Kevin Nathanael Ramanto

Indonesia International Institute for Life Sciences · Department of Bioinformatics

Breast cancer remains a significant concern worldwide, with a rising incidence in Indonesia. This study aims to evaluate the applicability of risk-based screening approaches in the Indonesian demographic through a case-control study involving 305 women. We developed a personalized breast cancer risk assessment workflow that integrates multiple risk...

Background: Previous studies showed that high expression of the Trop-2 gene, TACSTD2, is associated with higher cyclin D1 levels, lymph node and distant organ metastases in breast cancer. It would be interesting to investigate the interacting microRNAs and co-expressing genes with TACSTD2 in recurrent luminal A breast tumors. Material and methods:...

Background: Previous studies showed that high expression of the Trop-2 gene, TACSTD2, is associated with higher cyclin D1 levels, lymph node and distant organ metastases in breast cancer. It would be interesting to investigate the interacting microRNAs and co-expressing genes with TACSTD2 in recurrent luminal A breast tumors. Material and methods:...

The development of the anti-malaria vaccine holds a promising future in malaria control. One of the anti-malaria vaccine strategies known as the transmission-blocking vaccine (TBV) is to inhibit the parasite transmission between humans and mosquitoes by targeting the parasite gametocyte. Previously, we found that P48/45 included in the 6-Cysteine p...

Vaccine based strategies offer a promising future in malaria control by generating protective immunity against natural infection. However, vaccine development is hindered by the Plasmodium sp. genetic diversity. Previously, we have shown P41 protein from 6-Cysteine shared by Plasmodium sp. and could be used for cross-species anti-malaria vaccines....

miRNA has recently emerged as a potential biomarker for breast cancer. Even though many studies have identified ethnic variation affecting miRNA regulation, the effect of cancer stage within specific ethnicities on miRNA epigenetic remains unclear. The present study is designed to investigate miRNA regulation from two distinct ethnicities in specif...

The results showed that the strongest negative correlation was peaked at-0.595 (p-value < 0.001); the miRNA and gene interaction was found between miR-1307 and CBX7. Then, transcriptomic validation result also supported the correlation. Furthermore, the result of miR-1307-CBX7 pair is also identified in the previous study through literature review....

Iron is essential to fulfilling an indispensable role in the biological process in human physiology. Various proteins were known involved in iron metabolism. One of the proteins called iron-responsive element-binding protein (IRP) which acts as a master iron of cellular iron homeostasis. There are two IRP known to date, which is: IRP1 and IRP2. Pre...

Malaria is an endemic disease caused by Plasmodium parasite with female Anopheles mosquitoes as a vector. With the increase of drug resistance Plasmodium emerging around the world, a new method should be devised against the spread of Plasmodium sp lineage. Protein evolution of Plasmodium sp. can be an invaluable aid as an input for rational drug de...

The increase of current antimalarial drug resistance was reported and lead to the greatest threats to malaria control; therefore, new methods should be applied to encounter this problem. Although the protein evolution study of Plasmodium may contain valuable information in finding a new antimalarial drug candidate, the cross-species antimalaria dru...

Prostate cancer has the second highest death rate second only to lung cancer. Mutation in a single gene does not cause prostate cancer. Instead, many different genes are responsible, including NAT1 and NAT2 gene. By finding microRNAs that can suppress NAT1 and NAT2 gene, a novel prostate cancer treatment can be developed. Prostate cancer is also mo...

Human Epidermal growth Receptor 2 (HER2) plays an essential role in the pathogenesis of breast cancer. Previous studies have shown that HER 2 overexpression is associated with a higher histological tumor grade. Furthermore, the overexpression of HER 2 is associated with miRNAs expression. However, the interaction of HER2 and miRNAs in each stage of...

Diagnosis is a crucial step to identify the disease that experienced by the patient. Diagnosis includes information gathering, integration, and interpretation. However, diagnosis process is not an easy task. Diagnostic accuracy is depending on the experience and cognitive ability of diagnosticians. The new algorithm called deep learning that is dev...