Khodayar Goshtasbi

Khodayar Goshtasbi
University of California, Irvine | UCI · Department of Otolaryngology/Head and Neck Surgery

MD

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97
Publications
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429
Citations

Publications

Publications (97)
Article
Objective To determine demographic factors and clinicopathologic characteristics associated with survival in young patients (age <45 years) with early- (I-II) or late-stage (III-IV) oral tongue squamous cell carcinoma (OTSCC). Study Design Retrospective database review. Setting National Cancer Database. Methods A retrospective review of 3262 OTS...
Article
To evaluate the prognostic strengths of American Joint Committee on Cancer (AJCC) staging and American Thyroid Association (ATA) risk classification in well‐differentiated thyroid cancer (DTC), and their implications in guiding medical decision‐making and epidemiological study designs. The 2004–2017 National Cancer Database was queried for DTC pati...
Article
Objective: Pain control is an important topic that has not been extensively studied in patients undergoing endoscopic skull base surgery (ESBS). The purpose of this study is to identify opioid requirements after ESBS and the risk factors predictive of increased use. Methods: This study was a retrospective review of all patients undergoing ESBS a...
Article
Objectives: To analyze the variant-specific survival benefits and usage patterns of standardized treatment combinations of surgery (S), radioactive iodine ablation (RAI), and thyroid-stimulating hormone suppression therapy (THST) for high-risk differentiated thyroid cancer. Study design: Retrospective cohort study. Setting: National Cancer Dat...
Article
Objectives: To characterize clinical factors associated with esthesioneuroblastoma treatment delays and determine the impact of these delays on overall survival. Study design: Retrospective database analysis. Methods: The 2004-2016 National Cancer Database was queried for patients with esthesioneuroblastoma managed by primary surgery and adjuv...
Article
Long‐term survival and recurrence patterns of squamous cell carcinoma arising from inverted papilloma (IP‐SCC) have not been thoroughly investigated. Four electronic databases were searched and primary studies describing overall survival (OS), recurrence, and mean time to recurrence of patients with IP‐SCC were included for review. Our search yield...
Article
Objective: To determine the implications of obesity on postoperative adverse events following skull base surgery. Methods: The 2005-2017 American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried for adverse events in skull base surgery cases. Patients were stratified by body mass index (BMI) into...
Article
Objectives Skull base chordomas are locally aggressive malignant tumors derived from the notochord remnant. There are limited large-scale studies examining the role and extent of surgery and radiation therapy. Design Analysis of the National Cancer Database (NCDB) was performed to evaluate the survival outcomes of various treatments, and to assess...
Article
Objective To investigate the use of near-infrared (NIR) imaging as a tool for outpatient clinicians to quickly and accurately assess for maxillary sinusitis and to characterize its accuracy compared to computerized tomography (CT) scan. Methods In a prospective investigational study, NIR and CT images from 65 patients who presented to a tertiary c...
Article
Objectives/Hypothesis The objective of this study is to evaluate the impact of patient and surgical factors, including approach and reconstruction type, on postoperative nausea and vomiting episodes following endoscopic skull base surgery. Study Design Retrospective review. Methods We performed a retrospective chart review from July 2018 to Augus...
Article
Background No study to date has analyzed the progression of sinonasal symptoms over time in COVID-19 patients. The purpose of this study is to analyze the progression of sinonasal symptoms and risk factors for olfactory dysfunction in the mild severity COVID-19 patient. Methods An internet survey was used to assess sinonasal symptoms in patients w...
Article
Objective Chondrosarcomas of the skull base are rare tumors most commonly treated surgically with or without adjuvant radiation therapy. Using the National Cancer Database (NCDB), we analyzed overall survival (OS), treatment modalities, and prognosticators. Methods The NCDB was queried for all cases of histologically confirmed skull base chondrosa...
Article
Background Nasopharyngeal swab testing, which has greatly increased in utilization due to the COVID-19 pandemic, is generally safe and well-tolerated, although it may be rarely associated with adverse events. Methods Publicly reported adverse events associated with nasopharyngeal COVID-19 testing within the Manufacturer and User Facility Device Ex...
Article
The objective of this study is to evaluate the impact of preoperative frailty on short-term outcomes following intradural resection of skull base lesions. The 2005–2017 ACS-NSQIP database was queried for 30-day post-operative outcomes of patients undergoing intradural resection of the skull base, extracted by CPT codes 61601, 61606, 61608, and 6161...
Article
Full-text available
Objective To examine neurotologists' 2013 to 2016 Medicare Part-D data and evaluate commonly prescribed medications, longitudinal changes in prescribing patterns, presumed associated pathologies, and cost distribution across United States. Methods Comprehensive prescription data of Part-D-participating neurotologists was quiered from the 2013 to 2...
Article
Objectives/Hypothesis To identify prognosticators and determine the efficacies of surgery with adjuvant radiotherapy (SR) and surgery with immunotherapy (SI) of head and neck mucosal melanoma (HNMM). Study Design Retrospective database study. Methods The 2004 to 2017 National Cancer Database was queried for HNMM patients. Cox proportional hazards...
Article
Objective To review overall survival (OS), recurrence patterns, and prognostic factors of de novo sinonasal squamous cell carcinoma (DN-SCC). Data Sources PubMed, Scopus, OVID Medline, and Cochrane databases from 2006 to December 23, 2020. Review Methods The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PR...
Article
Full-text available
Objectives: To investigate whether migraine is independently associated with tinnitus and subjective hearing loss (HL) in a large national database. Methods: The de-identified 1999 to 2004 National Health and Nutrition Examination Survey database was retrospectively queried for subjects aged 18 to 65. HL and tinnitus were subjectively reported b...
Article
Objective To elucidate the associations between geographic locations, rankings, and size/funding of medical schools and residency programs among the current otolaryngology residents. Methods This retrospective cross-sectional study queried otolaryngology residency program websites for relevant publicly accessible information. Location was categori...
Article
Full-text available
Objectives: Facial paralysis is a debilitating condition with substantial functional and psychological consequences. This feline-model study evaluates whether facial muscles can be selectively activated in acute and chronic implantation of 16-channel multichannel cuff electrodes (MCE). Methods: Two cats underwent acute terminal MCE implantation...
Article
Objectives: To develop a multiclass-classifier deep learning model and website for distinguishing tympanic membrane (TM) pathologies based on otoscopic images. Methods: An otoscopic image database developed by utilizing publicly available online images and open databases was assessed by convolutional neural network (CNN) models including ResNet-...
Article
The emerging literature regarding the novel coronavirus disease 2019 (COVID-19) suggests that patients with olfactory dysfunction (OD) have a milder disease course with improved clinical symptomatology and outcomes. This study utilized the National Library of Medicine’s PubMed/MEDLINE database to query for articles describing major outcomes in pati...
Article
Background This study evaluates the influence of facility case‐volume on nasopharyngeal carcinoma (NPC) treatments and overall survival (OS). Methods The 2004–2015 National Cancer Database was queried for patients with NPC receiving definitive treatment. Results A total of 8260 patients (5‐year OS: 63.4%) were included. The 1114 unique facilities...
Article
Objectives To evaluate the impact of preoperative frailty on short-term outcomes following complex head and neck surgeries (HNSs). Study Design Cross-sectional database analysis. Setting American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Methods The 2005 to 2017 ACS-NSQIP was queried for patients und...
Article
Full-text available
Purpose This study uses a large-population national database to describe the presenting clinical, sociodemographic, treatment, and clinical outcome differences between pediatric and adult craniopharyngiomas. Methods This study utilized the 2004–2015 National Cancer Database and was queried for all cases of craniopharyngioma. Multivariate Cox propo...
Article
Objective Osteosarcomas of the skull base are rare and aggressive tumors that are most commonly treated with primary surgical resection and adjuvant chemoradiation. Using the National Cancer Database (NCDB), we analyzed demographic and clinical prognosticators for overall survival (OS). Methods The NCDB was queried for cases of histologically conf...
Article
Objectives/hypothesis: This study utilizes a large population national database to comprehensively analyze prognosticators and overall survival (OS) outcomes of varying treatment modalities in a large cohort of sinonasal diffuse large B-cell lymphoma (SN-DLBCL) patients. Study design: Retrospective database study. Methods: The National Cancer Dat...
Article
Objectives: To describe a cohort of patients presenting with long-term sudden sensorineural hearing loss (SSNHL) treated with prophylactic migraine and intratympanic steroid therapy. Methods: Patients presenting to a neurotology clinic at least 6 weeks from SSNHL onset were included. All patients received migraine prophylactic medication (nortri...
Article
Purpose This study evaluated whether stratified preoperative, pre- aspirin desensitization (AD) sinonasal symptom scores predict postoperative, post-AD outcomes in Aspirin exacerbated respiratory disease (AERD). Materials and methods Retrospective chart review of patients with aspirin challenge-proven AERD who underwent endoscopic sinus surgery fo...
Conference Paper
Introduction: There are currently no large-sample studies assessing the clinical outcomes of pituitary adenomas (PA) patients undergoing active surveillance (AS) versus definitive treatment (DT). This population-based analysis aims to identify clinical and sociodemographic predictors of undergoing AS and compare clinical outcomes of PA patients und...
Conference Paper
Introduction: There remain controversies regarding whether elderly patients are predisposed to more complications following pituitary adenoma (PA) surgical resection. This study utilizes a large-population national database to compare clinical outcomes between young and elderly patients receiving either endoscopic surgery (ES) or nonendoscopic surg...
Article
Objectives: To investigate the clinical presentation, treatment breakdown, and overall survival (OS) outcomes of patients with neurofibromatosis type 2 (NF2)-associated bilateral vestibular schwannoma (NVS). Methods: The 2004 to 2016 National Cancer Database was queried for patients with a diagnosis of VS. The "Laterality" code was used to strat...
Article
Introduction Chronic rhinosinusitis (CRS) and functional nasal airway obstruction are common but distinct medical problems which affect quality of life. In certain instances, patients often benefit from concomitant functional septorhinoplasty, or elect for cosmetic rhinoplasty, in addition to functional endoscopic sinus surgery (FESS) and prefer co...
Article
Objectives: To identify migraine features present in a cohort of patients with recurrent benign paroxysmal positional vertigo (BPPV). Methods: Patients presenting with recurrent BPPV were surveyed. Recurrent BPPV was defined as three episodes or greater in 6 months before presentation, with resolution of symptoms after Epley maneuver. Current or...
Article
Background Recently, there has been increased interest in patient satisfaction measures such as Press Ganey and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys. This systematic review aims to analyze the available spine surgery literature to evaluate factors predictive of patient satisfaction as measured by these s...
Article
Introduction The short-term adverse events and predictors of morbidity in surgical resection of esthesioneuroblastoma (ENB) are largely unknown, and investigating these variables can help direct planning for at-risk patients. Methods The 2005–2017 National Surgical Quality Improvement Program database was queried to identify patients with a diagno...
Article
Objectives To comprehensively investigate nasopharyngeal carcinoma (NPC) treatment, overall survival (OS), and the influence of clinical/sociodemographic factors on outcome. Study Design Retrospective database study. Setting National Cancer Database. Methods The 2004-2015 National Cancer Database was queried for all patients with NPC receiving d...
Article
Background: This study develops machine learning (ML) algorithms that use preoperative-only features to predict discharge-to-nonhome-facility (DNHF) and length-of-stay (LOS) following complex head and neck surgeries. Methods: Patients undergoing laryngectomy or composite tissue excision followed by free tissue transfer were extracted from the 20...
Article
Full-text available
Objectives: To develop a smartphone application providing sound therapy and cognitive behavioral therapy (CBT) for treating tinnitus and performing a proof-of-concept pilot study evaluating its potential efficacy. Methods: An interactive smartphone application available on iOS and Android platforms was developed, which provided an 8-week tinnitu...
Article
Objective: To describe rates of short-term morbidity following transcervical surgical treatment of hypopharyngeal diverticulum (HD) and analyze predictors of adverse events. Methods: The 2005 to 2017 National Surgical Quality Improvement Program database was queried to identify patients diagnosed with HD undergoing open transcervical diverticulecto...
Article
Objectives: To determine the factors that shape utilization of social media-based online support communities (OSCs) and study the influence of these communities on medical decision-making in patients with Idiopathic Subglottic Stenosis (iSGS). Study design: Survey study. Methods: A survey investigating OSC use was sent to the 1,056 members of...
Article
Introduction: The emergence of popular online rating websites, social media platforms, and public databases for industry payments and scholarly outputs provide a complete physician online presence which may guide choice and satisfaction. Methods: Websites of all U.S. otolaryngology academic institutions were queried for fellowship-trained rhinol...
Article
Objectives: Esthesioneuroblastoma (ENB) is a rare sinonasal malignancy arising from olfactory neuroepithelium. Recurrence typically occurs locoregionally at the primary site or in the form of cervical metastasis. Delayed local recurrence away from the initial primary site is exceedingly rare. Methods: Retrospective review of four patients with h...
Article
Objectives: To investigate how the decision to report United States Medical Licensing Examination (USMLE) Step 1 score as pass/fail will influence future otolaryngology residency application and match processes. Study design: Survey study. Methods: An anonymous and voluntary survey approved by the Otolaryngology Program Directors Organization...
Article
Full-text available
The current literature lacks strong guidelines regarding surgical management of patients with aspirin-exacerbated respiratory disease (AERD), who present with the clinical triad of chronic rhinosinusitis with nasal polyposis (CRSwNP), bronchial asthma, and aspirin/nonsteroidal anti-inflammatory drug intolerance. To further define the effectiveness...
Article
Objective To evaluate whether increased body mass index (BMI), age, or frailty influence vestibular schwannoma (VS) short-term surgical morbidity. Methods The 2005-2017 National Surgical Quality Improvement Program database was queried for patients with VS undergoing surgical resection. Age was stratified according to age <50, 50-64, and ≥65, whil...
Article
Objectives/Hypothesis There exists a lack of consensus on the optimal sequence of treatment for many sinonasal malignancies (SNMs). This study compares the overall survival (OS) outcomes for primary surgery (PS) versus salvage surgery (SS) in SNM patients across stage, histology, and primary site. Study Design Retrospective database review. Metho...
Article
Full-text available
PurposeTo assess fiberoptic endoscopic evaluation of swallowing (FEES) findings in individuals with cricopharyngeal bar (CPB) and Zenker’s diverticulum (ZD).Methods In this retrospective chart review spanning from 2010–2018, individuals diagnosed with CPB or ZD and undergoing FEES were identified. Patient demographics, radiographic studies, and tre...
Article
Objectives: To determine the relationship between vestibular migraine (VM) and motion sickness (MoS) susceptibility and their comorbidity in a large student population, and to assess whether experiencing MoS is associated with higher susceptibility for VM. Methods: Surveys including Motion Sickness Susceptibility Questionnaire (MSSQ) and questio...
Article
Full-text available
Much of the published literature regarding the novel corona-virus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, including chemosensory and/or sinonasal dysfunction. This study utilized the National Library of Medi...
Article
Objectives/Hypothesis To examine the hearing outcomes of patients with sudden sensorineural hearing loss (SSNHL) treated with oral and intratympanic (IT) steroid only or a combination of steroid and migraine treatment. Our hypothesis was that adjuvant migraine medications may improve outcomes in SSNHL. Methods A retrospective chart review at a ter...
Article
Objectives To assess the validity of a bench-top model of an optical tympanometry device to diagnose in vitro model of middle ear effusion (MEE). Methods and Materials We illuminated an in vitro model of ear canal and tympanic membrane with broadband light and relayed remitted light to a spectrometer system. We then used our proprietary algorithm...
Article
Objective The influence of graft type (non-autologous versus autologous) on surgical outcomes in endoscopic anterior skull base (EASB) reconstruction is not well-understood. This review systematically evaluated rates of post-operative complications of EASB repairs that utilized autologous or non-autologous grafts. Methods Original studies reportin...
Article
Objective: For symptomatic nonsecreting pituitary adenomas (PAs), resection remains a critical option for treatment. In this study, the authors used a large-population national database to compare endoscopic surgery (ES) to nonendoscopic surgery (NES) for the surgical management of PA. Methods: The National Cancer Database was queried for all pa...
Article
Objectives Nasogastric tubes (NGT) are often placed after surgery for cricopharyngeal muscle pathology due to risk of infection and mediastinitis. The aim of this study was to examine if this practice is necessary. Methods A retrospective case series of subjects who underwent surgery for hypopharyngeal diverticula or cricopharyngeal bars from Marc...
Article
Background: Sinonasal undifferentiated carcinoma (SNUC) is an uncommon malignancy of the nasal cavity and accessory sinuses with limited available studies evaluating role of induction chemotherapy (IC), demographics, and socioeconomic factors on overall survival (OS). Methods: The 2004-2015 National Cancer Database was queried for patients with...
Article
Full-text available
Objectives: To compare two statistical models, namely logistic regression and artificial neural network (ANN), in prediction of vestibular schwannoma (VS) recurrence. Methods: Seven hundred eighty-nine patients with VS diagnosis completed an online survey. Potential predictors for recurrence were derived from univariate analysis by reaching the...
Article
Objectives To evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis. Methods In a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modific...
Article
Objectives To review the literature regarding the use of intracranial imaging as a screening tool for idiopathic olfactory loss (IOL) and to review the incidence of identifying a sinonasal or intracranial neoplasm as a result of intracranial imaging. Methods A systematic review of published English-language literature was performed using PubMed, O...
Article
Between 2016 and 2017, several U.S. Diplomats in Havana, Cuba, experienced perplexing vestibular and neurological symptoms attributed to an unknown source. They presented with significant vestibular and headache symptoms similar to individuals who experience vestibular migraine (VM). As such, we hypothesize that VM may be a possible explanation for...
Article
Purpose for review: The aim of this article is to review the current literature regarding a novel method of topically delivering nasal steroids, namely exhalation delivery system-fluticasone (EDS-FLU), for the treatment of chronic rhinosinusitis (CRS). Recent findings: Recent Food and Drug Administration approval of EDS-FLU and increasing eviden...
Article
Full-text available
Objectives: To evaluate if patients with a diagnosis of vestibular migraine (VM) by the International Classification of Headache Disorders (ICHD) criteria have meaningful differences in symptomatology and disease characteristics when compared to patients with concurrent vestibular symptoms and migraine that do not meet ICHD criteria. Methods: Pa...
Article
Background: Recently, there has been mounting evidence suggesting the efficacy of steroid-eluting stents (SES) for management of chronic rhinosinusitis after endoscopic sinus surgery (ESS). This meta-analysis serves to evaluate the efficacy of SES in improving postoperative outcomes after ESS. Methods: A systematic literature search was performe...
Article
A novel in‐office and minimally‐invasive ossicular chain reconstruction using hydroxyapatite bone cement between the incus and stapes is demonstrated. Better adhesion between the cement and the bones was attained via partly removing the mucosa on the incus and stapes capitulum as well as preserving the fibrous band between the incus and stapes. Thi...
Article
Background and objectives: Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu disease, causes recurrent mucous membrane hemorrhage, especially epistaxis. In this systematic review, we discuss the efficacies of the three most common laser photocoagulation treatments for HHT-related epistaxis. Study design/materials and me...
Article
Background: Pituitary apoplexy (PA) can manifest with visual and endocrine defects. The literature lacks strong support for either surgical or conservative management with respect to symptomatic improvement of these deficits. This meta-analysis compared visual and endocrine outcomes in conservative and surgical treatment of PA. Methods: A system...