Khalid Saeed KhanUniversity of Granada | UGR · Department of Preventive Medicine and Public Health
Khalid Saeed Khan
Professor MBBS, FCPS, MSc, MMEd, FHEA
Professor Khalid Khan is Distinguished Investigator at the Faculty of Medicine, University of Granada, Spain.
About
922
Publications
174,365
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Introduction
Professor Khalid Khan is Distinguished Investigator at the Faculty of Medicine, University of Granada, Spain. With an h-index>100 he has published over 600 peer-reviewed papers and supervised 25 higher-degree theses. Professor Khalid Khan, gynaecologist formerly, has contributed to many trials and meta-analyses. He is the lead author of 'Systematic Reviews to Support Evidence-Based Medicine', which won a BMA Medical Book award. He is Topic Editor: Integrity of Randomized Clinical Trials.
Publications
Publications (922)
Evidence syntheses of randomized clinical trials (RCTs) offer the highest level of scientific evidence for informing clinical practice and policy. The value of evidence synthesis itself depends on the trustworthiness of the included RCTs. The rising number of retractions and expressions of concern about the authenticity of RCTs has raised awareness...
The integrity of randomized clinical trials (RCT) has become a concern owing to a recent rise in the number of retractions and the repercussions this has for evidence‐based patient care. However, there is little research on the subject of RCT integrity assessment. Recent literature reviews have revealed that journals' authors' instructions concerni...
Objective
To prepare a set of statements for randomised clinical trials (RCT) integrity through an international multi‐stakeholder consensus.
Methods
The consensus was developed via: multi‐country multidisciplinary stakeholder group composition and engagement; evidence synthesis of 55 systematic reviews concerning RCT integrity; anonymised two‐rou...
Background: The trustworthiness of randomised clinical trials (RCTs) is suffering a crisis of confidence. Objectives: We undertook an umbrella review of the research integrity literature concerning RCTs. Search strategy and selection criteria: Following prospective registration (https://osf.io/3ursn), two reviewers independently searched PubMed, Sc...
Purpose of review:
High-quality research underpins the best healthcare practice. This article focuses on analyzing the current literature to promote research integrity across clinical trials.
Recent findings:
Recent admissions of questionable practices by researchers have undermined practitioner and public confidence. There is limited evidence s...
Objective: To study the relationship between gestational weight gain (GWG) and Daily Life Impact of Pregnancy Symptoms (DLIPS) scores. Methods: A multivariable analysis of a clinical trial (the Walking Preg_Project (WPP), ClinicalTrials.gov NCT03735381) was conducted. The cohort data concerning GWG across gestational trimesters (T1, T2 and T3) was...
Introduction
Obstetric violence, or mistreatment of women in obstetric care, can have severe consequences such as fear of future childbirth, post‐traumatic stress disorder, and depression.
Material and Methods
The primary objective was to estimate the prevalence of obstetric violence in high‐income countries. The secondary objective was to extract...
doi: https://doi.org/10.12669/pjms.40.8.9779 How to cite this: Chien PFW, Khan KS, Fawzy M, Khalaf Y. Cairo Consensus Statement on Research Integrity of Randomised Clinical Trials. Pak J Med Sci. 2024;40(8):---------. doi: https://doi.org/10.12669/pjms.40.8.9779 This is an Open Access article distributed under the terms of the Creative Commons Attr...
Background
Female pelvic floor dysfunction (PFD) is a common condition affecting the emotional well‐being of women.
Objective
To estimate the prevalence of depressive and anxiety symptoms in women with PFD.
Search Strategy, Selection Criteria, Data Collection and Analysis
Following prospective registration (PROSPERO CRD42022362095) we conducted a...
Objective
To prepare a set of statements for randomised clinical trials (RCT) integrity through an international multi-stakeholder consensus.
Methods
The consensus was developed via multi-country multidisciplinary stakeholder group composition and engagement; evidence synthesis of 55 systematic reviews concerning RCT integrity; anonymized two-roun...
Background
Post‐publication handling of integrity concerns in randomized clinical trials (RCTs) is a contentious matter.
Objectives
We undertook a scoping systematic review to map the literature regarding post‐publication integrity issues in RCTs.
Search Strategy and Selection Criteria
Following prospective registration (https://osf.io/pgxd8) we...
Background
Systematic reviews and meta‐analyses are instrumental in shaping clinical practice. However, their findings can sometimes be marred by discrepancies and potential biases, thereby diluting the strength of the evidence presented. Umbrella reviews serve to comprehensively assess and synthesise these reviews, offering a clearer insight into...
Background
Effective pain control is crucial to optimise the success of medical procedures. Immersive virtual reality (VR) technology could offer an effective non-invasive, non-pharmacological option to distract patients and reduce their experience of pain. We aimed to evaluate the efficacy of Immersive virtual reality (VR) technology in reducing p...
Background
The rising number of retracted randomised clinical trials (RCTs) is a concern over their trustworthiness. In today's digital landscape electronic observational data is easily accessible for research purposes. This emerging perspective, in tandem with the growing scrutiny of RCT credibility, may steer some researchers towards favouring no...
Background
Findings related to the association between persistent organic pollutants (POPs) and gestational diabetes mellitus (GDM) are inconclusive.
Objectives
To estimate the strength of the association between POP exposure and GDM in a systematic review with meta‐analysis.
Search strategy
MEDLINE, Scopus and Web of Science were searched until...
Background
Motivating patients to take part in randomized controlled trials (RCTs) is challenging. Patient and public involvement (PPI), recommended for reporting since 2011, may potentially improve the recruitment and retention of participants in research.
Aim
In this systematic review we aimed to identify the extent of PPI reported in RCTs of li...
Background
There is no consensus on tests required to either diagnose unexplained infertility or use for research inclusion criteria. This leads to heterogeneity and bias affecting meta‐analysis and best practice advice.
Objectives
This systematic review analyses the variability of inclusion criteria applied to couples with unexplained infertility...
Background
Musculoskeletal disorders (MSDs) decrease productivity. The objective of this systematic review was to estimate the regional prevalence of MSD among healthcare professionals in Africa.
Methods
After prospective registration (PROSPERO CRD42023455517), a literature search was conducted in PubMed, Science Direct and Google Scholar in Augus...
Robotic-assisted breast surgery (RABS) is controversial. We systematically reviewed the evidence about RABS, comparing it to open conventional breast surgery (CBS). Following prospective registration (osf.io/97ewt), a search was performed in January 2023, without time or language restrictions, through bibliographic databases (PubMed, Web of Science...
Background
Numerous biomarkers have been proposed for diagnosis, therapeutic, and prognosis in sepsis. Previous evaluations of the value of biomarkers for predicting mortality due to this life-threatening condition fail to address the complexity of this condition and the risk of bias associated with prognostic studies. We evaluate the predictive pe...
Objective
This work contributed to the development of a core outcome set (COS) for heavy menstrual bleeding (HMB). The objective was to determine which research outcomes best reflect how HMB affects women’s lives and to identify additional research outcomes, not previously reported. It was important to explore and record participants’ reasoning for...
Introduction:
Physicians must share decisions and choose personalised treatments regarding patients´ beliefs and values.
Objective:
To analyse the quality of the recommendations about shared decision making (SDM) in colorectal (CRC) and anal cancer treatment clinical practice guidelines (CPGs) and consensus statements (CSs).
Methods:
Guideline...
Obesity represents a major global health challenge. Female sexual dysfunctions have a negative impact on quality of life and overall health balance. A higher rate of female sexual dysfunctions in obese women has been suggested. This systematic review summarized the literature on female sexual dysfunction prevalence in obese women. The review was re...
The aim of this work was to collect, evaluate and interpret the available evidence on the relationship between continuity in primary care (i.e., longitudinality), and the prevalence of polypharmacy and its associated problems. Following the PRISMA reporting statement, we carried out a systematic review of the literature searching PubMed and Scopus...
Introduction
Low dietary calcium intake is a risk factor for pre-eclampsia, a major contributor to maternal and perinatal mortality and morbidity worldwide. Calcium supplementation can prevent pre-eclampsia in women with low dietary calcium. However, the optimal dose and timing of calcium supplementation are not known. We plan to undertake an indiv...
Background: Endometriosis is a chronic, often debilitating condition with a current significant delay from symptom onset to diagnosis with much of this in primary care.
Methods: A systematic review and meta-analysis of the primary literature was conducted to investigate the accuracy of symptoms, clinical history and first-line non-invasive tests to...
Background
Randomized clinical trials (RCTs) are experiencing a crisis of confidence in their trustworthiness. Although a comprehensive literature search yielded several reviews on RCT integrity, an overarching overview is lacking.
Objectives
The authors undertook a scoping umbrella review of the research integrity literature concerning RCTs.
Sea...
Objective
To develop a core outcome set for heavy menstrual bleeding (HMB).
Design
Core outcome set (COS) development methodology described by the COMET initiative.
Setting
University hospital gynaecology department, online international survey and web‐based international consensus meetings.
Population or sample
An international collaboration of...
Background
Kangaroo mother care (KMC) intervention involves skin-to-skin contact between mother and infant. Some studies have shown a decrease in postpartum depression (PPD) in mothers of preterm and low birth weight (LBW) infants. However, the literature is scattered and of variable quality.
Aims
To conduct a systematic review of available litera...
Abstract: Objectives: Patients with primary Sjögren’s syndrome (pSS) often report smell and taste
disturbances. However, the correlation between smell impairment and mucosal dryness is not well
understood. The objectives of this study were to investigate the following: (1) the prevalence of
smell hypofunction in patients with SS; (2) the impact of...
Background
In cancer care, the promotion and implementation of shared decision‐making in clinical practice guidelines (CPG) and consensus statements may have potential differences by gender.
Objective
To systematically analyse recommendations concerning shared decision‐making in CPGs and consensus statements for the most frequent cancers exclusive...
Background: The findings of individual epidemiological studies that suggest an association between some Persistent Organic Pollutants (POPs) and Gestational Diabetes Mellitus (GDM) are inconclusive. Objectives: To estimate the strength of the association between POPs exposure and GDM in a systematic review with meta-analysis. Search strategy: MEDLI...
Unlabelled:
Smartphone applications or apps are increasingly being produced to help with protection against the risk of domestic violence. There is a need to formally evaluate their features.
Objective:
This study systematically reviewed app-based interventions for domestic violence prevention, which will be helpful for app developers.
Methods:...
Intimate partner violence (IPV) during pregnancy, a condition as common as obstetrics conditions like gestational diabetes, is associated with maternal and neonatal complications. Systematic detection of IPV is not well established in antenatal screening probably because the effectiveness of protective interventions has not been evaluated. E-health...
Background:
Risk-reducing salpingo-oophorectomy (RRSO) is the gold standard method of ovarian cancer risk reduction, but the data are conflicting regarding the impact on breast cancer (BC) outcomes. This study aimed to quantify BC risk/mortality in BRCA1/BRCA2 carriers after RRSO.
Methods:
We conducted a systematic review (CRD42018077613) of BRC...
Introduction
Public partnerships, a route to sharing expertise, networks and resources anchored in the United Nations Sustainable Development Goals, has been championed by multiple stakeholders.
Objective
To propose a new evidence-based medicine (EBM) curriculum for harnessing patient and public expertise to ensure that EBM teaching and learning c...
This article includes Author Insights, a video abstract available at: https://vimeo.com/785911255
Objectives:
High prevalence of risk factors for pelvic floor disorders (PFD) in the Eastern Mediterranean may result in higher rates of prevalence of PFD in comparison to other regions. Despite individual studies, there are no clear statistics on the cumulative prevalence of PFDs in the East Mediterranean region. The aim of this study was to inves...
Systematic reviews rank at the top of the evidence hierarchy. Concise writing implies drafting the systematic review article succinctly, i.e. using as few words to express as full an extent of the research effort as possible. Precise writing means drafting the text with accuracy especially with respect to the methodological and statistical aspects....
Locally advanced breast cancer (LABC) is a subset of breast cancer with locoregional progression without distant metastasis. The multimodality treatment (surgery, chemotherapy, radiotherapy, hormonal and targeted therapy if required) could significantly improve results in this specific group of patients. The complex and multiple options of treatmen...
Resumen
El último paso en una revisión sistemática es interpretar la evidencia de forma que pueda ser útil para sustentar la toma de resultados. Es importante presentar los resultados de forma claramente diferenciada, asignar el nivel de fuerza de la evidencia que respalda cada uno de ellos teniendo en cuenta factores como el diseño de los estudios...
Researchers preparing systematic review articles frequently face rejection by journal editors and peer-reviewers, leading invariably to time wastage in the rejection resubmission cycle. In addition to undertaking the review work, authors need to understand the manuscript assessment mechanisms and the publication process within medical journals. Pro...
This systematic review aims to evaluate gender differences in authorship of prevalence literature concerning intimate partner violence (IPV) during pregnancy and gestational diabetes mellitus (GDM). GDM studies were matched for publication year and study country as a gender-neutral obstetric disease with similar morbidity to IPV. Relevant studies w...
Purpose
To investigate the possibility that altered actions of endogenous progesterone affect receptivity and contribute to unexplained infertility (UI).
Methods
Two authors electronically searched MEDLINE, CINAHL and Embase databases from inception to 6 July 2022 and hand-searched according to Cochrane methodology. We included all published prima...
Objectives
Patients with primary Sjögren’s Syndrome (pSS) often report smell and taste disturbance. However, a correlation between the smell impairment and mucosal dryness is not well understood. The objectives of this study were to investigate: 1) The prevalence of smell hypofunction in patients with SS. 2) The impact of smell hypofunction on the...
Background
Cervical cancer affects 3197 women in the UK, and 604 000 women worldwide annually, with peak incidence seen in women between 30 and 34 years of age. For many, fertility‐sparing surgery is an appealing option where possible. However, absence of large‐scale data, along with a notable variation in reported outcomes in relevant studies, may...
Authoritative, clear and concise, this highly acclaimed book continues to be an essential text for all medical, surgical and allied health professionals who are seeking a quick and respected guide to systematically reviewing the literature. The third edition features a new chapter on 'Publishing systematic reviews’ and numerous new case studies cov...
Purpose
A tourniquet is routinely used during total knee arthroplasty (TKA) to reduce intra-operative hemorrhage, though surgery without a tourniquet is becoming popular. To address concerns about the effect of blood at cement interfaces on long-term implant stability, we conducted a systematic review among patients undergoing total knee arthroplas...
( Anaesthesia . 2022;77:175–184)
Fibrinogen levels play a key role in maintaining homeostasis during postpartum hemorrhage (PPH). Fibrinogen levels <2 g/L is significantly associated with adverse outcomes. Fibrinogen substitution effectively improves outcomes in severe PPH. However, the only studies evaluating early fibrinogen use describe the fibr...
High-quality clinical practice guidelines (CPGs) and consensus statements (CSs) are essential for evidence-based medicine. The purpose of this systematic review was to appraise the quality and reporting of colorectal cancer (CRC) screening CPGs and CSs. After prospective registration (Prospero no: CRD42021286156), a systematic review searched CRC g...
Background:
Non-anemic iron deficiency precedes iron deficiency anaemia and has an estimated prevalence of 1-2 billion worldwide. Few studies have comprehensively researched the idea of treating non-anemic iron deficiency (NAID) with iron to improve the outcome of the mother and the offspring.
Methods and analysis:
FAIR will be a multicenter ran...
Participation in randomised clinical trials (RCTs) entails taking part in the discovery of effects of health care interventions. The question of whether participants’ outcomes are different to those of non-participants remains controversial. This umbrella review was aimed at assessing whether there are health benefits of participation in RCTs, comp...
Background: Endometriosis is a chronic, often debilitating condition with a current significant delay from symptom onset to diagnosis. Objectives: To investigate the accuracy of symptoms, clinical history and non-invasive tests to predict pelvic endometriosis. Data sources: Medline, Embase, Web of Science and Scopus from conception to September 202...
Introduction/Background
Cervical cancer affects 3,197 UK-women and 570,000 women worldwide annually, with peak incidence seen between 30–34 years age. For many, fertility-sparing surgery is an appealing option where possible. However, absence of large-scale data, along-with a notable variation in reported outcomes in relevant studies may undermine...
Introduction/Background
BRCA1 and BRCA2 carriers face difficult choices/decisions regarding surgical prevention for breast and ovarian cancer. Clinician counselling must accurately reflect available evidence, which for breast cancer risk following risk reducing salpingo-oophorectomy (RRSO) is now conflicting.
Methodology
We searched seven database...
Introduction:
We aimed to systematically evaluate quality of shared decision-making (SDM) in colorectal cancer (CRC) screening clinical practice guidelines (CPGs) and consensus statements (CSs).
Methods:
Search for CRC screening guidances was from 2010 to November 2021 in EMBASE, Web of Science, MEDLINE, Scopus and CDSR, and the World Wide Web....
Background:
Physiologic processes such as childbirth and menopause can alter vulvovaginal aesthetic appearance, reduce sexual satisfaction, and cause symptoms of vulvovaginal atrophy which affects a woman's quality of life. There is debate about whether dynamic quadripolar radiofrequency (DQRF) can be used to improve such conditions. We conducted...