Khaled A Abdel-Sater

Al-Azhar University, Assiut, Egypt · Physiology

Introduction With thirty percent of the world’s population not getting enough exercise, Worldwide, physical inactivity ranks as one of the most common causes of premature mortality. Rapid drops in physical activity, decreased mobility, and early morbidity are aging characteristics. As the population over 80 continues to rise, aging raises the dange...

Background: The recent sub-classification of diabetes into five different subtypes or clusters, were known as Severe Autoimmune Diabetes (SAID), Severe Insulin-Deficient Diabetes (SIDD), Severe Insulin-Resistant Diabetes (SIRD), Mild Obesity-related Diabetes (MOD), and Mild Age-Related Diabetes (MARD). This new classification was based on six clini...

Diabetes mellitus is the most common metabolic illness. Type 2 diabetes mellitus (T2DM) accounts for about 537 million people worldwide with prediction of an increase in the future. T2DM has several complications including cardiovascular, renal, and neurological complications. A large growing data demonstrated that T2DM affects negatively the cogni...

Physiology is the study of life processes within the body. This review provides an overview of how the human body normally responds to the varied conditions underwater. This is a brief overview of respiratory, cardiovascular and sensations physiological reactions associated with diving. Breathing rate, gas exchange, lung volumes, heart rate, arteri...

Background: Metabolic syndrome (MetS) is increasing worldwide and correlates with serum uric acid and high fat combined with highfructose diet (HFFD). Fat raises triglycerides. Fructose increases uric acid. We hypothesized that HFFD in menopause may have a pathogenic role in MetS and using febuxostat may improve it by attenuating oxidative stress a...

Hyperthyroidism is common endocrine problem encountered in pregnancy. It is well known that hyperthyroidism induces an increase in the activity of hypothalamic-pituitary-adrenal (HPA) axis. There are a few reports about development of the HPA axis in rat pups of hyperthyroid mothers. Therefore, this study was designed to investigate that maternal h...

Aquaporins (AQPs) form pores in the membranes of cells and selectively conduct water molecules through the membrane, while preventing the passage of ions such as sodium and potassium and other small molecules. The water movement through AQPs is considered to be facilitated simply dependent on the osmotic gradient. There are subtypes of AQPs; classi...

Background: Cold exposure is a permanent part of human life. Response to cold varies according to different factors and individual differences. The main factors potentially differentiating thermoregulation in men and women are the properties of female physiology, anthropometric characteristics, body composition, social behavior and physical working...

Introduction The epidemic of metabolic syndrome is increasing worldwide and correlates with elevation in serum uric acid and marked increase in total fructose intake. Fructose raises uric acid and the latter inhibits nitric oxide bioavailability. We hypothesized that fructose-induced hyperuricemia may have a pathogenic role in metabolic syndrome an...

Background: The prevalence of metabolic syndrome is increasing and it is considered one of the main threats to human health worldwide. Fructose feeding induces hyper-insulinemia, insulin resistance and hyper-triglyceridemia. The main objective of the present study is to evaluate the pharmacological effects of the single and combined administration...

Background and aim: Under physiological conditions, maintenance of skeletal mass is the result of a tightly coupled process of bone formation and bone resorption. Disease states, osteoporosis included, arise when this delicate balance is disrupted, such as in menopause. The aim of the present work was to study the effect of leptin supplementation...

This study investigated the effects of losartan (Los; AT1 receptor antagonist) and acetylsalicylic acid (Aspirin; Asp) on dexamethasone (Dex)-induced hypertensive rats. Fifty adult male Wistar rats were used and divided into 5 equal groups; Control group (Con); Hypertensive group (HT0) i.p. injected with Dex (40 μg/kg/d); Hypertensive Los-treated g...

Free radicals are electrically charged molecules that are produced during the course of normal metabolism. They spontaneously attack lipids, proteins, nucleic acids and other biologically important molecules. Polyunsaturated lipids are particularly sensitive to their attack. Free radicals and oxidative stress have been reported to be involved in ti...

Objective: The main goal of the present work was to study the relationship between weight reducing effect of green tea and its effect on GABA and 5-HT neurotransmitters in obese mice. Furthermore, the antilipidemic activity of green tea was also evaluated. Methods: Adult male albino mice weighting (20 to 35 gm of both obese and non-obese) were used...

We investigated the gender difference of selective serotonin reuptake inhibitor, fluoxetine in adult rats with stress-induced gastric ulcer. The rats were randomly divided into six groups: Group I, control males and group II, control females; group III, acute cold restraint stressed males and group IV, acute cold restraint stressed females; group V...

Introduction. Under physiological conditions, maintenance of skeletal mass is the result of a tightly coupled process of bone formation and bone resorption. Disease states, osteoporosis included, arise when this delicate balance is disrupted such as in menopause. The aim of the present work was to study the effect of leptin supplementation on bone...

Testicular torsion, or more specifically, torsion of the spermatic cord, results in ischemic changes of the tissue which require early intervention for re-establishment of testicular perfusion and its salvage. However, gonadal re-perfusion has been reported to cause further testicular damage and the injury produced by re-perfusion could be more sev...

Free radicals are electrically charged molecules that are produced during the course of normal metabolism. They spontaneously attack lipids, proteins, nucleic acids and other biologically important molecules. Polyunsaturated lipids are particularly sensitive to their attack. Free radicals and oxidative stress have been reported to be involved in ti...

In positive feedback mechanisms, the response to a stimulus does not stop or reverse it but instead keeps the sequence of events going up. At first glance, this would appear to be a counter to the principle of homeostasis, since a positive feedback loop has no obvious means of stopping. Not surprisingly, therefore, the positive feedback is less com...

Background and Aim: Platelets play a role in the microvascular as well as macrovascular complications of diabetic patients with serious implications in the pathogenesis of vascular disease in patients with type 2 diabetes. Hyperglycemia changes platelet functions by impairing calcium homeostasis. So, it is important to study the effect of nifedipin...

The aim of this study was to assess the effects of hypothyroidism on the development of acute cold restraint stress gastritis in rats and protective effect of Nigella sativa at the beginning of the acute cold restraint stress. 60 rats were randomly divided into six groups; the control (groups I), surgically thyroidectomized group (group II), acute...

OBJECTIVE: The aim of this study was to assess the effects of hypothyroidism on the development of acute cold restraint stress gastritis in rats and protective effect of Nigella sativa at the beginning of the acute cold restraint stress. METHODS: 60 rats were randomly divided into six groups ; the control (groups I), surgically thyroidecto mized gr...

Smoking is known to adversely affect many organs and systems in human, where the cardiovascular system is one of the important targets. However, the exact mechanisms by which cigarette smoke alters myocardial and endothelial cells function and induces cardiovascular pathology are not clear. There are no reports especially with nitric oxide (NO•), u...