Kevin Seyssel

Kevin Seyssel
Claude Bernard University Lyon 1 | UCBL · Department of Physiology

PhD in Nutrition and Metabolism

About

40
Publications
26,295
Reads
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342
Citations
Citations since 2016
32 Research Items
319 Citations
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20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Introduction
I currently work at different private and public Universities as teacher. My research field interests are overfeeding and fructose. I'm really interested in all metabolic pathway and nutrition way that modulate insulin resistance.
Additional affiliations
September 2019 - present
Adonis
Position
  • Teacher
September 2019 - present
Diderot Education
Position
  • Teacher
September 2019 - present
Université Lumiere Lyon 2
Position
  • Teacher

Publications

Publications (40)
Article
Full-text available
Background Chronic exposure to high iron levels increases diabetes risk partly by inducing oxidative stress, but the consequences of acute iron administration on beta cells are unknown. We tested whether the acute administration of iron for the correction of iron deficiency influenced insulin secretion and the production of reactive oxygen species....
Article
Full-text available
Two randomized placebo-controlled double-blind paralleled trials (42 men in Lyon, 19 women in Lausanne) were designed to test 2 g/day of a grape polyphenol extract during 31 days of high calorie-high fructose overfeeding. Hyperinsulinemic-euglycemic clamps and test meals with [1,1,1- ¹³ C 3 ]-triolein were performed before and at the end of the int...
Article
Full-text available
Background and Aims Hyperuricemia is an independent risk factor for the metabolic syndrome and cardiovascular disease. We hypothesized that asymptomatic carriers for hereditary fructose intolerance (OMIM 22960) would have increased uric acid and altered component of the metabolic syndrome when exposed to fructose overfeeding. Methods Six heterozyg...
Article
Full-text available
Background: The mechanisms by which chronic stress increases the risk of non-communicable diseases remain poorly understood. On one hand, chronic stress may increase systemic vascular resistance (SVR) and blood pressure, which may lead to blood vessels injury and altered myocardial perfusion. On the other hand, chronic stress may promote the overco...
Article
Background & objectives: Obesity is often associated with increased postprandial triglyceride (TG) concentrations, mainly from chylomicrons- and VLDL-TG. These alterations are usually reverted to normal after gastric bypass surgery (GB), through mechanisms which remain unknown. The objective of this study was therefore to assess the contribution o...
Article
Full-text available
Introduction: Different factors, such as age, gender, preoperative weight but also the patient's motivation, are known to impact outcomes after Roux-en-Y gastric bypass (RYGBP). Weight loss prediction is helpful to define realistic expectations and maintain motivation during follow-up, but also to select good candidates for surgery and limit failu...
Article
Introduction et but de l’étude Des interactions entre le métabolisme du fer et le développement du tissu adipeux (TA) ont été mises en évidence [1], [2]. Nous avons voulu explorer les liens entre le métabolisme du fer et l’expression des gènes du TA sous-cutané (TASC) chez l’homme avec deux interventions en miroir modulant le volume de TA : une sur...
Article
Introduction et but de l’étude L’obésité et les troubles du comportement alimentaire (TCA), notamment l’hyperphagie boulimique et l’addiction à l’alimentation, sont fortement associés avec de possibles processus étiopathogéniques partagés. La restriction alimentaire peut induire des TCA et il est donc utile de pouvoir dépister les sujets obèses les...
Article
Background & aims: The presence of specific fructose transporters and fructose metabolizing enzymes has now been demonstrated in the skeletal muscle, brain, heart, adipose tissue and many other tissues. This suggests that fructose may be directly metabolized and play physiological or pathophysiological roles in extra-splanchnic tissues. Yet, the p...
Article
Background Overweight and obesity are major worldwide health concerns characterized by an abnormal accumulation of fat in adipose tissue (AT) and liver. Purpose To evaluate the volume and the fatty acid (FA) composition of the subcutaneous adipose tissue (SAT) and the visceral adipose tissue (VAT) and the fat content in the liver from 3D chemical‐...
Article
Context Iron overload has been associated with greater adipose tissue (AT) depots. We retrospectively studied the potential interactions between iron and AT during an experimental overfeeding in non-obese subjects. METHODS 26 subjects (BMI=24.7±3.1 kg/m²) underwent a 56-days overfeeding (+760 kcal/d). Serum iron biomarkers (ELISA), subcutaneous AT...
Article
Full-text available
An exploratory study was performed on eight healthy volunteers to assess how short-term changes in energy balance and dietary carbohydrate content impact breath acetone concentrations. Participants were studied on three occasions: on each occasion, they remained fasted and in resting conditions during the first 2 h to assess basal breath acetone an...
Article
Over the past decades, the daily consumption of fructose has drastically increased, associated with profound changes in our eating habits. The increased use of added sugars in a wide range of industrial products, as well as increased sugar-sweetened beverage consumption, have largely contributed to this phenomenon. In parallel with changes in energ...
Conference Paper
Full abstract available online at: http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4725.html
Article
Full-text available
Whether non-nutritive sweetener (NNS) consumption impacts food intake behavior in humans is still unclear. Discrepant sensory and metabolic signals are proposed to mislead brain regulatory centers, in turn promoting maladaptive food choices favoring weight gain. We aimed to assess whether ingestion of sucrose-and NNS-sweetened drinks would differen...
Article
Aim: Eating disorders (EDs), disordered eating (DE) and obesity are thought to have overlapping aetiological processes. DE in obesity can jeopardize weight-loss results, and acyl ghrelin (AG) is a hormone that stimulates food intake and reward processes. The main study objective was to determine whether higher-than-expected concentrations of AG in...
Poster
Full-text available
Introduction et but de l’étude: L’obésité et les troubles du comportement alimentaire (TCA), notamment l’hyperphagie boulimique et l’addiction à l’alimentation, sont fortement associés avec de possibles processus étiopathogéniques partagés. La restriction alimentaire peut induire des TCA et il est donc utile de pouvoir dépister les sujets obèses le...
Article
Purpose of review: The current article presents recent findings on the metabolic effects of fructose. Recent findings: Fructose has always been considered as a simple 'caloric' hexose only metabolized by splanchnic tissues. Nevertheless, there is growing evidence that fructose acts as a second messenger and induces effects throughout the human b...
Article
Full-text available
Recent findings have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to understanding their role in these pathologies. Through combinations of both animal and human intervention studies, we comprehensively investigated all possible contributions of these fatt...
Article
The authors are grateful to the Medical Research Council for core funding (Lipid Profiling and Signalling programme grant; number UD99999906, Cambridge Lipidomics Biomarker Research Initiative; grant G0800783, MRC Human Nutrition Research PhD programme). Grant GAČR: GA15–09518S and grant Czech Science Foundation GACR: 16-06326S funded part of the g...
Article
Introduction et but de l’étude: Les études de suralimentation expérimentale ont pour but de simuler les phases initiales de prise de poids et d’en regarder les conséquences métaboliques. Il faut cependant s’intéresser de façon globale à la balance énergétique et en observer les conséquences sur l’activité physique (AP) et la sédentarité. Des études...
Article
Scope: The aim of the study was to assess the effects of a high-fructose diet on skeletal muscle transcriptomic response in healthy offspring of patients with type 2 diabetes, a subgroup of individuals prone to metabolic disorders. Methods and results: Ten healthy normal weight first-degree relatives of type 2 diabetic patients were submitted to...
Article
Full-text available
Introduction L'utilisation croissante de sucres ajoutés dans les aliments transformés a contribué, ces dernières décennies, à fortement augmenter la consommation quotidienne de fructose. Il a bien été démontré chez l'animal et chez l'Homme qu'une surconsommation de fructose induit une lipogenèse et une insulino-résistance hépatique. Néanmoins peu d...
Article
Full-text available
La prise alimentaire est finement régulée chez l’homme pour assurer le maintien de l’homéostasie énergétique. L’hypothalamus joue un rôle clé dans cette régulation. Le noyau arqué hypothalamique comprend deux populations neuronales d’intérêt dans cette régulation : les neurones à NPY/AgRP de la voie de la faim et les neurones à POMC/ CART de la voi...
Thesis
Full-text available
Nous avons étudié les mécanismes adaptatifs induits par une surnutrition hyperlipidique (+757 kcal/j) de 56 jours sur le métabolisme énergétique et le muscle squelettique chez des sujets sains. En parallèle, nous avons étudié les mécanismes adaptatifs induits par une surnutrition en fructose de 7 jours sur le métabolisme énergétique et le muscle sq...
Article
Full-text available
Background/objectives: Plasma ghrelin secretion over time in humans is characterized by pre-prandial increases and by post-prandial decreases all day long. However, some authors who measured ghrelin concentrations around meals showed a rise in plasma ghrelin concentration after meal initiation followed by the typical post-prandial decrease. In ord...
Article
Full-text available
Context/objective: The aim of this study was to evaluate the regulation of the fuel partitioning and energy metabolism in skeletal muscle during lipid overfeeding in healthy men. Design/Participants/Intervention: Thirty-nine healthy volunteers were overfed for 56 days with a high-fat diet (3180 kJ/d). Energy metabolism (indirect calorimetry) was c...
Article
Full-text available
BACKGROUND/OBJECTIVES: Plasma ghrelin secretion over time in humans is characterized by pre-prandial increases and by post-prandial decreases all day long. However, some authors who measured ghrelin concentrations around meals showed a rise in plasma ghrelin concentration after meal initiation followed by the typical post-prandial decrease. In orde...
Article
Full-text available
Bien que le tissu adipeux ait été longtemps considéré comme un simple tissu de stockage des lipides, il est maintenant reconnu comme un organe hétérogène et complexe tant au niveau cellulaire, tissulaire qu’au niveau de l’organisme. De sa localisation, sa couleur et son environnement dépendent ses diverses fonctions. Le tissu adipeux brun produit d...

Questions

Question (1)
Question
Indeed we found in a recent study (doi: 10.1038/ejcn.2015.181), an increase in plasma acyl-ghrelin ten minutes after meal initiation and i'm wondering the physiological meaning of this observation. I would like to have your opinion about this feature.

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