Khalil Abdullah Khalil

university of Bisha · Medical Laboraories

A technique for exfoliating Boron nitride (BN) nanosheets was devised, which was then followed by a laser ablation-fragmentation process to produce lamellar hexagonal Boron nitride nanostructures (h-BNNs). The physicochemical properties of the nanoparticles were analyzed to investigate the effect of laser energy and wavelength in the two-step pre-t...

This study aimed to determine the histological and functional effects of Galangin (Gal) conjugated with Gold nanoparticles (AuNPs) on the kidneys of male albino mice treated with CCL4. Gold nanoparticles were prepared chemically by the Turkevich method. The characterization of the prepared AuNPs and AuNPs+Gal was carried out using UV Spectrophotome...

The study planned to estimate biological parameters linked to rheumatoid arthritis (RA) patients, detecting the influence of MTX and biotherapy treatments on these parameters and synthesizing methotrexate bovine serum albumin nanoparticles linked to folate (FA-MTX-BSA NPs) to reduce the overwhelming expression of inflammatory cytokines. Inflammator...

This study presents a comprehensive look into the potential therapeutic, antibacterial, and anticancer properties of a nanocomposite (NC) of gold (Au) and zinc oxide (ZnO). In this study, we analyzed the adherence between Au nanoparticles (NPs) and ZnO NPs. X-ray diffraction analysis showed high crystallinity and small crystallite sizes of Au NPs a...

Single-walled carbon nanotubes (SWCNTs) involving polyethylene glycol (PEG) and polyethyleneimine (PEI), which contain amines, were produced and analyzed using X-ray diffraction (XRD), UV–vis spectroscopy, Raman spectroscopy (RS), and transmission electron microscopy (TEM) for the spectral and structural analyses of PEG-PEI-SWCNTs. PEG-PEI-SWCNTs d...

The objective of the current study was to extract 2-(benzhydryl sulfinyl)-N-sec-butylacetamide), a novel compound from fig, and then determine its role in enhancing trastuzumab-triggered phagocytic killing of SKOV-3 cancer cells. In this study, Soxhlet was used to extract the compound from the mature and air-dried fig fruits. The production of the...

In this work, bismuth oxide nanoparticles (Bi2O3 NP) were prepared by laser ablation of a solid target in distilled water. The optical and structural properties of Bi2O3 NPs were studied using UV–VIS spectroscopy, energy-dispersive X-ray spectroscopy (EDS), transmission electron microscope (TEM), scanning electron microscopy (SEM), and Fourier tran...

Colorectal cancer (CRC) is considered as the fourth prevalent reason of cancer deaths. Interleukin 10 (IL10) and interleukin 17A (IL-17A) act as anti-inflammatory and pro-inflammatory cytokines, respectively, both being able to exert antitumor or pro-tumor roles in cancer. Serum levels for IL-10, IL-17A, and calcitriol were measured by ELISA. The C...

Lead (Pb) is a hazardous pollutant for living creatures including fish. This study addressed the possible ameliorating effect of dietary Beta-MOS® on Pb induced reproductive toxicity in Nile tilapia. One hundred eighty fish (35.43 ± 0.36 g, 8 weeks age) of mixed sex were randomly allocated into 4 equal groups (3 replicates/group). The first group w...

This study was designed to evaluate the cytotoxic effect of copper nanoparticles in murine adenocarcinoma cells (AMN-3). The exposure period of cell line was performed at 24 hr in a microtitration plate under complete sterile conditions. Different concentrations were used started from 0.39 μgmL-1to 50 μgmL-1 in three independent experiments. Firs...

The use of whole blood and some biological specimens, such as urine, saliva, and seminal fluid are limited in clinical laboratory analysis due to the interference of proteins with other small molecules in the matrix and blood cells with optical detection methods. Previously, we developed a microfluidic device featuring an electrokinetic size and mo...

The use of whole blood and some biological specimens, such as urine, saliva, and seminal fluid are limited in clinical laboratory analysis due to the interference of proteins with other small molecules in the matrix and blood cells with optical detection methods. Previously, we developed a microfluidic device featuring an electrokinetic size and mo...

In this study, we developed a new, efficient targeting and pH-responsive formulation using folate (FA)-conjugated human serum albumin (HSA) nanoparticles to deliver doxorubicin (DOX) drug to renal cell carcinoma. FA was conjugated to HSA, and DOX was loaded into obtained FA-HSA NP using the desolvation method. FA-HSA-DOX NPs were examined using zet...

metabolism of carbohydrates

L-asparaginase is an amidohydrolase enzyme that is widely identified as one of the most potential anti cancerous drugs. Nevertheless, this drug is poorly bioavailable and hence its pharmaceutical uses are limited. To improve its bioactivity, L-asparaginase was loaded on gold nanoparticles (GNPs) along with Arg-Gly-Asp (RGD) peptide that direct the...

L-asparaginase is an amidohydrolase enzyme that is widely identified as one of the most potential anti cancerous drugs. Nevertheless, this drug is poorly bioavailable and hence its pharmaceutical uses are limited. To improve its bioactivity, L-asparaginase was loaded on gold nanoparticles (GNPs) along with Arg-Gly-Asp (RGD) peptide that direct the...

Background: This study aimed to observe the lipid profile in diabeticpatients and to find out correlation between glycated hemoglobin (HbA 1C) and lipid profile. Methods: Lipid profiles, fasting blood sugar and HbA 1C values of 100 diabetic patients were studied. Blood samples of 41 male and 59 female diabetic patients were assessed for fasting blo...

CORRELATION OFLIPID PROFILE WITH GLYCATED HEMOGLOBIN (HBA1C) IN DIABETIC PATIENTS IN KING ABDULLAH HOSPITAL, BISHA, SAUDI ARABIA

Background: This study aimed to observe the lipid profile in diabeticpatients and to find out correlation between glycated hemoglobin (HbA1C) and lipid profile. Methods: Lipid profiles, fasting blood sugar and HbA1C values of 100 diabetic patients were studied. Blood samples of 41 male and 59 female diabetic patients were assessed for fasting blood...

The aim of this study is to determine the occurrence of Candida albicans in clinical specimens and studying its susceptibility to some plant extracts in Saudi Arabia. One hundred twenty eight human clinical specimens from 98 cases suffering from oral thrush and 30 cases suffering from vulvovaginitis were examined by mycological examination. C. albi...

Oil, ethanolic and total alkaloids extracts of neem (Azadirachta Indicia) seed kernels were analyzed for their antimicrobial activities against four pathogenic organisms; staphylococcus aures, Salmonella typhi, Escherichia coli and one yeast Candida albicans. Oil extract had a minimum inhibitory concentration (MIC) of 1500µg/ml against to the all o...

Ginger is one of the most important medicinal plants which is widely used in folk medicine, this study was designed to go further step and evaluate the hypoglycemic and hypolipidaemic effects of aqueous ginger root extract in normal and alloxan diabetic rabbits. Results revealed that the aqueous ginger has a significant hypoglycemic effect (P<0.05)...

Extracts of various plants material capable of decreasing blood sugar have been tested in experimental animal models and their effects confirmed. Neem or Margose (Azadirachta Indica) is an indigenous plant believed to have antiviral, antifungal, antidiabetic and many other properties. In this paper deals with a comparative study of effect of aqueou...