Konstantin Semash

National Children's Medical Center

Transplantation of the left lateral section (LLS) of the liver is now an established practice for treating advanced diffuse and unresectable focal liver diseases in children, with variants of the LLS primarily used in infants. However, the surgical challenge of matching the size of an adult donor's graft to the volume of a child's abdomen remains s...

Laparoscopic liver resection in living donors is a relatively novel surgical approach that has the potential to enhance donor safety and facilitate faster recovery. Following an initial development period during which donor safety was not effectively validated, the minimally invasive approach now yields better outcomes, provided that these procedur...

Introduction: Liver transplantation from living donors is an effective treatment method for patients with various types of terminal liver diseases. A key aspect of living liver donation is donor safety. Objective: The objective of this study was to assess the outcomes of the initial donor liver resections performed at our center. Materials and Meth...

Aim . To evaluate immediate and long-term results of surgical reconstruction of the biliary system in various types of benign obstructive jaundice. Materials and methods . The study enrolled 110 patients with choledocholithiasis, iatrogenic biliary strictures, common bile duct strictures, as well as strictures of biliodigestive and biliobiliary ana...

Biliary complications (BCs) are the most frequent complications following liver transplantation (LT). They are a major source of morbidity after LT. The incidence of BCs after LT is reported to range from 5% to 45%. The main post-LT biliary complications are strictures, biliary fistulas and bilomas, cholelithiasis, sphincter of Oddi dysfunction, he...

Introduction: Anastomotic portal vein stricture occasionally occurs as a post-operative complication of a living-donor liver transplantation. Portal vein stenosis decreases portal venous blood supply to the liver graft and increases extrahepatic portal venous pressure, which may lead to liver dysfunction, splenomegaly, gastrointestinal bleeding, pa...

Introduction: Living donor liver transplant (LDLT) is an effective method of treatment for patients with different types of terminal liver diseases. Unfortunately, patients undergoing such a treatment sometimes are getting various complications. Vascular complications, especially those which are related to the hepatic artery, may lead to graft fail...

ntroduction: Living donor liver transplant (LDLT) is an effective method of treatment in patients with different types of terminal liver diseases. The purpose of our work was to evaluate the results of the first series of living donor liver transplantation in our country and to show that in the conditions of our country liver transplantation is a f...

Введение. С момента первой трансплантации печени, проведенной Томасом Старзлом, прошло практически 60 лет. За это время медицинские технологии постепенно усовершенствовались, что дало возможность использовать все новые методы и подходы в данном виде медицинской помощи. Одной из новых методик последних десятилетий является роботизированная хирургия,...

In the Republic of Uzbekistan, the history of liver transplantation began in 2018, but this type of medical care was introduced regularly only in 2021. The selection, preparation, and perioperative management of living liver donors can be complicated and have importance in the type of responsible medical care, which requires maximum doctor involvem...

Цель: Оценить ближайшие и отдаленные результаты хирургической реконструкции желчевыводящей системы при различных видах механической желтухи доброкачественного генеза. Материал и методы. В исследование включили 110 пациентов с холедохолитиазом, ятрогенными стриктурами желчных протоков, стриктурами общего желчного протока, а также стриктурами билиоди...

Introduction: Anastomosing hemangiomas represent a rare variant of benign vascular heman-gioma which rarely arise from the liver parenchyma. The peculiarity of these tumors is that they can mimic malignant tumors, such as hepatocellular carcinoma, hepatoblastoma, and an-giosarcoma. Notably, all documented cases where this type of liver tumor was de...

The shortage of donor organs remains an unresolved issue in liver transplantation worldwide. Consequently, strategies for expanding the donor pool are currently being developed. Donors meeting extended criteria undergo thorough evaluation, as livers obtained from marginal donors yield poorer outcomes in recipients, including exacerbated reperfusion...

Background: Living donor liver transplantation (LDLT) is an effective treatment for patients with end-stage liver disease. This study was performed to evaluate the outcomes of the initial series of LDLT procedures performed in the Republic of Uzbekistan and to demonstrate that liver transplantation is viable under the conditions in this country. Me...

There have been nearly 60 years since Thomas Starzl's first liver transplant. During this period, advancements in medical technology have progressively enabled the adoption of new methods for transplantation. Among these innovations, robotic surgery has emerged in recent decades and is gradually being integrated into transplant medicine. Robotic he...

Background. Living donor liver transplant is an effective method of treatment in patients with different types of endstage liver diseases. Unfortunately, patients undergoing such a complex treatment sometimes develop various vascular complications. Splenic artery steal syndrome has emerged as a cause of graft ischemia in living donor liver transpla...

Актуальность: Трансплантация является единственным радикальным лечением терминальных стадий заболеваний печени. Улучшение результатов пересадки печени напрямую зависит от подготовки реципиентов, тщательности отбора доноров, хирургической техники и методов реабилитации в послеоперационном периоде. Несмотря на достигнутые положительные результаты в в...

Introduction: In the absence of the possibility of liver transplantation from a deceased donor, living donor liver transplantation (LDLT) is the only feasible alternative for treating liver cirrhosis. Study Objective: Analysis of our own experience with related liver transplantation at the V. Vakhidov Republican Specialized Scientific Practical Med...

Background: Mechanical jaundice represents an urgent pathology necessitating immediate surgical intervention. In certain cases, resolving acute mechanical jaundice with minimally invasive techniques proves unsuccessful. In such instances, reconstructive surgical correction of the biliary drainage represents a radical treatment approach. Research O...

Vascular complications (VCs) after liver transplantation (LT) are rare but are one of the most dreaded conditions that can potentially lead to graft loss and recipient death. This paper has analyzed the international experience in the early diagnosis of various VCs that can develop following LT, as well as the optimal timing and methods of treatmen...

Introduction. Liver resection is a surgical method of treatment of benign and malignant tumors including in infant patients. Materials and methods. We want to demonstrate a case of major right-sided hepatectomy in infant patient due to rare giant anastomosing hemangioma tumor firstly performed in our center. Results. Right hepatectomy in 5-month-ol...

Учебно-методическое пособие для практикующих врачей, клинических ординаторов, магистров и студентов 5-6 курсов высших медицинских учебных заведений.

Учебно-методическое пособие для практикующих врачей, клинических ординаторов, магистров и студентов 5-6 курсов высших медицинских учебных заведений.

Актуальность. При отсутствии возможности проведения трансплантации печени от посмертного донора, прижизненное донорство является единственно возможной альтернативой для лечения лечении тяжёлых диффузных и нерезектабельных очаго- вых болезней печени. Цель исследования - оценить результаты собственного опыта трансплантации печени от живого родственно...

Актуальность. Трансплантация печени от живого родственного донора является эффективным методом лечения пациентов с терминальными заболеваниями печени. Сосудистые осложнения наблюдается редко после трансплантации печени, однако могут приводить к необратимыми по- следствиям вплоть до потери трансплантата или реципиента. Цель исследования - оцениить р...

Цель исследования - анализ результатов хирургического лечения пациентов в декомпенсированной стадии печеночной недостаточности после родственной трансплантации печени от живого донора. Материалы и методы. Работа основана на анализе бли- жайших результатов 60 пациентов в декомпенисрованной ста- дии печеночной недостаточности, которым произведена род...

The selection, preparation and perioperative management of living related liver donors is a complex and responsi- ble type of medical care that requires maximum involvement from physicians at all stages. The selection and prepara- tion of a donor for liver resection, the basic principles of donor resection surgery, as well as postoperative manageme...

Introduction. Liver transplantation is a multi-component and complex type of operative treatment. Patients undergoing such a treatment sometimes are getting various complications. One of these complications is a portal hypertension associated with portal vein stenosis. Materials and methods. In 8 months after the right lobe transplantation from li...

Background. Liver transplantation from a living donor is an effective treatment option for patients with various types of end-stage liver disease. Unfortunately, patients undergoing such complex treatment sometimes experience various vascular complications. Splenic artery steal syndrome can cause graft ischemia in recipients and can lead to severe...

The selection, preparation, and perioperative management of the living liver donors is a complicated and responsible type of medical care, which requires the maximum of doctors' involvement at all stages. This article describes in detail donor selection and preparation for liver resection and the basic principles of donor resection surgery. Postope...

Objective: To demonstrate a clinical case of X-ray endovascular treatment of a patient with portal vein stenosis that occurred in the late period after liver transplantation. Material and methods: patient A., 48 years old, was observed at the RSNPMC named after V.I. acad. V. Vakhidov since January 2022 with a diagnosis of decompensated liver cirrh...

Background The mini-invasive (MIS) approach to living donor hepatectomy is a current trend in experienced centers. At the same time, there are only a few reports describing the utility of laparoscopic donor hepatectomy (LDH) in settings of pediatric living donor liver transplantation (LDLT). We aimed to provide our own experience as a path to imple...

Background: Since 2002, when D. Cherqui described the first laparoscopic left lateral sectionectomy (LLS) in living donor, the safety of LLS laparoscopic procurement has been proven in a series of studies around the world. At the same time, today only a few hospitals use this method routinely. In this study, we compared the laparoscopic and open a...

Living related liver transplantation has proved to be an effective, safe and radical method for treating end-stage liver diseases. In the last decade, a laparoscopic approach to donor hepatectomy has been gradually introduced into clinical practice. According to world literature, there are presently no uniform standards for performing laparoscopic...

Liver transplantation is the treatment of choice for patients with end-stage liver disease or acute liver failure. However, vascular complications, such as hepatic artery stenosis and/or thrombosis, graft portal vein stenosis and biliodigestive strictures following liver transplantation are still common despite improvements and innova- tions in sur...

Background The chronic shortage of organs makes the option of living liver donation particularly appealing, and living donor LLS transplantation remains the most common procedure for pediatric liver transplantation in Russia. Laparoscopic living donor left lateral sectionectomy (lapLDLLS) was recently established as a new standard practice. Purpos...

In pediatric practice, transplantation of liver fragments allows achieving high results [Bowring M.G., 2020] and, at the same time, fully guaranteeing the safety of related donors. At the same time, when performing an adult-child transplantation, there are practically no ethical issues, since, most often, one of the recipient's parents is the donor...

Background: Liver transplantation (LT) is the only possible treatment for patients with end-stage liver disease. ABO-incompatible (ABOi) LT is a valua- ble option for children without ABO-compatible (ABOc) possible living related donors. The aim of the study was to describe the outcome of ABOi LT in 122 pediatric recipients. Methods: ABOi pediatric...

Many studies have shown that biliary complications after transplantation of the left lateral segment (LLS) of the liver reduce graft and recipient survival. Thus, timely correction of biliary complications, and strictures in particular, improves long-term outcomes in transplantation. Objective: to analyze our own experience in cor- recting biliar...

Background: During the last few years laparoscopic approach for living donor hepatectomy (LLDH) widely spread among high volume centers and proved its safety for donors and recipients. Our LLDH program was launched at 2016. Since this period the method established as routine for LLS donors. Analysis of own experience focused on LDLT in children was...

With the presence of organ shortage, living donors remain important sources of grafts, especially for pediatric recipients. Laparoscopic nephrectomy has become the gold standard for living donors. Additionally, laparoscopic partial liver procurement in living donors has proven its safety and feasibility in the latest studies. We have combined both...

Background : Split liver transplantation is used worldwide and allows for an increase of donor organ pool, especially for pediatric recipients. Donor selection, some aspects of surgical techniques and long-term results remain to be important issues of split liver transplantation. Aim : To analyze our own clinical results of split liver transplantat...

Background Laparoscopic living donor liver procurement for transplantation has increased in popularity over the past decade. The purpose of this study was to compare the laparoscopic and open approaches in living donor left lateral sectionectomy (LLS) and to assess the safety and feasibility of this laparoscopic approach. Methods A total of 103 li...

Introduction Significant progress in percutaneous interventional correction of complications in children after liver transplantation was achieved during the period from May 2015 to October 2017. The method was established to be an effective technique of miniinvasive surgical care for children who developed complications after liver transplantation...

Background: Since 2002, when D. Cherqui described the first laparoscopic left lateral sectionectomy (LLS) in living donor, the safety of LLS laparoscopic procurement has been proven in a series of studies around the world. At the same time, today only a few hospitals use this method routinely. In this study, we compared the laparoscopic and open a...

Introduction . Liver transplantation is a multi-component and complex type of operative treatment. Patients undergoing such a treatment sometimes are getting various complications. One of these complications is a portal hypertension associated with portal vein stenosis. Materials and methods . In 6 years after the left lateral section transplantati...