Kholis A. Audah

Kholis A. Audah
Swiss German University · Biomedical Engineering

PhD
Director of Research and Community Services at the Swiss German University, Indonesia

About

35
Publications
9,625
Reads
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116
Citations
Citations since 2017
29 Research Items
77 Citations
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Introduction
Dr. Audah currently works at the Swiss German University as Director of Research and Community Services and a Faculty Member at Department of Biomedical Engineering . One of his research projects is exploration of Indonesian biodiversity for drug discovery through development of extract library. Another project is dealing with the investigation of drug resistant bacteria by employing various bioanalytical and biophysical methods. He also has a great interest in metagenomics of gut microbiome.
Additional affiliations
November 2019 - present
Swiss German University
Position
  • Managing Director
Description
  • Coordinating, managing, and directing research strategic plan at the University. Teaching some courses to biomedical engineering students.
February 2015 - November 2019
Swiss German University
Position
  • Managing Director
January 2008 - July 2009
Yale University
Position
  • PostDoc Position
Education
January 2008 - July 2009
Yale University
Field of study
  • Infectious Diseases/ Microbial Pathogens
January 2003 - December 2007
Auburn University
Field of study
  • Protein Biochemistry/ Enzymology
January 1998 - August 2000
University of Malaya
Field of study
  • Molecular Biology

Publications

Publications (35)
Article
Full-text available
The two-component alkanesulfonate monooxygenase system utilizes reduced flavin as a substrate to catalyze a unique desulfonation reaction during times of sulfur starvation. The importance of protein-protein interactions in the mechanism of flavin transfer was analyzed in these studies. The results from affinity chromatography and cross-linking expe...
Article
Full-text available
The opportunistic human pathogen Pseudomonas aeruginosa uses two surface organelles, flagella and pili, for motility and adhesion in biotic and abiotic environments. Polar flagellar placement and number are influenced by FlhF, which is a signal recognition particle (SRP)-type GTPase. The FlhF proteins of Bacillus subtilis and Campylobacter jejuni w...
Article
Full-text available
Indonesia is one of the world's most biodiverse countries. This study would be focused only on the Indonesian mangrove forests biodiversity. There are about three million hectares of mangrove forests that grow along the 95,000 km of Indonesian coastline. Mangrove forests have ecology, social, economic and medicinal values that have been used by peo...
Article
Full-text available
Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D ¹ H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibi...
Article
Full-text available
Methicillin-resistant Staphylococcus aureus (MRSA) is an S. aureus strain that has developed resistance against ß-lactam antibiotics, resulting in a scarcity of a potent cure for treating Staphylococcus infections. In this study, the anti-MRSA and antioxidant activity of the Indonesian mangrove species Sonneratia caseolaris, Avicennia marina, Rhizo...
Article
Full-text available
Indonesia is intensively developing plenty of coal-fired power plants to support electricity demand growth. Some research showed the utilization of coal as an electrical energy source may produce anthropogenic contaminants (ACs) that can bioaccumulate in plants. This research was carried out to investigate the severity of the heavy metals contamina...
Article
Protein-protein interactions are ubiquitous biological phenomena in all types of organism and play vital roles in various metabolic processes. Therefore, it is very important to understand how protein-protein interactions take place and govern different mechanisms at cellular and molecular levels. Thus, determination of protein-protein interactions...
Article
Full-text available
Background: Bruguiera gymnorrhiza mangrove and propolis are often used as natural wound treatments. Its constituent is believed to promote wound healing. Objective: This study aims to explore the effect of topical administration of ethanol extract of Bruguiera gymnorrhiza mangrove leaves and propolis on wound healing activity. Methods: Twenty-four...
Article
Full-text available
Introduction Syphilis is a treatable but highly contagious sexually transmitted disease (STI) that has a long history of infecting millions of people from diverse ethnicities and is mainly considered promiscuity. An uprise in syphilis cases is noted in the Coronavirus pandemic. This short communication discerns salient factors precipitating the syp...
Preprint
Full-text available
Since its first appearance in China, in the end of 2019, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has mutated into several variants. The genome analysis of the spike of SARS-CoV-2 is necessary to identify the mutations in each variant. In this study, we obtained the whole genome sequences of SARS-CoV-2 Wild Type and variants fro...
Preprint
Full-text available
Background SARS-CoV-2 is a virus that initially appeared in Wuhan, China, at the end of 2019. Since then, the virus has spread until to almost all countries resulting in a global pandemic. Over time, this virus continues to mutate and produce several other variants. In Indonesia, there are multiple variants of SARS-CoV-2 identified, as well as vari...
Article
Full-text available
Background Tuberculosis is one of the deadliest disease caused by Mycobacterium tuberculosis . Its treatment still becomes a burden for many countries including Indonesia. Drug resistance is one of the problems in TB treatment. However, a development in the molecular field through Whole-genome sequencing (WGS) can be used as a solution in detecting...
Article
Mangrove plants have been utilized by humankind for so long. It is widely suggested that there are still many benefits to these mangroves that are not yet discovered. This article examines the current researches in the usage of mangroves as medicine. Many of these researches revolve around the potential use of mangrove as anticancer, antitumor, ant...
Article
Full-text available
Ketersediaan air minum merupakan kebutuhan mutlak bagi masyarakat. Hal ini juga berlaku bagi masyarakat di Desa Marga Mulya, Kecamatan Mauk, Kabupaten Tangerang, Propinsi Banten. Menurut data yang diperoleh, lebih dari 90 persen masyarakat di desa ini tidak memiliki akses terhadap air bersih terlebih air minum. Untuk kebutuhan mandi, cuci dan kakus...
Article
Full-text available
Humans are at a continuous battle against different types of diseases, so that extraordinary effort to accelerate drug discovery has become a necessity. Indonesian biodiversity is abundant natural resources that can be utilized as potential drug sources. Mangroves are among potential plant medicines that grow nearly at all Indonesian coastlines. Th...
Article
Full-text available
Akses terhadap air bersih dan sarana sanitasi yang layak merupakan salah satu syarat mutlak terjaminnya kualitas hidup masyarakat. Namun hingga saat ini sebagian masyarakat kita belum mendapatkan akses terhadap air bersih dan sanitasi yang baik. Untuk itu diperlukan keterlibatan pihak Perguruan Tinggi dalam upaya penyediaan dan pemeliharaan fasilit...
Article
Full-text available
Road map the community service of Swiss German University activities in 2016 until 2020 about manage of non-organic wasted. In addition, Keranggan village is used as the pilot project to implement the program of non-organic waste management which is located in district of Tangerang, Banten, Indonesia. Swiss German University provides non-organic wa...
Chapter
Conventional drug discovery is believed to be much slower than the emerging of diseases. It could also cost pharmaceutical companies hundreds of million of dollars with no guarantee that the process would be a successful one. Therefore, new alternatives for drug discovery methods are urgently required. Nature has been known as long as human histo...
Article
Full-text available
Extraction method plays a critical role in the study of medicinal plants. Nowadays, a wide range of technologies is available to promote different methods of extraction with the better extraction output. The aim of the study was conducted to compare two extraction method, maceration and ultrasound-assisted extraction (UAE), for obtaining optimum an...
Article
Full-text available
Antimicrobial additives are used in numbers of products for their availability to prevent product degradation and to provide hygienic properties. These additives are also used for carpet application in controlling bio-contaminants in indoor environments. Bacteria contamination on the carpet has been recognized as one of the most common cause of dis...
Article
Full-text available
Background: Cigarette smoke is free radical that causing some pathological conditions such as inflammation, proteolysis, and oxidative stress. In previous studies, mangrove (Rhizophora apiculata) bark extract showed the potential effect as an antioxidant. Mangrove and mangrove associates are abundant plants that grow throughout Indonesian shoreline...
Article
Full-text available
Background: Cigarette smoke is free radical that causing some pathological conditions such as inflammation, proteolysis, and oxidative stress. In previous studies, mangrove (Rhizophora apiculata) bark extract showed the potential effect as an antioxidant. Mangrove and mangrove associates are abundant plants that grow throughout Indonesian shoreline...
Article
Biological Information is a priceless asset for many purposes. FromIndonesian perspective, this become more important due to the fact thatIndonesia is one of the richest country in the world in terms of biodiversityboth in the ocean and on the land. In addition, Indonesia is also a country withfourth largest population in the world. All these natur...
Article
Full-text available
Antibacterial drugs derived from natural sources play significant roles in the prevention and treatment of bacterial infections since antibiotics have become less effective against many infectious diseases. Mangroves are very potential natural antibacterial sources among great numbers of wild medicinal plants. Bruguiera cylindrica is one of the man...
Conference Paper
Full-text available
Biological Information is a priceless asset for many purposes. From Indonesian perspective, this become more important due to the fact that Indonesia is one of the richest country in the world in terms of biodiversity both in the ocean and on the land. In addition, Indonesia is also a country with fourth largest population in the world. All these n...
Conference Paper
Full-text available
ABSTRACT National independency is required for our national supremacy which includes independency in drugs sector. According to the Ministry of Health's data (2012), 95% of drug materials in Indonesia were imported from overseas. Therefore, some necessary steps need to be conducted to solve this problem. The availability of drugs potential from nat...
Conference Paper
Full-text available
Conventional drug discovery is a slow, lengthy and very expensive process. Drug discovery through screening process using extracts from natural products can be an alternative to solve this problem. Indonesian biodiversity is invaluable source to search for drugs for different types of diseases. One of the main problems of this drug discovery proces...
Book
Full-text available
The work presented in this book was to elucidate the importance of protein-protein interactions in protecting the reduced flavin transfer of being oxidized during transfer between two enzyme system in E. coli. Different biophysical and chromatography methods were employed to confirm the formation of protein-protein interactions between the two enzy...

Questions

Questions (2)
Question
Dear All,
Hope you are all fine...anyone would give me some insight on best practice of publishing patented product-related research?
Is it necessary to mention in details about the product including patent numbers, etc in the manuscript?
In this case, a pre-clinical study of an antimicrobial synthetic agent for PloS Medicine publication.
I really appreciate your feedback.
Sincerely,
Kholis
Question
I have a collection of natural product extracts that showed good anticancer potential. I'd like to screen against different cancer cell lines. I am open for any types of cooperation/ collaboration.
You can reach me at: audahka@gmail.com
Many thanks!

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Projects

Projects (9)
Project
1. To find the basic root of microbial resistant and understanding their mechanisms. 2. To discover therapeutics of drug resistant microbial from both synthetic and natural products chemistry.