Khwaja Nazim Uddin

Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital | BIRDEM · Internal Medicine

Background: Since starting of the SARS-COV 2 pandemic till date, in dengue endemic countries co-infection of COVID-19 and Dengue co-infection remains a healthcare concern and cases have been reported from some Asian countries. Bangladesh being a high endemic region for dengue infection bears risk of significant healthcare burden of such co-infectio...

Background: Since starting of the SARS-COV 2 pandemic till date, in dengue endemic countries co-infection of COVID -19 and Dengue co-infection remains a healthcare concern and cases have been reported from some Asian countries. Bangladesh being a high endemic region for dengue infection bears risk of significant healthcare burden of such co-infecti...

Introduction: Disease chronicity of chikungunya among patients with pre-existing rheumatological diseases is not well-described in the literature. The aim of the study is to discuss the clinical presentation and disease chronicity of chikungunya in cases with rheumatologic diseases supplemented by literature review. Methods: Patients' clinical and...

Background: Emphysematous pyelonephritis (EPN) is a rare severe necrotizing infection of the renal parenchyma, collecting system and/or perirenal tissues. Patients with diabetes mellitus, renal stones and renal tract obstruction are at risk for development of EPN. Escherichia coli is the most common aetiological agent and treatment is aimed at infe...

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Background: Musculoskeletal conditions are prevalent and their impact is pervasive. They are one of the most common causes of long-term pain; affect hundreds of millions of people around the world; they significantly affect the psychosocial status of the affected people as well as their families and carers. This study was done to evaluate the spect...

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Background: Emphysematous pyelonephritis (EPN) is a necrotizing infection of the renal parenchyma, collecting system and/or perinephric tissues, characterized by gas accumulation. We describe clinical, laboratory and imaging characteristics and in-hospital outcomes of patients with EPN. Methods: This retrospective observational study was carried...

Background: Diabetic ketoacidosis (DKA) is an acute metabolic complication of diabetes mellitus (DM). It may be the presenting feature in type 1 DM, but more commonly it complicates previously diagnosed diabetic patients, both type 1 and type 2. If not recognized early and treated in a judicious way the outcome is often fatal. Objectives: The objec...

Background: Dengue fever and dengue hemorrhagic fever is one of the most frequent febrile viral infections in our community as well as among patients admitted in Internal Medicine Department. This study examined the extent of hepatic involvement in dengue hemorrhagic fever Objectives: To evaluate the incidence of hepatic involvement and its correla...

Genito-urinary tract is one of the most common extra-pulmonary sites of involvement by tuberculosis. Genito-urinary tuberculosis poses significant diagnostic difficulty; not only because of non-specific symptoms, but also because of lack of diagnostic facility, specially, in resource constrain settings. We report two cases of genito-urinary tubercu...

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Background: Pancreatitis is a serious disorder of pancreas. This study was designed to investigate the clinical features and outcomes of the hospitalized patients with acute pancreatitis (AP) with or without diabetic mellitus (DM). Methods: A total of 90 adult hospitalized patients with AP diagnosed in three different tertiary hospitals were evalua...

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Genito-urinary tract is one of the most common extra-pulmonary sites of involvement by tuberculosis. Genitourinary tuberculosis poses significant diagnostic difficulty; not only because of non-specific symptoms, but also because of lack of diagnostic facility, specially, in resource constrain settings. We report two cases of genito-urinary tubercul...

Background and Aims Emphysematous pyelonephritis (EPN) is an uncommon, severe, necrotizing infection of the renoureteral unit and is recognized by accumulation of gas within the collecting system, renal parenchyma and/or perinephric tissue. Common risk factors for EPN are diabetes mellitus, renal stone, obstructive uropathy and immunosuppression. P...

Histoplasmosis is uncommon in many parts of the world, including Bangladesh, where, in recent years, cases are increasingly reported. We sought to describe the sociodemographic characteristics, clinical presentation, investigations, treatment, and outcome of histoplasmosis in Bangladesh. We conducted a retrospective data review of published literat...

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Background: Chikungunya is an emerging viral infection in Bangladesh. This self-limiting febrile illness may have acute life-threating features including cardiomyopathy and encephalitis. Acute kidney injury (AKI) is less well described complication of chikungunya. This study was designed to evaluate risk factors for AKI among patients with chikungu...

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Emphysematous pyelonephritis is a necrotizing renal parenchymal infection characterized by gas accumulation in kidney(s) and the surrounding tissues. Patients with diabetes mellitus and renal stones are the usual sufferers. We report a case of emphysematous pyelonephritis occurring in a middle aged Bangladeshi diabetic man who presented with fever,...

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Background: Chikungunya is a rapidly spreading viral infection of global concern. Initial presentation of chikungunya infection is often indistinguishable from other viral infections. In Bangladesh, chikungunya is an emerging infection. In this report, we describe socio-demographic, clinical and laboratory characteristics of chikungunya in a select...

Chikungunya and dengue are the two most rapidly spreading mosquito-borne viral infections of global public health concern. Dengue is endemic in Bangladesh and here chikungunya is anemerging infection. Because of the spacio-temporal relationship between chikungunya virus and dengue virus, their co-existence and concurrent outbreaks are not unlikely....

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p>A case of emphysematous pyelonephritis is reported here. A middle aged Bangladeshi lady presented with fever and left loin pain. She had tachycardia, dehydration and left renal angle tenderness. Investigations revealed diabetes mellitus, left renal stone and left sided emphysematous pyelonephritis complicated by acute kidney injury. She required...

Background and objectives: Low vitamin D is a global problem in all age groups as is osteoporosis in postmenopausal women. The present study was carried out in an urban hospital to assess serum 25-hydroxyvitamin D [25(OH)D] level and bone mineral density (BMD) in postmenopausal women (PMW) and to evaluate correlation between serum 25(OH)D levels an...

Background: Diabetic ketoacidosis (DKA) is an established presenting feature of type 1 diabetes mellitus, but infection and non-compliance to anti-diabetic treatment remain the major precipitating causes of DKA among diagnosed diabetic patients. This study was designed to evaluate the precipitating causes of DKA occurring among adult patients. Meth...

p>A natural disaster is defined as an event of nature, which overwhelms local resources and threatens the function and safety of the community. Our main natural disasters are related to Flood and torrential rain and related events.. Earth quake even tsunamis happened here but so far not to the devastating state. Technological disaster like collapse...

p>A case of concurrent chikungunya virus and dengue virus infection is reported here. The patient presented with fever and generalized body ache. Diagnostic work-up revealed chikungunya-dengue co-infection. Dengue is endemic in Bangladesh while chikungunya is a recently emerging infection. As both the viruses are transmitted by a common vector, Aed...

p>Hydatid disease in human is common and liver is the most common site of involvement followed by lungs. Within the abdomen, hydatid disease can disseminate to involve spleen, pancreas, mesentery, kidney, ovary, gut, supra-renal glands etc. Such disseminations are usually secondary to rupture of a cyst: spontaneous, iatrogenic or traumatic. Without...

p> Introduction: Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. Around 20 to 30% of type 1 and type 2 diabetic patients have diabetic nephropathy. General physicians can play an important role in the detection of diabetic nephropathy (DN) and its early primary managem...

p> Background: Diabetic ketoacidosis (DKA) is a medical emergency. DKA may be complicated by acute kidney injury (AKI) and may require renal replacement therapy. Early detection and treatment including treatment of underlying cause and complication(s), if present, is important in determining outcome of DKA. This study was designed to evaluate the i...

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We report the first case of chikungunya-dengue co-infection during pregnancy requiring emergency Caesarean section (CS) because of fetal distress in a Bangladeshi primigravida. Though previously unreported, this situation may become increasingly common.

Global and regional distribution of Burkholderia pseudomallei

Background/purpose: Diabetic ketoacidosis (DKA) is a medical emergency. DKA may be complicated by acute kidney injury (AKI) and may require renal replacement therapy. Early detection and treatment including treatment of underlying cause and complication(s) is important in determining outcome of DKA. This study was designed to evaluate the incidence...

Background: In spite of significant sero-epidemiological surveillance reports and identification of Burkholderia pseudomallei from soil specimens, till date, only a few cases of melioidosis, mostly occurring in the north-east region of the country, have been reported in/from Bangladesh. We report four cases of melioidosis occurring among returning...

Incidence of AKI in DKA

Background: Austrian syndrome—the combination of meningitis, pneumonia and infective endocarditis due to Streptococcus pneumoniae infection, is a rare entity. In literature only a few hundreds of cases are reported but surprisingly we did not find any report on Austrian syndrome in or from Bangladesh. Case presentation: We report the case history o...

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p>Human life is intricately related to it’s surrounding environment which also harbors other animals and some deadly infectious pathogens. Any threat to the environment can thus increase the threat of new and so-called ‘emerging infectious diseases’ (EIDs) especially novel viral infections called ‘emerging viral diseases’. This occurs partly due to...

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Background: Chikungunya is an emerging and rapidly spreading viral infection in many parts of the world including Bangladesh. It shares many epidemiological and clinical characteristics with dengue. So, a sound knowledge is required for its detection and differentiation from dengue, specially in endemic regions. Case presentation: We present sev...

p> Background: In Bangladesh prevalence of malignancy in diabetic patients seems to be increasing as case detection of both diseases are far more than before. No statistical data of diabetic patients with malignancy is currently available in Bangladesh. Treatment of both diabetes and malignancy in the same patient is challenging for the physician a...

p> Objective: To see the clinical presentation and biochemical abnormalities in hospitalized patients of Diabetic ketoacidosis. Methodology: This cross sectional observational study was carried enrolling 55 subjects with Diabetic ketoacidosis, in the Department of Medicine, BIRDEM General Hospital, Dhaka, over a period of six months starting from...

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p> Background: Diabetes mellitus (DM) is a complex multi-system disorder that may lead to diabetes specific complications and target organ damage which can be prevented or delayed by good or strict glycemic control. Our aims were to evaluate the glycemic status of adult type 2 DM (T2DM) patients on different anti-diabetic management, to evaluate ro...

p> Background: Urinary tract infection (UTI) due to extended-spectrum beta-lactamase (ESBL) producing organisms are increasing. This study was designed to evaluate the frequency of ESBL-positive Escherichia coli and Klebsiella pneumoniae causing UTI, their antibiotic sensitivity pattern and possible risk factors. Methods : This case-control study...

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Background and objectives: Diabetes mellitus is one of the most common causes of chronic kidney disease (CKD). The prevalence of CKD in type 2 diabetes mellitus (T2DM) in Bangladesh is not well described. The present study aimed to find out the prevalence of CKD stages 3-5 and its risk factors among selected Bangladeshi T2DM patients. Methods: Thi...

p>Herpes associated erythema multiforme (HAEM) is an acute exudative dermatic and mucosal disease caused by the Herpes simplex virus (HSV). It is the result of cell mediated immune reaction due to HSV antigen and has a presentation quite similar to Steven Johnsons Syndrome (SJS). Unlike SJS, use of steroids is not recommended in HAEM as it can aggr...

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Abstract Background: The spectrum of bacteria causing urinary tract infection (UTI) and their antibiotic sensitivity pattern is not uniform. Escherichia coli and Klebsiella sp. are two common organisms responsible for UTI through-out the world. The incidence of UTI due to infection with extended-spectrum beta-lactamase (ESBL) producing organisms ar...

p> Background: Melioidosis is caused by Burkholderia pseudomallei, a gram negative non-fermentative bacillus found in water and soil. Transmission to human is by contact and it causes disease mostly in the immunocompromised state. As melioidosis closely mimics tuberculosis it is often misdiagnosed and often empirically treated as tuberculosis. Incr...

Patients with diabetes mellitus are at increased risk of infections. Some infections almost exclusively occur in patients with diabetes. Here, we share our experiences of such infections.

Background: Melioidosis, a disease mostly occurring in immunocompromised states is caused

p> Background : Diabetic retinopathy is the commonest cause of blindness in the working age group of both developed and developing countries. It is the indicator of all micro-vascular complications of diabetes mellitus. This study was aimed to find out the frequency and pattern of diabetic retinopathy among hospitalized adult type 2 diabetic patien...

p> Background : Dealing oncologic emergencies are challenging tasks for any concerned physician. The task becomes even more challenging if the scenario is complicated with diabetes and vice-versa. The burden of non-communicable diseases such as cancer and diabetes is also increasing throughout the world resulting in increasing morbidity and mortali...

OP 359 HISTOPLASMOSIS IN BANGLADESH Muhammad Abdur Rahim1, Shahana Zaman2, Md. Robed Amin3, Khwaja Nazim Uddin1, MA Jalil Chowdhury4 1BIRDEM, 2NICVD, 3DMCH, 4BSMMU, Dhaka, Bangladesh Presenter: Muhammad Abdur Rahim Background/Rationale: In recent years, histoplasmosis has gained importance in clinical practice in Bangladseh, as evidenced by increas...