Khalid Saeed Khan

Khalid Saeed Khan
University of Granada | UGR · Department of Preventive Medicine and Public Health

Professor MBBS, FCPS, MSc, MMEd, FHEA
Professor Khalid Khan is Distinguished Investigator (Beatriz Galindo programme) at the University of Granada, Spain.

About

830
Publications
124,785
Reads
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37,093
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Introduction
Professor Khalid Khan is Distinguished Investigator (Beatriz Galindo programme) at the University of Granada, Spain. With an h-index>70 he has published over 400 peer-reviewed papers and supervised 25 higher-degree theses. Professor Khalid Khan, gynaecologist formerly, has contributed to many trials and meta-analyses. He is the lead author of 'Systematic Reviews to Support Evidence-Based Medicine', which won a BMA Medical Book award. He is Topic Editor: Integrity of Randomized Clinical Trials.
Additional affiliations
March 2020 - present
University of Granada
Position
  • Distinguished Investigator

Publications

Publications (830)
Article
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Purpose A tourniquet is routinely used during total knee arthroplasty (TKA) to reduce intra-operative hemorrhage, though surgery without a tourniquet is becoming popular. To address concerns about the effect of blood at cement interfaces on long-term implant stability, we conducted a systematic review among patients undergoing total knee arthroplas...
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Objective: To develop and validate novel prediction models to personalise the risk of conversion from laparoscopic to open hysterectomy in benign conditions DESIGN: Retrospective cohort study. Settings: English NHS Hospitals between 2011 and 2018. Population: 68,752 women undergoing laparoscopic hysterectomy for benign conditions. Methods: W...
Article
Resumen La evaluación de la calidad de los estudios desempeña un papel fundamental en cada paso del proceso de realización de una revisión sistemática. Para realizar una evaluación precisa se utilizan listas de comprobación que incluyen las cuestiones genéricas relevantes al diseño de los estudios incluidos en la revisión. Los elementos de la lista...
Article
This is the first in a series of five articles on the steps to follow to conduct a successful systematic review. This first article addresses how to formulate the right questions to initiate a systematic review. The key issues are: how to structure the questions appropriately according to the main components: the participants, the interventions or...
Article
Background & Objective: This study aimed to assess the clinical effectiveness of Hydroxychloroquine Sulfate (200 mg orally 8 hourlies thrice a day for 5 days), oseltamivir (75 mg orally twice a day for 5 days), and Azithromycin (500 mg orally daily on day 1, followed by 250 mg orally twice a day on days 2-5) alone and in combination (in seven group...
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Objective A rapidly developing scenario like a pandemic requires the prompt production of high-quality systematic reviews, which can be automated using artificial intelligence (AI) techniques. We evaluated the application of AI tools in COVID-19 evidence syntheses. Study design After prospective registration of the review protocol, we automated th...
Article
Resumen Este artículo, el segundo de la serie de revisiones sistemáticas, se centra en lo que debería ser el segundo paso: cómo identificar y seleccionar los estudios relevantes para la revisión planificada. La búsqueda bibliográfica, en la que se emplean términos relacionados con la pregunta formulada en el primer paso, habrá de ser exhaustiva y a...
Article
Resumen En este artículo, el cuarto de una serie de cinco sobre revisiones sistemáticas, se muestra cómo recopilar y resumir los resultados de los estudios incluidos en una revisión. La síntesis de los datos extraídos consiste en tabular las características y la calidad de los estudios incluidos, y resumir los efectos y la magnitud de las asociacio...
Preprint
BACKGROUND Intimate partner violence (IPV) during pregnancy is a serious public health issue with wide-ranging consequences for both the mother and the unborn child. Thus, interventions are needed to address this issue. OBJECTIVE The aim of the STOP study is to implement digital screening for IPV within antenatal care and provide video counselling...
Article
Background To assess the safety of minimally invasive surgery (MIS) for orthopedic spinal, upper limb and lower limb procedures, this systematic review of systematic reviews compared their complications with open procedures. Materials and methods A literature search was conducted electronically (PubMed, Cochrane library and Web of Science; 8th May...
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The women’s sexual and reproductive healthcare sector, one of the largest employers delivering services globally, does not always commit to equality, diversity, and inclusion. There is objective, published evidence that not only care provision but also workforce treatment permits inequality and discrimination. The black and ethnic minority workforc...
Article
(Acta Obstet Gynecol Scand. 2021;100:704–714) Annually, ~7 million women worldwide experience a maternal near miss (MNM), defined by the World Health Organization as nearly dying but surviving a complication in pregnancy, childbirth or within 42 days postpartum. A MNM can affect a patient’s health in a number of ways, but the extent of the impact o...
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Objectives To determine the feasibility and acceptability of conducting a randomised trial on the effects of myo-inositol in preventing gestational diabetes in high-risk pregnant women. Design A multicentre, double-blind, placebo-controlled, pilot randomised trial with nested qualitative evaluation. Setting Five inner city UK National Health Serv...
Article
OBJECTIVES: To determine the feasibility and acceptability of conducting a randomised trial on the effects of myo-inositol in preventing gestational diabetes in high-risk pregnant women. DESIGN: A multicentre, double-blind, placebo-controlled, pilot randomised trial with nested qualitative evaluation. SETTING: Five inner city UK National Health Ser...
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Psychological intimate partner violence (IPV), a global public health problem, affects mothers during pregnancy. We evaluated its relationship with preterm birth. We established a cohort of 779 consecutive mothers receiving antenatal care and giving birth in 15 public hospitals in Spain. Trained midwives collected IPV data using the Index of Spouse...
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Background Intimate partner violence (IPV) against women is a serious health problem that affects pregnancy more frequently than other obstetric complications usually evaluated in antenatal visits. We aimed to estimate the accuracy of the Women Abuse Screening Tool-Short (WAST-Short) and the Abuse Assessment Screen (AAS) for the detection of IPV du...
Article
Objective Lifestyle interventions (LSI) are recommended as first-line treatment for polycystic ovary syndrome (PCOS), yet the strength of evidence underpinning LSIs effectiveness remains unclear. We systematically reviewed the literature on LSIs in PCOS, evaluated evidence quality and summarised recommendations for clinical practice. Material and...
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Background: Mother-to-baby transmission of group B Streptococcus (Streptococcus agalactiae) is the main cause of early-onset infection. Objectives: We investigated if intrapartum antibiotic prophylaxis directed by a rapid intrapartum test reduces maternal and neonatal antibiotic use, compared with usual care (i.e. risk factor-directed antibiotic...
Article
Background: Randomized controlled trials (RCT) in mental disorders research commonly use active control groups including psychotherapeutic shams or inactive medication. This meta-analysis assessed whether placebo conditions (active controls) had an effect compared to no treatment or usual care (passive controls). Methods: PubMed, Scopus, PsycINF...
Article
Background Migrants, a population vulnerable to communicable diseases, face multiple barriers in access to immunization programs. Individual studies suggest that they suffer immunization inequity compared to non-migrants, but the gap in vaccination has not been quantified. This systematic review assessed quantitatively the level of vaccination cove...
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Background: Listeria monocytogenes is a commonly found organism in processed and prepared food and the disease of listeriosis is associated with a high morbidity and mortality. Compared to the general population, the risk of being diagnosed with listeriosis increased during pregnancy. Listeriosis can lead to miscarriage, spontaneous preterm labour...
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Background: Mother-to-baby transmission of group B Streptococcus (GBS) is the main cause of early-onset infection. We evaluated whether, in women with clinical risk factors for early neonatal infection, the use of point-of-care rapid intrapartum test to detect maternal GBS colonisation reduces maternal antibiotic exposure compared with usual care,...
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Background: Mother-to-baby transmission of group B Streptococcus (GBS) is the main cause of early-onset infection. We evaluated whether, in women with clinical risk factors for early neonatal infection, the use of point-of-care rapid intrapartum test to detect maternal GBS colonisation reduces maternal antibiotic exposure compared with usual care,...
Chapter
In health and medical sciences, with developments in computing, there is a rapid growth in data both in form of “Big” registries and published papers. Both offer opportunities to perform statistically powerful analyses, but each has its inherent challenges. Large datasets, in theory, offer consistent data, an assumption that ought to be tested conc...
Chapter
Medical researchers frequently face rejection by journal editors and peer-reviewers. They find it difficult to navigate the process of publication of medical manuscripts. There is a lack of knowledge about the journal assessment mechanisms, which makes it hard to obtain acceptance and wastes time in the rejection-resubmission cycle. The purpose of...
Chapter
Interest and appetite for health-related information in the COVID-19 era is higher than probably at any other time before. The communication infrastructure that connects the world today, with billions of smartphones being owned, is more than ready to play its role despite there being a technological gap between global North and South. In the last t...
Article
Introduction Clinical practice guidelines (CPGs) and consensus statements (CSs) are being promoted to provide high-quality healthcare guidance. This systematic review has assessed the breast cancer (BC) screening CPGs and CSs quality and reporting. Methods A search of bibliographic databases (MEDLINE, Embase, Web of Science, Scopus and CDSR), 12 g...
Article
Introduction: Shared decision making (SDM) is a collaborative process that involves the patient and the professional to reach a joint decision about care. Objectives: To evaluate the knowledge, attitude and application of SDM among health professionals involved in the treatment of breast cancer (BC). Materials and methods: Cross-sectional study b...
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Objectives: To evaluate patient safety attitudes of the frontline health workers in hospitals of Lahore, Pakistan. Methods: A self-administered Safety Attitudes Questionnaire (SAQ) survey was deployed in five hospitals across Lahore, Pakistan (July 2019 to June 2020). A total of 1250 consecutive consenting nurses and postgraduate trainee physici...
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There is a lack of evidence evaluating cryoprecipitate transfusion in severe postpartum haemorrhage. We performed a pilot cluster-randomised controlled trial to evaluate the feasibility of a trial on early cryoprecipitate delivery in severe postpartum haemorrhage. Pregnant women (>24 weeks gestation), actively bleeding within 24 h of delivery and w...
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Background: Intimate partner violence (IPV) affects outcomes of mothers and their offspring. This systematic review collated the worldwide literature on the prevalence rates of different types of IPV in pregnancy. Methods: Two reviewers independently identified cross sectional and cohort studies of IPV prevalence in pregnancy in online databases (P...
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The aim of this study was to systematically review all evidence evaluating obesity as a prognostic factor for PC mortality. Cohort and case-control studies reporting mortality among PC patients stratified by body mass index (BMI) were included. The risk of mortality among obese patients (BMI ≥ 30) was compared with the risk for normal weight (BMI <...
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Objective: Stillbirth is a potentially preventable complication of pregnancy. Identifying women at risk can guide decisions on closer surveillance or timing of birth to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none have yet been externally validated. We externally validated published predict...
Article
Study question Does endogenous progesterone play a role in unexplained infertility? A systematic review investigating the possibility of altered progesterone-mediated change leading to reduced endometrial receptivity in women with unexplained infertility. Summary answer The evidence suggests that many of the measurable actions of endogenous proges...
Article
Background Numerous iron preparations are available for the treatment of iron deficiency anaemia in pregnancy. We aimed to provide a summary of the effectiveness and safety of iron preparations used in this setting. Methods We did a systematic review and network meta-analysis of randomised trials. We searched MEDLINE, Embase, Cochrane Central Regi...
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Objectives We evaluated breast cancer (BC) care quality indicators (QIs) in clinical pathways and integrated health care processes. Methods Following protocol registration (Prospero no: CRD42021228867), relevant documents were identified, without language restrictions, through a systematic search of bibliographic databases (EMBASE, Scopus, Web of S...
Article
Background Shared decision making (SDM) is a key component of evidence-based and patient-centred care. The aim of this study is to systematically review the quality of SDM proposals in clinical practice guidelines (CPGs) and consensus statements (CSs) concerning breast cancer (BC) screening. Methods Guidances were identified, without language rest...
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Breast cancer (BC) management care requires an increment in quality. An initiative to improve the BC quality care is registered, and quality indicators (QIs) are studied. We appraised the appearance of QIs and their standards systematically in Spain. A prospective systematic search (Prospero no: CRD42021228867) for clinical pathways and integrated...
Chapter
This chapter includes clinical cases, background, evidence‐based practical management options, preventive measures, key‐point summaries of ART practice and answers to questions patients ask. The discipline of reproductive medicine has been progressing at a prolific pace with hundreds of new scientific discoveries published daily. ART specialists sh...
Article
Background Physical activity (PA) promotes health in pregnancy. Objective To collate the recent randomized controlled trial (RCT) on the effects of various types of PA during pregnancy on maternal-fetal health outcomes, among healthy mothers, and to report the variability in the outcomes reported. Search strategy Registered in PROSPERO (CRD420191...
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China-Pakistan economic corridor is the potential project that enhances local connectivity, industrialization, financial cooperation, trade and commerce, infrastructure, tourism, the solidity of the region and so on and so forth. It is beneficial for not only Pakistan and China but will have the constructive impact on Afghanistan, Iran, India and t...
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By the year 2025 over half of the global growth will be contributed by 577 "middle weight" cities in the top 600 and the vast majority of them will be in emerging economies, and two-thirds from Chinese and Indian cities. Accordingly, "Urbanization and economic growth are strongly associated, hence, urban areas, in general, and cities, in particular...
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BACKGROUND: Cesarean delivery is the most common surgical procedure worldwide. Intrapartum fetal surveillance is routinely offered to improve neonatal outcomes, but the effects of different methods on the risk of emergency cesarean deliveries remains uncertain. We conducted a systematic review and network meta-analysis to evaluate the effectiveness...
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Objectives: To evaluate the efficacy and safety of domperidone and metoclopramide used by breastfeeding women. Methods: A systematic literature search retrieved citations from PubMed, Embase, The Cochrane Library, Medline, EBSCO, Web of Science, ClinicalTrials.gov (from inception to January, 2021) and bibliographies of known articles. Randomized c...
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Objective: This systematic review assessed whether physician–patient language concordance, compared with discordance, is associated with better health outcomes. Methods: A systematic literature search was conducted, without language restrictions, using PubMed, EMBASE, Web of Science, and PsycINFO, from inception to July 2020. We included studies th...
Article
Introduction: Unsafe abortion is the cause of a substantial number of maternal mortalities and morbidities globally, but specifically in low- and middle-income countries. Medical abortion methods provided by non-physicians may be a way to reduce the burden of unsafe abortions. Currently, only one systematic review comparing non-physicians with phy...
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To determine the psychometric properties of the Perinatal Post-Traumatic Stress Disorder (PTSD) Questionnaire (PPQ) in Spanish. A cross-sectional study of 432 Spanish puerperal women was conducted, following ethical approval. The PPQ was administered online through midwives' associations across Spain. The Edinburgh Postnatal Depression Scale was us...
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Mucosal dryness and dyspareunia are symptoms that may signifcantly afect women with primary Sjӧgren syndrome (pSS). We investigated whether vaginal dryness is correlated with sexual function, and the impact may have on the quality of life (QoL) and mental health well-being in pSS patients. Ethically approved comparative cross-sectional study was de...
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Objectives: To assess shared decision-making (SDM) knowledge, attitude and application among health professionals involved in breast cancer (BC) treatment. Materials and methods: A cross-sectional study based on an online questionnaire, sent by several professional societies to health professionals involved in BC management. There were 26 questi...
Article
Introduction: Maternal near miss is a major global health issue and approximately seven million women worldwide experience it each year. Maternal near miss can have several different health consequences and affect the women's quality of life, yet little is known about the size and magnitude of this association. The aim of this study was to assess...
Article
Introduction: Unintended pregnancy, a major global health issue resulting in unsafe abortions and maternal deaths in low- and middle-income countries, could be significantly reduced through increased use of modern contraception, including long-acting reversible contraceptives (LARC). Training of healthcare providers to administer such contraceptiv...
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Background: Intimate partner violence (IPV) is a public health concern, especially during pregnancy, and needs to be urgently addressed. In order to establish effective actions for the prevention of IPV during pregnancy, authorities must be aware of the real burden of IPV. This review aimed to summarize the existing evidence about IPV prevalence d...
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Background CPGs are not uniformly successful in improving care and several instances of implementation failure have been reported. Performing a comprehensive assessment of the barriers and enablers is key to developing an informed implementation strategy. Our objective was to investigate determinants of guideline implementation and explore associat...
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Background Testing used in screening, diagnosis and follow-up of COVID-19 has been a subject of debate. Several organisations have developed formal advice about testing for COVID-19 to assist in the control of the disease. We collated, delineated and appraised current worldwide recommendations about the role and applications of tests to control SAR...
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Background: Adnexal torsion (AT), a serious gynaecological emergency, often presents with non-specific symptoms leading to delayed diagnosis. Objective: To compare the test accuracy of ultrasound (USS), computerized tomography (CT), and magnetic resonance (MRI) to diagnose AT. Search strategy: We searched EMBASE, MEDLINE, and Cochrane CENTRAL...
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Objective: To evaluate the effectiveness of virtual reality as a distraction technique in the management of acute pain and anxiety during outpatient hysteroscopy. Design: Parallel group, prospective randomised controlled trial. Setting: UK University Hospital. Methods: Forty consenting, eligible women were randomised to virtual reality inter...
Article
Investing in clinical research and evidence-based medicine has helped to improve the care for women with polycystic ovary syndrome (PCOS). However, several important questions remain unanswered on the optimal prevention and management strategies for PCOS. Addressing this uncertainty is often hindered by suboptimal research conduct leading to ineffi...