Kivanc Gorgulu- MD, PhD
- PostDoc Position at Technical University of Munich
Kivanc Gorgulu
- MD, PhD
- PostDoc Position at Technical University of Munich
Postdoctoral Researcher - Comprehensive Cancer Center Munich,TUM
About
57
Publications
26,315
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3,212
Citations
Introduction
Physician-scientist with an imagination for creating new concepts in cancer research by multidisciplinary
approaches.
“Logic will get you from A to B. Imagination will take you everywhere.” - Albert Einstein
Skills and Expertise
Current institution
Additional affiliations
March 2019 - present
November 2014 - April 2019
November 2014 - present
Education
November 2014 - April 2019
September 2006 - January 2013
September 2003 - June 2006
Izmir Science High School
Field of study
- Science
Publications
Publications (57)
Background and Aims: Cells in pancreatic ductal adenocarcinoma (PDAC) undergo autophagy, but its effects vary with tumor stage and genetic factors. We investigated the consequences of varying levels of the autophagy related 5 (Atg5) protein on pancreatic tumor formation and progression. Methods: We generated mice that express oncogenic Kras in prim...
The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, is involved in signal transduction downstream of multiple growth factor, cytokine and integrin receptors 1 . Its requirement for complete RAS-MAPK activation and its role as a negative regulator of JAK-STAT signaling have established SHP2 as an essential p...
Background & aims:
One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) is associated with progression of pancreatic and other solid tumors. We investigated whether loss of P53 function contributes t...
The six transmembrane protein of prostate 2 (STAMP2) is an androgen-regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show that STAMP2 protein expression is increased in human PCa compared with benign prostate that is also correlated with tumor grade and treatment response. We also show that STAMP2 significantly i...
Significance
All cancer lesions sustain alterations in signaling pathways, which are the drivers of disease initiation and progression. Study of altered signaling in cancer is thus important to develop more effective therapeutic regimens as well as better prognostic markers. In this study, we show that two of the most frequently altered signaling p...
Magnetic surface microrollers have demonstrated promise as active drug delivery agents for targeted and minimally invasive disease treatment. Specifically, it can be employed in the circulatory system to locally release therapeutic agents at disease sites, minimizing systemic exposure and reducing side effects, particularly in the treatment of dise...
In cancer research, genetically modified mouse models are used to mimic diseases relevant to human medicine. In our work, we characterize KCP mice that develop a form of pancreatic cancer based on their exocrine pancreatic functionality by determining the amylase activity at different points in the course of the tumor disease.
The results show the...
Pancreatic ductal adenocarcinoma remains one of the deadliest malignancies, with limited treatment options and a high recurrence rate. Recurrence happens often with metastasis, for which cancer cells must adapt to isolation stress to successfully colonize distant organs. While the fibronectin-integrin axis has been implicated in this adaptation, it...
Pancreatic ductal adenocarcinoma (PC) ranks among the deadliest cancers, with a less than 15% 5-year survival rate. Epidemiological studies project that it will become the second leading cause of cancer-associated mortalities in the following decades. The hallmarks of pancreatic cancer lead to tumor aggressiveness and therapeutic resistance. For th...
Advances in the digital pathology field have facilitated the characterization of histology samples for both clinical and preclinical research. However, uncovering subtle correlations between bioimaging, clinical and molecular parameters requires extensive statistical analysis. As a user-friendly software, Hourglass, simplifies multiparametric datas...
Solid cancers like pancreatic cancer (PDAC) frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modelled in genetically-engineered mouse models (GEMM) of PDAC. Here, we systematically screened for human-like NI in Europe's largest repository of GEMM of PDAC com...
Over 90% of pancreatic cancers present mutations in KRAS, one of the most common oncogenic drivers overall. Currently, most KRAS mutant isoforms cannot be targeted directly. Moreover, targeting single RAS downstream effectors induces adaptive resistance mechanisms. We report here on the combined inhibition of SHP2, upstream of KRAS, using the allos...
The use of preprints, research manuscripts shared publicly before completing the traditional peer-review process, is becoming a more common practice among life science researchers. Early-career researchers (ECRs) benefit from posting preprints as they are shareable, citable, and prove productivity. However, preprinting a manuscript involves a discu...
Objective
The lysyl oxidase-like protein 2 (LOXL2) contributes to tumour progression and metastasis in different tumour entities, but its role in pancreatic ductal adenocarcinoma (PDAC) has not been evaluated in immunocompetent in vivo PDAC models.
Design
Towards this end, we used PDAC patient data sets, patient-derived xenograft in vivo and in vi...
Over 90% of pancreatic cancers present mutations in KRAS, one of the most common oncogenic drivers overall. Currently, most KRAS mutant isoforms cannot be targeted directly. Moreover, targeting single RAS downstream effectors induces adaptive resistance mechanisms. We report here on the combined inhibition of SHP2, upstream of KRAS, using the allos...
Mutant KRAS is present in over 90% of pancreatic as well as 30-40% of lung and colorectal cancers and is one of the most common oncogenic drivers. Despite decades of research and the recent emergence of isoform-specific KRASG12C-inhibitors, most mutant KRAS isoforms, including the ones frequently associated with pancreatic ductal adenocarcinoma (PD...
BACKGROUNG & AIMS
The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms and personalized therapy. The contribution of mechanisms regulating the cancer stem cell (CSC) population in different s...
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this
topic has received increasing attention, and many scientists have entered the field. Our knowledge base
and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular
basis updated guidelines for monit...
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this
topic has received increasing attention, and many scientists have entered the field. Our knowledge base
and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular
basis updated guidelines for monit...
Ovarian cancer (OC) is the deadliest gynecological cancer and is currently incurable with standard treatment regimens. Early invasion, intraperitoneal metastasis, and an aggressive course are the hallmarks of OC. The major reason for poor prognosis is a lack of molecular targets and highly effective targeted therapies. Therefore, identification of...
the PDF can be download freely on pubmed.
https://pubmed.ncbi.nlm.nih.gov/33634751/
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monit...
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monit...
Recent advances in cancer neuroscience necessitate the systematic analysis of neural influences in cancer as potential therapeutic targets in oncology. Here we outline recommendations for future preclinical and translational research in this field.
Rationale: Glycogen storage disease type IA (GSD IA) is an inherited disorder of glycogen metabolism characterized by fasting hypoglycemia, hyperuricemia, and hyperlipidemia including hypertriglyceridemia (HTG). Patients have a higher risk of developing acute pancreatitis (AP) because of HTG. AP is a potentially life-threatening disease with a wide...
Neuro-glial activation is a recently identified hallmark of growing cancers. Targeting tumor hyperinnervation in preclinical and small clinical trials has yielded promising antitumor effects, highlighting the need of systematic analysis of neural influences in cancer (NIC). Here, we outline the strategies translating these findings from bench to th...
Pancreatic cancer is one of the deadliest cancer types urgently requiring effective therapeutic strategies. Autophagy occurs in several compartments of pancreatic cancer tissue including cancer cells, cancer associated fibroblasts, and immune cells where it can be subjected to a multitude of stimulatory and inhibitory signals fine-tuning its activi...
Aim: In this research, we aimed to investigate the effects extremely low frequency electromagnetic fields (ELF-EMF) on proliferation and apoptosis during treatment of primary and metastatic colon cancer cell lines. Material and Methods: Colon cell lines; COLO-320, COLO-741 and as control mouse fibroblast (STO) cells were cultured in 24 wells of tis...
Pancreatic ductal adenocarcinoma is a devastating malignancy, which is the result of late diagnosis, aggressive disease, and a lack of effective treatment options. Thus, pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer-related death by 2030. This review summarizes recent developments of oncological therapy...
OZET Amaç: Kronik hastalık yönetimi için en iyi bilinen, en etkili ve çok kullanılan model, " Kronik Bakım Modeli " dir. Kronik Hastalık Bakımını Değerlendirme Ölçeği hasta sürümü (KBDh) (PACIC) bu modele göre geliştirilmiş bir araçtır. Bu çalışmanın amaçları; 1-PACIC (KBDh) ölçüm gerecinin farklı hastalık ve sosyodemografik değişkenliklere olan du...
Pancreatic cancer belongs to the most aggressive cancer types, with an incidence rate equallig mortality rate. It is well‐known that type 2 diabetes is a significant risk factor for pancreatic cancer. Interestingly, several studies have shown that pancreatic cancer can also lead to type 2 diabetes, as part of the pancreatic cancer induced paraneopl...
Abstract
Aim: In this research, we aimed to investigate the effects extremely low frequency electromagnetic fields (ELF-EMF) on proliferation and apoptosis during treatment of primary and metastatic colon cancer cell lines.
Material and Methods: Colon cell lines; COLO-320, COLO-741 and as control mouse fibroblast (STO) cells were cultured in 24 wel...
Evidence that elongation factor 2 kinase (eEF-2K) has potential as a target for anticancer therapy and possibly for the treatment of depression is emerging. Here the steady-state kinetic mechanism of eEF-2K is presented using a peptide substrate and is shown to conform to an ordered sequential mechanism with ATP binding first. Substrate inhibition...
Objectives: Colon cancer is the second most frequent reason in the cancer-related
deaths in the world. It is reported that colon cancer is the 3rd most frequent cancer in
males and the 4th most frequent cancer in female. During cancer therapy, the correct
time and correct medicine is crucial for different patients. In addition, the primary and
meta...
Questions
Question (1)
I have been trying to use DMEM without amino acids + 10%FCS, but unfortunately I could not get any results. For colony formation assay, generally we seed around 300 cells per well, and after seeding them we change their mediums with amino acid starvation medium. How should I arrange timing for amino acid starvation? Should I leave the cells first in amino acid free medium and change with normal medium for last 3-4 days of colony formation assay as some papers show? Thank you very much for your response and time in advance.
