Kiran N S

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Verified

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• Doctor of Philosophy in Biotechnology
• Doctoral Researcher at REVA University

Neuroinflammation is a hallmark of various neurodegenerative and neuropsychiatric disorders, driven by complex interactions between neurotransmitter receptors and immune signaling pathways. Among these, heteroreceptor complexes—functional assemblies formed by the physical interaction of different G protein-coupled or ionotropic receptor subtypes wi...

The gastrointestinal mycobiome, comprising diverse fungal species, plays a significant role in gastrointestinal carcinogenesis and inflammatory bowel disease (IBD) pathogenesis. Recent studies have demonstrated that dysbiosis of the gut mycobiome, characterized by an overrepresentation of pathogenic fungi such as Candida albicans and Aspergillus, c...

Alzheimer’s, Parkinson’s, Huntington’s, multiple sclerosis, and other associated brain illnesses are largely caused by neurodegeneration. Their intricate pathophysiology frequently involves mitochondrial dysfunctions, misfolded polypeptide negativity, demyelination, genetic and neurochemical deficiencies, and genetic and neurochemical deficits. Neu...

Nanoparticle-based biomarkers have emerged as a transformative tool for the diagnosis and monitoring of neurological disorders, offering unparalleled sensitivity and specificity. This chapter explores the application of diverse nanoparticles, including gold nanoparticles, quantum dots, and magnetic nanoparticles, in detecting biomarkers for disease...

This review assesses the antiviral capabilities of antimicrobial peptides (AMPs) against SARS-CoV-2 and other respiratory viruses, focussing on their therapeutic potential. AMPs, derived from natural sources, exhibit promising antiviral properties by disrupting viral membranes, inhibiting viral entry, and modulating host immune responses. Preclinic...

Zebrafish (Danio rerio) have become indispensable models for advancing our understanding of multiple metabolic disorders such as obesity, diabetes mellitus, dyslipidemia, and metabolic syndrome. This review provides a comprehensive analysis of zebrafish as a powerful tool for dissecting the genetic and molecular mechanisms of these diseases, focusi...

This study aimed to develop and optimize glimepiride microparticles (GM) using the solvent evaporation technique, employing polymers like ethyl cellulose, Eudragit RL100, and RS100 in various ratios. The optimized GM formulation (F2) demonstrated a mean particle size of 1.75 μm, a polydispersity index (PDI) of 0.59, and a zeta potential of 1.396 mV...

The disposal of electronic waste (EW) in open landfills has caused several toxic environmental effects. The harmful metallic components released in the environment due to deposition of EW act as hazards for living systems. EW management has been widely studied in recent days across the world. Though, several processes are implemented in extraction,...

The current research divulges the synthesis of two new Schiff base (SB) (LNAPH/LO-VAN) derived from 8-aminoquinoline (8-AMQ) in the presence of 2-hydroxy naphthaldehyde (NAPH) and ortho-vanillin (O-VAN) in CH3OH solvent. They are structurally characterized by spectroscopic methods (IR/Raman/UV-vis/DRS/NMR) and SEM-EDX. SB compounds have a biologica...

Food production must undergo systems change to meet the sustainable development goals (SDGs). For example, organic farming can be empowered by soil microorganisms with plant growth promotion (PGP) and biocontrol features. In this context, there have been limited studies on pomegranate. We investigated microbial diversity in rhizosphere of the pomeg...

This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including the complexities involved and the perspectives on how to navigate them. In the realm of nanomedicines, ensuring the safety of nanomaterials is paramount due to their unique characteristics and potential interactions with biological systems....

Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted...

Zebrafish (Danio rerio) has ascended as a pivotal model organism in the realm of gut-brain axis research, principally owing to its high-throughput experimental capabilities and evolutionary alignment with mammals. The inherent transparency of zebrafish embryos facilitates unprecedented real-time imaging, affording unparalleled insights into the int...

Microbial exopolysaccharides (EPS) have gained significant attention as versatile biomolecules with multifarious applications across various sectors. This review explores the valorisation of EPS and its potential impact on diverse sectors, including food, pharmaceuticals, cosmetics, and biotechnology. EPS, secreted by microorganisms, possess unique...

Alzheimer’s disease (AD) is regarded as the most common neurological condition in terms of cognition. The disease progresses gradually, begin with a slight memory loss and maybe lead to the lack of communication as well as environmental awareness. Like the majority of neurological conditions, Alzheimer’s disease has no proven effective drug and tre...

On exposure to cosmetic pollutants, gastrointestinal dysbiosis, which is characterised by a disturbance in the gut microbiota, has come into focus as a possible contributor to the occurrence of neurotoxic consequences. It is normal practice to use personal care products that include parabens, phthalates, sulphates, triclosans/triclocarbans and micr...

In the clearest definition, phytochemicals are described as substances that plants generate. However, the phrase is frequently employed to refer to plant-derived compounds that might have biological effects but are not necessarily nutrients. Contrary to essential nutrients, phytochemicals are not necessary for cytological development, but they are...

Immunotherapy is a form of disease treatment that makes use of the patient’s own immune response. Immunotherapy can alter or enhance the immune system’s functioning to help it identify and combat defective cells. Contrary to various available therapies, immunotherapy has proven to be highly efficacious in the treatment of neurological disorders, es...

Diazinon is an organophosphate pesticide and its utilization ranges in numerous fields including agriculture, gardening and indoor pest managements, subsequently, they are marketized globally under several brand names. Despite the fact, that this compound has a versatile role on daily basis, its detrimental effects are unavoidable. Diazinon can dis...

An effective fumigant for protecting stored goods from insects is dichlorvos (DDVP) (62–73-7), a volatile organophosphate pesticide. Additionally, it's used as a flea collar for dogs, an anthelmintic for dogs, pigs, and horses, a botacide (to reduce fly larvae) for horses, and as an anti-fly medication for swine. The acetylcholinesterase enzyme is...

Tetrachlorvinphos ((Z)-2-Chloro-1-(2,4,5-trichlorophenyl)ethen-1-yl dimethyl phosphate) is an organophosphate insecticide used in cattle, hogs, goats, and horses as a cutaneous and oral fodder (feed supplement) biocontrol agent. It's also found in animal flea collars and resting locations. In acute toxicity investigations, tetrachlorvinphos was sho...

Trichlorfon (2,2,2 Trichloro-1-hydroxyethyl) is an organophosphate pesticide for widespread use. It is employed to manage pests on golf course grass, household gardens, non - food interaction areas of animal and feed processing factories, decorative bushes and trees, and decorative and baiting fish ponds after bio activation to dichlorvos. Like all...

Petroleum product is an essential resource for energy, that has been exploited by wide range of industries and regular life. A carbonaceous contamination of marine and terrestrial environments caused by errant runoffs of consequential petroleum-derived contaminants. Additionally, petroleum hydrocarbons can have adverse effects on human health and g...

The recent advancement and innovation in the field of nanotechnology brings new dimensions in its applicative potential in the food sector. The amalgamation of nanotechnology with food sector by applying the bio-based nanoparticles (NPs) enables the prospective application of these NPs in the areas of the food packaging , processing, enhancement of...

Elevated demand and extensive exploitation of cosmetics in day-to-day life have hiked up its industrial productions worldwide. Organic and inorganic chemicals like parabens, phthalates, sulfates, and so forth are being applied as constituents towards the formulations, which tend to be the mainspring ecological complication due to their enduring nat...

Pesticides are the chemical compounds that act on pests and harmful pathogens in the agricultural field therebyenhancing the yield. Herbicides, pesticides, and insecticides mainly constitute to a diverse range of chemicals calledorganophosphates. There has been extensive use of organophosphates in the major fields namely agriculture,horticulture, p...