Ki-Taek Lim

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Verified

Ki-Taek verified their affiliation via an institutional email.

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• Doctor of Engineering
• Professor at Kangwon National University

Bone hemorrhage, infection, and large bone defects following surgical treatment of traumatic bone injury have raised potential concerns, underscoring the urgent need to develop multifunctional therapeutic platforms that can effectively address traumatic bone regeneration. Advancements in three-dimensional (3D) printing technology have propelled the...

Antibiotics have revolutionized medical treatment by effectively combating bacterial infections, particularly those associated with chronic wounds and implant complications. Nevertheless, the persistent use of these drugs has resulted in an increase in antibiotic-resistant bacteria and biofilm infections, highlighting the urgent need for alternativ...

In this review, we explore the exciting potential of nanodiamonds (NDs) as innovative materials for future wound dressings. These materials aim to tackle important issues in wound care and offer fresh solutions. While NDs show promising mechanical and structural properties, their full potential in wound healing applications is still not fully explo...

Biomaterial composition and surface charge play a critical role in macrophage polarization, providing a molecular cue for immunomodulation and tissue regeneration. In this study, we developed bifunctional hydrogel inks for accelerating M2 macrophage polarization and exosome (Exo) cultivation for wound healing applications. For this, we first fabric...

Physical stimuli-responsive DNA hydrogels hold immense potential for tissue engineering due to their inherent biocompatibility, tunable properties, and capacity to replicate the mechanical environment of natural tissue, making physical stimuli-responsive DNA hydrogels a promising candidate for tissue engineering. These hydrogels can be tailored to...

The rise of antibiotic resistance has made bacterial infections a persistent global health issue. In particular, extracellular polymeric substances (EPS) secreted by bacteria limit the effectiveness of conventional antibiotics, making biofilm removal challenging. To address this, we created ND@PDA nanoparticles by coating the surface of nanodiamond...

Background: The shift towards sustainable and ethical food systems has accelerated advancements in cultured meat technology. Cultured meat, or lab-grown meat, offers a revolutionary approach to meat production by addressing environmental, ethical, and health issues associated with conventional livestock farming. Traditional meat production contribu...

The high bioactivity and biocompatibility of hydroxyapatite (HAP) make it a useful bone graft material for bone tissue engineering. However, the development superior osteoconductive and osteoinductive materials for bone regeneration remains a challenge. To overcome these constraints, Cu‐doped hydroxyapatite (HAP(Cu)) from waste eggshells has been p...

Traditional bioreactor systems involve the use of three-dimensional (3D) scaffolds or stem cell aggregates, limiting the accessibility to the production of cell-secreted biomolecules. Herein, we present the use a pulse electromagnetic fields (pEMFs)-assisted wave-motion bioreactor system for the dynamic and scalable culture of human bone marrow-der...

Nanocelluloses have garnered significant attention recently in the attempt to create sustainable, improved functional materials. Nanocellulose possesses wide varieties, including rod‐shaped crystalline cellulose nanocrystals and elongated cellulose nanofibers, also known as microfibrillated cellulose. In recent times, nanocellulose has sparked rese...

Rapid regeneration of the injured tissue or organs is necessary to achieve the usual functionalities of the damaged parts. However, bacterial infections delay the regeneration process, a severe challenge in the personalized healthcare sector. To overcome these challenges, 3D-printable multifunctional hydrogels of Zn/tannic acid-reinforced glycol fu...

A facile wet chemistry-based strategy was developed to synthesize orange emissive Carbon dots (O-CDs) based on dehydration-induced ring-fusion of the precursor (1,3-dihydroxynaphthalene) in a dehydrating sulfuric acid medium. The O-CDs revealed significant Near-infrared (808 nm) light harvesting potential with outstanding photothermal conversion ef...

Stimuli-responsive micro/nanorobots have revolutionized biomedical research by overcoming the therapeutic limitations that require critical medical interventions. These micro/nanorobots are designed to move through the body's circulatory system and hold promise for advanced micro/nano surgery, targeted drug delivery, immunotherapy, and combating ba...

Fabricating anisotropic multifunctional bioadhesive patches with tunable mechanical stiffness, electrical conductivity, antimicrobial activity, and modulating cellular behavior is crucial for the successful management of cardiac tissue injury and boosting immunogenic microenvironments. Direct ink writing (DIW)-based 3D printing holds tremendous pot...

Photosensitizing agents have received increased attention from the medical community, owing to their higher photothermal efficiency, induction of hyperthermia, and sustained delivery of bioactive molecules to their targets. Micro/nanorobots can be used as ideal photosensitizing agents by utilizing various physical stimuli for the targeted killing o...

The convergence of advanced nanotechnology with disease diagnosis has ushered in a transformative era in healthcare, empowering early and accurate detection of diseases and paving the way for timely interventions, improved treatment outcomes, and enhanced patient well‐being. The development of novel materials is frequently the impetus behind signif...

The convergence of advanced nanotechnology with disease diagnosis has ushered in a transformative era in healthcare, empowering early and accurate detection of diseases and paving the way for timely interventions, improved treatment outcomes, and enhanced patient well-being. The development of novel materials is frequently the impetus behind signif...

Macrophages play an essential role in immunotherapy and tissue regeneration owing to their remarkable plasticity and diverse functions. Recent bioengineering developments have focused on using external physical stimuli such as electric and magnetic fields, temperature, and compressive stress, among others, on micro/nanostructures to induce macropha...

Reconstruction of injured bone remains challenging in the clinic owing to the lack of suitable bone grafts. The utilization of PAI-1 transfected-conditioned media (P-CM) has demonstrated its ability to facilitate the differentiation process of mesenchymal stem cells (MSCs), potentially serving as a crucial mediator in tissue regeneration. This rese...

Nanocellulose-based tissue adhesives show promise for achieving rapid hemostasis and effective wound healing. Conventional methods, such as sutures and staples, have limitations, prompting the exploration of bioadhesives for direct wound adhesion and minimal tissue damage. Nanocellulose, a hydrolysis product of cellulose, exhibits superior biocompa...

Developing multifunctional hydrogels for wearable strain sensors has received significant attention due to their diverse applications, including human motion detection, personalized healthcare, soft robotics, and human-machine interfaces. However, integrating the required characteristics into one component remains challenging. To overcome these lim...

3D printing and electrospinning are versatile techniques employed to produce 3D structures, such as scaffolds and ultrathin fibers, facilitating the creation of a cellular microenvironment in vitro. These two approaches operate on distinct working principles and utilize different polymeric materials to generate the desired structure. This review pr...

The skin serves as the body's outermost barrier and is the largest organ, providing protection not only to the body but also to various internal organs. Owing to continuous exposure to various external factors, it is susceptible to damage that can range from simple to severe, including serious types of wounds such as burns or chronic wounds. Macrop...

The fluorescent carbon dots (C-dots) are attractive platforms in bioimaging, biosensing, and disease detection applications due to their attractive physicochemical characteristics. Herein, we synthesized fluorescent and biocompatible C-dots from banana biomass through heat treatment. The C-dots were soluble in water and showed a fluorescent behavio...

In recent years, additive manufacturing tools, such as 3D printing, has gained enormous attention in biomedical engineering for developing ionotropic devices, flexible electronics, skin‐electronic interfaces, and wearable sensors with extremely high precision and sensing accuracy. Such printed bioelectronics are innovative and can be used as multi‐...

Conductive hydrogels (CHs) are promising alternatives for electrical stimulation of cells and tissues in biomedical engineering. Wound healing and immunomodulation are complex processes that involve multiple cell types and signaling pathways. 3D printable conductive hydrogels have emerged as an innovative approach to promote wound healing and modul...

Electroactive polymer–metal composites (EAPMCs) have gained significant attention in tissue engineering owing to their exceptional mechanical and electrical properties. EAPMCs develop by combining an electroactive polymer matrix and a conductive metal. The design considerations include choosing an appropriate metal that provides mechanical strength...

Recent studies indicate that mitochondrial dysfunctions and DNA damage have a critical influence on cell survival, which is considered as one of the therapeutic targets for cancer therapy. In this study, we demonstrated a comparative study of the effect of polyphenolic carbon quantum dots (CQDs) on in vitro and in vivo anti-tumor efficacy. Dual emi...

Collagen and other natural polymers including hyaluronic acid and chitosan (CS) are common additives for improving the bone forming capacity and retain the structures of xenografts. The topography of the cell-attaching region on implants has a significant role in the cell behavior. To control the topography of calcium phosphate composites (CPCs) in...

Dynamic tracking of cell migration during tissue regeneration remains challenging owing to imaging techniques that require sophisticated devices, are often lethal to healthy tissues. Herein, we developed a 3D printable non-invasive polymeric hydrogel based on 2,2,6,6-(tetramethylpiperidin-1-yl) oxyl (TEMPO)-oxidized nanocellulose (T-CNCs) and carbo...

Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells determines the fate of healing or inflammation. Although several reports have demonstrated that tissue regeneration depends on spatial and temporal regulation of...

Transparent hydrogels have found increasing applications in wearable electronics, printable devices, and tissue engineering. Integrating desired properties, such as conductivity, mechanical strength, biocompatibility, and sensitivity, in one hydrogel remains challenging. To address these challenges, multifunctional hydrogels of methacrylate chitosa...

Pulsatile pressure assists early osteogenesis evaluation onto a 3D-printed soft hydrogel. Article 2202163 by Ki-Taek Lim and co-workers demonstrates the use of short-term pressure stimulation and its effect on proliferation, radical scavenging, and osteogenesis of stem cells. The results highlight the transcriptomic changes in stem cells toward bon...

One of the significant challenges in bone tissue engineering (BTE) is the healing of traumatic tissue defects which requires longer time to recover owing to the recruitment of local infection and delayed angiogenesis. Various strategies, such as hydrogel dressings, growth factors delivery, and stem cell therapy has been shown potential alternative...

Tissues are made up of cells and the extracellular matrix (ECM) which surrounds them. These cells and tissues are actively adaptable to enduring significant stress that occurs in daily life. This astonishing mechanical stress develops due to the interaction between the live cells and the non-living ECM. Cells in the matrix microenvironment can sens...

In recent years, three-dimensional (3D) bioprinting of conductive hydrogels has made significant progress in the fabrication of high-resolution biomimetic structures with gradual complexity. However, the lack of an effective cross-linking strategy, ideal shear-thinning, appropriate yield strength, and higher print fidelity with excellent biofunctio...

Biomimetic soft hydrogels used in bone tissue engineering frequently produce unsatisfactory outcomes. Here, it is investigated how human bone‐marrow‐derived mesenchymal stem cells (hBMSCs) differentiated into early osteoblasts on remarkably soft 3D hydrogel (70 ± 0.00049 Pa). Specifically, hBMSCs seeded onto cellulose nanocrystals incorporated meth...

The development of multifunctional wearable electronic devices has received considerable attention because of their attractive applications. However, integrating multifunctional abilities into one component remains a challenge. To address this, we have developed a tannic acid-functionalized spherical nanocellulose/polyvinyl alcohol composite hydrog...

Nanocellulose application has been increasing owing to its appealing physicochemical properties. Monitoring of the crystallinity, surface topography, and reactivity of this high-aspect-ratio nanomaterial is crucial for efficient tissue engineering. Controlling macrophage polarization phenotype remains a challenge in regenerative medicine and tissue...

The development of lab-on-a-chip technology is regarded as one of the most potent and reliable technologies for rapid and early detection of the pathogen with portable and on-site detection devices, the so-called point-of-care (PoC) detection systems. These are essentially easy to handle and cheap and offer rapid sample-to-answer results to nontech...

Rapid progress in biomedical engineering has allowed the design of nanoscale biomolecular nanodevices that act as smart nanobots. The realization of nanometer-sized robots assembled from biomolecules is one of the goals of targeted drug delivery and therapy. Numerous self-propelling nanobots capable of intrinsic navigation in biological fluids with...

Recently, additive manufacturing or 3D printing has gained enormous attention in developing nanorobots and microswimmers for biomedical advancement. 3D printing allows the translation of computer-aided designs into accurate 3D models through the layer-by-layer deposition method. Various printing methods, such as stereolithography (SLA), inkjet, las...

Polymer nanohybrid-based smart materials are considered promising platforms for targeted drug delivery and wound healing management. These systems have advantages over conventional systems where precise drug delivery and improved wound healing are required. Synthetic and naturally derived polymers with different nanomaterials are often utilized to...

Photothermal therapy using an ablation agent to generate enough heat under near-infrared light irradiation has been recognized as one of the most promising treatments in curing various ailments. As the normal cells have higher heat tolerance, thus upon increased temperature, the cancer cells and bacteria in wounds can be killed, avoiding any side e...

Nanosystem is structured at or below the micrometer range, made of assemblies of nanoscale components with individual dimensions ranging between 1 and 100 nm. “Nanorobotics and nanodiagnostics” is a new generation of biohybrid that translates fundamental biological principles into engineering design rules to create biorobots that perform like natur...

Nanotechnology offers various applications in disciplines such as nanomedicine, diagnostics, food packaging, and energy. It provides a platform for fabricating materials with enhanced capabilities and multiple designs on a nanoscale. Nanorobots are basically a subset of nanotechnology concerned with designing and constructing devices at the atomic,...

The microfluidic and lab-on-a-chip (LoC) devices are promising for disease modeling and drug screening. New bio-imaging agents that permit multiple imaging and therapeutic applications can lead to more accurate diagnosis and a better understanding of local diseased tissue. The spectroscopic properties of nanomaterials, such as carbon dots, can be c...

Presently, efficient protection from bacterial infections is considered a potential threat owing to the raise of multidrug resistant bacterial phenotypes. Hence, there is an urgent requirement to develop alternative strategies for eliminating bacterial infections. In this regard, near infra-red (NIR) responsive photothermal agents (PTAs) has receiv...

Fabrication of multifunctional hemostats is indispensable against chronic blood loss and accelerated wound healing. Various hemostatic materials that aid wound repair or rapid tissue regeneration has been developed in the last 5 years. This review provides an overview of the three-dimensional (3D) hemostatic platforms designed through the latest te...

Little progress has been achieved on the synthesis of hydrophilic carbon dots (CDs), derived from polycyclic aromatic hydrocarbons, as an excellent photothermal agent. In this study, a strategy was developed to synthesize highly photoluminescent greenish-yellow emissive CDs based on nitration followed by hydrothermal carbonization of the polycyclic...

The conversion of liquid resin into solid structures upon exposure to light of a specific wavelength is known as photopolymerization or photo‐curable 3D printing. In recent years, photopolymerization‐based 3D printing has gained enormous attention in tissue engineering for constructing highly complex and precise tissue structures. Due to the econom...

Lab-grown bovine meat analogues are emerging alternatives to animal sacrifices for cultured meat production. The most challenging aspect of the production process is the rapid proliferation of cells and establishment of the desired 3D structure for mass production. In this study, we developed a direct ink writing-based 3D-bioprinted meat culture pl...

The demand of multifunctional hydrogels has been significantly increased to develop wearable strain-sensing devices. However, integrating all desired properties into one component is still challenging. To address this, we developed polyvinyl alcohol (PVA)/polydopamine functionalized carbon dots (PDA@CDs) hydrogels for strain sensing application. Th...

Cellulose is the most venerable and essential natural polymer on the planet and is drawing greater attention in the form of nanocellulose, considered an innovative and influential material in the biomedical field. Because of its exceptional physicochemical characteristics, biodegradability, biocompatibility, and high mechanical strength, nanocellul...

Plants are anatomically and physiologically different from humans and animals; however, there are several possibilities to utilize the unique structures and physiological systems of plants and adapt them to new emerging technologies through a strategic biomimetic approach. Moreover, plants provide safe and sustainable results that can potentially s...

Upregulation of certain enzymes, such as collagenase, tyrosinase, and elastase, is triggered by several extrinsic environmental factors, such as temperature, UV radiation, humidity, and stress, and leads to elasticity loss and skin pigmentation. Herein, dual-emissive polyaromatic carbon quantum dots (CQDs) with abundant phenolic moieties, that is g...

Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. Recently, MSCs have been widely explored for their applicatio...

Titanium-dioxide nanotubes (TNTs) were fabricated by anodic oxidation of titanium (Ti) substrate and loaded with ciprofloxacin. A thin layer of Poly Lactic-co-Glycolic Acid (PLGA) was coated on top of the drug-loaded TNTs at various thicknesses. Field Emission Scanning Electron Microscopy (FESEM) was used to characterize the developed substrate. Th...

A strategy for the processing of photoluminescence emission tunable multicolor carbon quantum dots has been adopted based on the controllable acidic strength [different ratio mixtures of sulfuric and phosphoric acids (S:P)] using a single polyphenolic precursor. 1,3,5-trihydroxybenzene, a three-fold symmetric (C3h symmetry) triangulogen bearing –OH...

This cover describes the development of two-photon excitable carbon quantum dots that can be used for long-term bioimaging and drug delivery for synergistic tumor therapy. The proposed nanocarrier system is easy to make and could be used as a real-time in vivo tracker for tumor monitoring.

This study was focused on utilizing the magneto-responsiveness of cellulose nanocrystals (CNCs) in an alginate-silk fibroin (ASF) matrix under a low-strength (0.28 T) magnetic field (MF) for fabrication of a magnetically aligned, anisotropic, three-dimensional wound healing scaffold. The effect of the MF on three different concentrations of CNCs (0...

Natural calcium phosphate cements (CPCs) derived from sintered animal bone have been investigated to treat bone defects, but their low mechanical strength remains a critical limitation. Graphene improves the mechanical properties of scaffolds and promotes higher osteoinduction. To this end, reduced graphene oxide-incorporated natural calcium phosph...

Cellulose nanomaterials have received significant interest due to their superior physicochemical properties and biocompatibility. The nanomaterials-based hydrogel patches are widely explored for skin regeneration. However, the injectability and adhesiveness of the hydrogels are crucial challenges for tissue engineering applications. To overcome the...

Cellulose nanomaterials have received significant interest due to their superior physicochemical properties and biocompatibility. The nanomaterials-based hydrogel patches are widely explored for skin regeneration. However, the injectability and adhesiveness of the hydrogels are crucial challenges for tissue engineering applications. To overcome the...

Long-term dynamic tracking of cells with theranostics properties remains challenging due to difficulty in preparing and delivering drugs by the probes. Herein, we developed a highly fluorescent one- and two-photon (OP and TP) excitable polyphenolic carbon quantum dots (CQDs) for excellent membrane-targeting and drug delivery properties for synergis...

Biopolymers-induced immune microenvironment exhibited prominent effects on bone regeneration. Osteo-immunomodulatory responses of cellulose nanoparticles incorporated chitosan hydrogel scaffolds have not yet been reported. The objective of this study was to monitor the synergistic effects of silk fibroin and cellulose nanoparticles on the immune-mo...

Biopolymers-induced immune microenvironment exhibited prominent effects on bone regeneration. Osteo-immunomodulatory responses of cellulose nanoparticles incorporated chitosan hydrogel scaffolds have not yet been reported. The objective of this study was to monitor the synergistic effects of silk fibroin and cellulose nanoparticles on the immune-mo...

Microfluidic platforms gain popularity in biomedical research due to their attractive inherent features, especially in nanomaterials synthesis. This review critically evaluates the current state of the controlled synthesis of nanomaterials using microfluidic devices. We describe nanomaterials' screening in microfluidics, which is very relevant for...

Biocompatible nanomaterials have attracted enormous interest for biomedical applications. Carbonaceous materials, including carbon nanotubes (CNTs), have been widely explored in wound healing and other applications because of their superior physicochemical and potential biomedical properties to the nanoscale level. CNTs-based hydrogels are widely u...

Human mesenchymal stem cells (hMSCs) have the potential to differentiate into different types of mesodermal tissues. In vitro proliferation and differentiation of hMSCs are necessary for bone regeneration in tissue engineering. The present study aimed to design and develop a fluid flow mechanically-assisted cartridge device to enhance the osteogeni...

Nanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, and algae. Depending on the extraction process and d...

3D bioprinted hydrogel has gained enormous attention, especially in tissue engineering, owing to its attractive structure and excellent biocompatibility. In this study, we demonstrated that 3D bioprinted cell-laden 'thermoresponsive' poloxamer-407 (P407) gels have the potential to stimulate osteogenic differentiation of apical papilla stem cells (S...

Naturally-derived proteins or peptides are promising biopolymers for tissue engineering applications owing to their health-promoting activity. Herein, we extracted proteins (~90%) from two-spotted cricket (Gryllus bimaculatus) and evaluated their osteoinductive potential in human bone marrow-derived mesenchymal stem cells (hBMSCs) under in vitro co...

Graphene is a two-dimensional sp2 hybridized carbon material that has attracted tremendous attention for its stimuli-responsive applications, owing to its high surface area and excellent electrical, optical, thermal, and mechanical properties. The physicochemical properties of graphene can be tuned by surface functionalization. The biomedical field...

Graphene is a two-dimensional sp² hybridized carbon material that has attracted tremendous attention for its stimuli-responsive applications, owing to its high surface area and excellent electrical, optical, thermal, and mechanical properties. The physicochemical properties of graphene can be tuned by surface functionalization. The biomedical field...

Carbon nanotubes (CNTs) have attracted significant interest for various applications owing to their superior physicochemical properties. The unzipping of multi-walled carbon nanotubes was accomplished by strong acid treatment. The solution of unzipped carbon nanotubes (u-CNTs) was homogeneous and stable. The u-CNTs were characterized by Fourier tra...

Nanocellulose-assisted gold nanoparticles are considered promising materials for developing eco-friendly diagnostic tools for biosensing applications. In this study, we synthesized 2,2,6,6-tetramethylpiperidin-1-piperidinyloxy (TEMPO)-oxidized cellulose nanocrystal (TEMPO-CNC)-capped gold nanoparticles (AuNPs) for the colorimetric detection of unam...

Colorimetric detection of pathogenic DNA using TEMPO-cellulose nanocrystals capped gold nanoparticles

Nanocellulose-assisted gold nanoparticles are considered promising materials for developing eco-friendly diagnostic tools for biosensing applications. In this study, we synthesized 2,2,6,6-tetramethylpiperidin-1-piperidinyloxy (TEMPO)-oxidized cellulose nanocrystal (TEMPOCNC)-capped gold nanoparticles (AuNPs) for the colorimetric detection of unamp...

Polymers have gained importance for their ability to alter color, volume, or shape in response to specific physicochemical environments, such as temperature, light, or pH. The use of “smart” polymer-based material is rapidly increasing in personalized healthcare, electronics, and renewable energy resources. Thus, design, synthesis, and production o...

The enhanced popularity of the macromolecular class of functional polymers has been recognized recently in specific areas of academia and industrialization because of their unique features and applications. This class of materials is designed with a range of desirable properties on their surfaces. The present and future of polymer chemistry have a...

Biodegradable polymers are designed to degrade upon disposal by the action of living microorganisms. During the past two decades, remarkable advances have been made in the development of non-toxic, cheap, biodegradable, bioadsorbable, and water-soluble biopolymers that are suitable for commercial as well as biomedical applications. Significant prog...

Objective This study aimed to monitor the secretion of serotonin and melatonin in the blood serum of rats in the presence of rice bran (RB), and Sarcodon aspratus (S) extracts for sleep promotion. Background Sleep is a natural physiological phenomenon, and sleep disorders may cause severe mental hazards leading to excessive daytime sleepiness (EDS...

Cells exert, sense, and respond to the different physical forces through diverse mechanisms and translating them into biochemical signals. The adhesion of cells is crucial in various developmental functions, such as to maintain tissue morphogenesis and homeostasis and activate critical signaling pathways regulating survival, migration, gene express...

Mushrooms with enhanced medicinal properties focus on finding such compounds that could modulate the human body’s immune systems. Mushrooms have antimicrobial, antidiabetic, antiviral, hepatoprotective, antitumor, and immunomodulatory properties due to the presence of various bioactive components. β-glucans are the major constituent of the mushroom...

Cellulose nanocrystals (CNCs) have received tremendous attention in recent years for various applications because of their excellent physicochemical properties. Here, CNCs were isolated from coffee grounds through chemical treatment. The CNCs were analyzed by Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), and thermogravime...

Chitosan-based hydrogels have received significant interest in tissue engineering and regenerative medicine applications owing to their superior biocompatibility. However, their applications are restricted owing to their weak mechanical strength. Cellulose nanocrystals (CNCs) are often explored as reinforcing agents to improve the native properties...

Cellulose nanocrystals (CNCs)-based hydrogels are considered attractive biomaterials for tissue engineering due to their excellent physicochemical properties. Hydrogels of alginate and gelatin were prepared with or without CNCs and printed using CELLINK® BIOX 3D bio-printer. The 3D-printed scaffolds were characterized by Fourier transform infrared...

Cirsium setidens (Dunn) Nakai, commonly known as gondre, is a perennial herb that grows predominantly in South Korea. It contains several bioactive phytochemicals with antioxidant, anti‑cancer, anti‑tumor and anti‑inflammatory properties. The present study aimed to investigate the effects of methanolic extracts of gondre on osteogenic differentiati...