Kirsten L Erwin

Kirsten L Erwin
Temple University | TU · Department of Neurology

B.S.

About

40
Publications
2,972
Reads
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773
Citations
Introduction
In addition to working in the Department of Neurology at Temple University Hospital as a clinical research coordinator, I am also the general manager and chief editor for Dr. Robert J. Schwartzman's scholarly publishing company, RJS Medical Press LLC. Our first publication is now available, the second printing of the Neurologic Examination.
Additional affiliations
January 2020 - September 2020
RJS Medical Press LLC
Position
  • Editor
Description
  • RJS Medical Press LLC is a self-publishing company founded by Dr. Robert J. Schwartzman, MD, in 2020. Our focus is on publishing medical reference and text books. We are a member of Crossref, the member organization for scholarly publishers. As Chief Editor, I assist with manuscript preparations and as General Manager, I arrange for the publication and advertising needs of the books for both print and electronic format.
January 2020 - present
Temple University
Position
  • Project Manager
Description
  • I'm involved with information management for both research and research studies using Access databases and creating data collection tools for the ALS treatment and studies group.
January 2004 - December 2019
Drexel University College of Medicine
Position
  • Clinical Research and Administrative Coordinator

Publications

Publications (40)
Article
Full-text available
Quantitative sensory testing (QST), with thermal threshold determinations, is a routine part of the comprehensive clinical workup of patients suffering from chronic pain, especially those with Complex Regional Pain Syndrome seen at our outpatient pain clinic. This is done to quantitatively assess each patient's small fiber and sensory function in a...
Article
The spread of complex regional pain syndrome (CRPS) has been well documented. Many severe refractory long-standing patients have total body pain (TBP) that evolved from a single extremity injury. The purpose of this study was to document by objective sensory threshold testing the extent of body area involvement in 20 long-standing patients with CRP...
Article
BACKGROUND: Complex Regional Pain Syndrome (CRPS), formerly known as Reflex sympathetic disorder (RSD) is a neuropathic disorder following up to 5% of all minor trauma that is characterized by chronic pain, skin changes, and swelling. Literature supports that CRPS is a multiorgan disease with autonomic dysfunction but to our knowledge, no study to...
Article
To compare and contrast body mass indices calculated based on self-reported height and weight as compared with measured height and weight in migraine patients. Obesity is a risk factor for multiple neurological disorders including stroke, dementia, and migraine chronification. In addition, several cytokines and adipocytokines associated with migrai...
Article
Full-text available
Complex regional pain syndrome (CRPS) is a severe chronic pain condition characterized by sensory, autonomic, motor, and dystrophic signs and symptoms. This study was undertaken to expand our current knowledge of the evolution of CRPS signs and symptoms with duration of disease. This was a retrospective, cross-sectional analysis using data extracte...
Article
Full-text available
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disorder. While most cases of ALS are sporadic, 10-15% are familial, and of these 15-20% possess a mutation in the gene that codes for the enzyme Cu/Zn superoxide dismutase (SOD1). In families of ALS patients with specific SOD1 mutations, affected members demonstrate significant het...
Article
Full-text available
Transgenic mice expressing multiple copies of the G93A mutant form of SOD1 develop motor neuron pathology and clinical symptoms similar to those seen in patients with amyotrophic lateral sclerosis (ALS). The phenotype of these mice is dependent on the number of transgene copies in their genome. Changes in transgene copy number, although rare, can s...
Article
To determine sensitivity of equine skeletal muscle to tetrodotoxin and compare that with sensitivity of murine and human skeletal muscles. Semimembranosus, vastus lateralis, triceps brachii, and masseter muscle specimens from 22 euthanatized horses, vastus lateralis muscle biopsy specimens from 25 clinically normal humans, and diaphragmatic muscle...
Article
Previous studies have demonstrated that phenytoin decreases the levels of triacylglycerols in several tissues other than skeletal muscle. Since phenytoin is clinically effective in several skeletal muscle disorders, triacylglycerol metabolism in skeletal muscle from four normal Quarter horses and four Quarter horses with hyperkalemic periodic paral...
Article
Based on studies in swine, the malignant hyperthermia syndrome has been postulated to result from an enhanced sensitivity (low threshold) of the Ca2(+)-induced Ca2(+)-release process. However, fatty acid production is elevated in homogenates of skeletal muscle from pigs and humans susceptible to malignant hyperthermia. In the present study, we demo...
Article
The incorporation of [14C]oleic and [14C]linoleic acid into phospholipids and neutral lipids was compared in two recently immortalized airway epithelial cell lines. In addition, the effects of adrenergic stimulation on phospholipid turnover was examined. Both cell lines readily incorporated the fatty acids into all phospholipid and neutral lipid fr...
Article
Melittin from bee venom has been suggested to activate tissue phospholipase A2 (PLA2) activity, and subsequently has been used as a specific PLA2 probe. The melittin in most cases was obtained commercially and used without further purification or treatment. To test the hypothesis that commercially obtained melittin specifically activates tissue PLA...
Article
In the absence of halothane challenge, incubates of skeletal whole-muscle homogenates from malignant-hyperthermia-susceptible humans and pigs exhibit greater free fatty acid production than controls, which has been attributed to elevated phospholipase A2 activity. The present study examines lipid profiles of human muscle (vastus lateralis) prior to...
Article
Previous studies demonstrated that lipid profiles of humans and pigs susceptible to malignant hyperthermia (MH) differ from those of normal humans and pigs. Lipid extraction techniques retaining in vivo lipid profiles most closely were used in the present study to determine if stimulation of lipolysis by the processes of homogenization or extractio...
Article
Dantrolene is an effective antagonist of anesthesia-induced malignant hyperthermia due to a poorly understood action on skeletal muscle. The present study examines whether the red blood cell can be used as a model to investigate the mechanism of dantrolene action. Halothane (4.7 mm) caused 9% hemolysis of red blood cells. Phospholipase A2 (1 μm) al...
Article
Full-text available
The effects on erythrocyte fragility of two general anaesthetic agents (halothane and ethanol) and succinylcholine were examined using preparations from 13 normal and four malignant hyperthermia susceptible patients. Erythrocyte fragility was determined by the degree of haemolysis induced in solutions of decreasing osmolarity of NaCl. Halothane cau...
Article
The authors examined the lipid distribution and PLA2 activity of skeletal muscle from three pigs in each of three phenotypic groups. The three groups did not differ in respect to total FFA, cholesterol, triglycerides, or total lipid phosphorus. The distributions of phospholipids, as determined by 2-D TLC and phosphorus quantification, and fatty aci...
Conference Paper
The authors examined the lipid distribution and PLA2 activity of skeletal muscle from three pigs in each of three phenotypic groups. The three groups did not differ in respect to total FFA, cholesterol, triglycerides, or total lipid phosphorus. The distributions of phospholipids, as determined by 2-D TLC and phosphorus quantification, and fatty aci...
Article
Morphine, ketamine, ethylketocyclazocine and quipazine, drugs with an apparent local spinal serotonergic action, which contributes to their analgesic effects, were tested for their ability to alter the release of [3H]serotonin ([3H]5-HT) from a synaptosomal preparation from the spinal cord of the rat. Related compounds including [D-Ala2, D-Leu5]enk...
Article
We prepared FMoxLP by oxidation of FMLP and evaluated its ability to trigger a variety of granulocyte responses. FMoxLP was found to depolarize granulocyte membranes; increase granulocyte oxygen consumption, superoxide production, and hydrogen peroxide production; compete with FMLP for binding to granulocytes; and stimulate granulocyte chemotaxis....
Article
We prepared FMoxLP by oxidation of FMLP and evaluated its ability to trigger a variety of granulocyte responses. FMoxLP was found to depolarize granulocyte membranes; increase granulocyte oxygen consumption, superoxide production, and hydrogen peroxide production; compete with FMLP for binding to granulocytes; and stimulate granulocyte chemotaxis....

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