Klaus S Drese

Klaus S Drese
University of Applied Sciences Coburg · Institute of Sensor and Actuator Technology (ISAT)

Prof. Dr.

About

118
Publications
9,618
Reads
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1,940
Citations
Citations since 2016
18 Research Items
686 Citations
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
Klaus S Drese currently works at the Institute of Sensor and Actuator Technology (ISAT), University of Applied Sciences Coburg. Klaus does research in Computational Physics, Fluid Dynamics and Theoretical Physics. His most recent publication is 'Simulating copolymeric nanoparticle assembly in the Co-solvent method: How mixing rates control final particle sizes and morphologies.'
Additional affiliations
October 2016 - present
University of Applied Sciences Coburg
Position
  • Managing Director
January 2014 - September 2015
Fraunhofer ICT-IMM
Position
  • Managing Director
December 1998 - December 2013
Institut für Mikrotechnik Mainz
Institut für Mikrotechnik Mainz
Position
  • Managing Director
Education
August 1995 - September 1998
August 1992 - July 1993
State University of New York
Field of study
  • Physics
November 1989 - July 1995
University of Wuerzburg
Field of study
  • Physics

Publications

Publications (118)
Article
Full-text available
Guided acoustic waves are commonly used in domestic water meters to measure the flow rate. The accuracy of this measurement method is affected by factors such as variations in temperature and limescale deposition inside of the pipe. In this work, a new approach using signals from different sound propagation paths is used to determine these quantiti...
Article
Full-text available
Nondestructive evaluation of elastic properties plays a critical role in condition monitoring of thin structures such as sheets, plates or tubes. Recent research has shown that elastic properties of such structures can be determined with remarkable accuracy by utilizing the dispersive nature of guided acoustic waves propagating in them. However, ex...
Conference Paper
Many sensor principles are based on the excitation and detection of guided acoustic waves (GAW). These are usually generated by mechanical coupling of piezoceramic transducers with the help of thin coupling layers. With electromechanical transducers (EMAT) or pulsed lasers, GAW can also be excited without a coupling layer or direct coupling. A furt...
Article
Full-text available
In a biomimetic approach the feasibility of liquid flow actuation by vibrating protruding structures excited via guided acoustic waves is investigated. Inspired by periodically beating cilia the loop part of a punched metallic hook-and-loop tape with tilted protruding loops was used as a waveguide for plate waves in water. Such waves were excited i...
Conference Paper
Nowadays in almost all cases, the propulsion of ships is generated by mechanically moved propellers, which causes wa-ter flow and thrust. The disadvantage of this technology is the wear of the mechanical moving parts as well as the dan-ger of the rotating parts in the water for example for living beings. The only alternative is still the sail or wi...
Conference Paper
The demand for homogeneous gas mixtures with defined concentration ratios is increasing in the diverse branches of industry. In the production of these gas mixtures, the most important factors are how the gases are combined and, above all, how homogeneously they are mixed. Currently, gas mixtures are produced with purely mechanical gas mixers, whic...
Article
Background Miniaturization has not only driven microelectronics and generated new unforeseen options but has also dramatically changed sensors and analytics. Developments The Lab on a Chip (LOC) technology enables laboratory processes to run fully automated in canals in the micrometre range. The biggest challenge for LOC is to keep production cost...
Article
Full-text available
An ultrasound sensor system based on the transmission-mode approach is developed to enable the monitoring and sensing of cryogenic liquids and gases—especially gaseous bubbles and gas-liquid interfaces in liquid nitrogen (LN2). Common sensors do not meet requirements of cryogenic and microgravity-environments. Therefore, a special encapsulation des...
Article
Background Miniaturization has not only driven microelectronics and generated new unforeseen options but has also dramatically changed sensors and analytics. Developments The Lab on a Chip (LOC) technology enables laboratory processes to run fully automated in canals in the micrometre range. The biggest challenge for LOC is to keep production cost...
Conference Paper
Conventional data transmission via cable or electromagnetic waves reaches their limits in harsh or hard-to-reach environments. For example in bore hole inspection, cables can break and electromagnetic waves cannot pass different earth layers [1]. Actual studies showing that guided waves are a possible instrument for cable less data transmission [2,...
Article
Full-text available
The monitoring of liquid-filled tubes with respect to the formation of soft deposition layers such as biofilms on the inner walls calls for non-invasive and long-term stable sensors, which can be attached to existing pipe structures. For this task a method is developed, which uses an ultrasonic clamp-on device. This method is based on the impact of...
Article
Full-text available
A previous experiment showed that the rate of the electropolishing of a copper anode may be increased by twofold when generating a 60 KHz to 1.7 MHz frequency vibration in the anode. In this work we use theory to elucidate the mechanisms by which the vibration may enhance the transport of ions in the electrolyte solution and support the formation o...
Article
Full-text available
The self-assembly of copolymeric vesicles and micelles in micromixers is studied by External Potential Dynamics (EPD) simulations – a dynamic density functional approach that explicitly accounts for the polymer architecture both at the level of thermodynamics and dynamics. Specifically, we focus on the co-solvent method, where nanoparticle precipit...
Article
In this work, a falling film micro reactor was investigated regarding its ability to continuously eliminate tetrahydrofuran (THF) out of a THF-water mixture via nitrogen stripping. Mass transfer measurements were performed at different temperatures and flow rates. The residual content of THF in the eluate was quantified with high precision (<0.1%)...
Article
The co-solvency method is a method for the size controlled preparation of nanoparticles like polymersomes, where a poor co-solvent is mixed into a homogeneous copolymer solution to trigger precipitation of the polymer. The size of the resulting particles is determined by the rate of co-solvent addition. We use the Cahn-Hilliard equation with a Flor...
Article
Der Segré-Silberberg-Effekt beschreibt die laterale Anordnung von Partikeln in laminaren Kanalströmungen. Besonders interessant ist seine Nutzung in mikrofluidischen Kanälen, die entscheidend für die Funktionen eines Lab-on-a-Chip sind. In solchen Kanälen bestimmt dieser Effekt die Positionen von Partikeln sowie ihre Geschwindigkeiten, die man mit...
Conference Paper
Seit dem Experiment von Segré und Silberberg ist bekannt, dass Partikel in laminarer Strömung bei ausreichend hoher Reynoldszahl zu einer lateralen Gleichgewichtsposition migrieren, wo sie sich mit der sogenannten Gleichgewichtsgeschwindigkeit in Strömungsrichtung fortbewegen. Unsere Messergebnisse haben gezeigt, dass letztere von der Partikelgröße...
Patent
Full-text available
A microvalve for controlling fluid flows, and a sealing device for sealing cavities in a microfluidic system, particularly in a lab-on-a-chip system, and a method for the production thereof. A sealing surface of a valve body, or a sealing element, respectively, rests on a sealing surface of a substrate and is pressed against the sealing surface of...
Article
Full-text available
In this paper, we describe the development of an automated sample preparation procedure for etiological agents of community-acquired lower respiratory tract infections (CA-LRTI). The consecutive assay steps, including sample re-suspension, pre-treatment, lysis, nucleic acid purification, and concentration, were integrated on a microfluidic lab-on-a...
Article
An ultrafast microfluidic PCR module (30 PCR cycles in 6 min) based on the oscillating fluid plug concept was developed. A robust amplification of native genomic DNA from whole blood samples could be achieved at operational conditions established from systematic investigations of key parameters including heat transfer and in particular flow velocit...
Article
Preventing bacterial contaminations is a significant challenge in applications across a variety of industries, e.g. in food processing, the life sciences or biohazard detection. Here we present a fully automated lab-on-a-chip system wherein a disposable microfluidic chip moulded by polymeric injection is inserted into an operating device. Liquid sa...
Article
Full-text available
The paper presents the development of a "proof-of-principle" hands-free and self-contained diagnostic platform for detection of human papillomavirus (HPV) E6/E7 mRNA in clinical specimens. The automated platform performs chip-based sample preconcentration, nucleic acid extraction, amplification, and real-time fluorescent detection with minimal user...
Article
During the developmental cycle of lab-on-a-chip devices, various microstructuring techniques are required. While in the designing and assay implementation phase direct structuring or so-called rapid-prototyping methods such as milling or laser ablation are applied, replication methods like hot embossing or injection moulding are favourable for larg...
Article
Point-of-care (PoC) testing followed by personalized efficient therapy of infectious diseases may result in a considerable reduction of associated health care costs. Lab-on-a-chip (LoC) systems represent a potentially high efficient class of PoC tools. Here, we present a LoC system for automated pathogen analysis of respiratory viruses from nasopha...
Article
Full-text available
The development of a fully automated microsystem housing an amperometric immunosensor is presented. The microfluidic cell integrates reagent storage and electrochemical immunodetection and was applied for the detection of breast cancer markers. The main advantage of this system is that no external fluidic storage is required and the instrumental se...
Article
Taking advantage of microfluidics technology, a Lab-on-Chip system was developed offering the possibility of performing HLA (Human Leukocyte Antigen) typing to test genetic predisposition to coeliac disease and measure the level of immunodeficiency at the point-of-care. These analysis procedures are implemented on two different microfluidic cartrid...
Article
A microsystem integrating electrochemical detection for the simultaneous detection of protein markers of breast cancer is reported. The microfluidic platform was realized by high precision milling of polycarbonate sheets and features two well distinguishable sections: a detection zone incorporating the electrode arrays and the fluid storage part. T...
Conference Paper
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Article
Full-text available
Stopped-flow technology is frequently used to monitor rapid (bio)chemical reactions with high temporal resolution, e.g., in dynamic investigations of enzyme reactions, protein interactions, or molecular transport mechanisms. However, conventional stopped-flow devices are often overly complex, voluminous, or costly. Moreover, excessive amounts of sa...
Article
Detection of proteins that signal the presence or recurrence of cancer is a powerful therapeutic tool for effective early diagnosis and treatment. Carcinoembryonic antigen (CEA) has been extensively studied as a tumor marker in clinical diagnosis. We report on the development of an amperometric biosensor for the detection of CEA based on the immobi...
Conference Paper
Full-text available
A microsystem integrating electrochemical biosensoric detection for the simultaneous multiplexed detection of protein markers of breast cancer is reported. The immobilization of antibodies against each of carcinoembryonic antigen (CEA), prostate specific antigen (PSA) and cancer antigen 15-3 (CA15-3) was achieved via crosslinking to a bipodal dithi...
Chapter
Full-text available
Cancer is a leading cause of death worldwide. Resistance of tumor cells to radiation and chemotherapy is the major obstacle in cancer treatment. The serious toxicity that follows the administration of certain drugs can be associated with Single Nucleotide Polymorphisms (SNPs) of genes involved in drug metabolism and can ultimately reduce the clinic...
Conference Paper
Early diagnosis followed by personalised efficient therapy of infectious diseases (e.g. respiratory diseases, meningitis, sepsis) can lead to considerable reduction of costs in health care. Point-of-care testing (POCT) can provide early detection since this kind of decentralised analysis can be done by unskilled personnel at any time. Other advanta...
Conference Paper
Conventional Stopped-Flow devices often need high sample volumes, display complex designs, take up much space and are very expensive in purchasing and maintenance. Here, a powerful microfluidic based Stopped-Flow system is described that is flexible in application, simple, easy to handle, and cost-efficient in terms of acquisition and operation. Wi...
Article
Full-text available
Coeliac disease is an inflammatory disease of the upper small intestine and results from gluten ingestion in genetically susceptible individuals, and is the only life-long nutrient-induced enteropathy. The only treatment is a strict gluten-free diet and the longer the individual fails to adhere to this diet, the greater the chance of developing mal...
Article
A Lab-On-Chip system with an instrument is presented which is capable of performing total sample preparation and automated extraction of nucleic acid from human cell samples fixed in a methanol based solution. The target application is extraction of mRNA from cervical liquid based cytology specimens for detection of transformed HPV-infections. The...
Article
We present the rapid prototyping of electrochemical sensor arrays integrated to microfluidics towards the fabrication of integrated microsystems prototypes for point-of-care diagnostics. Rapid prototyping of microfluidics was realised by high-precision milling of polycarbonate sheets, which offers flexibility and rapid turnover of the desired desig...
Article
Full-text available
Routine prenatal diagnosis of chromosomal anomalies is based on invasive procedures, which carry a risk of approximately 1%-2% for loss of pregnancy. An alternative to these inherently invasive techniques is to isolate fetal DNA circulating in the pregnant mother's plasma. Free fetal DNA circulates in maternal plasma primarily as fragments of lengt...
Conference Paper
Full-text available
A universal microfluidic platform as a multisensor device for cancer diagnostics, developed within the framework of the EU project SmartHEALTH [1], will be presented. Based on a standardization concept, a microfluidic platform was realized that contains various functional modules in order to allow in its final setup to run a complete diagnostic ass...
Article
In electrokinetic trapping (EKT), the electroosmotic velocity of a buffer solution in one area of a microfluidic device opposes the electrophoretic velocity of the analyte in a second area, resulting in transport of DNA to a location where the electrophoretic and electroosmotic velocities are equal and opposite and DNA concentrates at charged nanoc...
Article
The separation of cells from a complex sample by immunomagnetic capture has recently obtained increased attention for microfluidic applications. Here, we present a simulation approach for immunomagnetic separation in a flow-through microfluidic environment that for the first time takes binding kinetics of beads to target cells as well as binding of...
Conference Paper
Isotachophoresis (ITP) is a well established method for the separation of single species from complex mixtures. We show that ITP can also be applied for realizing further microfluidic operations, such as the merging and mixing of multiple samples. Using FEM simulations we investigate such ITP contacting and analyse the relevant time scale. Furtherm...
Article
Full-text available
The aim of the MicroActive project is to develop an instrument for molecular diagnostics. The instrument will first be tested for patient screening for a group of viruses causing cervical cancer. Two disposable polymer chips with reagents stored on-chip will be inserted into the instrument for each patient sample. The first chip performs sample pre...
Article
Full-text available
A consortium of seven European partners has undertaken the challenging task to develop a miniaturized system capable to isolate and characterize circulating tumor cells (CTC), which should have its use as a time and labor saving, minimally invasive tool for cancer therapy selection and monitoring and for the detection of recurrent disease. This pap...
Article
Full-text available
This work reports on protein transport phenomena discovered in partitioning experiments with a novel setup for continuous-flow two-phase electrophoresis consisting of a microchannel in which a phase boundary is formed in flow direction. Proteins can be partitioned exploiting their affinity to different aqueous phases in two-phase systems. This sepa...
Article
Full-text available
One of the most basic sources of information in biology is nucleic acid. While the nature of DNA (desoxyribonucleic acid) is comparable to a library where all details are stored, RNA (ribonucleic acid) is more involved in information transfer. In the century of information technology, it is only natural to analyze both kinds of nucleic acids for id...
Article
Fully integrated lab-on-chip systems are relatively rare, and no current system can claim to be able to perform all the roles of a laboratory. This article outlines ways of combining specific single modules to form a fully integrated lab-on-a-chip system for deoxyribonucleic acid analysis.
Article
This work aims at a new class of methods for electric field-mediated separation of biomolecules. In contrast to standard techniques, electrophoretic transport was not performed in a single-phase homogenous fluid, but in a system of stratified layers. The large surface-to-volume ratio characteristic for microfluidic systems allows the interactions o...