Kevin Devine

Kevin Devine
London Metropolitan University · School of Human Sciences

About

15
Publications
2,801
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983
Citations
Additional affiliations
December 2006 - December 2007
University College Dublin
Position
  • PostDoc Position
January 1997 - September 2000
University of Florida
Position
  • PostDoc Position

Publications

Publications (15)
Article
Full-text available
Traces of life are nearly ubiquitous on Earth. However, a central unresolved question is whether these traces always indicate an active microbial community or whether, in extreme environments, such as hyperarid deserts, they instead reflect just dormant or dead cells. Although microbial biomass and diversity decrease with increasing aridity in the...
Article
We have recently developed a novel and efficient method for synthesising Erlenmeyer azlactones under mild and rapid conditions. The reaction is performed by reacting 2-phenyl-5-oxazolone with an aldehyde in dichloromethane using alumina as a catalyst. The materials react instantly at room temperature, negating the need for high temperatures and lon...
Article
Standard nucleobases all present electron density as an unshared pair of electrons to the minor groove of the double helix. Many heterocycles supporting artificial genetic systems lack this electron pair. To determine how different DNA polymerases use the pair as a substrate specificity determinant, three Family A polymerases, three Family B polyme...
Article
Full-text available
GC-MS on the Viking 1976 Mars missions did not detect organic molecules on the Martian surface, even those expected from meteorite bombardment. This result suggested that the Martian regolith might hold a potent oxidant that converts all organic molecules to carbon dioxide rapidly relative to the rate at which they arrive. This conclusion is influe...
Article
Novel aryl phosphate derivatives of the anti-HIV nucleoside analogue AZT have been prepared by phosphorochloridate chemistry. These materials are designed to act as membrane-soluble pro-drugs of the bio-active free nucleotides. In vitro evaluation revealed the compounds to have a pronounced, selective antiviral activity, which, in one case, was mor...
Article
Full-text available
A number of zidovudine phosphoramidate and phosphorodiamidate derivatives were prepared, including some previously unreported benzyl esterified amino acyl compounds. These were found to be active in vitro against the human immunodeficiency virus (HIV-1), and were tested subsequently in the S+L-tissue culture assay against urethane leukaemia virus (...
Article
Phosphate, phosphoramidate, and phosphorodiamidate derivatives of the anti-HIV nucleoside analogue FdT were prepared as potential pro-drugs of the bio-active free nucleotide. Two synthetic routes were adopted. The anti-viral activity of the derivatives varies greatly with the phosphate structure, but several are active below 1μM.
Article
Phosphate triester derivatives of AZT have been prepared as membrane-soluble pro-drugs of the bio-active nucleotides, and have been evaluated against HIV-1 in vitro. In particular, the phosphorus centre carries a trichloro- or trifluoroethyl group and a carboxyl-protected, amino-linked amino acid. The compounds are prepared using phosphorochloridat...
Article
A series of phosphoramidate derivatives of the anti-HIV drug AZT has been prepared as membrane soluble pro-drugs of the bio-active nucleotide forms and evaluated in vitro against HIV-1. Terminal substituted alkyl amines have a pronounced anti-HIV effect: this effect declines upon increasing the length of the methylene spacer. The results are consis...
Article
Full-text available
A series of monophosphate triester derivatives of 3′-azido-3′-deoxythymidine (AZT), designed as membrane-soluble pro-drugs of the nucleotide (AZTMP), have been tested for activity against the human immunodeficiency virus (HIV-1). It has been found that when carboxyl-protected, amino-linked amino acids, and alkyl chains, are asymmetrically substitut...
Article
The sulfonic acid derivatives (I) are employed as reagents in the synthesis of the nucleotides (IV) from (II) and (III).
Article
4,6-Dinitro-1-(mesitylene-2-sulphonyloxy)-benzotriazole [DMBT, ()], 1-(mesitylene-2-sulphonyloxy)-4-nitro-6-trifluoromethylbenzotriazole () and 1-(mesitylene-2-sulphonyl)-4-nitro-1,2,3-triazole [iso-MSNT, ()1 are more reactive condensing agents in the phosphotriester approach to oligonucleotide synthesis than 1-(mesitylene-2-sulphonyl)-3-nitro-1,2,...

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