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Kieron J Sweeney

Kieron J Sweeney
National centre for NeurosuregeryBeaumont Hospital

MB BCH BAO MD FRCSI (SN)

About

52
Publications
3,106
Reads
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158
Citations
Introduction
Consultant Neurosurgeon Honorary Clinical Senior Lecturer Royal College of Surgeons in Ireland
Additional affiliations
July 2012 - present
Royal College of Surgeons in Ireland
Position
  • Clinical Lecturer in Neurosurgery
July 2011 - July 2013
Royal College of Surgeons in Ireland
Position
  • MD research student in Neurosurgery

Publications

Publications (52)
Article
Background Glioblastoma (GBM) is the most common and malignant primary brain tumour having a median survival of just 12-18 months following standard therapy protocols. Local recurrence, post-resection and adjuvant therapy occurs in most cases. New Method U87MG-luc2-bearing GBM xenografts underwent 4.5 mm craniectomy and tumour resection using micr...
Article
Current therapeutic strategies against glioblastoma multiforme (GBM) have failed to prevent disease progression and recurrence effectively. The part played by molecular imaging (MI) in the development of novel therapies has gained increasing traction in recent years. For the first time, using expertise from an integrated multidisciplinary group of...
Article
Object: McLone and Knepper's unified theory of Chiari malformation Type II (CM-II) describes how the loss of CSF via the open posterior neuropore fails to create adequate distending pressure for the developing rhomboencephalic vesicle. The authors of the present article describe the relationship between the posterior fossa volume and intracranial...
Conference Paper
Purpose: Considerable circuitry differences exist between human and rodent brain tissue, which may hinder translation of scientific discoveries to clinical practice. Ex vivo human brain tissue allows experimental investigation of pathophysiological mechanisms. In particular, an assessment of the contribution of synaptic transmission at the level of...
Conference Paper
Purpose: Conventional knowledge suggests that fast synaptic excitation mediated by the activation of AMPA receptors (AMPAr) plays a key role in ictogenesis. Recent work has demonstrated the existence of a slow to desensitise AMPAr in cortical pyramidal neurones. The slow AMPAr has a high affinity for glutamate and can remain open for several hundre...
Conference Paper
Background Advances in sequencing technologies has driven genetic discovery in epilepsy. The contri- bution of somatic variants in epilepsy has recently been demonstrated, particularly in the aetiology of malformations of cortical development (MCD). The aim of this study was to determine the diagnostic yield of somatic variants in somatic and germl...
Article
Historically, pre-clinical GBM models have largely failed to predict response in the clinical setting. Here, we establish a more clinically faithful model using the syngeneic NFpp10a-Luc2 mesenchymal-GBM cell line to study response to resection and temozolomide (TMZ), adjuvant/neo-adjuvant anti-PD1 and Regorafenib (REGO) therapy. Cells were orthoto...
Article
Objective Refractory idiopathic generalised epilepsy (IGE; also known as genetic generalised epilepsy) is a clinical challenge due to limited available therapeutic options. While vagus nerve stimulation (VNS) is approved as an adjunctive treatment for drug-resistant focal epilepsy, there is limited evidence supporting its efficacy for refractory IG...
Article
Full-text available
Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤ 9 months, Short term survivors, STS) and long survival (...
Article
Full-text available
We describe the management of a 39-year-old woman with intractable focal epilepsy whose condition deteriorated during pregnancy and who required emergency neurosurgery. A literature search did not identify any previous reports of epilepsy surgery in pregnancy. To our knowledge, this is the first time surgery was planned and executed in rapid order...
Article
Full-text available
Vagus nerve stimulation is a well-established treatment option for patients with drug-resistant epilepsy and has an expanding range of other clinical indications. Side effects of vagus nerve stimulation therapy include: cough; voice changes; vocal cord adduction; rarely, obstructive sleep apnoea; and arrhythmia. Patients with implanted vagus nerve...
Preprint
Full-text available
Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤9 months, Short term survivors, STS) and long survival (≥36 months,...
Article
Full-text available
Malignant gliomas are a type of primary brain tumour that originates in glial cells. Among them, glioblastoma multiforme (GBM) is the most common and the most aggressive brain tumour in adults, classified as grade IV by the World Health Organization. The standard care for GBM, known as the Stupp protocol includes surgical resection followed by oral...
Article
Background New precision medicine therapies are urgently required for glioblastoma (GBM). However, to date, efforts to subtype patients based on molecular profiles, have failed to direct treatment strategies. We hypothesized that interrogation of the GBM tumor microenvironment (TME) and identification of novel TME specific subtypes could inform new...
Article
Clinically faithful pre-clinical models are essential for screening therapies and studying resistance mechanisms. Historically models have failed to predict response in the clinical setting. Current models seldom incorporate surgical resection, and commonly use young animals whose immune contexture differs from older patients. Here, we have establi...
Article
New precision medicine therapies are urgently required for glioblastoma (GBM). However, to date, efforts to subtype patients based on molecular profiles, have failed to direct treatment strategies. We hypothesized that interrogation of the GBM tumor microenvironment (TME) and identification of novel TME-specific subtypes could inform new precision...
Article
While magnetic resonance imaging (MRI) is the predominant imaging modality for glioblastoma (GBM), pre-clinical MRI scanner availability is limited. As pre-clinical CT is more widely available and cost-effective, this study aimed to 1) establish preclinical-GBM CT and CT-radiomic workflows, 2) identify whether CE-CT could detect murine orthotopic G...
Article
Full-text available
Antisense inhibition of microRNAs is an emerging preclinical approach to pharmacoresistant epilepsy. A leading candidate is an ‘antimiR’ targeting microRNA‐134 (miR‐134), but testing to date has used rodent models. Here, we develop an antimiR testing platform in human brain tissue sections. Brain specimens were obtained from patients undergoing res...
Article
Full-text available
Glioblastoma (GBM) is the most aggressive adult brain tumour with a dismal 2-year survival rate of 26–33%. Maximal safe resection plays a crucial role in improving patient progression-free survival (PFS). Neurosurgeons have the significant challenge of delineating normal tissue from brain tumour to achieve the optimal extent of resection (EOR), wit...
Preprint
Full-text available
Introduction An emerging pre-clinical approach for the treatment of pharmacoresistant epilepsy is targeting the microRNA (miRNA) system. MiRNAs are short noncoding RNAs that suppress gene expression at the post-transcriptional level. Targeting miRNAs, which is possible using antisense oligonucleotide ‘antimiRs’ can produce broad effects on gene exp...
Article
Full-text available
Background The surgical management of deep brain lesions is challenging, with significant morbidity. Advances in surgical technology have presented the opportunity to tackle these lesions. Methods We performed a complete resection of a thalamic/internal capsule CM using a tubular retractor system via a parietal trans-sulcal para-fascicular (PTPF)...
Article
The surgical management of brainstem glioma is challenging and has significant morbidity. Advances in surgical armamentarium has presented the opportunity to tackle these lesions. We present the case of a paediatric patient with a 2.3cm midbrain pilocytic astrocytoma. With the aid of tractography, neuro-navigation, 3-dimensional exoscope and a tubu...
Article
The surgical management of brainstem glioma is challenging and has significant morbidity. Advances in surgical armamentarium has presented the opportunity to tackle these lesions. We present the case of a paediatric patient with a 2.3cm midbrain pilocytic astrocytoma. With the aid of tractography, neuro-navigation, 3-dimensional exoscope and a tubu...
Article
Full-text available
Glioblastoma (GBM), a highly invasive and vascular malignancy is shown to rapidly develop resistance and evolve to a more invasive phenotype following bevacizumab (Bev) therapy. Rho Guanine Nucleotide Exchange Factor proteins (RhoGEFs) are mediators of key components in Bev resistance pathways, GBM and Bev-induced invasion. To identify GEFs with en...
Article
Full-text available
GBM is a devastating disease with peak incidence in the seventh decade. Pre-clinical models are essential for studying resistance mechanisms and screening novel therapies. However, historically these models have failed to predict response in humans. Current models seldom incorporate surgical resection, and commonly use young animals whose immune co...
Article
Full-text available
Background: Intracranial and orbital abscesses in combination together are rare complications of sinusitis. They can be life-threatening and can result in multiple sequelae. Case presentation: A 9-year-old female presented with left periorbital swelling, gaze restriction and headache. Following scans, she underwent emergency endoscopic sinus surge...
Article
Spontaneous extensive spinal epidural haematoma poses a unique challenge for the neurosurgeon. Performing extensive laminectomies to remove all of the compressive haematoma can destabilise the patient’s spinal column, which may require fixation. This is further complicated in patients with significant coagulopathy. We present a novel use of recombi...
Chapter
Despite some apparent similarities several differences exist between adult and paediatric craniopharyngiomas starting from the histology. Papillary CPs occur almost exclusively in adults, whereas adamantinomatous CPs can occur in a bimodal age distribution but have been found in any age group. Adamantinomatous CPs tend to be more complicated lesion...
Chapter
The thoracic spine occupies a unique position with respect to anatomical, biomechanical, pathological, and surgical considerations. The kyphosis of the thoracic spine is offset by the lordosis in the mobile cervical spine and the principal load bearing lumbar spine maintaining a sagittal balanced posture. Due to the biomechanical properties of the...
Chapter
Due to the high incidence carotid artery disease and cerebral ischaemia, accurate and timely diagnosis and treatment is required to reduce the significant morbidity and mortality associated with these conditions. This chapter discusses the epidemiology, pathophysiology, clinical presentation, investigation, and treatment of these conditions. Cerebr...
Article
Full-text available
Background Postnatal closure of a myelomeningocele remains the standard of care in many countries. The prenatal closure has given hope for decreasing the damage to the neural placode and has challenged classic management. However, this technique presents potential sources of complications. Patients with MMC with an anatomical level of L4 and below...
Article
DNMT3A codes for a DNA methyl transferase enzyme that plays a central role embryogenesis. Somatic mutations in this gene have been associated with tumorigenesis and are associated with a number of cancers. The recently described Tatton‐Brown–Rahman syndrome (TBRS) is due to heterozygous germline mutations in the DNMT3A gene. So far, only one case o...
Article
Full-text available
The development of an effective and safe treatment for glioblastoma (GBM) represents a significant challenge in oncology today. Downregulation of key mediators of cell signal transduction by RNA interference is considered a promising treatment strategy but requires efficient, intracellular delivery of siRNA into GBM tumor cells. Here, we describe n...
Conference Paper
Introduction Nombreuses techniques chirurgicales ont été proposées pour agrandir et remodeler le front dans le cadre de la trigonocéphalie. Toutes ces techniques présentent un risque de saignement au cours des ostéotomies, en particulier dans la région du sinus sagittal supérieur (SSS) enfoui dans la suture soudée précocement et au niveau des émiss...
Article
Introduction Les craniopharyngiomes de l’enfant représentent un sujet de débat et un challenge chirurgical pour le neurochirurgien pédiatrique pour assurer des meilleurs résultats visuels, endocriniens, neuropsychologique et en termes de qualité de vie. Nous rapportons une série de patients traités entre 2004 et 2017 à Lyon. Matériel et méthodes N...
Article
Full-text available
Glioblastoma (GBM), a highly invasive brain malignancy, remains an incurable disease. Angiogenesis, the formation of new vasculature, is a defining feature of this disease. Targeting GBM angiogenesis with Bevacizumab (Bev) is associated with improved progression free survival, but may also enhance tumour invasion into the surrounding parenchyma (No...
Conference Paper
Full-text available
Introduction: Beaumont Hospital is the Neurosurgical centre for Ireland serving a population of 3.6 million. We present data on all perinatal patients who required ICU admission for Neurosurgical conditions over an 8 year period. Our data presents an insight into the incidence and outcome of Neurosurgical conditions during pregnancy Methods: Searc...
Article
Introduction: Grade II and III intramedullary ependymomas [IME] are circumscribed with a plane of cleavage that should facilitate high gross total resection rates (GTR). Gross total resection of grade II/III IME is superior to subtotal resection (STR) and radiotherapy (RTx) for progression-free and overall survival. We sought to compare our GTR wit...
Article
Full-text available
Introduction: Subarachnoid haemorrhage (SAH) may arise spontaneously or as a result of trauma. Spontaneous SAH accounts for about 5% of all strokes. Ruptured aneurysms are the cause of 85% of spontaneous SAH. The most characteristic clinical feature is sudden-onset severe headache. Other features include vomiting, photophobia, and focal neurologic...
Article
Pancreatic neuroendocrine tumor (NET) is frequently encountered in patients with von Hippel-Lindau disease (VHL) and uncommonly metastasizes to the central nervous system. Here, we present the case of a VHL patient with symptomatic pancreatic NET metastases to both the cervical spinal cord and a preexisting brainstem hemangioblastoma (e.g., tumor-...
Article
Full-text available
Isolated intracranial Rosai-Dorfman Disease is rare. Here, we describe a patient who developed an asymptomatic, right parietal RDD lesion over 18 months while being followed radiographically for another brain lesion. To our knowledge, rapid, de novo radiographic formation of isolated intracranial RDD has never been reported in an asymptomatic patie...

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