Korkut Ulucan

Marmara University · Department of Medical Biology

Research has been conducted to explore the genetic basis of trigeminal neuralgia, a persistent pain condition that impacts the trigeminal nerve. COMT is an enzyme responsible for inactivating substances and hormones containing catechol and catecholamines. Previous research has linked COMT gene polymorphism with various pain conditions, including mi...

This study investigated the minichromosome maintenance 6 (MCM6) rs4988235 polymorphism in professional football players, comparing genotype and allele frequencies with a sedentary control group. The control group comprised 64 participants with no history of athletic activity, while the athlete group included 20 football players. DNA extraction from...

Medication-related osteonecrosis of the jaw (MRONJ) is a serious condition associated with the use of antiresorptive and antiangiogenic medications. Despite extensive research, the pathophysiology of MRONJ remains poorly understood. Bibliometric analysis provides insights into the academic impact of research, helping identify influential works and...

Objective Caries formation is a process affected by various factors. Studies have shown that genetic factors also play a role in caries formation. The aim of our study is to examine the effects of matrix metalloproteinase (MMP)3 (rs679620) and vitamin D receptor (VDR) (rs731236) gene polymorphisms on caries formation. Materials and Methods Followin...

The alpha actinin-3 gene (ACTN3) is a significant candidate gene among genetic markers that determine athletic ability. The ACTN3 gene is responsible for the creation of the actin protein in fast-twitch muscle fibers, which is associated with muscle power and speed. The objective of this study was to analyze the changes in performance of the arrowh...

The aim of this study is twofold: (1) to identify differences in certain anaerobic parameters (10m sprint, 30m sprint, anaerobic power, and Illinois agility tests) between professional and amateur soccer players, and (2) to determine whether there is a difference in the ACTN3 gene polymorphism between professional and amateur soccer players. Ultima...

Sprint and anaerobic power with the soccer-specific ACTN3 gene: A distintive example. Int. J. Morphol., 42(2):538-548, 2024. SUMMARY: The aim of this study is twofold: (1) to identify differences in certain anaerobic parameters (10m sprint, 30m sprint, anaerobic power, and Illinois agility tests) between professional and amateur soccer players, and...

The aim of this study is twofold: (1) to identify differences in certain anaerobic parameters (10m sprint, 30m sprint, anaerobic power, and Illinois agility tests) between professional and amateur football players, and (2) to determine whether there is a difference in the ACTN3 gene polymorphism between professional and amateur football players. Ul...

ABS TRACT Objective: Athletic performance is affected by genetic and environmental factors. Bodybuilding has been increasing around the world in recent years and it is accepted that the factors affecting athletic performance are the most important influences to achieve success in bodybuilding. The aim of our study is to determine the distribution o...

Purpose: The purpose of this research is to investigate the occurrence of ACE I/D and ACTN3 rs1815739 variations in sub-elite fitness athletes and to determine which gene is distinctive by comparing genotype and allele frequencies with sedentary individuals. Material and Methods: 41 sub-elite fitness athletes and 41 sedentary volunteers participate...

Skin aging is affected by internal and external factors. The stratum corneum consists of keratinocytes, and as these mature in the epidermis, their proliferative potential gradually decreases and the skin undergoes programmed destruction. There are many single nucleotid polymorphism (SNP)s associated with skin aging. The COL1A1, MMP1, and CYP1A2 ge...

The purpose of this study was to reveal the differences between ACTN3 genotype (RR, RX, XX) and aerobic performance [Yo-Yo IRT1 (m), VO2 max (ml/kg/min)] in professional and regional amateur league soccer players and to reveal which of these parameters was a distinctive factor in these athletes.71 professional soccer players (age: 23.66 ± 4.11 year...

Background Current research on athletic performance focuses on genetic variants that contribute significantly to individuals’ performance. ACTN3 rs1815739 and PPARA-α rs4253778 gene polymorphisms are variants frequently associated with athletic performance among different populations. However, there is limited research examining the pre-and post-te...

The aim of the study was to examine the genotype-allele determination of CYP1A2 rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19 and to determine their effectiveness as prognostic criteria in COVID-19. The study consists of 60 patients who were hospitalized in intensive care or outpatient treatment due to COVID-19 in I...

Running is one of the most popular sports branches in the world, attracting the interest of hundreds of thousands of people of all ages. The main reason behind this is regarded as the accessibility, low-cost and ease of application as well as the physiological and psychological benefits of running. Objective: The present study aims to examine inves...

While the term “safety vests” has been used to capture these products to reduce the potential for harm in jockeys under the Personal Protective Equipment (PPE) umbrella, much of the research in this area has focused on factors typically echoing health, well-being, physiological and cognitive function, and performance of horse riders with very littl...

Vitamin D is an important molecule responsible for the development, contraction and regeneration of muscles, and activates its biological functions by means of its receptors, the vitamin D receptor (VDR), which is a member of the nuclear receptor group. In the present study, we aimed to analyze the rs731236 distribution in Turkish rugby players. A...

Sport genetics has become increasingly important in recent years. The concept of performance includes genetic and anthropometric factors. These factors have not been adequately examined when the current literature is examined. One of the aims of this study is to identify a possible interaction between the ACE ID and ACTN3 R577X polymorphisms and th...

In the present study, the effect of ACE rs1799752 polymorphism on maximal oxygen consumption (VO2max) in ice hockey players was analyzed. For this reason, 21 male National Ice Hockey players, aged between 18-25, were recruited for the study. The conventional polymerase chain reaction (PCR) was used on the genotype rs1799752 polymorphism. The VO2max...

Introduction: The efficiency of psychiatric therapy depends on various factors and drug metabolism is one of them. The liver plays a significant role in drug metabolism through the P450 enzyme systems. However, pharmacogenetics aims to assist clinicians in determining the effectiveness of a particular drug and minimizing potential side effects. Cas...

Monocarboxylate transporter 1 (MCT1; SLC16A1) is a proton-dependent cotransporter/exchanger, located on the apical membrane of cells. MCT1 is able to transport several monocarboxylates including lactate, pyruvate and acetate, which makes this protein critical in terms of the athletic performances. The rs1049434 polymorphism in the MCT1gene was freq...

Pathological fractures in children can be seen in various conditions such as tumors, metabolic diseases and infection. Among these conditions, we encounter patholog- ical fractures most frequently caused by benign or malignant tumors. Pathological fractures resulting from benign and malignant bone tumors should be recognized early and treated appro...

The aim of the study was to identify genetic variants associated with personal best scores in Turkish track and field athletes and to compare allelic frequencies between sprint/power and endurance athletes and controls using a whole-exome sequencing (WES) approach, followed by replication studies in independent cohorts. The discovery phase involved...

The present study aimed to examine the vitamin D receptor (VDR), rs2228570 polymorphism, and its effect on elite athletes’ performance. A total of 60 elite athletes (31 sprint/power and 29 endurance) and 20 control/ physically inactive, aged 18–35, voluntarily participated in the study. The International Association of Athletics Federations (IAAF)...

Citation: Bulgay, C.; Bayraktar, I.; Kazan, H.H.; Yıldırım, D.S.; Zorba, E.; Akman, O.; Ergun, M.A.; Cerit, M.; Ulucan, K.; Eken, Ö.; et al. Evaluation of the Association of VDR rs2228570 Polymorphism with Elite Track and Field Athletes' Competitive Performance. Healthcare 2023, 11, 681. Abstract: The present study aimed to examine the vitamin D re...

The purpose of the study is to determine the prevalence of interleukin (IL)-1A (rs1800587), IL-1B (rs1143634) and vitamin D receptor (VDR) (TaqI, rs731236) gene poly-morphisms in the Turkish population and their association with Stage III Grade B/C periodontitis. Systemically and periodontally healthy individuals (N = 100) and Stage III Grade B/C p...

Limited number of researches exist on the relationship between PPARGC1A gene polymorphism (rs8192678) and affects the athletic performance. Thus, the present study aims to decipher any possible association of the rs8192678 polymorphism in the PPARGC1A gene with the competitive performances of Turkish elite track and field athletes. A total of 60 el...

PPARGC1A (rs8192678) gen polimorfizmi ve atletik performans arasıdaki ilişkiler konusunda sınırlı sayıda araştırma mevcuttur. Bu nedenle, bu çalışmada PPARGC1A genindeki rs8192678 polimorfizminin Türk elit atletizm sporcularının yarışma performansları ile olası ilişkisin araştırılması amaçlamaktadır. Çalışmaya 18-35 yaşları arasında toplam 60 elit...

Background: Athletic performance can be improved with regular training, the contribution of genetic factors, nutrition and psychological factors. The aim of this study is to determine the effect of IL-6 rs1800795 polymorphism in Turkish swimmers and to compare the results with sedentary individuals. Material and Methods: 75 people, including 45 pro...

Objective: A functional polymorphism on the 16th exon of the alpha-actinin-3 gene has an effect on the protein structure and cellular signaling and therefore on muscle contraction. In this study, we aimed to analyze the alpha-actinin-3 rs1815739 polymorphism in 3-dimensional malocclusions and different craniofacial skeletal patterns. Methods: Fo...

α-Actinin-3 is one of the key components of the Z-line structure of sarcomeres and also have importance in muscle cell signaling processes. Therefore, α-Actinin-3 gene rs1815739 polymorphism is one of the most analysed potential genetic biomarkers in sports genetic studies. We aimed to evaluate the genotypic and allelic distribution of α-Actinin-3...

Z Düzenli egzersiz toplum sağlığı açısından çok önemli olmakla birlikte ve fiziksel aktivitenin de desteklenmesi ayrı bir önem arz etmektedir. Uzun dönem, bireye özel uygun dozda, düzenli uygulanan egzersizin, kardiyovasküler sistem, kas-iskelet sistemi, endokrin sistemi üzerine ve ayrıca psikolojiye de olumlu etkilerinin olduğu bilinmektedir. Bunu...

Purpose: We suggested that polymorphic differences affect the performance of cyclists. In this study we designed the experiment to identify collagen type I alpha 1 (COL1A1) rs1800012 polymorphism in cyclists. Methods: We isolated genomic DNA from buccal epithelial cells of 38 cyclists. We followed COL1A1 rs1800012 single nucleotide polymorphism gen...

Background Linguists first coined the term anxiety in the 1600s to define a state of severe restlessness and worry. When we look at the Turkish dictionaries and printed sources, we see that the definition of anxiety is made simply as anxiety, fear, and worry. Anxiety; which we can describe as a mental and physical reaction, a defense strategy, agai...

Purpose: The aim of this study is to examine the genotype and allele distributions of angiotensinogen (AGT) rs699 gene polymorphism among soccer players and sedentary individuals. Material & Method: A total of 158 participants, including 52 football players and 106 sedentary individuals, were included in the study voluntarily. Genomic DNA was isol...

İnsan psikolojisini etkileyen ve en önemli bir biyobelirteç olan serotonin, sporcunun atletik performansını da olumsuz yönde etkileyebilmektedir. Çalışmamızın amacı, sağlıklı profesyonel futbolcularda anksiyete ile bağlantılı SLC6A4 geni promotör bölgesinde “S” ve “L” allel dağılımının incelenmesidir. Çalışmamıza aktif olarak haftada en az 4 gün an...

Objective: Adrenergic receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system. The rs1800544 polymorphism in 3’-untranslated region of ADRA2A is caused by C-1291>G nucleotide change. In this study, we aimed to analyze the rs1800544 distribution in kickboxing...

Aim Most tissues in the body contain cytochrome P450 enzymes, which play an important role in many functions, especially metabolizing drugs and other xenobiotics. The CYP2C9 gene in humans codes for an enzyme called CYP2C9. The goal of this study was to figure out the genotype and allele distributions of the CYP2C9 gene rs1799853 (CYP2C9*2), rs1057...

Objective: Interleukin-6 (IL-6) is an effective and functional protein with a cytokine structure. IL-6 is effective in the immune system like a pro/anti-inflammatory response, and muscle tissue hypertrophy and repair. Our study aimed to investigate the IL-6 rs1800795 polymorphism distribution in Turkish National Cross-Country Skiing Athletes and to...

The purpose of this study was to examine the effects of PPAR-a (rs4253778) on serum lipids in elite cross-country skiers. This study included 34 cross-country skiers (23 males and 11 females who participated in the Turkish skiing national team camp). Genotyping for the PPAR-a gene rs4253778 G/C polymorphism was performed by PCR on Tercyk multicanal...

The purpose of this study was to examine the effects of PPAR-a (rs4253778) on serum lipids in elite crosscountry skiers. This study included 34 crosscountry skiers (23 males and 11 females who participated in the Turkish skiing national team camp). Genotyping for the PPAR-a gene rs4253778 G/C polymorphism was performed by PCR on Tercyk multicanal a...

Aim and Objective: Escitalopram (SCT) shows an antidepressant effect due to its mechanism of increasing the serotonin level by inhibiting the serotonin transporter protein (5HTT). 5HTT is encoded by solute carrier family 6 member 4 gene (SLC6A4) in the brain. Recognition of SCT plasma level of patients and pharmacodynamics of individuals during SCT...

Findings related to sports injuries seem to play an important role related to genetic factors in the etiology of acute and chronic musculoskeletal soft tissue injuries. The aim of this study is to analyze the genotype and allele distribution of the Collagen type V alpha 1 gene (COL5A1) rs12722, which is effective in non-impact-related injuries of a...

Object�ve: Understanding the genetic nature of injuries in athletes may be conceived as an important step in the prevention and rehabilitation process of the injuries. The aim of this study is to analyze the rs1800012 genotype and allele distribution of the collagen type I alpha 1 gene (COL1A1), which is effective in non-contact injuries of long di...

CONTENTS 3.1 General Information on Amino Acids and Peptides........................................25 3.2 Functions of Amino Acids...............................................................................27 3.3 Important Amino Acids....................................................................................29 3.4 Importance to Synthes...

Aims: The aim of the study was to determinate the CYP1A2 gene rs762551 polymorphism responsible for caffeine in healthy individuals. Study Design: DNA was isolated from saliva samples taken from healthy individuals. Analysis of A and C allele distribution of CYP1A2 gene rs762551 polymorphism was performed by amplifying DNA regions from individuals....

L-arginine is a well-known growth hormone (GH) stimulator. The aim of the present study was to investigate the effect of L-arginine supplementation on growth velocity in prepubertal boys with idiopathic short stature. In this retrospectively designed study, prepubertal boys over 5 years of age who were diagnosed with idiopathic short stature were r...

The determination of the genetic profiles of successful athletes and the effects of these genetic parameters on athletic performance is gaining increasing interest. The majority of studies assessing the genetics of athletes usually analyse the most well-known genetic variations in athletes associated with the different specialties. The aim of the p...

Study Objectives: The purpose of this study was to define ACTN3 and ACE genes affecting the athletic performance of sprinters and mid-long distance athletes. Methods: A total of 184, elite sprinters and mid-long distance athletes and sedantary participated in the study. Subjects were categorized into three groups as sprinters, mid-long distance ath...

Athletic performance is considered to be determined by the effect of genetic endowment and environmental factors like nutrition, regular training and psychology. Aim of the present study is to determine the effect of Interleukin-6 (IL-6) rs1800795 poly-morphisms in Turkish National Skiing running athletes. A total of 55 individuals, 34 skiers and 2...

Athletic performance is considered to be determined by the effect of genetic endowment and environmental factors like nutrition, regular training and psychology. Aim of the present study is to determine the effect of Interleukin-6 (IL-6) rs1800795 poly-morphisms in Turkish National Skiing running athletes. A total of 55 individuals, 34 skiers and 2...

Bu çalışmanın amacı Türk Iroman triatlon sporcularının IL-6 (rs1800795), HIF1A (rs11549465), MCT1 (rs1049434), PPAR-a (rs4253778), genotip dağılımlarının ve allel frekanslarının belirlenmesidir. Çalışmaya 10 elit erkek İronman triatlon sporcusu katılmıştır. Deneklerin DNA örnekleri venöz kandan elde edilmiştir. Örneklerin genotiplemesi Real-Time PC...

The apoptotic protease activating factor 1 (APAF1) gene encodes a cytoplasmic protein that initiates apoptosis and is a crucial factor in the mitochondria-dependent death pathway. APAF1 is implicated in many pathways such as apoptosis, neurodegenerative diseases, and cancer. The purpose of this study was to predict deleterious/damaging SNPs in the...

Studies in sports genetics have increased nowadays and the identification of genotype and allelic distributions of candidate genes in different athletes has provided important information to sports scientists. One of the candidate genes studied in sports genetics is the hypoxia-inducible factor 1-alpha (HIF1A) gene, which is associated with the end...

Alzheimers disease (AD) is a progressive neurodegenerative disease characterized by pathological accumulation of ?-amyloid (A?) senile plaques and neurofibrillary tangles. ?-secretase produces the amyloid ? peptide (A?), which causes AD. ?-secretase is a macromolecular complex and the protein encoded by the APH1A gene is located in this complex. In...