Kevin D. Donohue

Kevin D. Donohue
University of Kentucky | UKY · Department of Electrical and Computer Engineering

Ph.D. Electrical Engineering, Illinois Institute of Technology, Chicago, Illinois, December 1987

About

152
Publications
15,950
Reads
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2,078
Citations
Introduction
My research contributes to the general area of signal processing with applications in medical imaging, biomedical signal analysis, non-destructive evaluation, radar, and audio systems. Current research interests include distributed audio systems, auditory scene analysis, vocal fold imaging/characterization, and novel sensor systems for tracking animal behavior. I co-founded Signal Solutions, LLC, ( http://sigsoln.com/ )which designs and sells sensor systems for tracking of animal behavior.
Additional affiliations
January 1991 - present
University of Kentucky
Description
  • My research work has contributed to the general area of signal processing systems with applications in medical imaging, biomedical signal analysis, non-destructive evaluation, radar detection, and audio sensor networks .
September 1988 - May 1991
Drexel University
Description
  • Focused on ultrasonic imaging for medical and industrial applications, and radar signal processing.
August 1985 - December 1987
Illinois Institute of Technology
Description
  • Focused on radar and ultrasonic signal processing. Introduced a method of analyzing and designing order statistics filters based on classical signal characterizations.
Education
August 1985 - December 1987
Illinois Institute of Technology
Field of study
  • Electrical Engineering

Publications

Publications (152)
Poster
Full-text available
South Eastern Conference (SEC) of Agrology practitioners conference on AI held at Auburn University from March 9 - 11, 2022
Article
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Codling moth (CM) (Cydia pomonella L.), a devastating pest, creates a serious issue for apple production and marketing in apple-producing countries. Therefore, effective nondestructive early detection of external and internal defects in CM-infested apples could remarkably prevent postharvest losses and improve the quality of the final product. In t...
Article
Full-text available
Abstract: Codling moth (CM) (Cydia pomonella L.), a devastating pest, creates a serious issue for apple production and marketing in apple-producing countries. Therefore, effective nondestructive early detection of external and internal defects in CM-infested apples could remarkably prevent postharvest losses and improve the quality of the final pro...
Article
Codling moth (CM) is the most devastating global pest of apples with a huge potential impact on the post-harvest quality and yield of the product. Due to the small size of its larvae and potentially hidden behavior, simple visual inspection is ill-suited for accurate infestation detection. The characteristic vibro-acoustic signals of multiple behav...
Article
Full-text available
Dairy cows that are restricted from lying down have a reduced ability to sleep. In other species, sleep loss is a key risk factor for disease, mediated by changes in metabolic and inflammatory responses. The cumulative effect of lying and sleep deprivation on cow health is unknown. The objective was to determine the effects of lying and sleep depri...
Chapter
It is sometimes necessary to locate the source of machinery-induced vibrations in buildings when the generated vibration exceeds the acceptable limits. The objective of this study is to localize stationary source of vibration using floor vibration measurements with the steered response power (SRP) method. While this method has been used in micropho...
Article
Full-text available
In the U.S., opioid prescription for treatment of pain nearly quadrupled from 1999 to 2014. The diversion and misuse of prescription opioids along with increased use of drugs like heroin and fentanyl, has led to an epidemic in addiction and overdose deaths. The most common cause of opioid overdose and death is opioid-induced respiratory depression...
Article
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In the last two decades, food scientists have attempted to develop new technologies that can improve the detection of insect infestation in fruits and vegetables under postharvest conditions using a multitude of non-destructive technologies. While consumers’ expectations for higher nutritive and sensorial value of fresh produce has increased over t...
Preprint
Full-text available
In the U.S., opioid prescription for treatment of pain nearly quadrupled from 1999 to 2014, leading to an epidemic in addiction and overdose deaths. The most common cause of opioid overdose and death is opioid-induced respiratory depression (OIRD), a life-threatening depression in respiratory rate thought to be caused by stimulation of opioid recep...
Article
Full-text available
Host genetic diversity provides a variable selection environment and physiological context for microbiota and their interaction with host physiology. Using a highly diverse mouse population, Bubier et al. identified that Odoribacter abundance influences sleep archi-tecture in a manner... The microbiome influences health and disease through complex...
Article
The objective of this study was to describe the effect of penetrating or non-penetrating captive bolt using an occipital approach in 4–5 month old, Holstein steers weighing between 100–200 kg. Twelve calves were divided into two treatment groups; penetrating captive bolt (PCB; n = 6) and non-penetrating captive bolt (NPCB; n = 6). This sample size...
Article
Full-text available
The objective was to determine the effects of sleep or lying deprivation on the behavior of dairy cows. Data were collected from 8 multi- and 4 primiparous cows (DIM = 199 ± 44 (mean ± SD); days pregnant = 77 ± 30). Using a crossover design, each cow experienced: 1) sleep deprivation implemented by noise or physical contact when their posture sugge...
Preprint
Full-text available
The objective was to determine the effects of sleep or lying deprivation on the behavior of dairy cows. Data were collected from 8 multi- and 4 primiparous cows (DIM = 199 ± 44 (mean ± SD); days pregnant = 77 ± 30). Using a crossover design, each cow experienced: 1) sleep deprivation implemented by noise or physical contact when their posture sugge...
Preprint
Full-text available
Sleep is a critical process that is well-conserved across mammalian species, and perhaps most animals, yet its functions and underlying mechanisms remain poorly understood. Identification of genes and pathways that can influence sleep may shed new light on these functions. Genomic screens enable the detection of previously unsuspected molecular pro...
Preprint
Full-text available
Background: Assessment of sleep/wake by electroencephalography (EEG) and electromyography (EMG) is invasive, resource intensive, and not amenable to rapid screening at scale for drug discovery. In the preclinical development of therapeutics for narcolepsy, efficacy tests are hindered by the lack of a non-EEG/EMG based translational test of symptom...
Preprint
Full-text available
The role of the microbiome in health and disease involves complex networks of host genetics, genomics, microbes and environment. Identifying the mechanisms of these interactions has remained challenging. Systems genetics in the laboratory mouse enables data-driven discovery of network components and mechanisms of host-microbial interactions underly...
Article
Full-text available
Introduction Assessment of sleep states in rodents by EEG and EMG requires significant resources, limiting sleep research, especially when the study requires many animals. While sleep in mammals is typically defined by brain state, it also affects other physiological states including breathing and other movements which can be measured noninvasively...
Article
Full-text available
Introduction The role of REM sleep in normal physiological function and health is widely studied, most commonly by selectively interrupting it when it occurs. Many protocols developed for experimental REM sleep restriction (RSR) are stressful to the animal or modify its normal behavior. To address these limitations, we have developed an automated s...
Article
Full-text available
Limited research has been conducted to assess sleep in production livestock primarily because of limitations with monitoring capabilities. Consequently, biological understanding of production circumstances and facility options that affect sleep is limited. The objective of this study was to assess if data collected from a proof-of-concept, noninvas...
Conference Paper
Many methods for sleep restriction in rodents have emerged, but most are intrusive, lack fine control, and induce stress. Therefore, a versatile, non-intrusive means of sleep restriction that can alter sleep in a controlled manner could be of great value in sleep research. In previous work, we proposed a novel system for closed-loop somatosensory s...
Article
Full-text available
The goal of this study is to quantify the effects of vocal fold nodules on vibratory motion in children using high-speed videoendoscopy. Differences in vibratory motion were evaluated in 20 children with vocal fold nodules (5-11 years) and 20 age and gender matched typically developing children (5-11 years) during sustained phonation at typical pit...
Article
Background: Changes in autonomic control cause regular breathing during NREM sleep to fluctuate during REM. Piezoelectric cage-floor sensors have been used to successfully discriminate sleep and wake states in mice based on signal features related to respiration and other movements. This study presents a classifier for noninvasively classifying RE...
Patent
Monitoring behavior of a rodent within a cage includes applying a vibration stimulus to a component of the cage and after applying the vibration stimulus, sensing a signal from a piezoelectric sensor within the cage, the sensed signal indicative of a behavioral response of the rodent.
Conference Paper
Full-text available
Conclusion A piezoelectric (piezo) sensor laid on the floor of the mouse cage generates an electrical voltage in response to applied pressure. This signal can be used to categorize the animal's behavior and can pick up subtle movements including that associated with thoracic respiratory patterns, especially when the animal is relatively quiet. With...
Research
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This research was presented at American Epilepsy Society 67th Annual Meeting, Washington, DC, Dec 2013.
Research
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This research was presented at American Epilepsy Society 68th Annual Meeting, Seattle, WA, Dec 2014.
Research
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This research was presented at two professional meeting in 2012: 1) Society for Neuroscience, 42th Annual Meeting, New Orleans, LA 2) Neural Interfaces Conference, 40th Annual Meeting, Salt lake City, UT
Research
Full-text available
This research was presented at Society for Neuroscience, 41th Annual Meeting, Washington, DC, Oct 2011.
Article
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This paper presents a quantitative method for assessing instantaneous and average lateral vocal fold motion from high-speed digital imaging, with a focus on developmental changes in vocal-fold kinematics during childhood. Vocal-fold vibrations were analyzed for 28 children (5-11 years) and 28 adults (21-45 years) without voice disorders. The follow...
Article
Full-text available
Sleep perturbations including fragmented sleep with frequent night-time awakenings and daytime naps are common in patients with Alzheimer's disease (AD), and these daily disruptions are a major factor for institutionalization. The objective of this study was to investigate if sleep-wake patterns are altered in 5XFAD mice, a well-characterized doubl...
Conference Paper
Full-text available
Experimental manipulation of sleep in rodents is an important tool for analyzing the mechanisms of sleep and related disorders in humans. Sleep restriction systems have relied in the past on manual sensory stimulation and recently on more sophisticated automated means of delivering the same. The ability to monitor and track behavior through the ele...
Article
Study objectives: Traditionally, sleep studies in mammals are performed using electroencephalogram/electromyogram (EEG/EMG) recordings to determine sleep-wake state. In laboratory animals, this requires surgery and recovery time and causes discomfort to the animal. In this study, we evaluated the performance of an alternative, noninvasive approach...
Conference Paper
Experimental manipulation of sleep in rodents is an important tool for analyzing the mechanisms of sleep and related disorders in humans. Sleep restriction systems have relied in the past on manual sensory stimulation and recently on more sophisticated automated means of delivering the same. The ability to monitor and track behavior through the ele...
Conference Paper
Full-text available
Abstract Text: Lack of sleep in dairy cattle may indicate shortcomings in housing, environment, or increased physiological disturbances. Little research has been conducted to assess sleep in production livestock, primarily because of limitations with monitoring abilities. Consequently, biological understanding of the production circumstances and...
Conference Paper
Distributed microphone systems can be used to enhance intelligibility for a speaker of interest (SOI) in a noisy environment of multiple speech sources (cocktail party scenario). For finite microphone distributions, however, interfering speech sources leak into the beamformed signal and degrade intelligibility. This article introduces an auditory i...
Conference Paper
Efficient sound source detection and location with microphone arrays is important for many applications, including teleconferencing, surveillance, and smart rooms. While the steered response power algorithms exhibit robust performance relative to other approaches, their applications are limited by the high computational load required. For dynamic a...
Article
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Clinical observations report excessive sleepiness immediately following traumatic brain injury (TBI); however, there is a lack of experimental evidence to support or refute the benefit of sleep following a brain injury. The aim of this study is to investigate acute post-traumatic sleep. Sham, mild or moderate diffuse TBI was induced by midline flui...
Conference Paper
Full-text available
Acute brain injury can disrupt normal sleep and diurnal rhythms. The ability to track changes in the microstructure of sleep in the post-traumatic period could help assess the efficacy of intervention and perhaps offer clues about the likelihood of epileptogenesis. Convenient metrics that track sleep-wake dynamics over time—beyond simplistic measur...
Article
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Complex relationships between array gain patterns and microphone distributions limit the application of optimization algorithms on irregular arrays. This paper proposes a Genetic Algorithm (GA) for microphone array optimization in immersive (near-field) environments. Geometric descriptors for irregular arrays are proposed for use as objective funct...
Article
A system and method for rendering a virtual sound source using a plurality of speakers in an arbitrary arrangement includes expanding a wave field of the virtual sound source and a composite wave field generated by the plurality of speakers into multi-pole expansions, and equating the multi-pole expansions to each other to form a continuous equatio...
Article
The aim of the study was to present the development of a miniature structured light laser projection endoscope and to quantify vocal fold length and vibratory features related to impact stress of the pediatric glottis using high-speed imaging. The custom-developed laser projection system consists of a green laser with a 4-mm diameter optics module...
Patent
Full-text available
A system and method for rendering a virtual sound source using a plurality of speakers in an arbitrary arrangement includes expanding a wave field of the virtual sound source and a composite wave field generated by the plurality of speakers into multi-pole expansions, and equating the multi-pole expansions to each other to form a continuous equatio...
Article
Full-text available
Performance analysis for microphone arrays with irregular geometries typically requires direct computation of beamforming gains over the spatial and frequency ranges of interest. However, theses computations can be very consuming and limit synthesis methods for applications that require rapid answers, as in the case of surveillance and mobile platf...
Article
We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated cohorts 2-3 weeks after complete high thoracic (T4) spinal cord injury (SCI). Here we employed long-...
Article
Full-text available
Objective To clinically evaluate changes in vocal fold vibration and voice production caused by voice therapy in hoarseness resulting from contact granuloma. Design Single-subject before-after prospective study using multiple measures of vocal function. A 6-week program of vocal function exercises (VFEs) was conducted using multiple assessments of...
Article
Full-text available
The aim of the study is to characterize normal vibratory patterns of both glottal closure and phase closure in the pediatric population with the use of high speed digital imaging. For this prospective study a total of 56 pre-pubertal children, 5-11 years (boys=28, girls=28) and 56 adults, 21-45 years (males=28, females=28) without known voice probl...
Conference Paper
The quantitative characterization of vocal fold (VF) motion can greatly enhance the diagnosis and treatment of speech pathologies. The recent availability of high-speed systems has created new opportunities to understand VF dynamics. This paper presents quantitative methods for analyzing VF dynamics with high-speed digital phonoscopy, with a focu...
Article
The aim of the study was to present the development of a miniature laser projection endoscope and to quantify vocal fold length and vibratory amplitude of the pediatric glottis using high-speed digital imaging coupled with the laser endoscope. For this prospective study, absolute measurement of entire vocal fold length, membranous length of the voc...
Conference Paper
This research compares 2 estimation methods of parameters critical for acoustic simulation and microphone array applications. In particular, sound speed and attenuation were estimated directly with actual microphone and speaker arrangements and indirectly based measurement of temperature, humidity and air pressure. It is more practical to measure t...
Conference Paper
The complex relationship between irregular microphone distributions and its spatial gain hinders the efficient use of beamforming in various applications. This paper examines beamformer performance based on statistical descriptions of microphone geometries. In particular, array centroid, dispersion, and entropy based statistics are used to characte...
Article
Full-text available
Genetic reference populations in model organisms are critical resources for systems genetic analysis of disease related phenotypes. The breeding history of these inbred panels may influence detectable allelic and phenotypic diversity. The existing panel of common inbred strains reflects historical selection biases, and existing recombinant inbred p...
Article
Full-text available
Applications related to distributed microphone systems are typically initiated with sound source detection. This paper introduces a novel method for the automatic detection of sound sources in images created with steered response power (SRP) algorithms. The method exploits the near-symmetric coherent power noise distribution to estimate constant fa...
Article
One approach for reducing noise from non-target locations in array beamformer applications is to use an adaptive noise cancellation algorithm referred to as the Generalized Sidelobe Canceller (GSC). An analysis is performed to derive a closed-form expression showing the relationship between stability, the number of array channels, adaptive step siz...
Conference Paper
The speech of a person speaking in a noisy environment can be enhanced through electronic beamforming with spatially distributed microphones. The need to precisely determine microphone locations, however, can limit the application of this approach, especially where microphones must be placed quickly or changed on a regular basis. A precise calibrat...