Khalida Kadhim Abbas Al-Kelaby

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Khalida verified their affiliation via an institutional email.

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• PhD- Prof/ virology
• Lecturer at University of Kufa

Cancer is a disorder that, basically, occurs as a result of genetic and epigenetic abnormalities. It's one of the leading causes of death in the globe, and it's still a major social and economic problem. According to statistics , over 10 million people die with malignancies, and cancer rates are expected to increase by 50% in the next ten years, cu...

PREPARATION, CHARACTERIZATION AND STUDY OF THE BIOLOGICAL SCREENING OF THE AU (III) COMPLEX WITH NOVEL (AZO -SCHIFF BASE) LIGAND

The coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which is responsible for the disease COVID-19 (coronavirus disease 2019), has infected over 9.5 million people and has caused more than 480,000 deaths globally, as of 24 June 2020.These are positive-sense single-strand RNA viruses with around 24 similar species from the f...

The rising prevalence of cancer worldwide has led to the emergence of several biotechnological advancements, including oncolytic virotherapy, a novel treatment strategy for multiple tumors. Among these approaches, herpes simplex virus (HSV) based vectors have garnered significant attention as extensively researched oncolytic agents on a global scal...

The coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which is responsible for the disease COVID-19 (coronavirus disease 2019), has infected over 9.5 million people and has caused more than 480,000 deaths globally, as of 24 June 2020. These are positive-sense single-strand RNA viruses with around 24 similar species from the...

Colorectal cancer (CRC) is the third most prevalent form of cancer and the second leading cause of cancer-related deaths worldwide. oncolytic virotherapy shows promise as a targeted therapy for various cancer types, including CRC. In this study, we constructed a novel oncolytic herpes simplex virus type 2 (oHSV-2) are derived from the wild type HSV...

Toxoplasmosis is a well-known and widespread parasite infection. Although diagnosis has come a long way, therapeutic approaches have not changed since the 1940s. Using SOCl2/EtOH as a catalyst, the Claisen-Schmidt condensation method has been used in this study to effectively synthesize chalcone. The anti-parasitic effect of the synthesized chalcon...

The hydroxylated chalcone derivative (HCD) has been synthesized efficiently utilizing of Claisen-Schmidt condensation of para-hydroxylated derivatives of both acetophenone and benzaldehyde using a catalyst SOCl2/ETOH. The confirmation and characterization of the chemical structure of the synthesized chalcone derivative was done using melting points...

Heterocyclic compounds showed a wide range of applications but in medicinal chemistry are of particular interest. Heterocyclic were the active compounds in many natural drugs also some are still used today, for instance, quinine derivatives and morphine. Colorectal carcinoma is the world's third most common neoplasm and the second leading cause of...

Heterocyclic compounds possess a cyclic structure with two or more different kinds of atoms in the ring. The history of heterocyclic chemistry began in the 1800s, in step with the development of organic chemistry. Since rings can be of any size, from three-membered upwards, and since the heteroatoms can be drawn in almost any combination from a lar...

Toxoplasmosis is a worldwide, well-known, parasitic infection. Despite the great advance in diagnosis, therapeutic schemes have barely evolved since 1940s. In this study, chalcone has been synthesized by Claisen-Schmidt condensation method using SOCl 2 /ETOH as a catalyst. The synthesized chalcone was evaluated in its potency as antiparasitic agent...

Cutaneous leishmaniasis, is a diseases transmitted by sand-flies, which infect both genders and all age groups; the study was conducted in Al-Najaf /Iraq, during the period (September 2018-April 2019). Data collected from four Hospitals (Al-Sadr Teaching Hospital, Al-Hakeem Teaching Hospital, Al-Forat Teaching Hospital and Al-Sajad Teaching Hospita...

The second leading cause of mortality throughout the world is colorectal cancer (CRC), and the existing treating of this situation needs to be improved. Many efforts had been focused on the therapeutic approach of cancer for a long time studying nanoparticles activity. In this study, zinc oxide nanoparticles (ZnO-NPs) were applied against the HCT11...

The research includes the preparation of new heterocyclic imidazolodine-4-one derivative ,starting from 2-hydroxy-5-((4-nitrophenyl)diazenyl)benzaldehyde (F1). This work involved the synthesis and identification of imidazolodine-2-one derivative (F2) from the Schiff base derivative(F1). These compounds were characterized by Fourier-transform infrar...

A tumor marker is a term usually refers to proteins that is indicating the presence of a tumor biochemically. They are mainly found in blood or urine and other body fluids, those markers may be used to detect expected primary or secondary tumor. GDF_ 15 is one of the tumor markers that engaged in controlling apoptosis & inflammatory response during...

This work was planned as diagnostic study to evaluate the prevalence of Toxoplasma Gondi (T. Gondi) among the population of 146 pregnant women of ages ranging from 14-45 years old, during the period from 20th of October 2018 to 14th of January 2019 at Al Najaf Public Health laboratory, and 50 normal pregnant women (control group), these cases were...

The second leading cause of mortality throughout the world is colorectal cancer (CRC), and the existing treating of this situation needs to be improved. Many efforts had been focused on the therapeutic approach of cancer for a long time studying nanoparticles activity. In this study, zinc oxide nanoparticles (ZnO-NPs) were applied against the HCT11...

Developing a new effective anticancer agent is a real hope and challenge, in this concern protein specific targeting provides very selective and promising approach, on the other hand cell culture model enables the researcher to make a rapid surveying of a wide number of investigational agents. Hedgehog receptors (SMO) are of the key bio-targets tha...

Many efforts had been focused on the therapeutic approach of cancer for a long time by studying cytotoxic nanoparticles' activities. In this study, a mix of PVA 60% and PVP 35 %, with 5% reinforced bioceramic triple (ZnO, MgO, Tio2) was applied against LS 174T colorectal adenocarcinoma cell line. This study was planned to evaluate MZT cytotoxicity...

The number of deceased mice was recorded for each dose level of our compound (DMT), which is shown in table (4.10). The percentage mortality at each dose level was converted to prohibit using Finney's method (appendix3). The graph was plotted between probit vs. log dose, and LD50 value of DMT was determined by the graph, which was the dose at probi...

Different phytochemicals have pharmacophore properties. Target proteins of the Herpes simplex virus could be targeted by such phytochemicals namely lycopene. In vitro HS model was designed to assess that effect.

Cancer is one of the most mortal diseases in the world .This work was planned to prepare a new chemical cross linking starch/gum Arabic hydrogel system in the presence of potassium persulfate(K2S2O8)as initiator, to describe the characteristic of the new material , and to investigate its potential utilizations in controlled drug delivery and cancer...

Many efforts had been focused on the therapeutic approach of cancer for a long time by studying cytotoxic nanoparticles' activities. In this study, a mix of PVA 60% and PVP 35 %, with 5% reinforced bioceramic triple (ZnO, MgO, Tio2) was applied against LS 174T colorectal adenocarcinoma cell line. This study was planned to evaluate MZT cytotoxicity...

Many efforts had been focused on the therapeutic approach of cancer for a long time by studying cytotoxic nanoparticles' activities. In this study, a mix of PVA 60% and PVP 35 %, with 5% reinforced bioceramic triple (ZnO, MgO, Tio2) was applied against LS 174T colorectal adenocarcinoma cell line. This study was planned to evaluate MZT cytotoxicity...

High selectivity of Cytotoxic Activity of Compounded Anthracycline against Rhabdomyosarcoma Cancer Cell Line that effect of DMT between cancer cell and normal cell line increase the prospects that this compound could serve as leads for novel anticancer drugs and hence may be potential candidates for use in human cancer therapy, however, further inv...

In this work, a mix of PMMA 50% and PLA 50%, and reinforced bioceramic triple (ZnO, MgO, TiO 2 ). For the purpose of testing for the absorption of the simulated solution of body fluids and water, After submerging it for one month and after calculating the surface hardness of the submerged and non-submerged. Laboratory results showed an improvement...

Objectives: The present study was planned to detect the frequency of genes that is responsible for enterotoxin excretion in S. aureus isolated from dermal lesions of atopic dermatitis (AD) cases in AL-Najaf city, and to evaluate the single and combined existence of enterotoxins coding genes. Methodology: A total of 54 Staphylococcus aureus isolates...

In this work, a mix of PMMA 50% and PLA 50%, and reinforced bioceramic triple (ZnO, MgO, TiO2). For the purpose of testing for the absorption of the simulated solution of body fluids and water, After submerging it for one month and after calculating the surface hardness of the submerged and nonsubmerged. Laboratory results showed an improvement in...

In this work, a mix of PMMA 50% and PLA 50%, and reinforced bioceramic triple (ZnO, MgO, TiO2). For the purpose of testing for the absorption of the simulated solution of body fluids and water, After submerging it for one month and after calculating the surface hardness of the submerged and nonsubmerged. Laboratory results showed an improvement in...

The conventional drug delivery system has serious limitations. These limitations can be overcome by using the smart materials to produce an effective drug delivery system. Corn starch cross-linked chitosan using potassium persulfate as an accelerator with different ratios of corn starch/chitosan blends were prepared as smart materials for drug deli...

Doxorubicin is one of the most important anticancer agents, but its clinical uses are limited due to cardiotoxicity, the present study evaluated the effects of new derivatives of doxorubicin on cardiac tissue by the measurement of serum cardiac troponin I (cTnI) and CK-BM assays as biomarkers as well as heart tissue after 3 weeks of treatment in al...

Doxorubicin is one of the most important anticancer agents, but its clinical uses are limited due to cardiotoxicity, the present study evaluated the effects of new derivatives of doxorubicin on cardiac tissue by the measurement of serum cardiac troponin I (cTnI) and CK-BM assays as biomarkers as well as heart tissue after 3 weeks of treatment in al...

ABSTRACT Objectives: This study was planned to evaluate the prevalence of Staphylococcus aureus in cases of atopic dermatitis (AD) in Najaf city. A total of 100 skin swabs were obtained from the effected skin areas of patients who were attending to AL-Sader Teaching Hospital in AL-Najaf city during the period from May to October 2014.with (AD), alo...

Many efforts have focused on the therapeutic approach of cancer for a long time by studying of cytotoxic activities of plant constituents. This study was planned to evaluate cytotoxicity of nitrochalcone derivative (NCD) on rhabdomyosarcoma cell line (RMS) as compared with methotrexate (MTX) and Doxorubicin (DOX), then assessment of monoterpene (MT...

This study was planned to evaluate the prevalence and immunological aspects of Herpse simplex virus2 (HSV2) in the semen of men with genitourinary tract infection compared with control group in Al-Najaf City /Iraq. The attempts to investigate the sexually transmitted diseases (STDs) among individuals inhabit in highly restricted religions society c...

ABSTRACT This study was planned to evaluate the antiviral effect of lycopene against HSV-1 infection compared with acyclovir. The protocol of MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was done for the determination of cell viability and antiviral effect of lycopene as compared with acyclovir by measuring drug half-max...

Diabetes mellitus has repeatedly attracted attention of researchers to design different therapeutic approaches to achieve an optimal treatment for this serious health challenge. The purpose of the study is to evaluate treatment option for controlling hyperglycemia at site of glucose absorption through designing computerized and in vivo models to te...

Objectives: This study was planned to evaluate the use of peripheral blood lymphocytes as cell line for propagation of human herpes simplex 1, by the using of modern diagnostic techniques. Methodology: Primarily, 40 samples were collected from dermal lesions, investigated by RT-PCR techniquedirected to certify human herpes simplex1 infections Bosph...

During a period extending from July 2012 to July 2013, a total of 251 avian cases admitted for medically care unit in the veterinary hospital in Al-Najaf governorate were examined and involved in this study. The study was applied to determine risk factors affecting by avian influenza virus infection among poultry flocks in Al-Najaf-Iraq. The study...

Diabetes mellitus has repeatedly attracted attention of researchers to design different therapeutic approaches to achieve an optimal treatment for this serious health challenge. The purpose of the study is to evaluate treatment option for controlling hyperglycemia at site of glucose absorption through designing computerized and in vivo models to te...