Kosta Y. Mumcuoglu

Kosta Y. Mumcuoglu
Hebrew University of Jerusalem | HUJI · Department of Microbiology and Molecular Genetics

PhD

About

338
Publications
131,104
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Introduction
Kosta Y. Mumcuoglu, PhD currently works at the Department of Microbiology and Molecular Genetics, Hebrew University of Jerusalem, Israel. Kosta does research in Medical and Veterinary Entomology, as well as in Biotherapy (Maggot debridement therapy and Hirudotherapy). His main subjects of interest are lice and louse-borne diseases, lice in archaeological remains, fleas, midges, bed bugs, Demodex, Scabies and house-dust mites, ticks and tick-borne diseases, the use of maggots for the treatment of chronic wounds, the use of leeches in plastic surgery,

Publications

Publications (338)
Article
Rhipicephalus sanguineus sensu lato and Rhipicephalus turanicus are very prevalent in Israel and are known to be vectors of human and animal diseases. The aim of this study was to identify the pathogens found in questing ticks and such parasitizing domestic and wild animals. Ticks were collected from 16 localities in Israel with the flagging techni...
Article
The chigger mites of Israel were reviewed based on the examination of museum collections, one new sample, and literature data. At present, seven species of chiggers are known from this country. Kepkatrombicula acomys (Radford, 1957) comb. n. was re-described based on a paratype. Neotrombicula tadjikistanica Kudryashova and Abou-Taka, 1987, the type...
Article
Rhipicephalus secundus is reestablished as a valid tick name within the Rhipicephalus sanguineus group and removed from the synonymy list of Rhipicephalus turanicus. Morphological re-description of both male and female of R. secundus and the analysis of its phylogenetic position based on mitochondrial DNA sequences are presented. The morphological...
Article
Scabies is a parasitic infestation of human and animal skin caused by different strains of the itch mite, Sarcoptes scabiei. The World Health Organization (WHO) has declared scabies in human as a neglected tropical disease and today over 200 million people worldwide are affected. The two most commonly reported clinical manifestation of the conditio...
Article
Ticks were collected from 30 Greek tortoise (Testudo graeca), and 10 Arabian camels (dromedary) (Camelus dromedarius) in Israel. All those collected from Greek tortoises belonged to Hyalomma aegyptium, while all specimens collected from the camels belonged to Hyalomma dromedarii. Out of 84 specimens of H. aegyptium, 31 pools were examined by PCR, w...
Article
Full-text available
Domestic felines' re-emerging infectious and neglected zoonotic diseases are a significant focus of global "One Health" efforts. This study aimed to rapidly diagnose 14 pathogens, including zoonoses by using PCR primers in 167 client-owned symptomatic cats, routinely accepted to the Veterinary Clinics of Tekirdag. The prevalence of pathogens invest...
Article
Three species of chigger mites, which are supposed to be agents of human trombiculiasis in Europe, have been studied based on museum collections and specimens collected by the authors. Trombicula toldti Winkler, 1953 has been transferred to the monotypic genus Blanciella Vercammen-Grandjean, 1960. The type species of this genus, Blanciella deschien...
Article
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Ticks (Acari: Ixodida) are hematophagous ectoparasites of a wide variety of mammals, birds, reptiles, and amphibians, and are the vectors of many pathogenic agents, such as bacteria, protozoa, and viruses. The seasonal movement and migration of birds is one of the main causes of the dispersal of ticks and tick-borne pathogens. Therefore, identifica...
Article
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Chronic wounds are still regarded as a serious public health concern, which are on the increase mainly due to the changes in life styles and aging of the human population. There are different types of chronic wounds, each of which requires slightly different treatment strategies. Nevertheless, wound bed preparation is included in treatment of all t...
Article
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ABST RACT Myiasis is the infestation of live humans or animals by the larvae (maggots) of Diptera flies, usually developing on damaged skin or inside body orifices of their host while feeding on its vital or necrotic tissue. We describe post traumatic myiasis due to Wohlfahrtia magnifica in a mixed Pit-Bull Terrier dog in Israel. The dog was succes...
Article
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Head louse infestations continue to be a concern of public health in most countries, including the most developed ones. The present recommendations are intended to inform and stress the role and impact of the different authorities, institutions, industry, and the public in the control of head lice in order to reduce the prevalence of this parasite....
Article
Rhipicephalus turanicus ticks are widely distributed across the Palearctic and Afrotropics. These two continental populations display differences in morphological characters that raise the question of a potential species boundary. However, the taxonomic status of these morphologically divergent lineages is uncertain because R. turanicus from Cyprus...
Article
Hyalomma aegyptium (L., 1758) (Ixodida: Ixodidae) is a hard tick and the main host for adults are Palearctic tortoises of the genus Testudo, while larvae and nymphs are less host-specific and nymphs also attach to humans. In the present study, a total of 261 H. aegyptium ticks were removed from 26 Testudo graeca L., 1758 in Corum Province of Turkey...
Article
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Purpose. To report a case of massive orbital myiasis caused by the larvae of Sarcophaga argyrostoma, complicating eyelid malignancy. Observations. A 98-year-old man first presented to our clinic noted to have a fast-growing lesion on his right upper and lower eyelids. Squamous cell carcinoma of the eyelids was highly suspected, and surgical excisio...
Article
Background The global prevalence of allergic diseases has increased dramatically in recent years and are now recognized as significant chronic diseases worldwide. One of the most important allergens that causes allergic diseases is house dust mites. Objective This study aims to present a bibliometric overview of research published on dust mites be...
Article
Theileria equi Mehlhorn and Schein, 1998 (Piroplasmida: Babesiidae) is an important tick‐borne pathogen of horses that is highly endemic in many parts of the world, including Israel. The present study evaluated the potential roles of five hard tick species [Hyalomma excavatum Koch, 1844; Hyalomma marginatum Koch, 1844; Rhipicephalus turanicus Pomer...
Article
A fine-toothed comb found in the Judean Desert and resembling an ancient louse comb was examined. Based on radiocarbon dating, it ranged between 1660 AD and 1950 AD. From the material accumulated between the teeth, an oribatid mite, a pseudoscorpion, exuviae of beetle larvae, a sucking louse (Polyplax brachyrrhyncha Cummings, 1915), as well as a fu...
Article
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Demodex mites are saprophytic parasites of the mammalian skin, mostly found in or near pilo‐sebaceous units of hairy regions. While they can be found in healthy humans and animals without causing any clinical manifestations, they were suggested to create pathogenic symptoms when they appear in high densities under favourable conditions (i.e. demodi...
Article
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Background Hirudotherapy, also known as medicinal leech therapy, has been used to treat a wide range of disorders for thousands of years since Ancient Egypt. Leech therapy is also mentioned as a minimal invasive technique called Jalaukavacharana in the Sushruta Samhita, an ancient Sanskrit text of Ayurvedic medicine. Although hirudotherapy has beco...
Article
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Babesia microti (Aconoidasida: Piroplasmida) (Franca, 1910) is an important tick-borne zoonotic parasite with rodents serving as reservoir hosts. In the present study, 536 rodents were captured from Burdur, Bartin, Giresun, and Yozgat provinces of Turkey between the years 2010 and 2012, and blood samples were examined for the presence of Babesia sp...
Article
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Aims Our aim was to investigate the skin‐homing T‐cell immune responses triggered in patients with Demodex infestation and/or rosacea. Methods Collected whole blood samples were divided into four groups: control subjects; non‐rosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patients without Demodex infestatio...
Article
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The larval developmental sites of Culicoides species were assessed from 1155 samples collected during the years 1969–2003. Culicoides circumscriptus was most prolific in mud with medium organic matter with proportional representation of 55.8%. Culicoides imicola breeds mainly in damp mixture of rotten, decomposed animal dung with or without some mu...
Article
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Background Ticks are important ectoparasites of horses that can affect animal welfare and vector several infectious, including zoonotic, diseases. In order to investigate the species distribution, epidemiology and seasonal dynamics of ticks infesting horses in Israel, 3267 ticks were collected from 396 horses in 24 farms across the country from Jul...
Article
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We report a unique case of a mixed-type, wound and furuncular, myiasis caused by the larvae of Wohlfahrtia magnifica in a 5-year old child, who was diagnosed with a kerion two months prior to admission. removing the larvae, and treatment with systemic antibiotics and antifungals resulted in a quick and full recovery of the patient.
Article
Using polymerase chain reaction targeting the 18S rRNA gene and DNA sequencing the prevalence and diversity of Apicomplexa and Piroplasmida infections in rodents from Nigeria was studied. Overall, 13 of 194 (7.7%) rodent blood samples tested were positive for Hepatozoon spp. while 2 (1.0%) were positive for Sarcocystis dispersa. Hepatozoon spp. DNA...
Article
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Background: Delusional parasitosis (DP) is a somatic type of delusional disorder, usually mono-symptomatic, in which the patients are convinced they are being infested with animal parasites while no objective evidence exists to support this belief. The complaints are usually about skin infestation, but involvement of the gastrointestinal tract has...
Article
This study was conducted to determine the prevalence of pathogenic and endosymbiont apicomplexans in the cat flea, Ctenocephalides felis (Bouché) infesting 185 stray cats in Jerusalem, Israel using PCR assay and sequencing approach. Two pathogens, Hepatozoon felis and Babesia vogeli and an endosymbiont Steinina ctenocephali were detected in 1.9%, 0...
Article
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Head lice infestation is a public health challenge even in developed nations, and 4-14-year old children are most affected; information regarding the infestation rates of adults in developed countries is scarce. an Internet-based survey on lice infestation was distributed to mothers in Israel and their responses were ana lyzed. out of 959 responder...
Article
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Background Tick-borne diseases are increasing all over the word, including Turkey. The aim of this study was to determine the bacterial and protozoan vector-borne pathogens in ticks infesting humans in the Corum province of Turkey. Methodology/Principal findings From March to November 2014 a total of 322 ticks were collected from patients who atte...
Data
Phylogenetic tree of rickettsial ompA gene. Phylogenetic tree based on aligned sequences of the rickettsial ompA gene, constructed using UPMGA in MEGA5.1 software. GenBank accession numbers of the Rickettsiae are given after the names of bacteria. (TIF)
Data
Phylogenetic tree of Borrelia flaB gene. Phylogenetic tree based on aligned sequences of the Borrelia flaB gene, constructed using UPGMA in MEGA5.1 software. GenBank accession numbers of sequences are given after the names of bacteria. (TIF)
Data
Phylogenetic tree of 18S ribosomal RNA gene. Phylogenetic tree based on aligned sequences of 18S ribosomal RNA gene, constructed using UPGMA in MEGA5.1 software. GenBank accession numbers of sequences are given after the names of the protozoa. (TIF)
Data
Phylogenetic tree of rickettsial gltA gene. Phylogenetic tree based on aligned sequences of the rickettsial gltA gene, constructed using UPGMA in MEGA5.1 software. GenBank accession numbers of sequences are given after the names of bacteria. (TIF)
Data
Phylogenetic tree of Ehrlichia heat shock protein (groEL) gene. Phylogenetic tree based on aligned sequences of the heat shock protein (groEL) gene, constructed using UPGMA in MEGA5.1 software. GenBank accession numbers of sequences are given after the names of bacteria. (TIF)
Article
Rodents are hosts of numerous pathogenic agents of public health importance globally. Their ability to harbor these pathogens without showing overt clinical signs of disease has epidemiologic consequences. In some rural settings in Nigeria, humans and rodents do not only share feeds and abode, but the latter may end up on the table of the former as...
Article
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Hyalomma ticks (Acari: Ixodidae) are hosts for Francisella-like endosymbionts (FLE) and may serve as vectors of zoonotic disease agents. This study aimed to provide an initial characterization of the interaction between Hyalomma and FLE and to determine the prevalence of pathogenic Rickettsia in these ticks. Hyalomma marginatum, Hyalomma rufipes, H...
Article
HyalommaKoch, 1844 are ixodid ticks that infest mammals, birds and reptiles, to which 27 recognized species occur across the Afrotropical, Palearctic and Oriental regions. Despite their medical and veterinary importance, the evolutionary history of the group is enigmatic. To investigate various taxonomic hypotheses based on morphology, and also som...
Article
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Background: The aim of this study was to determine the prevalence and density of Demodex folliculorum and Demodex brevis in students and staff of the Erzincan University, Turkey, and to define the influence of age, gender, educational level, and hygiene as well as skin moisture, pH, and temperature on the presence of Demodex mites. Methods: Heal...
Article
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Abstract Background The aim of this study was to determine the prevalence and density of Demodex folliculorum and Demodex brevis in students and staff of the Erzincan University, Turkey, and to define the influence of age, gender, educational level, and hygiene as well as skin moisture, pH, and temperature on the presence of Demodex mites. Methods...
Article
This study aimed to genetically characterize spotted fever group rickettsiae (SFGR) in questing ixodid ticks from Israel and to identify risk factors associated with SFGR-positive ticks using molecular techniques and geographic information systems (GIS) analysis. 1039 ticks from the genus Rhipicephalus were collected during 2014. 109/1039 (10·49%)...
Conference Paper
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Data based on 25 years of sampling breeding sites of Culicoides was analyzed statistically and provided means to characterize simply and reliably the biotopes of seven species: C. cirumscriptus, C. puncticollis. C. schultzei gr., C. imicola, C. cataneii, C. distinctipennis and C. obsoletus. These precise data enable's using specific control measure...
Article
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The human head louse, Pediculus humanus capitis, is subdivided into several significantly divergent mitochondrial haplogroups, each with particular geographical distributions. Historically, they are among the oldest human parasites, representing an excellent marker for tracking older events in human evolutionary history. In this study, ancient DNA...
Data
Real-time PCR amplification cuves for ancient DNA, Pediculus humanus, using cytb and 12S gens with negative controls (NC). 1, 2 and 3 showed qPCR amplification targeted a 88-bp DNA fragment of cytb gene (24/24 positive with Ct varied between 32 to 38); 4 showed qPCR amplification targeted a 100-bp DNA fragment of 12S gene (22/24 positive with Ct va...
Data
Agarose gel stained with syber safe showing the 277-bp amplification for Pediculus humanus cytb gene fragment obtained from ancient DNA with negative controls (T-). (PPTX)
Data
Geographic occurrences and frequencies of cytb haplotypes of human head and body lice. Haplotypes highlighted in blue are the newly identified haplotypes from sequences available in GenBank. (XLSX)
Chapter
Lice are a classic example of cospeciation. Human lice confirm this cospeciation with lice specialized in hominids which differ from those of gorillas and chimpanzees. Head lice and body lice seem to belong to closely related species with different ecotypes and a different geographical distribution which may reflect population movements. Paleo-ento...
Article
Four hundred and sixty seven Ctenocephalides felis fleas removed from 185 feral cats living in residential areas of Jerusalem, Israel, were screened for bacterial infections of public health importance. The fleas were screened for bartonellae, rickettsiae and Coxiella burnetii by PCR and sequencing. Bartonella DNA was detected in 156 individual fle...
Article
Full-text available
Background Tick-borne rickettsioses are caused by obligate intracellular bacteria belonging to the spotted fever group (SFG) rickettsiae. Although Spotted Fever is prevalent in the Middle East, no reports for the presence of tick-borne pathogens are available or any studies on the epidemiology of this disease in the West Bank. We aimed to identify...
Article
Full-text available
Human bed bug infestations have dramatically increased worldwide since the mid-1990s. A similar phenomenon was also observed in Israel since 2005, when infestations were reported from all over the country. Two single nucleotide polymorphisms (V419L and L925I) in the bed bug voltage-sensitive sodium channel confer kdr-type resistance to pyrethroids....
Article
Full-text available
Lice are among the oldest parasites of humans representing an excellent marker of the evolution and migration of our species over time. Here, we analyzed by real-time polymerase chain reaction (RT-PCR) developed in this study the mitochondrial DNA of seven ancient head louse eggs found on hair remains recovered from two sites in Israel: 1) five nit...
Article
Cutaneous myiasis is a well-established diagnosis in returning travelers from tropical countries. The most common form of myiasis seen in this population is localized furuncular myiasis caused by Dermatobia hominis and Cordylobia anthropophaga. There are limited data on the disease course and outcome in travelers to tropical countries. A retrospect...
Article
Fleas represent an acknowledged burden on dogs worldwide. The characterization of flea species infesting kennel dogs from two localities in Israel (Rehovot and Jerusalem) and their molecular screening for Bartonella species (Rhizobiales: Bartonellaceae) was investigated. A total of 355 fleas were collected from 107 dogs. The fleas were morphologica...
Article
Full-text available
Infestation with head lice is a worldwide public health concern. In high income countries pediculosis capitis is a problem mainly in school-aged children. In the last two decades and mainly as a result of resistance to pediculicides with a neurotoxic mode of action and due to the toxicological concerns, a new trend to products acting by physical me...
Article
Full-text available
Head lice infestation is still a public health problem worldwide, with an intracountry and intercountry prevalence variation of 0.7 to 59 %. There is a large variety of over-the-counter anti-louse products, but their efficacy is not always well assessed. Our objective was to test the pediculicidal and ovicidal efficacy of 21 over-the-counter head l...
Article
Several species of the spotted fever group rickettsiae have been identified as emerging pathogens throughout the world, including in Africa. In this study, 197 Hyalomma ticks (Ixodida: Ixodidae) collected from 51 camels (Camelus dromedarius) in Kano, northern Nigeria, were screened by amplification and sequencing of the citrate synthase (gltA), out...
Article
Bartonellosis is an infectious bacterial disease. The prevalence and genetic characteristics of Bartonella spp. in fleas of wild and domestic animals from Palestinian territories are described. Flea samples (n=289) were collected from 121 cats, 135 dogs, 26 hyraxes and seven rats from northern (n=165), central (n=113), and southern Palestinian terr...
Article
Full-text available
Ophthalmomyiasis in humans caused by the larvae of the sheep nasal botfly (Oestrus ovis) and is a rare phenomenon in Israel. We describe the utilization of the dermatoscope as a diagnostic tool for the facilitation of early diagnosis of conjunctivitis due to the infestation of the eyes by the sheep nasal botfly in two patients. After the physical r...
Article
Full-text available
Abstract Previous and ongoing studies have incriminated bats as reservoirs of several emerging and re-emerging zoonoses. Most of these studies, however, have focused on viral agents and neglected important bacterial pathogens. To date, there has been no report investigating the prevalence of Bartonella spp. in bats and bat flies from Nigeria, despi...
Article
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Bartonella spp. are worldwide-distributed facultative intracellular bacteria that exhibit an immense genomic diversity across mammal and arthropod hosts. The occurrence of cattle-associated Bartonella species was investigated in the cattle tail louse Haematopinus quadripertusus and in dairy cattle blood from Israel. Lice were collected from cattle...