Khairi Mustafa Salem Fahelelbom

Khairi Mustafa Salem Fahelelbom
Al Ain University · College of Pharmacy

B.Pharm., PhD.

About

56
Publications
42,732
Reads
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339
Citations
Citations since 2017
23 Research Items
241 Citations
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2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
Introduction
Development and validation of HPLC and spectrophotometric methods for drug analysis Evaluation of splitted tablets in solid dosage forms Techniques: HPLC, UV-Visible spectrophotometry. IR and FTIR technique, Spectroflurometry etc... Working on: Development and validation of HPLC analytical methods for certain ACE inhibitors Development of FTIR methods for drug analysis and In-Vitro and In-Vivo Evaluation methods
Additional affiliations
January 2011 - present
United Arab Emirates University
January 2011 - present
Al Ain University of Science and Technology
January 2004 - December 2007
Ajman University of Science & Technology
Education
September 1983 - June 1989
Trinity College Dublin
Field of study
  • Pharmaceutical sciences
September 1976 - June 1981
University of Tripoli
Field of study
  • Pharmacy

Publications

Publications (56)
Article
Full-text available
Purpose of present study was to develop eight formulations of chlorpheniramine (CPM) niosomes according to 2 3 factorial design, characterise on the basis of various evaluation tests, i.e. in vitro drug release, SEM, FTIR, TGA and release kinetics, optimise the eight formulation on the basis in vitro drug release data, formulate gel of optimised di...
Article
Full-text available
Background Amid the turbulent nature of the COVID-19 pandemic, telepharmacy has shifted the paradigm of patient care by leveraging digital medicine. Government mandated lockdowns and norms of social distancing have further underscored the need for telepharmacy. Many developed and developing countries implemented such initiatives where pharmacists h...
Article
Full-text available
Qualitative Fourier transform infrared (FTIR) spectroscopy has long been established and implemented in a wide variety of fields including pharmaceutical, biomedical, and clinical fields. While the quantitative applications are yet to reach their full potential, this technique is flourishing. It is tempting to shed light on modern engaging and the...
Article
Full-text available
The current research aimed to fabricate ondansetron nanostructured lipid carriers (OND-NLCs) and incorporate them into a suppository base to manage chemotherapy-induced vomiting and nausea, which offer the advantage of both rapid onset and prolonged release. NLCs were fabricated by adopting the solvent diffusion method. The binary lipid mixture of...
Article
Full-text available
Objectives: The objective of this study was to determine the identification rate of substandard and falsified medications and its association with knowledge among public. Methods: This descriptive cross-sectional study was conducted in different geographic areas among a convenient sample of people aged 18 or older. A validated web-based electronic...
Article
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Factors reported in the literature associated with inappropriate prescribing of antimicrobials include physicians with less experience, uncertain diagnosis, and patient caregiver influences on physicians' decisions. Monitoring antimicrobial resistance is critical for identifying emerging resistance patterns, developing, and assessing the effectiven...
Article
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Naproxen (NAP) is commonly used for pain, inflammation, and stiffness associated with arthritis. However, systemic administration is linked with several gastrointestinal tract (GIT) side effects. The present work aims to prepare and evaluate NAP nanoparticulate shells of chitosan (CS) and carrageenan (CRG) loaded into a Carbopol 940 (Ca-940) gel sy...
Preprint
Full-text available
(1) Background: Factors reported in literature associated with inappropriate prescribing of antimicrobials, such as physicians with less experience, uncertain diagnosis, and patient caregiver influences on physicians' decisions. Monitoring antimicrobial resistance is critical for identifying emerging resistance patterns, developing, and assessing t...
Article
Full-text available
Background Micro-RNAs (miRNAS) are non-coding, small RNAs that have essential roles in different biological processes through silencing genes, they consist of 18-24 nucleotide length RNA molecules. Recently, miRNAs have been viewed as important modulators of viral infections they can function as suppressors of gene expression by targeting cellular...
Article
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Background and purpose: There has been a long-standing belief that generic drugs are of lower value in comparison to their branded name counterparts. They are in particular under scrutiny due to their low market price. Even though the reduction in costs is largely based on skipping expensive preclinical studies and clinical trials for generic drug...
Article
Currently, the synthesis of multi-polymer based hydrogels called interpenetrating networks (IPNs) is more in practice due to enhanced tunability and effective drug release features in comparison to single components. IPNs are synthesized by crosslinking two or more polymeric networks where one of the networks is synthesized in the presence of the o...
Article
Full-text available
Objective: The aim of this study is to develop and optimize a new an RP-HPLC method for the analysis of lisinopril from pure samples, full and split tablet dosage forms by investigating all relevant factors in order to obtain a simple, reproducible and sensitive technique for the quantitative determination of lisinopril. Method: A number of chromat...
Article
The skeletal system is fundamental for the structure and support of the body consisting of bones, cartilage, and connective tissues. Poor fracture healing is a chief clinical problem leading to disability, extended hospital stays and huge financial liability. Even though most fractures are cured using standard clinical methods, about 10% of fractur...
Article
Full-text available
Background : Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy is a rapid quantitative method which has been applied for pharmaceutical analysis. This work describes the utility of first derivative ATR-FTIR spectroscopy in the quantitative determination of diclofenac sodium tablets. Methods : This analytical quantitativ...
Article
Full-text available
Background : Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy is a rapid quantitative method which has been applied for pharmaceutical analysis. This work describes the utility of first derivative ATR-FTIR spectroscopy in the quantitative determination of diclofenac sodium tablets. Methods : This analytical quantitativ...
Article
Full-text available
Objective: The aim of this study was the utilization of synchronous fluorimetry using conventional and first order derivative for the simultaneous determination of dipyridamole (DPR) and acetylsalicylic acid (ASA) in pharmaceutical preparations and biological fluids. Methods: These methods are based on the native fluorescence of both compounds at c...
Article
Full-text available
Background: Tobacco use is the major cause of preventable morbidity and mortality. The main objectives of this study were to identify smokers willing to participate in quit smoking campaigns using social media and to identify smoking habits of everyday smokers in Al Ain City, United Arab Emirates (UAE). Research design and methods: Everyday smok...
Article
Full-text available
Bacterial resistance and antibiotic drug effectiveness can be related to administering generic products with a subtherapeutic dose or poor in vivo drug release. The aim of this study was to investigate whether locally marketed amoxicillin tablets have the required chemical and physical attributes, including in vitro bioequivalence performance. Five...
Article
Full-text available
Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets as a result of splitting the tablets either by hand or with a splitting device. The impact of the s...
Article
Full-text available
Objective: To investigate whether particular courses in modern pharmacy curriculum equips enrolled students with knowledge/skills to differentiate between different claims of weight loss products. Methods: Claims from weight loss products in UAE market were identified and classified to three categories: indicating safety, indicating effectiveness o...
Conference Paper
Full-text available
Abstract Drug counterfeiting has steadily evolved from small-scale, opportunistic, activities in less regulated parts of the world to what has become a widespread global threat to consumer, brand owners, health systems and the world economy. In 2010, it was estimated that the counterfeit drug market was over $ 70 billion, representing a 90 percen...
Conference Paper
Full-text available
The purpose of this study was to assess the in vitro performances of ''vegetable'' capsules in comparison to hard gelatin capsules in terms of shell weight variation, reaction to different humidity conditions, resistance to stress in the absence of moisture, powder leakage, disintegration and dissolution. Two types of capsules made of HPMC produced...
Article
Full-text available
Abstract The purpose of this study was to assess the in vitro performances of "vegetable" capsules in comparison to hard gelatin capsules in terms of shell weight variation, reaction to different humidity conditions, resistance to stress in the absence of moisture, powder leakage, disintegration and dissolution. Two types of capsules made of HPMC p...
Conference Paper
Full-text available
Objective: The purpose of this study was to verify the claimed acid-resistant properties and other performance indicators for AR Caps (Capsule 5 from CapsCanada) and DRcaps (Capsule 6 from Capsugel) and compare them with the immediate release hydroxypropyl methylcellulose " HPMC " capsules (K-CAPS from CapsCanada). Methods: Shell weight variability...
Article
Full-text available
Objective: The purpose of this study was to verify the claimed acid-resistant properties and other performance indicators for AR Caps (Capsule 5 from CapsCanada) and DRcaps (Capsule 6 from Capsugel) and compare them with the immediate release hydroxypropyl methylcellulose "HPMC" capsules (K-CAPS from CapsCanada). Methods: Shell weight variability,...
Data
A number of 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl) benzamides (1a–h) were synthesized via reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate (2) as a key intermediate with several substituted primary aromatic amines. The new compounds were characterized by proton nuclear magnetic resonance (1 H-NMR), car-bon-13 nuc...
Article
Full-text available
A number of 2-((4-ethylphenoxy)methyl)-N-(substituted-phenylcarbamothioyl) benzamides (1a-h) were synthesized via reaction of 2-((4-ethylphenoxy)methyl)benzoyl isothiocyanate (2) as a key intermediate with several substituted primary aromatic amines. The new compounds were characterized by proton nuclear magnetic resonance ((1)H-NMR), carbon-13 nuc...
Article
Full-text available
ABSTRACT The purpose of this study was to find out if the pharmacists working in community pharmacy and outpatient pharmacy have undergone any formal education regarding drug information, and to describe the drug information resources available, utilization of Internet as drug information resource and whether the available resources are sufficient...
Article
Full-text available
A series of 1,3-oxazole, 1,3-thiazole, isomeric 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,3,4-tetrazole heterocycles was synthesized. All the compounds shared as a common feature the presence of a 4-hydroxyphenyl substituent. The structures of the synthesized compounds were confirmed by MS, ¹H-NMR, and elemental analysis. In vitro antimicrobial a...
Article
Full-text available
A new series of 1,3-thiazole and benzo[d]thiazole derivatives 10-15 has been developed, characterized, and evaluated for in vitro antimicrobial activity at concentrations of 25-200 μg/mL against Gram+ve organisms such as methicillin-resistant Staphylococcus aureus (MRSA), Gram-ve organisms such as Escherichia coli (E. coli), and the fungal strain A...
Article
Full-text available
Problem statement: Several studies on the synthesis of new nifedipine analogs have beencarried out, but the literature reveled that no study on the synthesis and calcium channel blocking activity of the substituted ester with an amide (5-phenylcarbamoyl) moiety has been reported. Approach: Six new derivatives of m-nifedipine have been successfully...
Article
Full-text available
The increased availability of iminophenazines with polar substitute in the N-2 side chain (notably B826 with a (3 diethylaminopropyl) imino substituent) in the spleen of mice following oral administration prompted an investigation of a possible correlation between the partition coefficient (log P) values and electronic properties expressed by sigma...
Article
Full-text available
Problem statement: Several studies were carried out to develop and validate a simple, rapid and accurate spectrophotometric method for the analysis of tetracycline (TC) and oxytetracycline (OTC) in the pure form and in pharmaceutical dosage forms, despite the varieties of these analytical techniques, the literature revealed that no spectrophotometr...
Conference Paper
Full-text available
An Approach Seminar by Innovative Medical Environment Commission FOPHS, Ajman University of Science & Technology The Role of W.H.O and the International Health Authorities in the Pharmaceutical Quality Assurance The quality of pharmaceuticals has been the concern of WHO and many international health authorities; Included under this heading is the q...
Article
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Preservatives are substances that commonly added to various foods and pharmaceutical products in order to prolong their shelf life. The addition of preservatives to such products, especially to those that have higher water content, is essential for avoiding alteration and degradation by microorganisms during storage 1-3 . Other ingredients are also...
Article
Full-text available
A highly sensitive kinetic spectrophotometric method was developed for the determination of captopril (CPL) and ethamsylate (ESL) in pharmaceutical preparations and biological fluids. The method is based on a catalytic acceleration of the reaction between sodium azide and iodine in an aqueous solution. Concentration range of 0.1-1.5 microg ml(-1) f...
Article
Nifedipine is a calcium channel blocking dihydropyridine derivative, which undergoes a photochemical conversion to the corresponding pyridine derivative when exposed to normal U.V. light. The photooxidation leads to a remarkable decrease of its pharmacological activity. In this study, an evaluation of the chromatographic and spectrophotometric meth...
Article
Full-text available
The partition coefficient of eight N2-substituted phenazines was measured at four temperatures (range 20–55°C) in the n-octanol/water system. The apparent molal partition coefficients, Km', were calculated from the distribution results. Plots of log Km vs. T−1 were linear and the thermodynamic parameters for the solute transfer were evaluated from...
Article
Full-text available
http://www.jstor.org/discover/10.2307/20494515?uid=3737432&uid=4580606247&uid=2134&uid=17371768&uid=16739312&uid=2&uid=70&uid=3&uid=67&uid=62&uid=60&sid=21102160940237

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Projects

Projects (3)
Project
The aim of this study investigate whether locally marketed Amoxicillin tablets have the required chemical & physical attributes including in - vitro bio-equivalence performance.
Project
to evaluate these counterfeit drugs and compare them with approval ones