Konstantin A. Kolbe

This work focuses on DBD (dielectric barrier discharge) surface modification of polylactide (PLA) films. The film samples were treated in a cold plasma in order to optimize their biological properties and interaction with human skin fibroblasts. Optimal film processing modes for the increased proliferative activity of cells have been found.

Biocompatible electrically conducting chitosan-based films filled with single-wall carbon nanotubes were obtained. Atomic force microscopic studies of the free surface topography revealed a change in the morphology of chitosan films filled with single-wall carbon nanotubes. Introducing 0.5 wt.% of single-wall carbon nanotubes into chitosan results...

Surface modification of films of the laboratory R‐BAPB polyimide based on 1,3‐bis(3,3′,4,4′‐dicarboxyphenoxy)benzene (dianhydride R) and 4,4′‐bis(4‐aminophenoxy)biphenyl (diamine BAPB) was performed using a dielectric barrier discharge (DBD) with the aim of increasing proliferative activity of human fibroblasts on these films. The optimal duration...

In this work, an electrically conductive composite based on thermoplastic polyimide and graphene was obtained and used as a bioelectrode for electrical stimulation of human dermal fibroblasts. The values of the electrical conductivity of the obtained composite films varied from 10-15 to 102 S/m with increasing graphene content (from 0 to 5.0 wt.%)....

Structural and functional characteristics of various systems for delivery of antitumor preparation doxorubicin were compared. Two types of delivery systems were studied: submicron porous calcium carbonate cores coated with a polyanion (sodium dextran sulfate) and nanoparticles based on random amphiphilic copolymers of different amino acids. Scannin...

Conducting composite based on biocompatible chitosan and single wall carbon nanotubes was used as a matrix for electrical stimulation of human fibroblasts. Parameters of ionic and electronic currents passing through the matrix upon applying cyclic potentials (±100 mV) were studied; the scaffold demonstrated high stability in the course of prolonged...

In this work, the surface of polyimide films of PMDA-ODA was modified using a barrier discharge in order to optimize their biological properties when interacting with a culture of human dermal fibroblasts. The optimal modes of processing films in a gas discharge, which allows to increase the proliferative activity of cells, are found.

In this study, bioactive composite systems based on natural polymers (chitosan and lignin) were prepared in this study. The structural, mechanical, and morphological properties of chitosan-based materials containing various amounts of lignin filler were investigated. The infra-red IR spectroscopy data confirmed the formation of chemical bonds betwe...

The paper is devoted to the study of influence of chitin nanofibrils on the structure, surface morphology, mechanical properties, and electrical conductivity of chitosan-based composite films intended for use in biomedical technologies. It was demonstrated that the optimal concentration of chitin nanofibrils in the composite film is 5 wt.%. For the...

Conducting composite based on biocompatible chitosan and single wall carbon nanotubes was used as a matrix for electrical stimulation of human fibroblasts. Parameters of ionic and electronic currents passing through the matrix upon applying cyclic potentials (±100 mV) were studied; the scaffold demonstrated high stability in the course of prolonged...

In the work composite films based on chitosan and single-walled carbon nanotubes (0.01%, 0.1%, 0.5% and 1%) were obtained. The electrical and mechanical properties of the composite films were measured. It was shown that a film with 1% SWCNT has sufficient electrical conductivity and optimal mechanical properties for the bioactivity of a culture of...

We have demonstrated the possibility of application of electroconducting polymers for fabricating bioactive matrices for tissue engineering. Polypyrrole is most promising among such polymers in the context of its biomedical applications. Polypyrrole possesses a number of properties that make it an adequate basis for preparing “smart” bioactive mate...

The method of scanning electron microscopy in complex with energy dispersive spectrometric analysis is applied for the first time for studying the composition of materials used or medical purposes. Cartilage implants have been formed based on polyacrylamide hydrogels reinforced by bacterial and plant celluloses, and the dynamics of variation of com...

This paper discusses the electrical conductivity of chitosan-based film matrices, as well as optimization of these properties by adding chitin nanofibrils. It has been shown that the filler addition increase the conductivity of the composite material. By changing the concentration of chitin nanofibrils, it is possible to obtain matrices with differ...

Scanning electron microscopy (SEM) in combination with energy-dispersive spectrometric (EDS) analysis was used for the first time in the studies of composition of several materials being developed for medical uses. Cartilage implants were obtained on the basis of poly(acrylamide) hydrogels, bacterial and plant cellulose samples; dynamics of changes...

It was demonstrated that conducting polymers can be used in development of bioactive matrices for tissue engineering. The most promising conducting polymer for biomedical applications is polypyrrole. Due to a number of useful properties, polypyrrole can be used in designing “smart” biologically active materials. In order to improve mechanical prope...

Thermal plasma effects have long been employed for tissue coagulation, cutting, desiccation, and cauterizing for a long time. Nevertheless, there have been significant developments in cold atmospheric plasma (CAP) with well-controlled temperatures below 40℃. Thereby, in the last decade, a new innovative field, often referred to as plasma medicine,...

Nanocomposite films based on chitosan and filler in the form of chitin nanofibrils were prepared. An analysis of the film morphology by scanning electron microscopy demonstrated a uniform distribution of filler nanoparticles in the bulk of a film and their predominantly planar orientation. The influence exerted by chitin nanofibrils on the elastici...

This paper discusses the mechanical properties of chitosan-based film matrices, as well as optimization of these properties by adding chitin nanofibrils. It has been shown that the filler addition stabilizes the mechanical properties of the composite material. By changing the concentration of chitin nanofibrils, it is possible to obtain matrices wi...

This paper discusses the mechanical and physicochemical properties of film matrices based on chitosan, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It is shown that with the introduction of chitin nanofibrils as a filler, the mechanical stability of the composite materials increases. By varying the concent...