Khairul Najmi Muhammad Nawawi

Universiti Kebangsaan Malaysia | ukm · Department of Medicine

Background Inflammatory bowel disease (IBD) was once considered as a Western disease. However, recent epidemiological data showed an emerging trend of IBD cases in the Eastern Asia countries. Clinico-epidemiological data of IBD in Malaysia is scarce. This study aimed to address this issue. Methods Retrospective analysis of ulcerative colitis (UC)...

Background: Our study aimed to determine the effect of probiotic consumption containing six viable microorganisms of 30 × 1010 cfu Lactobacillus and Bifidobacteria strains for six months on clinical outcomes and inflammatory cytokines (TNF-α, IFN-γ, IL-6, IL-10, IL-12, IL-17A, IL-17C and IL-22) in patients with colorectal cancer. Methods: Fifty-...

Introduction There is growing evidence that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) improves symptoms in irritable bowel syndrome (IBS) patients. We aimed to retrospectively investigate the effects of this diet in Irish IBS cohort over a 12-month follow-up period, including after re-introduct...

Obesity has become a worldwide health concern among the pediatric population. The prevalence of non-alcoholic fatty liver disease (NAFLD) is growing rapidly, alongside the high prevalence of obesity. NAFLD refers to a multifactorial disorder that includes simple steatosis to non-alcoholic steatohepatitis (NASH) with or devoid of fibrosis. NAFLD is...

Patients with irritable bowel syndrome (IBS) are increasingly presenting with a wide range of neuropsychiatric symptoms, such as deterioration in gastroenteric physiology, including visceral hypersensitivity, altered intestinal membrane permeability, and gastrointestinal motor dysfunction. Functional imaging of IBS patients has revealed several abn...

Chronic relapsing inflammatory bowel disease is strongly linked to an increased risk of colitis-associated cancer (CAC). One of the well-known inflammatory carcinogenesis pathways, phosphatidylinositol 3-kinase (PI3K), was identified to be a crucial mechanism in long-standing ulcerative colitis (UC). The goal of this study was to identify somatic v...

Background The local studies on Helicobacter pylori (H. pylori) eradication following standard triple therapy demonstrated a suboptimal eradication rate with an emerging clarithromycin resistance rate from 6.8% to 14.8%. In this study, we aim to investigate the efficacy of Lactobacillus reuteri probiotic in improving the eradication rate of H. pylo...

Background The role of tocotrienol in treating fatty liver is not widely explored. We aimed to investigate the potential benefit of palm tocotrienol-rich fraction (TRF) in patients with fatty liver disease. Methods Patients were treated and followed up from February 2016 until September 2020. Inclusion criteria include ultrasound-diagnosed fatty l...

Obscure gastrointestinal bleeding is defined as recurrent or persistent gastrointestinal bleeding in the setting of normal upper and lower endoscopies. There are reported use of numerous pharmacological agents to halt the bleeding, including oestrogen. We report a case of middle age gentleman with multiple comorbidities, presented with life threate...

Food insecurity (FI) has an impact on food intake, and it can make it difficult for people to eat enough nutritious food at all times to sustain an active and healthy lifestyle. The COVID‐19 outbreak has hampered people's capacity to obtain nutritious and affordable food. Although FI has been studied in Malaysia, the extent to which it is linked to...

Colorectal cancer (CRC) is a heterogeneous disease that commonly affects individuals aged more than 50 years old globally. Regular colorectal screening, which is recommended for individuals aged 50 and above, has decreased the number of cancer death toll over the years. However, CRC incidence has increased among younger population (below 50 years o...

Background The incidence rate of colorectal cancer (CRC) in Asian countries is increasing. Furthermore, recent studies have shown a concerning rise in the incidence of CRC among younger patients aged less than 50 years. This study aimed to analyze the incidence trends and clinicopathological features in patients with early-onset CRC (EOCRC) and lat...

Introduction: Coronary Artery Disease (CAD) is an important extrahepatic cardiovascular complication of Non Alcoholic Fatty Liver Disease (NAFLD). Aim: To determine the prevalence of NAFLD in young (≤45 years) Acute Coronary Syndrome (ACS) patients, and to assess the association between severity of NAFLD and severity of CAD. Materials and Methods:...

Treatment for non-alcoholic fatty liver disease (NAFLD) currently consists of lifestyle modifications such as a low-fat diet, weight loss, and exercise. The gut microbiota forms part of the gut–liver axis and serves as a potential target for NAFLD treatment. We investigated the effect of probiotics on hepatic steatosis, fibrosis, and biochemical bl...

Background Growing attention has been given to the effects of dysbiosis in the gastrointestinal tract that possibly modulate intestinal permeability. This will trigger the secretion of pro-inflammatory cytokines that induces inflammation. Thus, probiotics are suggested to reverse the mechanism by promoting the growth of good bacteria that participa...

Thrombotic thrombocytopenic purpura and acute myeloid leukemia are rarely associated with Crohn's disease. Early recognition of these conditions with timely referral to hematologist is paramount. Acute myeloid leukemia should be suspected despite the absence of blast cells from peripheral blood film. Although is rare, thiopurines like azathioprine...

Introduction: Recent studies have published the roles of exosomal miRNAs in the pathogenesis of various type of malignancies and can be developed as potential biomarkers for diagnostic, prognostic and therapeutic purposes. The aim of this study was to identify the expression level of selected miRNAs (miR-182, miR-301a, and miR-373) in exosomes of...

Pneumatosis intestinalis (PI) is a rare radiological finding, characterized by the presence of gas in the bowel wall. It has a wide spectrum of possible underlying diagnosis ranging from benign to life-threatening conditions. We present a case of a previously healthy male who was initially presented with missed diagnosis of acute appendicitis which...

Pancreatic pseudocyst is a cystic pancreatic mass filled with pancreatic enzymes, which is typically a complication of chronic pancreatitis. It is usually located at the head of pancreas or at the lesser sac of stomach and can be diagnosed with different radiology modalities such as computed tomography and endoscopic ultrasound. However, an ectopic...

Hiccup is an intermittent spasmodic contraction of the diaphragm, which is usually a benign and self-limiting condition. However, persistent hiccups may indicate a more sinister underlying pathology. Hiccups have been reported in the literature as an unusual manifestation in hyponatremia. Some literature had linked the severity of hiccups to the le...

Distal oesophageal spasm is a rare condition that affects the motility of the oesophagus. It can be diagnosed by high-resolution oesophageal manometry and the diagnosis is supported by other modalities such as barium swallow and esophagogastroduodenoscopy examinations. Treatment options include pharmacological therapy, endoscopy and surgical interv...

Upper gastrointestinal bleeding as a result of gastrointestinal metastases from lung cancer is extremely rare. We report two cases of patients with duodenal metastases from lung adenocarcinoma presented with recurrent melena. Histopathological examination and immunohistochemical staining of the duodenal biopsies supported the diagnosis of metastati...

Background The objective of this study was to identify the presence of selected miRNAs in exosomes of the serum and ascitic fluid and to determine their expression levels in patients with NASH-related liver cirrhosis with or without HCC Methods A literature search was performed to identify potential miRNAs involved in the pathogenesis of HCC. The...

Hepatic haemangioma is a solitary liver lesion and prevalent among the female patients. We report a case of diffuse hepatic haemangiomatosis in a 62-year-old man, who was referred for an incidental finding of multiple liver nodules. History and physical examinations were unremarkable. Computed tomography and magnetic resonance imaging of the liver...

Background Coronary artery disease (CAD), which clinically manifested as an acute coronary syndrome (ACS) is an important extrahepatic cardiovascular complication of non-alcoholic fatty liver disease (NAFLD). To date, little is known about the correlation between young patients with ACS and NAFLD. Aim to assess the correlation between NAFLD and sev...