is among the leading causes of death worldwide. Most cancers represent specific symptoms; however, to comprehend and understand them we need proper diagnostic measures and the expertise of experienced health personals. There are also screening tests available for particular cancer types. The major challenges for the physicians are...

Current drugs are inadequate for the treatment of visceral leishmaniasis an immunosuppressive ailment caused by Leishmania donovani. Regrettably, there is no plant-origin antileishmanial drug present. P2X7R is constitutively present on macrophage surfaces and can be a putative therapeutic target in intra-macrophage pathogens with function attribute...

COVID-19 pandemic is still a major risk to human civilization. Besides the global immunization policy, more than 5lac new cases are documented every day. Some countries newly implement partial/complete nationwide lockdown to mitigate recurrent community spreading. To avoid the new modified stain of SARS-CoV-2 spreading, some countries imposed any r...

Sulphonamide derived oxazoline hybrid compounds showed neuroprotective effects by inducing autophagy. In the present study, a series of sulphonamide containing oxazoline hybrids were synthesized and their neuroprotective efficacy in neuronal cell lines was explored. All the compounds showed moderate to good neuroprotection against adrenal medulla c...

Leishmaniasis, a vector-borne disease, is caused by intracellular parasite Leishmania donovani. Unlike most intracellular pathogens, Leishmania donovani are lodged in parasitophorous vacuoles and replicate within the phagolysosomes in macrophages. Effective vaccines against this disease are still under development, while the efficacy of the availab...

To evaluate the cytotoxic potential of metal-based chemotherapeutic candidate towards the colorectal cancer, we have synthesized a new copper(II) complex [Cu(qmbn)(q)(Cl)] (1) (where, qmbn = 2-(quinolin-8-yloxy)(methyl)benzonitrile and q = 8-hydroxyquinoline) and structurally characterized by single crystal X-ray, Powder-XRD, FTIR and thermogravime...

Asthma, one of the significant public health problem, is triggered by certain inflammatory processes in the airways that are not addressed propitiously by current therapies. Though pieces of evidence on allergic asthma mitigation by the anti-inflammatory bioflavonoid chrysin (CHR) are accumulating, poor bioavailability, and low solubility curtail d...

The development of drug carriers based on nanomaterials that can selectively carry chemotherapeutic agents to cancer cells has become a major focus in biomedical research. A novel pH-sensitive multifunctional envelope-type mesoporous silica nanoparticle (SBA-15) was fabricated for targeted drug delivery to human colorectal carcinoma cells (HCT-116)...

sı Supporting Information 5 ABSTRACT: We report here the preparation of an aminoxy amide-based 6 pseudopeptide-derived building block using furanoid sugar molecules. Through 7 the cyclo-oligomerization reaction, we generate a hybrid triazole/aminoxy 8 amide macrocycle using the as-prepared building block. The novel 9 conformation of the macrocycle...

Given that basal levels of reactive oxygen species (ROS) are higher in cancer cells, there is a growing school of thought that endorses pro-oxidants as potential chemotherapeutic agents. Intriguingly, cerium oxide (CeO2) nanoparticles can manifest either anti- or pro-oxidant activity as a function of differential pH of various subcellular localizat...

A tridentate N,N,O-donor ligand, in the form a Schiff base of aminoguanidine (LH) with salicylaldehyde, and its Cu(II) complex [Cu2(LH)2](ClO4)2,have been synthesized. The single crystal X-ray structure of the complex is reported. The complex shows strong DNA binding affinity, with binding constant value, comparable to classical intercalators like...

A set of unique triptycene-based and organic Schiff-base-linked polymers (TBOSBLs) are conveniently synthesized in which triptycene motifs are connected with 1,3,5-triformylphloroglucinol units via Schiff-base linkages. TBOSBLs are amorphous, thermally stable with a reasonable surface area (SABET up to 649 m²/g), and have abundant nanopores (pore s...

Current drugs are inadequate for the treatment of visceral leishmaniasis an immunosuppressive ailment caused by Leishmania donovani . Regrettably, there is no plant-origin antileishmanial drug present. P2X 7 R is constitutively present on macrophage surfaces and can be a putative therapeutic target in intra-macrophage pathogens with function attrib...

Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio-relevant mononuclear zinc(II) complexes [Zn(L1)Cl2].2H2O(1), [Zn(L2)Cl2](2) and [Zn(L3)Cl2](3) were syn...

Aim: Tannic acid and vitamin E loaded-poly D, L-lactide-co-glycolic acid (PLGA) nanoparticles (NP) were developed to achieve hepatoprotection in alcoholic liver disease mice model. Materials & methods: PLGA NPs were formed by emulsion solvent evaporation and characterized and delivered to mice. Histology studies were performed, serum enzyme levels...

The major drawback of anticancer therapy is the development of resistance against drugs and radiation at the later phase of treatment which may lead to recurrences of the disease. Therefore, strategy was taken to enhance radiation sensitivity of lung (A549) and liver (HepG2) carcinoma cells by treatment with ferulic acid (FA) prior to irradiation....

The major drawback of anticancer therapy is the development of resistance against drugs and radiation at the later phase of treatment which may lead to recurrences of the disease. Therefore, strategy was taken to enhance radiation sensitivity of lung (A549) and liver (HepG2) carcinoma cells by treatment with ferulic acid (FA) prior to irradiation....

Background Many of present chemotherapeutics are inadequate and also resistant against visceral leishmaniasis (VL), an immunosuppressive ailment caused by Leishmania donovani. Despite the interest in plant-based drug development, no antileishmanial drugs from plant source are currently available. Glinus oppositifolius had been reported in favor of...

Mesoporous alumina and its modifications are in vogue for their medical applications. These are mostly used for controlled delivery of different drugs for their internal porous configuration. However, studies on their candidature to be used for destruction of live cancer and normal cells are still in dearth. Herein, we report the synthesis and char...

Palladium (II) and platinum(II) complexes of types [Pd(LNHPhH2)Cl2] (1), [Pd(LNH(ClPh)H2)Cl2] (2), [Pt(LNHPhH2)Cl2] (3) and [Pt(LNH(ClPh)H2)Cl2] (4) were successfully isolated, where LNHPhH2 and LNH(ClPh)H2 are osazone ligands. Molecular and electronic structures of 1-4 and their reduced analogues were confirmed by single crystal X-ray crystallogra...

Corticosteroids commonly prescribed in asthma show several side-effects. Relatively non-toxic andrographolide (AG) has an anti-asthmatic potential. But its poor bioavailability and short plasma half-life constrain its efficacy. To overcome them, we encapsulated AG in nanoparticle (AGNP) and evaluated AGNP for anti-asthmatic efficacy on murine asthm...

Quercetin has been found to possess diverse pharmacological properties including in different types of cancers. The application of quercetin in the pharmaceutical field is limited due to its poor bioavailability resulting from poor water solubility and poor permeability. We report a systematic chemical modification of quercetin toward the developme...

Quercetin has been found to possess diverse pharmacological properties including in different types of cancers. The application of quercetin in the pharmaceutical field is limited due to its poor bioavailability resulting from poor water solubility and poor permeability. We report a systematic chemical modification of quercetin toward the developme...

Hepatocellular carcinoma (HCC), is the most leading cause of cancer‐related death in all over the world (seems to more than 80% of death cases). It is frequently linked with continuous hepatocytes death, inflammatory cell infiltration, and compensatory liver regeneration with higher angiogenic rate. Considering the different signalling process duri...

Gold nanoparticle formulated tannic acid (AuNP-TA) was synthesized, and its anticancer activity was compared to that of free tannic acid (TA). The half maximal inhibitory concentration (IC 50 ) was reduced by half when cell lines were treated with AuNP-TA as compared to IC 50 values upon free TA treatment. Both showed better cytotoxic activity in H...

Background Diabetic nephropathy (DN), an end-stage renal disorder, has posed a menace to humankind globally, because of its complex nature and poorly understandable intricate mechanism. In recent times, functional foods as potential health benefits have been gaining attention of consumers and researchers alike. Rich in antioxidants, the peel and se...

Lipid droplets (LD) are newly characterized dynamic cytoplasmic organelle which is the storehouse of different immunosuppressive cytokines and enzymes like cyclooxygenase and lipoxygenase. Tumors are known to modulate the immune system by immune-editing the microenvironment. Immuno-editing comprises of three steps namely cancer immune-surveillance,...

A bolaamphiphilic cross-linked nanoassembly endows with pH responsive degradation feature has been designed and fabricated for stable noncovalent guest encapsulation and controlled release. The self-assembled bola amphiphile is utilized to prepare cross-linked nanoassemblies to further stabilize at a concentration below its critical aggregation con...

In the present study, we have designed and synthesized a new hybrid ligand (SCG) which can selectively detect cysteine in the free and protein bound states within minutes at a sub-nanomolar level of detection. The photo induced electron transfer (PET) was responsible for the visible color change as well as a large increase in steady state fluoresce...

A series of triazole-substituted quinazoline hybrid compounds were designed and synthesized for anticancer activity targeting epidermal growth factor receptor (EGFR) tyrosine kinase. Most of the compounds showed moderate to good antiproliferative activity against four cancer cell lines (HepG2, HCT116, MCF-7, and PC-3). Compound 5b showed good antip...

Present chemotherapeutics are inadequate against visceral leishmaniasis (VL) an immunosuppressive ailment caused by Leishmania donovani. Despite the interest in plant-based drug development, an antileishmanial drug from plant source is unavailable. Glinus oppositifolius had been reported in favor of being immunomodulators along with other tradition...

Correction for ‘A new triazine based π-conjugated mesoporous 2D covalent organic framework: its in vitro anticancer activities’ by Sabuj Kanti Das et al. , Chem. Commun. , 2018, 54 , 11475–11478.

We report a new highly crystalline 2D π-conjugated hexagonal mesoporous covalent organic framework material TrzCOF through the solvothermal polycondensation of 1,3,5-tri(4-formylbiphenyl) benzene [Ph7(CHO)3, TFBPB] with 2,4,6-tris(4-aminophenyl)-1,3,5-triazine (TAPT) and it displayed...

Rhodamine derivatives are excellent fluorescent probe and have shown sharp descending trends of emission intensity on interacting with specific analyte which reasons for opening of spirolactam ring. In this work Rhodamine-allyl Schiff base (RD-2) is used as highly sensitive colorimetric and fluorescent chemosensor for total Palladium determination...

8,8'-((1Z,1'Z)-(((Propane-1,3-diylbis(oxy))bis(2,1-phenylene))bis(azanylylidene))bis (methanylylidene))bis(7-hydroxy-4-methyl-2H-chromen-2-one) (H2L) recognizes Zn2+ via turn-on emission at 510 nm in MeCN-Water (9:1, v/v) solution in presence of large number of biologically important cations with very low limit of detection (LOD), 11 nM which is ab...

Cancers are leading cause of human mortality. Most of deaths are due cancer because of its high resistance to the chemotherapeutic drugs. Thus, there is an ongoing demand for generation of new potent and more effective therapies for cancer treatment. Hepatocellular carcinoma (HCC), is the most leading cause of cancer-related death in all over the w...

TTo elucidate the intrinsic biological activities displayed by platinum- versus gold-based organometallic reagents, the isoelectronic and isostructural square planar complexes [Pt(C∩N)(C)Cl][PF6] (2) and [Au(C∩N)(C)Cl][PF6]2 (3), which are supported by a novel annulated imidazolium salt, 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexa...

Cancer is one of the most deadly diseases worldwide. Although several chemotherapeutic agents are available at present for its treatment, they have their own limitations. The main problems of these chemotherapeutic agents are cost involvement and severe life-threatening antagonistic effects. Here, we report a new biodegradable N-rich porous organic...

An allyloxynitrophenylimio-propylhydroxyl appended rhodamine (RD-3) specifically recognises Cr 3+ in aqueous buffer medium at pH (7.4). The visible light excitable reagent (ex 505 nm) on selective binding to Cr 3+ has resulted in a strong fluorescence turn-on response with powerful emission at 557 nm and tail of that luminescence band is extended...

We report, based on biophysical studies and molecular mechanical calculations that curcumin binds DNA hairpin in the minor groove adjacent to the loop region forming a stable complex. UV-Vis and fluorescence spectroscopy indicated interaction of curcumin with DNA hairpin. In this novel binding motif, two ɣ H of curcumin heptadiene chain are closely...

Covalent organic frameworks (COFs) having periodicity in pores of nanoscale dimensions can be suitably designed for the organic building units bearing reactive functional groups at their surfaces. Thus, they are an attractive option as an anticancer agent to overcome the limitations of chemotherapy. Herein, we first report a new porous biodegradabl...

Hepatocellular carcinoma (HCC), is the most leading cause of cancer-related death in all over the world (seems to more than 80% of death cases). It is frequently linked with continuous hepatocytes death, inflammatory cell infiltration, and compensatory liver regeneration with higher angiogenic rate. Considering the different signalling process duri...

Reaction of N1,N3-bis(3-methoxysalicylidene) diethylenetriamine (H2Vd) and Zn(NO3)2.6H2O, ZnBr2, ZnI2 and Cd(NO3)2.4H2O in methanol solution led to zinc and cadmium complexes of different nuclearities, [Zn2(Vd.H)2(X)2].CH3OH (X = NO3, Br, I) [1a, 1b and 1c] and Cd3(Vd)2(NO3)2 (2). In 1(a-c), two H2Vd ligands bridge the two metal centers whereas in...

A new rhodamine based allyl-ether Schiff base (RD) is spectroscopically characterized and used as colorimetric and fluorimetric sensor. RD acts as turn-on highly selective fluorescent chemosensor for Pd(II) only from the mixture of Pd(0) and Pd(II) in presence of 25 other cations in aqueous-acetonitrile medium. The mechanism of Pd(II) sensing of RD...

Organic-Inorganic nanohybrids are becoming popular for their potential biological applications including diagnosis and treatment of cancerous cells. The motive of this study is to synthesis a nanohybrid for the diagnosis and therapy of colorectal cancer. Here we have developed a facile and cost effective synthesis of Folic Acid (FA) templated Fe2O3...

Gold nanoparticles are predominantly used in diagnostics, therapeutics and biomedical applications. The present study has been designed to synthesize differently capped gold nanoparticles (AuNps) by a simple, one-step, room temperature procedure and to evaluate the potential of these AuNps for biomedical applications. The AuNps are capped with gluc...

1-Hydroxy-diaza-15-Crown-4 (HL) is a macrocycle and is a chromogenic sensor (red; λabs, 505 nm) to Al³⁺ in DMSO-water medium. The probe is an effective turn-on fluorescent reagent at two different emission wavelengths (λem) for Al³⁺ at 580 nm and Zn²⁺ at 505 nm. The limit of detections (LOD) are 1.2 μM (Al³⁺) and 21 nM (Zn²⁺). HL is stable in the p...

The coumarinyl thioether Schiff base, H2L, demonstrates turn-on fluorescence sensing towards Zn²⁺ ion with a limit of detection (LOD) of 0.068 μM. Different physicochemical techniques (mass, ¹H NMR, Job's) support the formation of a 1:1 metal-to-ligand complex, [ZnL]. The fluorogenic complex [ZnL] recognizes ATP in the presence of all other common...

Broad range of selectivity possesses serious limitation for the development of matrix metalloproteinase-2 (MMP-2) inhibitors for clinical purposes. To develop potent and selective MMP-2 inhibitors, initially multiple molecular modeling techniques were adopted for robust design. Predictive and validated regression models (2D and 3D QSAR and ligand-b...

Starting from the proligand 2-[(6-methylpyridin-2-yl)]imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate (1.PF6), three new complexes, viz. [Au(1)2] [PF6] (2), [1/2AuCl2, 1/2AuCl4]– [(1H)]+ (3), and [Au(1)Cl3] (4) have been synthesized and characterized employing different spectroscopic methods. [Au(1)Cl3] (4) has been synthesized by disproportionat...

Background/aims: Cytotoxic effect of attenuated Leishmania on liver cancer cells by inducing ROS generation. Methods: Spectrophotometric study to analyze cell death and levels of different active caspases. Flow cytometric study was done to analyze apoptosis induction and ROS generation and levels of different protein. Western blot analysis was p...

Promastigote form of Leishmania, an intracellular pathogen, delays phagosome maturation and resides inside macrophages. But till date limited study has been done to manipulate the phagosomal machinery of macrophages to restrict Leishmania growth. Attenuated Leishmania strain exposed RAW 264.7 cells showed a respiratory burst and enhanced production...

Melanoma is one of the most aggressive forms of cancer, usually resistant to standard chemotherapeutics. Despite a huge number of clinical trials, any success to find a chemotherapeutic agent that can effectively destroy melanoma is yet to be achieved. Para-phenylenediamine (p-PD) in the hair dyes is reported to purely serve as an external dyeing a...

We report the synthesis of self-aggregated mesoporous ZnS nanoparticles with large mesoscopic void spaces via anionic surfactant mediated templating pathway. High BET surface area and mesoporosity of the material has motivated us to use it as a drug-delivery vehicle employing doxorubicin as a chemotherapeutic drug. The study indicates the novel app...

A new series of 13-pyridinealkyl berberine analogues was synthesized and their DNA binding efficacy studied by employing spectroscopic, calorimetric and molecular modeling techniques. Analogues with more than one CH2 group showed better intercalative binding than berberine. The analogue with one CH2 group bound DNA weaker than berberine. The bindin...

Recent analyses have highlighted the promotion of cancer migration and invasion, mediated through HDAC via MMP-2 and MMP-9. Since both class 1 HDACs and MMP-2/9 are involved in the migration and invasion of cancer, an attempt has been taken to design dual MMP-2/HDAC-8 inhibitors by pharmacophore mapping and molecular docking approaches. The designe...

Antimitotic agents are potential compounds for the treatment of breast cancer. Cytotoxicity is one of the parameters required for anticancer activity. A validated comparative molecular modeling study was performed on a set of phenylindole derivatives through R-group QSAR (RQSAR), regression-based and linear discriminant analysis (LDA)-based 2D QSAR...

Very often conventional therapy, i.e. chemotherapeutic treatment, develops resistance in cancer cells and fails to be effective against disease states. An alternative strategy or a new entity may resolve the problem. Interestingly, the microbial world has begun to be explored in medicinal research as a potential new source to deliver bio-active mol...

Very promising approaches towards the microbes, its cellular component(s) or metabolites are exposed as new therapeutic entities. Among several microbial component(s), leishmanial lipids (pLLD) isolated from L. donovani has emerged for its biological potential. The lipid isolated from L . major was reported to act by inhibiting NO production in sti...